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Compile Data Set for Download or QSAR

Found 24 hits Enz. Inhib. hit(s) with all data for entry = 50005023   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031568
PNG
(CHEMBL2369874 | [D-Asp2]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C77H129N25O16/c1-7-45(6)62(73(117)97-54(25-17-35-90-77(86)87)74(118)102-36-18-26-59(102)72(116)96-51(22-12-14-32-79)67(111)99-55(37-43(2)3)69(113)93-50(63(81)107)21-11-13-31-78)101-68(112)53(24-16-34-89-76(84)85)94-66(110)52(23-15-33-88-75(82)83)95-70(114)56(38-44(4)5)100-71(115)57(40-46-19-9-8-10-20-46)92-60(104)42-91-65(109)58(41-61(105)106)98-64(108)49(80)39-47-27-29-48(103)30-28-47/h8-10,19-20,27-30,43-45,49-59,62,103H,7,11-18,21-26,31-42,78-80H2,1-6H3,(H2,81,107)(H,91,109)(H,92,104)(H,93,113)(H,94,110)(H,95,114)(H,96,116)(H,97,117)(H,98,108)(H,99,111)(H,100,115)(H,101,112)(H,105,106)(H4,82,83,88)(H4,84,85,89)(H4,86,87,90)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58+,59+,62-/m0/s1
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0.0130n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031568
PNG
(CHEMBL2369874 | [D-Asp2]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C77H129N25O16/c1-7-45(6)62(73(117)97-54(25-17-35-90-77(86)87)74(118)102-36-18-26-59(102)72(116)96-51(22-12-14-32-79)67(111)99-55(37-43(2)3)69(113)93-50(63(81)107)21-11-13-31-78)101-68(112)53(24-16-34-89-76(84)85)94-66(110)52(23-15-33-88-75(82)83)95-70(114)56(38-44(4)5)100-71(115)57(40-46-19-9-8-10-20-46)92-60(104)42-91-65(109)58(41-61(105)106)98-64(108)49(80)39-47-27-29-48(103)30-28-47/h8-10,19-20,27-30,43-45,49-59,62,103H,7,11-18,21-26,31-42,78-80H2,1-6H3,(H2,81,107)(H,91,109)(H,92,104)(H,93,113)(H,94,110)(H,95,114)(H,96,116)(H,97,117)(H,98,108)(H,99,111)(H,100,115)(H,101,112)(H,105,106)(H4,82,83,88)(H4,84,85,89)(H4,86,87,90)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58+,59+,62-/m0/s1
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0.0130n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031574
PNG
(CHEMBL2369884 | cyclo[D-Asp2,Dab5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C75H124N26O15/c1-5-43(4)60(71(115)97-53(23-15-34-89-75(84)85)72(116)101-36-16-24-57(101)70(114)96-49(20-10-12-31-77)65(109)99-54(37-42(2)3)68(112)92-48(61(79)105)19-9-11-30-76)100-67(111)51(22-14-33-88-74(82)83)94-64(108)50(21-13-32-87-73(80)81)93-66(110)52-29-35-86-58(103)40-56(98-62(106)47(78)38-45-25-27-46(102)28-26-45)63(107)90-41-59(104)91-55(69(113)95-52)39-44-17-7-6-8-18-44/h6-8,17-18,25-28,42-43,47-57,60,102H,5,9-16,19-24,29-41,76-78H2,1-4H3,(H2,79,105)(H,86,103)(H,90,107)(H,91,104)(H,92,112)(H,93,110)(H,94,108)(H,95,113)(H,96,114)(H,97,115)(H,98,106)(H,99,109)(H,100,111)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56+,57+,60-/m0/s1
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0.130n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031574
PNG
(CHEMBL2369884 | cyclo[D-Asp2,Dab5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C75H124N26O15/c1-5-43(4)60(71(115)97-53(23-15-34-89-75(84)85)72(116)101-36-16-24-57(101)70(114)96-49(20-10-12-31-77)65(109)99-54(37-42(2)3)68(112)92-48(61(79)105)19-9-11-30-76)100-67(111)51(22-14-33-88-74(82)83)94-64(108)50(21-13-32-87-73(80)81)93-66(110)52-29-35-86-58(103)40-56(98-62(106)47(78)38-45-25-27-46(102)28-26-45)63(107)90-41-59(104)91-55(69(113)95-52)39-44-17-7-6-8-18-44/h6-8,17-18,25-28,42-43,47-57,60,102H,5,9-16,19-24,29-41,76-78H2,1-4H3,(H2,79,105)(H,86,103)(H,90,107)(H,91,104)(H,92,112)(H,93,110)(H,94,108)(H,95,113)(H,96,114)(H,97,115)(H,98,106)(H,99,109)(H,100,111)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56+,57+,60-/m0/s1
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0.130n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031574
PNG
(CHEMBL2369884 | cyclo[D-Asp2,Dab5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C75H124N26O15/c1-5-43(4)60(71(115)97-53(23-15-34-89-75(84)85)72(116)101-36-16-24-57(101)70(114)96-49(20-10-12-31-77)65(109)99-54(37-42(2)3)68(112)92-48(61(79)105)19-9-11-30-76)100-67(111)51(22-14-33-88-74(82)83)94-64(108)50(21-13-32-87-73(80)81)93-66(110)52-29-35-86-58(103)40-56(98-62(106)47(78)38-45-25-27-46(102)28-26-45)63(107)90-41-59(104)91-55(69(113)95-52)39-44-17-7-6-8-18-44/h6-8,17-18,25-28,42-43,47-57,60,102H,5,9-16,19-24,29-41,76-78H2,1-4H3,(H2,79,105)(H,86,103)(H,90,107)(H,91,104)(H,92,112)(H,93,110)(H,94,108)(H,95,113)(H,96,114)(H,97,115)(H,98,106)(H,99,109)(H,100,111)(H4,80,81,87)(H4,82,83,88)(H4,84,85,89)/t43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56+,57+,60-/m0/s1
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0.130n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031573
PNG
(CHEMBL2369870 | [D-Asp2,Dab(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#7]=[#6](-[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C80H136N28O16/c1-9-47(4)64(75(123)102-57(27-19-38-93-79(89)90)76(124)108-40-20-28-61(108)74(122)101-53(24-14-16-35-82)69(117)104-58(41-46(2)3)72(120)97-52(65(84)113)23-13-15-34-81)105-71(119)55(26-18-37-92-78(87)88)99-68(116)54(25-17-36-91-77(85)86)98-70(118)56(33-39-94-80(106(5)6)107(7)8)100-73(121)59(43-48-21-11-10-12-22-48)96-62(110)45-95-67(115)60(44-63(111)112)103-66(114)51(83)42-49-29-31-50(109)32-30-49/h10-12,21-22,29-32,46-47,51-61,64,109H,9,13-20,23-28,33-45,81-83H2,1-8H3,(H2,84,113)(H,95,115)(H,96,110)(H,97,120)(H,98,118)(H,99,116)(H,100,121)(H,101,122)(H,102,123)(H,103,114)(H,104,117)(H,105,119)(H,111,112)(H4,85,86,91)(H4,87,88,92)(H4,89,90,93)/t47-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60+,61-,64-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031569
PNG
(CHEMBL414773 | Dyn A-(1-13)NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N25O14/c1-7-45(6)61(71(113)96-54(25-17-35-88-75(84)85)72(114)100-36-18-26-58(100)70(112)95-51(22-12-14-32-77)65(107)97-55(37-43(2)3)67(109)92-50(62(79)104)21-11-13-31-76)99-66(108)53(24-16-34-87-74(82)83)93-64(106)52(23-15-33-86-73(80)81)94-68(110)56(38-44(4)5)98-69(111)57(40-46-19-9-8-10-20-46)91-60(103)42-89-59(102)41-90-63(105)49(78)39-47-27-29-48(101)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,101H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H2,79,104)(H,89,102)(H,90,105)(H,91,103)(H,92,109)(H,93,106)(H,94,110)(H,95,112)(H,96,113)(H,97,107)(H,98,111)(H,99,108)(H4,80,81,86)(H4,82,83,87)(H4,84,85,88)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58+,61-/m0/s1
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0.150n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031570
PNG
(CHEMBL2369885 | [D-Asp2,Dap(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6](\[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C79H134N28O16/c1-9-46(4)63(74(122)100-55(27-19-37-92-78(88)89)75(123)107-38-20-28-60(107)73(121)99-52(24-14-16-34-81)68(116)102-56(39-45(2)3)70(118)96-51(64(83)112)23-13-15-33-80)104-69(117)54(26-18-36-91-77(86)87)97-67(115)53(25-17-35-90-76(84)85)98-72(120)59(43-94-79(105(5)6)106(7)8)103-71(119)57(41-47-21-11-10-12-22-47)95-61(109)44-93-66(114)58(42-62(110)111)101-65(113)50(82)40-48-29-31-49(108)32-30-48/h10-12,21-22,29-32,45-46,50-60,63,108H,9,13-20,23-28,33-44,80-82H2,1-8H3,(H2,83,112)(H,93,114)(H,95,109)(H,96,118)(H,97,115)(H,98,120)(H,99,121)(H,100,122)(H,101,113)(H,102,116)(H,103,119)(H,104,117)(H,110,111)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58+,59-,60-,63-/m0/s1
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0.160n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031570
PNG
(CHEMBL2369885 | [D-Asp2,Dap(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6](\[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C79H134N28O16/c1-9-46(4)63(74(122)100-55(27-19-37-92-78(88)89)75(123)107-38-20-28-60(107)73(121)99-52(24-14-16-34-81)68(116)102-56(39-45(2)3)70(118)96-51(64(83)112)23-13-15-33-80)104-69(117)54(26-18-36-91-77(86)87)97-67(115)53(25-17-35-90-76(84)85)98-72(120)59(43-94-79(105(5)6)106(7)8)103-71(119)57(41-47-21-11-10-12-22-47)95-61(109)44-93-66(114)58(42-62(110)111)101-65(113)50(82)40-48-29-31-49(108)32-30-48/h10-12,21-22,29-32,45-46,50-60,63,108H,9,13-20,23-28,33-44,80-82H2,1-8H3,(H2,83,112)(H,93,114)(H,95,109)(H,96,118)(H,97,115)(H,98,120)(H,99,121)(H,100,122)(H,101,113)(H,102,116)(H,103,119)(H,104,117)(H,110,111)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58+,59-,60-,63-/m0/s1
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0.160n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031569
PNG
(CHEMBL414773 | Dyn A-(1-13)NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N25O14/c1-7-45(6)61(71(113)96-54(25-17-35-88-75(84)85)72(114)100-36-18-26-58(100)70(112)95-51(22-12-14-32-77)65(107)97-55(37-43(2)3)67(109)92-50(62(79)104)21-11-13-31-76)99-66(108)53(24-16-34-87-74(82)83)93-64(106)52(23-15-33-86-73(80)81)94-68(110)56(38-44(4)5)98-69(111)57(40-46-19-9-8-10-20-46)91-60(103)42-89-59(102)41-90-63(105)49(78)39-47-27-29-48(101)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,101H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H2,79,104)(H,89,102)(H,90,105)(H,91,103)(H,92,109)(H,93,106)(H,94,110)(H,95,112)(H,96,113)(H,97,107)(H,98,111)(H,99,108)(H4,80,81,86)(H4,82,83,87)(H4,84,85,88)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58+,61-/m0/s1
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0.190n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031570
PNG
(CHEMBL2369885 | [D-Asp2,Dap(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]\[#7]=[#6](\[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C79H134N28O16/c1-9-46(4)63(74(122)100-55(27-19-37-92-78(88)89)75(123)107-38-20-28-60(107)73(121)99-52(24-14-16-34-81)68(116)102-56(39-45(2)3)70(118)96-51(64(83)112)23-13-15-33-80)104-69(117)54(26-18-36-91-77(86)87)97-67(115)53(25-17-35-90-76(84)85)98-72(120)59(43-94-79(105(5)6)106(7)8)103-71(119)57(41-47-21-11-10-12-22-47)95-61(109)44-93-66(114)58(42-62(110)111)101-65(113)50(82)40-48-29-31-49(108)32-30-48/h10-12,21-22,29-32,45-46,50-60,63,108H,9,13-20,23-28,33-44,80-82H2,1-8H3,(H2,83,112)(H,93,114)(H,95,109)(H,96,118)(H,97,115)(H,98,120)(H,99,121)(H,100,122)(H,101,113)(H,102,116)(H,103,119)(H,104,117)(H,110,111)(H4,84,85,90)(H4,86,87,91)(H4,88,89,92)/t46-,50-,51-,52-,53-,54-,55-,56-,57-,58+,59-,60-,63-/m0/s1
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0.210n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031571
PNG
(CHEMBL2369883 | cyclo[D-Asp2,Dap5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C74H122N26O15/c1-5-42(4)59(70(114)95-51(23-15-33-87-74(83)84)71(115)100-34-16-24-56(100)69(113)94-48(20-10-12-30-76)64(108)97-52(35-41(2)3)66(110)91-47(60(78)104)19-9-11-29-75)99-65(109)50(22-14-32-86-73(81)82)92-63(107)49(21-13-31-85-72(79)80)93-68(112)55-39-88-57(102)38-54(96-61(105)46(77)36-44-25-27-45(101)28-26-44)62(106)89-40-58(103)90-53(67(111)98-55)37-43-17-7-6-8-18-43/h6-8,17-18,25-28,41-42,46-56,59,101H,5,9-16,19-24,29-40,75-77H2,1-4H3,(H2,78,104)(H,88,102)(H,89,106)(H,90,103)(H,91,110)(H,92,107)(H,93,112)(H,94,113)(H,95,114)(H,96,105)(H,97,108)(H,98,111)(H,99,109)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t42-,46-,47-,48-,49-,50-,51-,52-,53-,54+,55-,56+,59-/m0/s1
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0.220n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031572
PNG
(CHEMBL2369873 | [D-Asp2,Orn(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C81H138N28O16/c1-9-48(4)65(76(124)103-58(29-20-39-94-80(90)91)77(125)109-41-21-30-62(109)75(123)102-54(25-14-16-36-83)71(119)105-59(42-47(2)3)73(121)98-53(66(85)114)24-13-15-35-82)106-72(120)57(27-18-38-93-79(88)89)100-69(117)55(26-17-37-92-78(86)87)99-70(118)56(28-19-40-95-81(107(5)6)108(7)8)101-74(122)60(44-49-22-11-10-12-23-49)97-63(111)46-96-68(116)61(45-64(112)113)104-67(115)52(84)43-50-31-33-51(110)34-32-50/h10-12,22-23,31-34,47-48,52-62,65,110H,9,13-21,24-30,35-46,82-84H2,1-8H3,(H2,85,114)(H,96,116)(H,97,111)(H,98,121)(H,99,118)(H,100,117)(H,101,122)(H,102,123)(H,103,124)(H,104,115)(H,105,119)(H,106,120)(H,112,113)(H4,86,87,92)(H4,88,89,93)(H4,90,91,94)/t48-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61+,62-,65-/m0/s1
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0.280n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031572
PNG
(CHEMBL2369873 | [D-Asp2,Orn(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C81H138N28O16/c1-9-48(4)65(76(124)103-58(29-20-39-94-80(90)91)77(125)109-41-21-30-62(109)75(123)102-54(25-14-16-36-83)71(119)105-59(42-47(2)3)73(121)98-53(66(85)114)24-13-15-35-82)106-72(120)57(27-18-38-93-79(88)89)100-69(117)55(26-17-37-92-78(86)87)99-70(118)56(28-19-40-95-81(107(5)6)108(7)8)101-74(122)60(44-49-22-11-10-12-23-49)97-63(111)46-96-68(116)61(45-64(112)113)104-67(115)52(84)43-50-31-33-51(110)34-32-50/h10-12,22-23,31-34,47-48,52-62,65,110H,9,13-21,24-30,35-46,82-84H2,1-8H3,(H2,85,114)(H,96,116)(H,97,111)(H,98,121)(H,99,118)(H,100,117)(H,101,122)(H,102,123)(H,103,124)(H,104,115)(H,105,119)(H,106,120)(H,112,113)(H4,86,87,92)(H4,88,89,93)(H4,90,91,94)/t48-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61+,62-,65-/m0/s1
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0.280n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031573
PNG
(CHEMBL2369870 | [D-Asp2,Dab(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#7]=[#6](-[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C80H136N28O16/c1-9-47(4)64(75(123)102-57(27-19-38-93-79(89)90)76(124)108-40-20-28-61(108)74(122)101-53(24-14-16-35-82)69(117)104-58(41-46(2)3)72(120)97-52(65(84)113)23-13-15-34-81)105-71(119)55(26-18-37-92-78(87)88)99-68(116)54(25-17-36-91-77(85)86)98-70(118)56(33-39-94-80(106(5)6)107(7)8)100-73(121)59(43-48-21-11-10-12-22-48)96-62(110)45-95-67(115)60(44-63(111)112)103-66(114)51(83)42-49-29-31-50(109)32-30-49/h10-12,21-22,29-32,46-47,51-61,64,109H,9,13-20,23-28,33-45,81-83H2,1-8H3,(H2,84,113)(H,95,115)(H,96,110)(H,97,120)(H,98,118)(H,99,116)(H,100,121)(H,101,122)(H,102,123)(H,103,114)(H,104,117)(H,105,119)(H,111,112)(H4,85,86,91)(H4,87,88,92)(H4,89,90,93)/t47-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60+,61-,64-/m0/s1
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0.320n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031573
PNG
(CHEMBL2369870 | [D-Asp2,Dab(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#7]=[#6](-[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C80H136N28O16/c1-9-47(4)64(75(123)102-57(27-19-38-93-79(89)90)76(124)108-40-20-28-61(108)74(122)101-53(24-14-16-35-82)69(117)104-58(41-46(2)3)72(120)97-52(65(84)113)23-13-15-34-81)105-71(119)55(26-18-37-92-78(87)88)99-68(116)54(25-17-36-91-77(85)86)98-70(118)56(33-39-94-80(106(5)6)107(7)8)100-73(121)59(43-48-21-11-10-12-22-48)96-62(110)45-95-67(115)60(44-63(111)112)103-66(114)51(83)42-49-29-31-50(109)32-30-49/h10-12,21-22,29-32,46-47,51-61,64,109H,9,13-20,23-28,33-45,81-83H2,1-8H3,(H2,84,113)(H,95,115)(H,96,110)(H,97,120)(H,98,118)(H,99,116)(H,100,121)(H,101,122)(H,102,123)(H,103,114)(H,104,117)(H,105,119)(H,111,112)(H4,85,86,91)(H4,87,88,92)(H4,89,90,93)/t47-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60+,61-,64-/m0/s1
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0.320n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031572
PNG
(CHEMBL2369873 | [D-Asp2,Orn(Tmg)5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7](-[#6])-[#6])-[#7](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O |r|
Show InChI InChI=1S/C81H138N28O16/c1-9-48(4)65(76(124)103-58(29-20-39-94-80(90)91)77(125)109-41-21-30-62(109)75(123)102-54(25-14-16-36-83)71(119)105-59(42-47(2)3)73(121)98-53(66(85)114)24-13-15-35-82)106-72(120)57(27-18-38-93-79(88)89)100-69(117)55(26-17-37-92-78(86)87)99-70(118)56(28-19-40-95-81(107(5)6)108(7)8)101-74(122)60(44-49-22-11-10-12-23-49)97-63(111)46-96-68(116)61(45-64(112)113)104-67(115)52(84)43-50-31-33-51(110)34-32-50/h10-12,22-23,31-34,47-48,52-62,65,110H,9,13-21,24-30,35-46,82-84H2,1-8H3,(H2,85,114)(H,96,116)(H,97,111)(H,98,121)(H,99,118)(H,100,117)(H,101,122)(H,102,123)(H,103,124)(H,104,115)(H,105,119)(H,106,120)(H,112,113)(H4,86,87,92)(H4,88,89,93)(H4,90,91,94)/t48-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61+,62-,65-/m0/s1
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0.360n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031568
PNG
(CHEMBL2369874 | [D-Asp2]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C77H129N25O16/c1-7-45(6)62(73(117)97-54(25-17-35-90-77(86)87)74(118)102-36-18-26-59(102)72(116)96-51(22-12-14-32-79)67(111)99-55(37-43(2)3)69(113)93-50(63(81)107)21-11-13-31-78)101-68(112)53(24-16-34-89-76(84)85)94-66(110)52(23-15-33-88-75(82)83)95-70(114)56(38-44(4)5)100-71(115)57(40-46-19-9-8-10-20-46)92-60(104)42-91-65(109)58(41-61(105)106)98-64(108)49(80)39-47-27-29-48(103)30-28-47/h8-10,19-20,27-30,43-45,49-59,62,103H,7,11-18,21-26,31-42,78-80H2,1-6H3,(H2,81,107)(H,91,109)(H,92,104)(H,93,113)(H,94,110)(H,95,114)(H,96,116)(H,97,117)(H,98,108)(H,99,111)(H,100,115)(H,101,112)(H,105,106)(H4,82,83,88)(H4,84,85,89)(H4,86,87,90)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58+,59+,62-/m0/s1
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0.450n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50031575
PNG
(CHEMBL2369871 | cyclo[D-Asp2,Orn5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C76H126N26O15/c1-5-44(4)61(72(116)98-54(25-16-36-90-76(85)86)73(117)102-37-17-26-58(102)71(115)97-50(21-10-12-32-78)67(111)100-55(38-43(2)3)69(113)93-49(62(80)106)20-9-11-31-77)101-68(112)53(24-15-35-89-75(83)84)95-65(109)51(23-14-34-88-74(81)82)94-66(110)52-22-13-33-87-59(104)41-57(99-63(107)48(79)39-46-27-29-47(103)30-28-46)64(108)91-42-60(105)92-56(70(114)96-52)40-45-18-7-6-8-19-45/h6-8,18-19,27-30,43-44,48-58,61,103H,5,9-17,20-26,31-42,77-79H2,1-4H3,(H2,80,106)(H,87,104)(H,91,108)(H,92,105)(H,93,113)(H,94,110)(H,95,109)(H,96,114)(H,97,115)(H,98,116)(H,99,107)(H,100,111)(H,101,112)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t44-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57+,58-,61-/m0/s1
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0.680n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor kappa 1 of guinea pig cerebellum using [3H]-bremazocine as the radioligand using ...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031575
PNG
(CHEMBL2369871 | cyclo[D-Asp2,Orn5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C76H126N26O15/c1-5-44(4)61(72(116)98-54(25-16-36-90-76(85)86)73(117)102-37-17-26-58(102)71(115)97-50(21-10-12-32-78)67(111)100-55(38-43(2)3)69(113)93-49(62(80)106)20-9-11-31-77)101-68(112)53(24-15-35-89-75(83)84)95-65(109)51(23-14-34-88-74(81)82)94-66(110)52-22-13-33-87-59(104)41-57(99-63(107)48(79)39-46-27-29-47(103)30-28-46)64(108)91-42-60(105)92-56(70(114)96-52)40-45-18-7-6-8-19-45/h6-8,18-19,27-30,43-44,48-58,61,103H,5,9-17,20-26,31-42,77-79H2,1-4H3,(H2,80,106)(H,87,104)(H,91,108)(H,92,105)(H,93,113)(H,94,110)(H,95,109)(H,96,114)(H,97,115)(H,98,116)(H,99,107)(H,100,111)(H,101,112)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t44-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57+,58-,61-/m0/s1
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0.680n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031575
PNG
(CHEMBL2369871 | cyclo[D-Asp2,Orn5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C76H126N26O15/c1-5-44(4)61(72(116)98-54(25-16-36-90-76(85)86)73(117)102-37-17-26-58(102)71(115)97-50(21-10-12-32-78)67(111)100-55(38-43(2)3)69(113)93-49(62(80)106)20-9-11-31-77)101-68(112)53(24-15-35-89-75(83)84)95-65(109)51(23-14-34-88-74(81)82)94-66(110)52-22-13-33-87-59(104)41-57(99-63(107)48(79)39-46-27-29-47(103)30-28-46)64(108)91-42-60(105)92-56(70(114)96-52)40-45-18-7-6-8-19-45/h6-8,18-19,27-30,43-44,48-58,61,103H,5,9-17,20-26,31-42,77-79H2,1-4H3,(H2,80,106)(H,87,104)(H,91,108)(H,92,105)(H,93,113)(H,94,110)(H,95,109)(H,96,114)(H,97,115)(H,98,116)(H,99,107)(H,100,111)(H,101,112)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t44-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57+,58-,61-/m0/s1
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0.680n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031569
PNG
(CHEMBL414773 | Dyn A-(1-13)NH2)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C75H127N25O14/c1-7-45(6)61(71(113)96-54(25-17-35-88-75(84)85)72(114)100-36-18-26-58(100)70(112)95-51(22-12-14-32-77)65(107)97-55(37-43(2)3)67(109)92-50(62(79)104)21-11-13-31-76)99-66(108)53(24-16-34-87-74(82)83)93-64(106)52(23-15-33-86-73(80)81)94-68(110)56(38-44(4)5)98-69(111)57(40-46-19-9-8-10-20-46)91-60(103)42-89-59(102)41-90-63(105)49(78)39-47-27-29-48(101)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,101H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H2,79,104)(H,89,102)(H,90,105)(H,91,103)(H,92,109)(H,93,106)(H,94,110)(H,95,112)(H,96,113)(H,97,107)(H,98,111)(H,99,108)(H4,80,81,86)(H4,82,83,87)(H4,84,85,88)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58+,61-/m0/s1
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3.88n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031571
PNG
(CHEMBL2369883 | cyclo[D-Asp2,Dap5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C74H122N26O15/c1-5-42(4)59(70(114)95-51(23-15-33-87-74(83)84)71(115)100-34-16-24-56(100)69(113)94-48(20-10-12-30-76)64(108)97-52(35-41(2)3)66(110)91-47(60(78)104)19-9-11-29-75)99-65(109)50(22-14-32-86-73(81)82)92-63(107)49(21-13-31-85-72(79)80)93-68(112)55-39-88-57(102)38-54(96-61(105)46(77)36-44-25-27-45(101)28-26-44)62(106)89-40-58(103)90-53(67(111)98-55)37-43-17-7-6-8-18-43/h6-8,17-18,25-28,41-42,46-56,59,101H,5,9-16,19-24,29-40,75-77H2,1-4H3,(H2,78,104)(H,88,102)(H,89,106)(H,90,103)(H,91,110)(H,92,107)(H,93,112)(H,94,113)(H,95,114)(H,96,105)(H,97,108)(H,98,111)(H,99,109)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t42-,46-,47-,48-,49-,50-,51-,52-,53-,54+,55-,56+,59-/m0/s1
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10.2n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against delta opioid receptor of rat forebrain using [3H]-DPDPE as the radioligand using competition bind...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50031571
PNG
(CHEMBL2369883 | cyclo[D-Asp2,Dap5]Dyn A-(1-13)NH2)
Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#7]-[#6](=O)-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c2ccccc2)-[#6](=O)-[#7]-1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](-[#7])=O
Show InChI InChI=1S/C74H122N26O15/c1-5-42(4)59(70(114)95-51(23-15-33-87-74(83)84)71(115)100-34-16-24-56(100)69(113)94-48(20-10-12-30-76)64(108)97-52(35-41(2)3)66(110)91-47(60(78)104)19-9-11-29-75)99-65(109)50(22-14-32-86-73(81)82)92-63(107)49(21-13-31-85-72(79)80)93-68(112)55-39-88-57(102)38-54(96-61(105)46(77)36-44-25-27-45(101)28-26-44)62(106)89-40-58(103)90-53(67(111)98-55)37-43-17-7-6-8-18-43/h6-8,17-18,25-28,41-42,46-56,59,101H,5,9-16,19-24,29-40,75-77H2,1-4H3,(H2,78,104)(H,88,102)(H,89,106)(H,90,103)(H,91,110)(H,92,107)(H,93,112)(H,94,113)(H,95,114)(H,96,105)(H,97,108)(H,98,111)(H,99,109)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t42-,46-,47-,48-,49-,50-,51-,52-,53-,54+,55-,56+,59-/m0/s1
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PubMed
10.2n/an/an/an/an/an/an/an/a



Oregon State University

Curated by ChEMBL


Assay Description
Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...


J Med Chem 38: 2410-7 (1995)


BindingDB Entry DOI: 10.7270/Q2CV4GS8
More data for this
Ligand-Target Pair