Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acetylcholinesterase (Homo sapiens (Human)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 6.90 | -46.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM24710 (6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | 49 | -41.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM24709 (6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | 490 | -35.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM24710 (6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | 5.80E+3 | -29.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM24709 (6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | 1.71E+4 | -26.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM24710 (6-chloro-2-methoxyacridin-9-amine | 9-Amino-6-Chlo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | >1.00E+5 | >-22.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | >1.00E+5 | >-22.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Liver carboxylesterase 1 (Homo sapiens (Human)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | >1.00E+5 | >-22.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Coagulation factor XII (Homo sapiens (Human)) | BDBM24709 (6,9-Diamino-2-Ethoxyacridine | 7-ethoxyacridine-3,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents | Article PubMed | >1.00E+5 | >-22.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
University of North Carolina at Chapel Hill | Assay Description Inhibition constants were calculated by assessment of the reduction in the formation of o-nitrophenol, as monitored by a spectrophotometric assay at ... | Chem Biol 10: 341-9 (2003) Article DOI: 10.1016/s1074-5521(03)00071-1 BindingDB Entry DOI: 10.7270/Q2N014T9 | |||||||||||
More data for this Ligand-Target Pair |