BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with all data for entry = 50044167
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of TNKS-2 (unknown origin) by TCF/beta-catenin-dependent reporter assay				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50318567 (2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of TNKS-1 (unknown origin) by TCF/beta-catenin-dependent reporter assay				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50007582 (CHEMBL3238252) Show SMILES Cc1cc(NCCc2ccc(O)cc2)c2nncn2n1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of recombinant human TNKS-1				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Mus musculus)	BDBM50007583 (CHEBI:62882 \| CHEMBL562310) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assay				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Mus musculus)	BDBM50007583 (CHEBI:62882 \| CHEMBL562310) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assay				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50007582 (CHEMBL3238252) Show SMILES Cc1cc(NCCc2ccc(O)cc2)c2nncn2n1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of recombinant human TNKS-2				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50007582 (CHEMBL3238252) Show SMILES Cc1cc(NCCc2ccc(O)cc2)c2nncn2n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP-1				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM50007582 (CHEMBL3238252) Show SMILES Cc1cc(NCCc2ccc(O)cc2)c2nncn2n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Perugia Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP-2				J Med Chem 57: 2807-12 (2014) Article DOI: 10.1021/jm401356t BindingDB Entry DOI: 10.7270/Q2W37XT9
Universit£ degli Studi di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair