Compile Data Set for Download or QSAR

Found 15 hits Enz. Inhib. hit(s) with all data for entry = 50007983   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (GUINEA PIG)	BDBM22904 ((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...) Show SMILES C[C@@H](N)Cc1cnc[nH]1 |r| Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity of compound towards Histamine H3 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine radioligand				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069825 (4-Pyrrolidin-3-yl-1H-imidazole | CHEMBL79983) Show SMILES C1CC(CN1)c1cnc[nH]1 Show InChI InChI=1S/C7H11N3/c1-2-8-3-6(1)7-4-9-5-10-7/h4-6,8H,1-3H2,(H,9,10)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069816 (4-((3R,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C[C@H]1CNC[C@@H]1c1cnc[nH]1 |r| Show InChI InChI=1S/C8H13N3/c1-6-2-9-3-7(6)8-4-10-5-11-8/h4-7,9H,2-3H2,1H3,(H,10,11)/t6-,7-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069823 (4-((3S,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C[C@H]1CNC[C@H]1c1cnc[nH]1 Show InChI InChI=1S/C8H13N3/c1-6-2-9-3-7(6)8-4-10-5-11-8/h4-7,9H,2-3H2,1H3,(H,10,11)/t6-,7+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50034708 (4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C[C@H]1NCC[C@@H]1c1cnc[nH]1 Show InChI InChI=1S/C8H13N3/c1-6-7(2-3-10-6)8-4-9-5-11-8/h4-7,10H,2-3H2,1H3,(H,9,11)/t6-,7+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069822 (4-((3S,4S)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C[C@@H]1CNC[C@H]1c1cnc[nH]1 Show InChI InChI=1S/C8H13N3/c1-6-2-9-3-7(6)8-4-10-5-11-8/h4-7,9H,2-3H2,1H3,(H,10,11)/t6-,7-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069818 (4-((2R,3S)-2-Methyl-azetidin-3-yl)-1H-imidazole | ...) Show SMILES C[C@H]1NC[C@@H]1c1cnc[nH]1 Show InChI InChI=1S/C7H11N3/c1-5-6(2-9-5)7-3-8-4-10-7/h3-6,9H,2H2,1H3,(H,8,10)/t5-,6+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069819 (4-((2S,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C[C@@H]1NCC[C@@H]1c1cnc[nH]1 Show InChI InChI=1S/C8H13N3/c1-6-7(2-3-10-6)8-4-9-5-11-8/h4-7,10H,2-3H2,1H3,(H,9,11)/t6-,7-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069817 (4-((3S,5S)-5-Methyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C[C@H]1C[C@@H](CN1)c1cnc[nH]1 Show InChI InChI=1S/C8H13N3/c1-6-2-7(3-10-6)8-4-9-5-11-8/h4-7,10H,2-3H2,1H3,(H,9,11)/t6-,7-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069820 (4-((2R,3S)-2-Ethyl-pyrrolidin-3-yl)-1H-imidazole |...) Show SMILES CC[C@H]1NCC[C@@H]1c1cnc[nH]1 Show InChI InChI=1S/C9H15N3/c1-2-8-7(3-4-11-8)9-5-10-6-12-9/h5-8,11H,2-4H2,1H3,(H,10,12)/t7-,8+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069815 (4-((S)-3-Methyl-pyrrolidin-3-yl)-1H-imidazole | CH...) Show SMILES C[C@@]1(CCNC1)c1cnc[nH]1 Show InChI InChI=1S/C8H13N3/c1-8(2-3-9-5-8)7-4-10-6-11-7/h4,6,9H,2-3,5H2,1H3,(H,10,11)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069821 (4-((2R,3S)-2-Benzyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C([C@H]1NCC[C@@H]1c1cnc[nH]1)c1ccccc1 Show InChI InChI=1S/C14H17N3/c1-2-4-11(5-3-1)8-13-12(6-7-16-13)14-9-15-10-17-14/h1-5,9-10,12-13,16H,6-8H2,(H,15,17)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50069824 ((2R,3S)-3-(1H-Imidazol-4-yl)-2-methyl-piperidine |...) Show SMILES C[C@H]1NCCC[C@@H]1c1cnc[nH]1 Show InChI InChI=1S/C9H15N3/c1-7-8(3-2-4-11-7)9-5-10-6-12-9/h5-8,11H,2-4H2,1H3,(H,10,12)/t7-,8+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50069816 (4-((3R,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...) Show SMILES C[C@H]1CNC[C@@H]1c1cnc[nH]1 |r| Show InChI InChI=1S/C8H13N3/c1-6-2-9-3-7(6)8-4-10-5-11-8/h4-7,9H,2-3H2,1H3,(H,10,11)/t6-,7-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity of the compound to H-1 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine ligand				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM22904 ((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...) Show SMILES C[C@@H](N)Cc1cnc[nH]1 |r| Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity of the compound to H-1 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine ligand				Bioorg Med Chem Lett 8: 243-8 (1999) BindingDB Entry DOI: 10.7270/Q2ST7P0Z
					More data for this Ligand-Target Pair