Found 31 hits Enz. Inhib. hit(s) with all data for entry = 50013083 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126336
(4-{[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3...)Show SMILES Cn1cncc1CN(Cc1ccnc(c1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H22N6/c1-34-20-32-17-26(34)19-35(18-21-11-12-33-24(13-21)16-31)25-10-9-23(15-30)29(14-25)28-8-4-6-22-5-2-3-7-27(22)28/h2-14,17,20H,18-19H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126339
(4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETH...)Show SMILES Cn1cncc1CN(Cc1cccc(c1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H23N5/c1-34-21-33-18-27(34)20-35(19-23-7-4-6-22(14-23)16-31)26-13-12-25(17-32)30(15-26)29-11-5-9-24-8-2-3-10-28(24)29/h2-15,18,21H,19-20H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126340
(4-[(3-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cn1cncc1CN(Cc1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H23ClN4/c1-33-20-32-17-26(33)19-34(18-21-6-4-9-24(30)14-21)25-13-12-23(16-31)29(15-25)28-11-5-8-22-7-2-3-10-27(22)28/h2-15,17,20H,18-19H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126335
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3 | PDB
MMDB
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PC cid
PC sid
UniChem
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| MMDB
PubMed
| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126330
(5-[(3-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cc1ccccc1-c1cc(ccc1C#N)N(Cc1cncn1C)Cc1cccc(c1)C#N Show InChI InChI=1S/C27H23N5/c1-20-6-3-4-9-26(20)27-13-24(11-10-23(27)15-29)32(18-25-16-30-19-31(25)2)17-22-8-5-7-21(12-22)14-28/h3-13,16,19H,17-18H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.970 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM17325
((2S)-2-[(4-{[butyl(2-cyclohexylethyl)amino]methyl}...)Show SMILES CCCCN(CCC1CCCCC1)Cc1ccc(C(=O)N[C@@H](CCSC)C(O)=O)c(c1)-c1ccccc1C |r| Show InChI InChI=1S/C32H46N2O3S/c1-4-5-19-34(20-17-25-12-7-6-8-13-25)23-26-15-16-28(29(22-26)27-14-10-9-11-24(27)2)31(35)33-30(32(36)37)18-21-38-3/h9-11,14-16,22,25,30H,4-8,12-13,17-21,23H2,1-3H3,(H,33,35)(H,36,37)/t30-/m0/s1 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126331
(4-[Cyclohexyl-(3-methyl-3H-imidazol-4-ylmethyl)-am...)Show SMILES Cn1cncc1CN(Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H24N4/c1-32-21-31-18-26(32)20-33(19-22-8-3-2-4-9-22)25-15-14-24(17-30)29(16-25)28-13-7-11-23-10-5-6-12-27(23)28/h2-16,18,21H,19-20H2,1H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126337
(4-[(4-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cn1cncc1CN(Cc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H23N5/c1-34-21-33-18-27(34)20-35(19-23-11-9-22(16-31)10-12-23)26-14-13-25(17-32)30(15-26)29-8-4-6-24-5-2-3-7-28(24)29/h2-15,18,21H,19-20H2,1H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126331
(4-[Cyclohexyl-(3-methyl-3H-imidazol-4-ylmethyl)-am...)Show SMILES Cn1cncc1CN(Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H24N4/c1-32-21-31-18-26(32)20-33(19-22-8-3-2-4-9-22)25-15-14-24(17-30)29(16-25)28-13-7-11-23-10-5-6-12-27(23)28/h2-16,18,21H,19-20H2,1H3 | PDB
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PC cid
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| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126333
(4-[Cyclohexyl-(3-methyl-3H-imidazol-4-ylmethyl)-am...)Show SMILES Cn1cncc1CN(C1CCCCC1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C28H28N4/c1-31-20-30-18-25(31)19-32(23-10-3-2-4-11-23)24-15-14-22(17-29)28(16-24)27-13-7-9-21-8-5-6-12-26(21)27/h5-9,12-16,18,20,23H,2-4,10-11,19H2,1H3 | PDB
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| PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM14459
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1 | PDB
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| MMDB
PDB
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126334
(5-[(4-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cc1ccccc1-c1cc(ccc1C#N)N(Cc1cncn1C)Cc1ccc(cc1)C#N Show InChI InChI=1S/C27H23N5/c1-20-5-3-4-6-26(20)27-13-24(12-11-23(27)15-29)32(18-25-16-30-19-31(25)2)17-22-9-7-21(14-28)8-10-22/h3-13,16,19H,17-18H2,1-2H3 | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126344
(5-[Benzyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]...)Show SMILES Cc1ccccc1-c1cc(ccc1C#N)N(Cc1cncn1C)Cc1ccccc1 Show InChI InChI=1S/C26H24N4/c1-20-8-6-7-11-25(20)26-14-23(13-12-22(26)15-27)30(17-21-9-4-3-5-10-21)18-24-16-28-19-29(24)2/h3-14,16,19H,17-18H2,1-2H3 | PDB
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126329
(CHEMBL28588 | N-(4-Cyano-3-naphthalen-1-yl-phenyl)...)Show SMILES Cn1cncc1CN(C(=O)c1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H22N4O/c1-32-20-31-18-25(32)19-33(29(34)22-9-3-2-4-10-22)24-15-14-23(17-30)28(16-24)27-13-7-11-21-8-5-6-12-26(21)27/h2-16,18,20H,19H2,1H3 | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126338
(CHEMBL28490 | N-(4-Cyano-3-naphthalen-1-yl-phenyl)...)Show SMILES Cn1cncc1CN(c1ccc(C#N)c(c1)-c1cccc2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C28H22N4O2S/c1-31-20-30-18-24(31)19-32(35(33,34)25-10-3-2-4-11-25)23-15-14-22(17-29)28(16-23)27-13-7-9-21-8-5-6-12-26(21)27/h2-16,18,20H,19H2,1H3 | PDB
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| PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126328
(4-[(3-Methyl-3H-imidazol-4-ylmethyl)-amino]-2-naph...)Show InChI InChI=1S/C22H18N4/c1-26-15-24-13-19(26)14-25-18-10-9-17(12-23)22(11-18)21-8-4-6-16-5-2-3-7-20(16)21/h2-11,13,15,25H,14H2,1H3 | PDB
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126328
(4-[(3-Methyl-3H-imidazol-4-ylmethyl)-amino]-2-naph...)Show InChI InChI=1S/C22H18N4/c1-26-15-24-13-19(26)14-25-18-10-9-17(12-23)22(11-18)21-8-4-6-16-5-2-3-7-20(16)21/h2-11,13,15,25H,14H2,1H3 | PDB
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126341
(4-[Methyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]...)Show SMILES CN(Cc1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C23H20N4/c1-26(15-20-14-25-16-27(20)2)19-11-10-18(13-24)23(12-19)22-9-5-7-17-6-3-4-8-21(17)22/h3-12,14,16H,15H2,1-2H3 | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126341
(4-[Methyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]...)Show SMILES CN(Cc1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C23H20N4/c1-26(15-20-14-25-16-27(20)2)19-11-10-18(13-24)23(12-19)22-9-5-7-17-6-3-4-8-21(17)22/h3-12,14,16H,15H2,1-2H3 | PDB
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PC cid
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UniChem
Similars
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126343
(5-[Benzyloxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2...)Show SMILES Cc1ccccc1-c1cc(ccc1C#N)C(OCc1ccccc1)c1cncn1C Show InChI InChI=1S/C26H23N3O/c1-19-8-6-7-11-23(19)24-14-21(12-13-22(24)15-27)26(25-16-28-18-29(25)2)30-17-20-9-4-3-5-10-20/h3-14,16,18,26H,17H2,1-2H3 | PDB
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UniChem
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| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126332
(5-[Benzyl-(3H-imidazol-4-ylmethyl)-amino]-2'-methy...)Show SMILES Cc1ccccc1-c1cc(ccc1C#N)N(Cc1cnc[nH]1)Cc1ccccc1 Show InChI InChI=1S/C25H22N4/c1-19-7-5-6-10-24(19)25-13-23(12-11-21(25)14-26)29(17-22-15-27-18-28-22)16-20-8-3-2-4-9-20/h2-13,15,18H,16-17H2,1H3,(H,27,28) | PDB
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UniChem
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| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126339
(4-[(3-CYANO-BENZYL)-(3-METHYL-3H-IMIDAZOL-4-YLMETH...)Show SMILES Cn1cncc1CN(Cc1cccc(c1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H23N5/c1-34-21-33-18-27(34)20-35(19-23-7-4-6-22(14-23)16-31)26-13-12-25(17-32)30(15-26)29-11-5-9-24-8-2-3-10-28(24)29/h2-15,18,21H,19-20H2,1H3 | PDB
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| MMDB
PDB
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126333
(4-[Cyclohexyl-(3-methyl-3H-imidazol-4-ylmethyl)-am...)Show SMILES Cn1cncc1CN(C1CCCCC1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C28H28N4/c1-31-20-30-18-25(31)19-32(23-10-3-2-4-11-23)24-15-14-22(17-29)28(16-24)27-13-7-9-21-8-5-6-12-26(21)27/h5-9,12-16,18,20,23H,2-4,10-11,19H2,1H3 | PDB
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UniChem
| PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126340
(4-[(3-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cn1cncc1CN(Cc1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H23ClN4/c1-33-20-32-17-26(33)19-34(18-21-6-4-9-24(30)14-21)25-13-12-23(16-31)29(15-25)28-11-5-8-22-7-2-3-10-27(22)28/h2-15,17,20H,18-19H2,1H3 | PDB
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UniChem
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| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126329
(CHEMBL28588 | N-(4-Cyano-3-naphthalen-1-yl-phenyl)...)Show SMILES Cn1cncc1CN(C(=O)c1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H22N4O/c1-32-20-31-18-25(32)19-33(29(34)22-9-3-2-4-10-22)24-15-14-23(17-30)28(16-24)27-13-7-11-21-8-5-6-12-26(21)27/h2-16,18,20H,19H2,1H3 | PDB
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UniChem
Similars
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| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126336
(4-{[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3...)Show SMILES Cn1cncc1CN(Cc1ccnc(c1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C29H22N6/c1-34-20-32-17-26(34)19-35(18-21-11-12-33-24(13-21)16-31)25-10-9-23(15-30)29(14-25)28-8-4-6-22-5-2-3-7-27(22)28/h2-14,17,20H,18-19H2,1H3 | PDB
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PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126334
(5-[(4-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cc1ccccc1-c1cc(ccc1C#N)N(Cc1cncn1C)Cc1ccc(cc1)C#N Show InChI InChI=1S/C27H23N5/c1-20-5-3-4-6-26(20)27-13-24(12-11-23(27)15-29)32(18-25-16-30-19-31(25)2)17-22-9-7-21(14-28)8-10-22/h3-13,16,19H,17-18H2,1-2H3 | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126337
(4-[(4-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cn1cncc1CN(Cc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 Show InChI InChI=1S/C30H23N5/c1-34-21-33-18-27(34)20-35(19-23-11-9-22(16-31)10-12-23)26-14-13-25(17-32)30(15-26)29-8-4-6-24-5-2-3-7-28(24)29/h2-15,18,21H,19-20H2,1H3 | PDB
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UniProtKB/SwissProt
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PC cid
PC sid
UniChem
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of geranylgeranyltransferase. |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126342
(2'-Methyl-5-[(3-methyl-3H-imidazol-4-ylmethyl)-ami...)Show InChI InChI=1S/C19H18N4/c1-14-5-3-4-6-18(14)19-9-16(8-7-15(19)10-20)22-12-17-11-21-13-23(17)2/h3-9,11,13,22H,12H2,1-2H3 | PDB
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UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126330
(5-[(3-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmeth...)Show SMILES Cc1ccccc1-c1cc(ccc1C#N)N(Cc1cncn1C)Cc1cccc(c1)C#N Show InChI InChI=1S/C27H23N5/c1-20-6-3-4-9-26(20)27-13-24(11-10-23(27)15-29)32(18-25-16-30-19-31(25)2)17-22-8-5-7-21(12-22)14-28/h3-13,16,19H,17-18H2,1-2H3 | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50126338
(CHEMBL28490 | N-(4-Cyano-3-naphthalen-1-yl-phenyl)...)Show SMILES Cn1cncc1CN(c1ccc(C#N)c(c1)-c1cccc2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C28H22N4O2S/c1-31-20-30-18-24(31)19-32(35(33,34)25-10-3-2-4-11-25)23-15-14-22(17-29)28(16-23)27-13-7-9-21-8-5-6-12-26(21)27/h2-16,18,20H,19H2,1H3 | PDB
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PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against farnesyltransferase (FTase) |
Bioorg Med Chem Lett 13: 1367-71 (2003)
BindingDB Entry DOI: 10.7270/Q20K27ZP |
More data for this
Ligand-Target Pair | |
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