BindingDB PrimarySearch

Found 56 hits Enz. Inhib. hit(s) with all data for entry = 50040364
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	924	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP12				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP8				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP13				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP9				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50393111 (CHEMBL2153261) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cccs1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP2				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP1				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50393108 (CHEMBL2153266) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cnc2ccccc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50215927 (4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccc[nH]1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50393113 (CHEMBL2153265) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Sus scrofa)	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant PIM1 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50393112 (CHEMBL2153263) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccsc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50393112 (CHEMBL2153263) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccsc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50393115 (CHEMBL575945) Show SMILES Nc1nc2c(nccc2[nH]1)-c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50393111 (CHEMBL2153261) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50393110 (CHEMBL2153260) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccco1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.59E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50393112 (CHEMBL2153263) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccsc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50393110 (CHEMBL2153260) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccco1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50393115 (CHEMBL575945) Show SMILES Nc1nc2c(nccc2[nH]1)-c1c[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50393108 (CHEMBL2153266) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cnc2ccccc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant PIM1 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50393114 (CHEMBL2153267) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50393114 (CHEMBL2153267) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50393111 (CHEMBL2153261) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cccs1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50393115 (CHEMBL575945) Show SMILES Nc1nc2c(nccc2[nH]1)-c1c[nH]c2ccccc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant PIM1 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Sus scrofa)	BDBM50215926 (4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cc(Br)c(Br)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50215927 (4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccc[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50393113 (CHEMBL2153265) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cccnc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50393110 (CHEMBL2153260) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccco1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM50215927 (4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccc[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM50393111 (CHEMBL2153261) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cccs1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation counting				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50393112 (CHEMBL2153263) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccsc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to C-terminal kinase domain 2 of RPS6KA1				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50393108 (CHEMBL2153266) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cnc2ccccc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to JH domain of TYK2				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ULK1 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to ULK1				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase 32B (Homo sapiens (Human))	BDBM50393108 (CHEMBL2153266) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cnc2ccccc2c1 Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to YANK2				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 19 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to YSK4				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase-like 5 (Homo sapiens (Human))	BDBM50393108 (CHEMBL2153266) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cnc2ccccc2c1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to CDKL5				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to CDK7				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase kinase 1 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to CAMKK1				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit gamma (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to CAMK2G				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human))	BDBM50393108 (CHEMBL2153266) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cnc2ccccc2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to BMPR1B				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to AAK1				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50393108 (CHEMBL2153266) Show SMILES Nc1nc2c(nccc2[nH]1)-c1cnc2ccccc2c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to CLK2				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase kinase 2 (Homo sapiens (Human))	BDBM50393109 (CHEMBL2153264) Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a
Macquarie University Curated by ChEMBL					Assay Description Binding affinity to CAMKK2				J Med Chem 54: 2492-503 (2011) Article DOI: 10.1021/jm200039m BindingDB Entry DOI: 10.7270/Q2QV3NMT
Macquarie University Curated by ChEMBL					More data for this Ligand-Target Pair

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