BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with all data for entry = 50000596
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brain				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50007568 (1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brain				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)	BDBM50007568 (1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]KET to 5-hydroxytryptamine 2 receptor in rat cortex				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)	BDBM50007567 (1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]KET to 5-hydroxytryptamine 2 receptor in rat cortex				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Serotonin 2 (5-HT2) receptor (RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]KET to 5-hydroxytryptamine 2 receptor in rat cortex				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007567 (1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007568 (1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SPI to dopamine receptor D2 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50007567 (1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brain				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50007568 (1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM22872 (1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...) Show SMILES CN1CCN(CC1)C1Cc2ccccc2Sc2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SPI to dopamine receptor D2 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50007567 (1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]-SPI to dopamine receptor D2 in rat striatal membranes				J Med Chem 34: 2023-30 (1991) BindingDB Entry DOI: 10.7270/Q2KD1WVC
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair