Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus) | BDBM25191 (4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | 20 | -43.5 | 59 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GSK | Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM25980 (BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | 240 | -37.4 | 1.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM25191 (4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents | DrugBank MMDB PDB Article PubMed | 400 | -36.2 | 2.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM25981 (BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | DrugBank MMDB PDB Article PubMed | 480 | -35.7 | 3.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM25979 (BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 1.60E+3 | -32.7 | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus) | BDBM25979 (BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80E+3 | -31.4 | 8.40E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GSK | Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 10 (Homo sapiens (Human)) | BDBM25981 (BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | >4.00E+3 | >-30.5 | >1.60E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 10 (Homo sapiens (Human)) | BDBM25980 (BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | >4.00E+3 | >-30.5 | >1.60E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 10 (Homo sapiens (Human)) | BDBM25191 (4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | >4.00E+3 | >-30.5 | >1.60E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 10 (Homo sapiens (Human)) | BDBM25979 (BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | >4.00E+3 | >-30.5 | >1.60E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GSK | Assay Description Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus) | BDBM25980 (BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | >5.40E+3 | >-29.8 | >1.60E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GSK | Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus) | BDBM25981 (BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | >5.40E+3 | >-29.8 | >1.60E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GSK | Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin... | Bioorg Med Chem Lett 18: 318-23 (2008) Article DOI: 10.1016/j.bmcl.2007.10.076 BindingDB Entry DOI: 10.7270/Q2KP80G3 | |||||||||||
More data for this Ligand-Target Pair |