Compile Data Set for Download or QSAR

Found 129 hits Enz. Inhib. hit(s) with all data for entry = 2959   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26381 (1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cc(F)cc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H29F4N7O2/c1-19-3-4-24(38-28(43)20-13-21(31(33,34)35)15-22(32)14-20)16-27(19)29(44)39-25-17-36-30(37-18-25)40-23-5-7-26(8-6-23)42-11-9-41(2)10-12-42/h3-8,13-18H,9-12H2,1-2H3,(H,38,43)(H,39,44)(H,36,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26367 (Aminoquinazoline amide, 35 | N-[3-(2-aminoquinazol...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C23H17F3N4O/c1-13-5-7-18(29-21(31)15-3-2-4-17(10-15)23(24,25)26)11-19(13)14-6-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26366 (4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(ccc3C)C(=O)Nc3cccc(c3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C31H30F3N7O2/c1-20-6-7-21(28(42)37-24-5-3-4-22(17-24)31(32,33)34)16-27(20)29(43)38-25-18-35-30(36-19-25)39-23-8-10-26(11-9-23)41-14-12-40(2)13-15-41/h3-11,16-19H,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26369 (4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H30F3N7O2/c1-20-6-7-24(37-28(42)21-4-3-5-22(16-21)31(32,33)34)17-27(20)29(43)38-25-18-35-30(36-19-25)39-23-8-10-26(11-9-23)41-14-12-40(2)13-15-41/h3-11,16-19H,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26372 (2-methyl-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]a...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)Nc4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H31F3N8O2/c1-20-6-7-24(40-30(44)39-23-5-3-4-21(16-23)31(32,33)34)17-27(20)28(43)37-25-18-35-29(36-19-25)38-22-8-10-26(11-9-22)42-14-12-41(2)13-15-42/h3-11,16-19H,12-15H2,1-2H3,(H,37,43)(H,35,36,38)(H2,39,40,44)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26382 (4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4C)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C32H32F3N7O2/c1-20-7-8-23(38-29(43)26-5-4-6-28(21(26)2)32(33,34)35)17-27(20)30(44)39-24-18-36-31(37-19-24)40-22-9-11-25(12-10-22)42-15-13-41(3)14-16-42/h4-12,17-19H,13-16H2,1-3H3,(H,38,43)(H,39,44)(H,36,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26379 (1-N-benzene-4-methyl-3-N-(2-{[4-(4-methylpiperazin...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccccc4)ccc3C)cn2)cc1 Show InChI InChI=1S/C30H31N7O2/c1-21-8-9-24(33-28(38)22-6-4-3-5-7-22)18-27(21)29(39)34-25-19-31-30(32-20-25)35-23-10-12-26(13-11-23)37-16-14-36(2)15-17-37/h3-13,18-20H,14-17H2,1-2H3,(H,33,38)(H,34,39)(H,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26367 (Aminoquinazoline amide, 35 | N-[3-(2-aminoquinazol...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C23H17F3N4O/c1-13-5-7-18(29-21(31)15-3-2-4-17(10-15)23(24,25)26)11-19(13)14-6-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26383 (2,2-difluoro-N-{4-methyl-3-[(2-{[4-(4-methylpipera...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H29F2N7O4/c1-19-3-5-22(36-28(41)20-4-10-26-27(15-20)44-31(32,33)43-26)16-25(19)29(42)37-23-17-34-30(35-18-23)38-21-6-8-24(9-7-21)40-13-11-39(2)12-14-40/h3-10,15-18H,11-14H2,1-2H3,(H,36,41)(H,37,42)(H,34,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26385 (1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...) Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26384 (1-N-(4-tert-butylbenzene)-4-methyl-3-N-(2-{[4-(4-m...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc(cc4)C(C)(C)C)ccc3C)cn2)cc1 Show InChI InChI=1S/C34H39N7O2/c1-23-6-11-27(37-31(42)24-7-9-25(10-8-24)34(2,3)4)20-30(23)32(43)38-28-21-35-33(36-22-28)39-26-12-14-29(15-13-26)41-18-16-40(5)17-19-41/h6-15,20-22H,16-19H2,1-5H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26386 (Aminopyrimidine amide, 32 | N-{4-chloro-3-[(2-{[4-...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3Cl)cn2)cc1 Show InChI InChI=1S/C30H26ClF2N7O4/c1-39-10-12-40(13-11-39)22-6-3-19(4-7-22)38-29-34-16-21(17-35-29)37-28(42)23-15-20(5-8-24(23)31)36-27(41)18-2-9-25-26(14-18)44-30(32,33)43-25/h2-9,14-17H,10-13H2,1H3,(H,36,41)(H,37,42)(H,34,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26372 (2-methyl-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]a...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)Nc4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H31F3N8O2/c1-20-6-7-24(40-30(44)39-23-5-3-4-21(16-23)31(32,33)34)17-27(20)28(43)37-25-18-35-29(36-19-25)38-22-8-10-26(11-9-22)42-14-12-41(2)13-15-42/h3-11,16-19H,12-15H2,1-2H3,(H,37,43)(H,35,36,38)(H2,39,40,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26381 (1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cc(F)cc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H29F4N7O2/c1-19-3-4-24(38-28(43)20-13-21(31(33,34)35)15-22(32)14-20)16-27(19)29(44)39-25-17-36-30(37-18-25)40-23-5-7-26(8-6-23)42-11-9-41(2)10-12-42/h3-8,13-18H,9-12H2,1-2H3,(H,38,43)(H,39,44)(H,36,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26385 (1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...) Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26380 (1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...) Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26379 (1-N-benzene-4-methyl-3-N-(2-{[4-(4-methylpiperazin...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccccc4)ccc3C)cn2)cc1 Show InChI InChI=1S/C30H31N7O2/c1-21-8-9-24(33-28(38)22-6-4-3-5-7-22)18-27(21)29(39)34-25-19-31-30(32-20-25)35-23-10-12-26(13-11-23)37-16-14-36(2)15-17-37/h3-13,18-20H,14-17H2,1-2H3,(H,33,38)(H,34,39)(H,31,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26366 (4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(ccc3C)C(=O)Nc3cccc(c3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C31H30F3N7O2/c1-20-6-7-21(28(42)37-24-5-3-4-22(17-24)31(32,33)34)16-27(20)29(43)38-25-18-35-30(36-19-25)39-23-8-10-26(11-9-23)41-14-12-40(2)13-15-41/h3-11,16-19H,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26369 (4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H30F3N7O2/c1-20-6-7-24(37-28(42)21-4-3-5-22(16-21)31(32,33)34)17-27(20)29(43)38-25-18-35-30(36-19-25)39-23-8-10-26(11-9-23)41-14-12-40(2)13-15-41/h3-11,16-19H,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26376 (4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...) Show SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C26H27F3N6O2/c1-16-6-7-20(32-23(36)17-4-3-5-18(12-17)26(27,28)29)13-22(16)24(37)33-21-14-30-25(31-15-21)34-19-8-10-35(2)11-9-19/h3-7,12-15,19H,8-11H2,1-2H3,(H,32,36)(H,33,37)(H,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26388 (2,4-dimethyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)ph...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3c(C)ccc(NC(=O)c4cccc(c4)C(F)(F)F)c3C)cn2)cc1 Show InChI InChI=1S/C32H32F3N7O2/c1-20-7-12-27(40-29(43)22-5-4-6-23(17-22)32(33,34)35)21(2)28(20)30(44)38-25-18-36-31(37-19-25)39-24-8-10-26(11-9-24)42-15-13-41(3)14-16-42/h4-12,17-19H,13-16H2,1-3H3,(H,38,44)(H,40,43)(H,36,37,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26387 (Aminopyrimidine amide, 33 | N-{4-ethyl-3-[(2-{[4-(...) Show SMILES CCc1ccc(NC(=O)c2ccc3OC(F)(F)Oc3c2)cc1C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C32H31F2N7O4/c1-3-20-4-6-23(37-29(42)21-5-11-27-28(16-21)45-32(33,34)44-27)17-26(20)30(43)38-24-18-35-31(36-19-24)39-22-7-9-25(10-8-22)41-14-12-40(2)13-15-41/h4-11,16-19H,3,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26386 (Aminopyrimidine amide, 32 | N-{4-chloro-3-[(2-{[4-...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3Cl)cn2)cc1 Show InChI InChI=1S/C30H26ClF2N7O4/c1-39-10-12-40(13-11-39)22-6-3-19(4-7-22)38-29-34-16-21(17-35-29)37-28(42)23-15-20(5-8-24(23)31)36-27(41)18-2-9-25-26(14-18)44-30(32,33)43-25/h2-9,14-17H,10-13H2,1H3,(H,36,41)(H,37,42)(H,34,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26375 (4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1 Show InChI InChI=1S/C26H27F3N6O3/c1-17-5-6-20(33-23(36)18-3-2-4-19(13-18)26(27,28)29)14-22(17)24(37)34-21-15-31-25(32-16-21)30-7-8-35-9-11-38-12-10-35/h2-6,13-16H,7-12H2,1H3,(H,33,36)(H,34,37)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26367 (Aminoquinazoline amide, 35 | N-[3-(2-aminoquinazol...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C23H17F3N4O/c1-13-5-7-18(29-21(31)15-3-2-4-17(10-15)23(24,25)26)11-19(13)14-6-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26370 (3-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-1-[3...) Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C23H18F3N5O/c1-13-5-7-18(30-22(32)29-17-4-2-3-16(10-17)23(24,25)26)11-19(13)14-6-8-20-15(9-14)12-28-21(27)31-20/h2-12H,1H3,(H2,27,28,31)(H2,29,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26380 (1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...) Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1 Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26389 (2,6-dichloro-N-(2-{[4-(4-methylpiperazin-1-yl)phen...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3c(Cl)cccc3Cl)cn2)cc1 Show InChI InChI=1S/C22H22Cl2N6O/c1-29-9-11-30(12-10-29)17-7-5-15(6-8-17)28-22-25-13-16(14-26-22)27-21(31)20-18(23)3-2-4-19(20)24/h2-8,13-14H,9-12H2,1H3,(H,27,31)(H,25,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26374 (4-methyl-3-N-(2-{[3-(morpholin-4-yl)propyl]amino}p...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCCN2CCOCC2)nc1 Show InChI InChI=1S/C27H29F3N6O3/c1-18-6-7-21(34-24(37)19-4-2-5-20(14-19)27(28,29)30)15-23(18)25(38)35-22-16-32-26(33-17-22)31-8-3-9-36-10-12-39-13-11-36/h2,4-7,14-17H,3,8-13H2,1H3,(H,34,37)(H,35,38)(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26366 (4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(ccc3C)C(=O)Nc3cccc(c3)C(F)(F)F)cn2)cc1 Show InChI InChI=1S/C31H30F3N7O2/c1-20-6-7-21(28(42)37-24-5-3-4-22(17-24)31(32,33)34)16-27(20)29(43)38-25-18-35-30(36-19-25)39-23-8-10-26(11-9-23)41-14-12-40(2)13-15-41/h3-11,16-19H,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26383 (2,2-difluoro-N-{4-methyl-3-[(2-{[4-(4-methylpipera...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H29F2N7O4/c1-19-3-5-22(36-28(41)20-4-10-26-27(15-20)44-31(32,33)43-26)16-25(19)29(42)37-23-17-34-30(35-18-23)38-21-6-8-24(9-7-21)40-13-11-39(2)12-14-40/h3-10,15-18H,11-14H2,1-2H3,(H,36,41)(H,37,42)(H,34,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26382 (4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4C)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C32H32F3N7O2/c1-20-7-8-23(38-29(43)26-5-4-6-28(21(26)2)32(33,34)35)17-27(20)30(44)39-24-18-36-31(37-19-24)40-22-9-11-25(12-10-22)42-15-13-41(3)14-16-42/h4-12,17-19H,13-16H2,1-3H3,(H,38,43)(H,39,44)(H,36,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26386 (Aminopyrimidine amide, 32 | N-{4-chloro-3-[(2-{[4-...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3Cl)cn2)cc1 Show InChI InChI=1S/C30H26ClF2N7O4/c1-39-10-12-40(13-11-39)22-6-3-19(4-7-22)38-29-34-16-21(17-35-29)37-28(42)23-15-20(5-8-24(23)31)36-27(41)18-2-9-25-26(14-18)44-30(32,33)43-25/h2-9,14-17H,10-13H2,1H3,(H,36,41)(H,37,42)(H,34,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26368 (3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(N)nc1 Show InChI InChI=1S/C20H16F3N5O2/c1-11-5-6-14(8-16(11)18(30)28-15-9-25-19(24)26-10-15)27-17(29)12-3-2-4-13(7-12)20(21,22)23/h2-10H,1H3,(H,27,29)(H,28,30)(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26378 (5-methyl-N-{4-methyl-3-[(2-{[4-(4-methylpiperazin-...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cnoc4C)ccc3C)cn2)cc1 Show InChI InChI=1S/C28H30N8O3/c1-18-4-5-21(32-27(38)25-17-31-39-19(25)2)14-24(18)26(37)33-22-15-29-28(30-16-22)34-20-6-8-23(9-7-20)36-12-10-35(3)11-13-36/h4-9,14-17H,10-13H2,1-3H3,(H,32,38)(H,33,37)(H,29,30,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26368 (3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(N)nc1 Show InChI InChI=1S/C20H16F3N5O2/c1-11-5-6-14(8-16(11)18(30)28-15-9-25-19(24)26-10-15)27-17(29)12-3-2-4-13(7-12)20(21,22)23/h2-10H,1H3,(H,27,29)(H,28,30)(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26365 (3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...) Show SMILES Cc1ccc(cc1C(=O)Nc1cnc(N)nc1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C20H16F3N5O2/c1-11-5-6-12(7-16(11)18(30)28-15-9-25-19(24)26-10-15)17(29)27-14-4-2-3-13(8-14)20(21,22)23/h2-10H,1H3,(H,27,29)(H,28,30)(H2,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26381 (1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cc(F)cc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H29F4N7O2/c1-19-3-4-24(38-28(43)20-13-21(31(33,34)35)15-22(32)14-20)16-27(19)29(44)39-25-17-36-30(37-18-25)40-23-5-7-26(8-6-23)42-11-9-41(2)10-12-42/h3-8,13-18H,9-12H2,1-2H3,(H,38,43)(H,39,44)(H,36,37,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM14949 (2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...) Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM26367 (Aminoquinazoline amide, 35 | N-[3-(2-aminoquinazol...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C23H17F3N4O/c1-13-5-7-18(29-21(31)15-3-2-4-17(10-15)23(24,25)26)11-19(13)14-6-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26384 (1-N-(4-tert-butylbenzene)-4-methyl-3-N-(2-{[4-(4-m...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc(cc4)C(C)(C)C)ccc3C)cn2)cc1 Show InChI InChI=1S/C34H39N7O2/c1-23-6-11-27(37-31(42)24-7-9-25(10-8-24)34(2,3)4)20-30(23)32(43)38-28-21-35-33(36-22-28)39-26-12-14-29(15-13-26)41-18-16-40(5)17-19-41/h6-15,20-22H,16-19H2,1-5H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26369 (4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H30F3N7O2/c1-20-6-7-24(37-28(42)21-4-3-5-22(16-21)31(32,33)34)17-27(20)29(43)38-25-18-35-30(36-19-25)39-23-8-10-26(11-9-23)41-14-12-40(2)13-15-41/h3-11,16-19H,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26374 (4-methyl-3-N-(2-{[3-(morpholin-4-yl)propyl]amino}p...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCCN2CCOCC2)nc1 Show InChI InChI=1S/C27H29F3N6O3/c1-18-6-7-21(34-24(37)19-4-2-5-20(14-19)27(28,29)30)15-23(18)25(38)35-22-16-32-26(33-17-22)31-8-3-9-36-10-12-39-13-11-36/h2,4-7,14-17H,3,8-13H2,1H3,(H,34,37)(H,35,38)(H,31,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26370 (3-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-1-[3...) Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C23H18F3N5O/c1-13-5-7-18(30-22(32)29-17-4-2-3-16(10-17)23(24,25)26)11-19(13)14-6-8-20-15(9-14)12-28-21(27)31-20/h2-12H,1H3,(H2,27,28,31)(H2,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26384 (1-N-(4-tert-butylbenzene)-4-methyl-3-N-(2-{[4-(4-m...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc(cc4)C(C)(C)C)ccc3C)cn2)cc1 Show InChI InChI=1S/C34H39N7O2/c1-23-6-11-27(37-31(42)24-7-9-25(10-8-24)34(2,3)4)20-30(23)32(43)38-28-21-35-33(36-22-28)39-26-12-14-29(15-13-26)41-18-16-40(5)17-19-41/h6-15,20-22H,16-19H2,1-5H3,(H,37,42)(H,38,43)(H,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26372 (2-methyl-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]a...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)Nc4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1 Show InChI InChI=1S/C31H31F3N8O2/c1-20-6-7-24(40-30(44)39-23-5-3-4-21(16-23)31(32,33)34)17-27(20)28(43)37-25-18-35-29(36-19-25)38-22-8-10-26(11-9-22)42-14-12-41(2)13-15-42/h3-11,16-19H,12-15H2,1-2H3,(H,37,43)(H,35,36,38)(H2,39,40,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair

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