Found 61 hits Enz. Inhib. hit(s) with all data for entry = 50037403 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM81767
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 | PDB
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0830 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM81767
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 | Reactome pathway
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PC cid
PC sid
UniChem
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PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169465
(3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]tri...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)CCSc1nnc(-c2ccc3ccccc3n2)n1CCCCN Show InChI InChI=1S/C27H28N6OS/c1-18-7-6-9-20-21(17-29-25(18)20)24(34)13-16-35-27-32-31-26(33(27)15-5-4-14-28)23-12-11-19-8-2-3-10-22(19)30-23/h2-3,6-12,17,29H,4-5,13-16,28H2,1H3 | Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM81767
(15-28-Somatostatin-28 | CAS_38916-34-6 | CB6417646...)Show SMILES C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O |r| Show InChI InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 | Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| 0.440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169468
(4-{3-[2-(6-Fluoro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3cc(F)ccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25FN6S/c26-19-8-9-20-18(16-28-23(20)15-19)11-14-33-25-31-30-24(32(25)13-4-3-12-27)22-10-7-17-5-1-2-6-21(17)29-22/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169462
(4-{3-[2-(7-Methyl-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES Cc1cccc2c(CCSc3nnc(-c4ccc5ccccc5n4)n3CCCCN)c[nH]c12 Show InChI InChI=1S/C26H28N6S/c1-18-7-6-9-21-20(17-28-24(18)21)13-16-33-26-31-30-25(32(26)15-5-4-14-27)23-12-11-19-8-2-3-10-22(19)29-23/h2-3,6-12,17,28H,4-5,13-16,27H2,1H3 | PDB
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UniChem
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| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169465
(3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]tri...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)CCSc1nnc(-c2ccc3ccccc3n2)n1CCCCN Show InChI InChI=1S/C27H28N6OS/c1-18-7-6-9-20-21(17-29-25(18)20)24(34)13-16-35-27-32-31-26(33(27)15-5-4-14-28)23-12-11-19-8-2-3-10-22(19)30-23/h2-3,6-12,17,29H,4-5,13-16,28H2,1H3 | PDB
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PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169462
(4-{3-[2-(7-Methyl-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES Cc1cccc2c(CCSc3nnc(-c4ccc5ccccc5n4)n3CCCCN)c[nH]c12 Show InChI InChI=1S/C26H28N6S/c1-18-7-6-9-21-20(17-28-24(18)21)13-16-33-26-31-30-25(32(26)15-5-4-14-27)23-12-11-19-8-2-3-10-22(19)29-23/h2-3,6-12,17,28H,4-5,13-16,27H2,1H3 | Reactome pathway
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PC cid
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UniChem
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| Article
PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169467
(4-{3-[2-(5-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccc(Cl)cc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25ClN6S/c26-19-8-10-22-20(15-19)18(16-28-22)11-14-33-25-31-30-24(32(25)13-4-3-12-27)23-9-7-17-5-1-2-6-21(17)29-23/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169468
(4-{3-[2-(6-Fluoro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3cc(F)ccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25FN6S/c26-19-8-9-20-18(16-28-23(20)15-19)11-14-33-25-31-30-24(32(25)13-4-3-12-27)22-10-7-17-5-1-2-6-21(17)29-22/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169471
(4-{3-[2-(7-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3c(Cl)cccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25ClN6S/c26-20-8-5-7-19-18(16-28-23(19)20)12-15-33-25-31-30-24(32(25)14-4-3-13-27)22-11-10-17-6-1-2-9-21(17)29-22/h1-2,5-11,16,28H,3-4,12-15,27H2 | PDB
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PC cid
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UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169467
(4-{3-[2-(5-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccc(Cl)cc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25ClN6S/c26-19-8-10-22-20(15-19)18(16-28-22)11-14-33-25-31-30-24(32(25)13-4-3-12-27)23-9-7-17-5-1-2-6-21(17)29-23/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | PDB
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PC cid
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UniChem
Similars
| Article
PubMed
| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169469
(4-{3-(6-Fluoro-quinolin-2-yl)-5-[2-(1H-indol-3-yl)...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2cc(F)ccc2n1 Show InChI InChI=1S/C25H25FN6S/c26-19-8-10-21-17(15-19)7-9-23(29-21)24-30-31-25(32(24)13-4-3-12-27)33-14-11-18-16-28-22-6-2-1-5-20(18)22/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169471
(4-{3-[2-(7-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3c(Cl)cccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25ClN6S/c26-20-8-5-7-19-18(16-28-23(19)20)12-15-33-25-31-30-24(32(25)14-4-3-13-27)22-11-10-17-6-1-2-9-21(17)29-22/h1-2,5-11,16,28H,3-4,12-15,27H2 | Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169473
(3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]tri...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)C(C)(C)CSc1nnc(-c2ccc3ccccc3n2)n1CCCCN Show InChI InChI=1S/C29H32N6OS/c1-19-9-8-11-21-22(17-31-25(19)21)26(36)29(2,3)18-37-28-34-33-27(35(28)16-7-6-15-30)24-14-13-20-10-4-5-12-23(20)32-24/h4-5,8-14,17,31H,6-7,15-16,18,30H2,1-3H3 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169475
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-quinolin-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H26N6S/c26-14-5-6-15-31-24(23-12-11-18-7-1-3-9-21(18)28-23)29-30-25(31)32-16-13-19-17-27-22-10-4-2-8-20(19)22/h1-4,7-12,17,27H,5-6,13-16,26H2 | Reactome pathway
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169469
(4-{3-(6-Fluoro-quinolin-2-yl)-5-[2-(1H-indol-3-yl)...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2cc(F)ccc2n1 Show InChI InChI=1S/C25H25FN6S/c26-19-8-10-21-17(15-19)7-9-23(29-21)24-30-31-25(32(24)13-4-3-12-27)33-14-11-18-16-28-22-6-2-1-5-20(18)22/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169475
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-quinolin-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H26N6S/c26-14-5-6-15-31-24(23-12-11-18-7-1-3-9-21(18)28-23)29-30-25(31)32-16-13-19-17-27-22-10-4-2-8-20(19)22/h1-4,7-12,17,27H,5-6,13-16,26H2 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169473
(3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]tri...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)C(C)(C)CSc1nnc(-c2ccc3ccccc3n2)n1CCCCN Show InChI InChI=1S/C29H32N6OS/c1-19-9-8-11-21-22(17-31-25(19)21)26(36)29(2,3)18-37-28-34-33-27(35(28)16-7-6-15-30)24-14-13-20-10-4-5-12-23(20)32-24/h4-5,8-14,17,31H,6-7,15-16,18,30H2,1-3H3 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169476
(4-{3-(4-Ethyl-phenyl)-5-[2-(1H-indol-3-yl)-ethylsu...)Show SMILES CCc1ccc(cc1)-c1nnc(SCCc2c[nH]c3ccccc23)n1CCCCN Show InChI InChI=1S/C24H29N5S/c1-2-18-9-11-19(12-10-18)23-27-28-24(29(23)15-6-5-14-25)30-16-13-20-17-26-22-8-4-3-7-21(20)22/h3-4,7-12,17,26H,2,5-6,13-16,25H2,1H3 | Reactome pathway
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169470
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C26H27N5S/c27-14-5-6-15-31-25(21-12-11-19-7-1-2-8-20(19)17-21)29-30-26(31)32-16-13-22-18-28-24-10-4-3-9-23(22)24/h1-4,7-12,17-18,28H,5-6,13-16,27H2 | Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169478
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-quinoxali...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cnc2ccccc2n1 Show InChI InChI=1S/C24H25N7S/c25-12-5-6-13-31-23(22-16-27-20-9-3-4-10-21(20)28-22)29-30-24(31)32-14-11-17-15-26-19-8-2-1-7-18(17)19/h1-4,7-10,15-16,26H,5-6,11-14,25H2 | PDB
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 3
(Homo sapiens (Human)) | BDBM50169462
(4-{3-[2-(7-Methyl-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES Cc1cccc2c(CCSc3nnc(-c4ccc5ccccc5n4)n3CCCCN)c[nH]c12 Show InChI InChI=1S/C26H28N6S/c1-18-7-6-9-21-20(17-28-24(18)21)13-16-33-26-31-30-25(32(26)15-5-4-14-27)23-12-11-19-8-2-3-10-22(19)29-23/h2-3,6-12,17,28H,4-5,13-16,27H2,1H3 | Reactome pathway
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst3 receptor at 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169477
(4-{3-(3-Bromo-phenyl)-5-[2-(1H-indol-3-yl)-ethylsu...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cccc(Br)c1 Show InChI InChI=1S/C22H24BrN5S/c23-18-7-5-6-16(14-18)21-26-27-22(28(21)12-4-3-11-24)29-13-10-17-15-25-20-9-2-1-8-19(17)20/h1-2,5-9,14-15,25H,3-4,10-13,24H2 | Reactome pathway
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| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169478
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-quinoxali...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cnc2ccccc2n1 Show InChI InChI=1S/C24H25N7S/c25-12-5-6-13-31-23(22-16-27-20-9-3-4-10-21(20)28-22)29-30-24(31)32-14-11-17-15-26-19-8-2-1-7-18(17)19/h1-4,7-10,15-16,26H,5-6,11-14,25H2 | Reactome pathway
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| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169463
(4-{3-Benzo[b]thiophen-2-yl-5-[2-(1H-indol-3-yl)-et...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cc2ccccc2s1 Show InChI InChI=1S/C24H25N5S2/c25-12-5-6-13-29-23(22-15-17-7-1-4-10-21(17)31-22)27-28-24(29)30-14-11-18-16-26-20-9-3-2-8-19(18)20/h1-4,7-10,15-16,26H,5-6,11-14,25H2 | Reactome pathway
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| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 1
(Homo sapiens (Human)) | BDBM50169468
(4-{3-[2-(6-Fluoro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3cc(F)ccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25FN6S/c26-19-8-9-20-18(16-28-23(20)15-19)11-14-33-25-31-30-24(32(25)13-4-3-12-27)22-10-7-17-5-1-2-6-21(17)29-22/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | KEGG
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PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst1 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169474
(4-{3-(1H-Indol-7-yl)-5-[2-(1H-indol-3-yl)-ethylsul...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cccc2cc[nH]c12 Show InChI InChI=1S/C24H26N6S/c25-12-3-4-14-30-23(20-8-5-6-17-10-13-26-22(17)20)28-29-24(30)31-15-11-18-16-27-21-9-2-1-7-19(18)21/h1-2,5-10,13,16,26-27H,3-4,11-12,14-15,25H2 | Reactome pathway
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| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169479
(3-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C25H25N5S/c26-13-5-14-30-24(20-11-10-18-6-1-2-7-19(18)16-20)28-29-25(30)31-15-12-21-17-27-23-9-4-3-8-22(21)23/h1-4,6-11,16-17,27H,5,12-15,26H2 | Reactome pathway
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| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169466
(5-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C27H29N5S/c28-15-6-1-7-16-32-26(22-13-12-20-8-2-3-9-21(20)18-22)30-31-27(32)33-17-14-23-19-29-25-11-5-4-10-24(23)25/h2-5,8-13,18-19,29H,1,6-7,14-17,28H2 | Reactome pathway
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| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 4
(Homo sapiens (Human)) | BDBM50169468
(4-{3-[2-(6-Fluoro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3cc(F)ccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25FN6S/c26-19-8-9-20-18(16-28-23(20)15-19)11-14-33-25-31-30-24(32(25)13-4-3-12-27)22-10-7-17-5-1-2-6-21(17)29-22/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | PDB
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| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst4 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 3
(Homo sapiens (Human)) | BDBM50169471
(4-{3-[2-(7-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3c(Cl)cccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25ClN6S/c26-20-8-5-7-19-18(16-28-23(19)20)12-15-33-25-31-30-24(32(25)14-4-3-13-27)22-11-10-17-6-1-2-9-21(17)29-22/h1-2,5-11,16,28H,3-4,12-15,27H2 | Reactome pathway
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PubMed
| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst3 receptor at 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 3
(Homo sapiens (Human)) | BDBM50169468
(4-{3-[2-(6-Fluoro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3cc(F)ccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25FN6S/c26-19-8-9-20-18(16-28-23(20)15-19)11-14-33-25-31-30-24(32(25)13-4-3-12-27)22-10-7-17-5-1-2-6-21(17)29-22/h1-2,5-10,15-16,28H,3-4,11-14,27H2 | Reactome pathway
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PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst3 receptor at 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169470
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C26H27N5S/c27-14-5-6-15-31-25(21-12-11-19-7-1-2-8-20(19)17-21)29-30-26(31)32-16-13-22-18-28-24-10-4-3-9-23(22)24/h1-4,7-12,17-18,28H,5-6,13-16,27H2 | PDB
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| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 4
(Homo sapiens (Human)) | BDBM50169471
(4-{3-[2-(7-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3c(Cl)cccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25ClN6S/c26-20-8-5-7-19-18(16-28-23(19)20)12-15-33-25-31-30-24(32(25)14-4-3-13-27)22-11-10-17-6-1-2-9-21(17)29-22/h1-2,5-11,16,28H,3-4,12-15,27H2 | PDB
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst4 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 1
(Homo sapiens (Human)) | BDBM50169462
(4-{3-[2-(7-Methyl-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES Cc1cccc2c(CCSc3nnc(-c4ccc5ccccc5n4)n3CCCCN)c[nH]c12 Show InChI InChI=1S/C26H28N6S/c1-18-7-6-9-21-20(17-28-24(18)21)13-16-33-26-31-30-25(32(26)15-5-4-14-27)23-12-11-19-8-2-3-10-22(19)29-23/h2-3,6-12,17,28H,4-5,13-16,27H2,1H3 | KEGG
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst1 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 4
(Homo sapiens (Human)) | BDBM50169462
(4-{3-[2-(7-Methyl-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES Cc1cccc2c(CCSc3nnc(-c4ccc5ccccc5n4)n3CCCCN)c[nH]c12 Show InChI InChI=1S/C26H28N6S/c1-18-7-6-9-21-20(17-28-24(18)21)13-16-33-26-31-30-25(32(26)15-5-4-14-27)23-12-11-19-8-2-3-10-22(19)29-23/h2-3,6-12,17,28H,4-5,13-16,27H2,1H3 | PDB
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| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst4 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169472
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cccc2ccccc12 Show InChI InChI=1S/C26H27N5S/c27-15-5-6-16-31-25(23-12-7-9-19-8-1-2-10-21(19)23)29-30-26(31)32-17-14-20-18-28-24-13-4-3-11-22(20)24/h1-4,7-13,18,28H,5-6,14-17,27H2 | PDB
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| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169463
(4-{3-Benzo[b]thiophen-2-yl-5-[2-(1H-indol-3-yl)-et...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cc2ccccc2s1 Show InChI InChI=1S/C24H25N5S2/c25-12-5-6-13-29-23(22-15-17-7-1-4-10-21(17)31-22)27-28-24(29)30-14-11-18-16-26-20-9-3-2-8-19(18)20/h1-4,7-10,15-16,26H,5-6,11-14,25H2 | PDB
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| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 3
(Homo sapiens (Human)) | BDBM50169465
(3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]tri...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)CCSc1nnc(-c2ccc3ccccc3n2)n1CCCCN Show InChI InChI=1S/C27H28N6OS/c1-18-7-6-9-20-21(17-29-25(18)20)24(34)13-16-35-27-32-31-26(33(27)15-5-4-14-28)23-12-11-19-8-2-3-10-22(19)30-23/h2-3,6-12,17,29H,4-5,13-16,28H2,1H3 | Reactome pathway
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| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst3 receptor at 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 1
(Homo sapiens (Human)) | BDBM50169471
(4-{3-[2-(7-Chloro-1H-indol-3-yl)-ethylsulfanyl]-5-...)Show SMILES NCCCCn1c(SCCc2c[nH]c3c(Cl)cccc23)nnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C25H25ClN6S/c26-20-8-5-7-19-18(16-28-23(19)20)12-15-33-25-31-30-24(32(25)14-4-3-13-27)22-11-10-17-6-1-2-9-21(17)29-22/h1-2,5-11,16,28H,3-4,12-15,27H2 | KEGG
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| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst1 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169474
(4-{3-(1H-Indol-7-yl)-5-[2-(1H-indol-3-yl)-ethylsul...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cccc2cc[nH]c12 Show InChI InChI=1S/C24H26N6S/c25-12-3-4-14-30-23(20-8-5-6-17-10-13-26-22(17)20)28-29-24(30)31-15-11-18-16-27-21-9-2-1-7-19(18)21/h1-2,5-10,13,16,26-27H,3-4,11-12,14-15,25H2 | PDB
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| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169477
(4-{3-(3-Bromo-phenyl)-5-[2-(1H-indol-3-yl)-ethylsu...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cccc(Br)c1 Show InChI InChI=1S/C22H24BrN5S/c23-18-7-5-6-16(14-18)21-26-27-22(28(21)12-4-3-11-24)29-13-10-17-15-25-20-9-2-1-8-19(17)20/h1-2,5-9,14-15,25H,3-4,10-13,24H2 | PDB
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| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169472
(4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1cccc2ccccc12 Show InChI InChI=1S/C26H27N5S/c27-15-5-6-16-31-25(23-12-7-9-19-8-1-2-10-21(19)23)29-30-26(31)32-17-14-20-18-28-24-13-4-3-11-22(20)24/h1-4,7-13,18,28H,5-6,14-17,27H2 | Reactome pathway
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| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169476
(4-{3-(4-Ethyl-phenyl)-5-[2-(1H-indol-3-yl)-ethylsu...)Show SMILES CCc1ccc(cc1)-c1nnc(SCCc2c[nH]c3ccccc23)n1CCCCN Show InChI InChI=1S/C24H29N5S/c1-2-18-9-11-19(12-10-18)23-27-28-24(29(23)15-6-5-14-25)30-16-13-20-17-26-22-8-4-3-7-21(20)22/h3-4,7-12,17,26H,2,5-6,13-16,25H2,1H3 | PDB
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| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 1
(Homo sapiens (Human)) | BDBM50169465
(3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]tri...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)CCSc1nnc(-c2ccc3ccccc3n2)n1CCCCN Show InChI InChI=1S/C27H28N6OS/c1-18-7-6-9-20-21(17-29-25(18)20)24(34)13-16-35-27-32-31-26(33(27)15-5-4-14-28)23-12-11-19-8-2-3-10-22(19)30-23/h2-3,6-12,17,29H,4-5,13-16,28H2,1H3 | KEGG
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| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst1 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169466
(5-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C27H29N5S/c28-15-6-1-7-16-32-26(22-13-12-20-8-2-3-9-21(20)18-22)30-31-27(32)33-17-14-23-19-29-25-11-5-4-10-24(23)25/h2-5,8-13,18-19,29H,1,6-7,14-17,28H2 | PDB
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| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 2
(Homo sapiens (Human)) | BDBM50169479
(3-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthale...)Show SMILES NCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C25H25N5S/c26-13-5-14-30-24(20-11-10-18-6-1-2-7-19(18)16-20)28-29-25(30)31-15-12-21-17-27-23-9-4-3-8-22(21)23/h1-4,6-11,16-17,27H,5,12-15,26H2 | PDB
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| 640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst2 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 4
(Homo sapiens (Human)) | BDBM50169465
(3-[4-(4-Amino-butyl)-5-quinolin-2-yl-4H-[1,2,4]tri...)Show SMILES Cc1cccc2c(c[nH]c12)C(=O)CCSc1nnc(-c2ccc3ccccc3n2)n1CCCCN Show InChI InChI=1S/C27H28N6OS/c1-18-7-6-9-20-21(17-29-25(18)20)24(34)13-16-35-27-32-31-26(33(27)15-5-4-14-28)23-12-11-19-8-2-3-10-22(19)30-23/h2-3,6-12,17,29H,4-5,13-16,28H2,1H3 | PDB
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| 800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Binding affinity against human sst4 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
Somatostatin receptor type 5
(Homo sapiens (Human)) | BDBM50169464
((4-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthal...)Show SMILES CN(C)CCCCn1c(SCCc2c[nH]c3ccccc23)nnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C28H31N5S/c1-32(2)16-7-8-17-33-27(23-14-13-21-9-3-4-10-22(21)19-23)30-31-28(33)34-18-15-24-20-29-26-12-6-5-11-25(24)26/h3-6,9-14,19-20,29H,7-8,15-18H2,1-2H3 | Reactome pathway
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| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut Henri Beaufour
Curated by ChEMBL
| Assay Description
Inhibitory constant against human sst5 receptor at a dose of 10 uM |
Bioorg Med Chem Lett 15: 3555-9 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.061
BindingDB Entry DOI: 10.7270/Q2W66MH6 |
More data for this
Ligand-Target Pair | |
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