Found 49 hits Enz. Inhib. hit(s) with all data for entry = 50007984 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069833
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)Show InChI InChI=1S/C14H22N2O/c1-3-5-12-8-14(10-15-9-12)17-11-13-6-4-7-16(13)2/h8-10,13H,3-7,11H2,1-2H3/t13-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50049756
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)Show InChI InChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069846
(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C15H24N2O/c1-3-4-6-13-9-15(11-16-10-13)18-12-14-7-5-8-17(14)2/h9-11,14H,3-8,12H2,1-2H3/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069852
(3-Isobutyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)...)Show InChI InChI=1S/C15H24N2O/c1-12(2)7-13-8-15(10-16-9-13)18-11-14-5-4-6-17(14)3/h8-10,12,14H,4-7,11H2,1-3H3/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069827
(3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-4-2-3-10(14)8-15-11-5-9(12)6-13-7-11/h5-7,10H,2-4,8H2,1H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory concentration to antagonise cation efflux in nAChR subtype human alpha3betaX, expressed in IMR-32 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069834
(3-Hexyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C17H28N2O/c1-3-4-5-6-8-15-11-17(13-18-12-15)20-14-16-9-7-10-19(16)2/h11-13,16H,3-10,14H2,1-2H3/t16-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069837
(3-Ethyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C13H20N2O/c1-3-11-7-13(9-14-8-11)16-10-12-5-4-6-15(12)2/h7-9,12H,3-6,10H2,1-2H3/t12-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069839
(3-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-6-12(8-13-7-10)15-9-11-4-3-5-14(11)2/h6-8,11H,3-5,9H2,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.480 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069851
(3-Chloro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C11H15ClN2O/c1-14-4-2-3-10(14)8-15-11-5-9(12)6-13-7-11/h5-7,10H,2-4,8H2,1H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069848
(5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin-3-...)Show InChI InChI=1S/C11H17N3O/c1-14-4-2-3-10(14)8-15-11-5-9(12)6-13-7-11/h5-7,10H,2-4,8,12H2,1H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069843
(2-Chloro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C11H15ClN2O/c1-14-6-2-3-9(14)8-15-10-4-5-11(12)13-7-10/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069844
(3-Fluoro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C11H15FN2O/c1-14-4-2-3-10(14)8-15-11-5-9(12)6-13-7-11/h5-7,10H,2-4,8H2,1H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069841
(1-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)Show InChI InChI=1S/C13H18N2O2/c1-10(16)11-6-13(8-14-7-11)17-9-12-4-3-5-15(12)2/h6-8,12H,3-5,9H2,1-2H3/t12-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069826
(2-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-5-6-12(8-13-10)15-9-11-4-3-7-14(11)2/h5-6,8,11H,3-4,7,9H2,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069829
(5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-nicotinic ...)Show InChI InChI=1S/C13H18N2O3/c1-15-5-3-4-11(15)9-18-12-6-10(7-14-8-12)13(16)17-2/h6-8,11H,3-5,9H2,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069836
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-trifluor...)Show InChI InChI=1S/C12H15F3N2O/c1-17-4-2-3-10(17)8-18-11-5-9(6-16-7-11)12(13,14)15/h5-7,10H,2-4,8H2,1H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069840
(2-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-6-2-3-9(14)8-15-10-4-5-11(12)13-7-10/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069850
(2-Fluoro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C11H15FN2O/c1-14-6-2-3-9(14)8-15-10-4-5-11(12)13-7-10/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069830
(CHEMBL84537 | Ethyl-[5-((S)-1-methyl-pyrrolidin-2-...)Show InChI InChI=1S/C13H21N3O/c1-3-15-11-7-13(9-14-8-11)17-10-12-5-4-6-16(12)2/h7-9,12,15H,3-6,10H2,1-2H3/t12-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069828
(4-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-5-6-13-8-12(10)15-9-11-4-3-7-14(11)2/h5-6,8,11H,3-4,7,9H2,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069847
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-nitro-py...)Show InChI InChI=1S/C11H15N3O3/c1-13-4-2-3-9(13)8-17-11-5-10(14(15)16)6-12-7-11/h5-7,9H,2-4,8H2,1H3/t9-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069832
(CHEMBL82954 | [5-((S)-1-Methyl-pyrrolidin-2-ylmeth...)Show InChI InChI=1S/C16H23N3O2/c1-18-6-4-5-14(18)12-21-15-9-13(10-17-11-15)16(20)19-7-2-3-8-19/h9-11,14H,2-8,12H2,1H3/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50056148
(2-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-12(6-3-7-13-10)15-9-11-5-4-8-14(11)2/h3,6-7,11H,4-5,8-9H2,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069835
(4-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-6-2-3-9(14)8-15-11-7-13-5-4-10(11)12/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069838
(3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O2/c1-13-4-2-3-10(13)8-16-11-5-9(12)6-14(15)7-11/h5-7,10H,2-4,8H2,1H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069849
(CHEMBL412372 | [5-((S)-1-Methyl-pyrrolidin-2-ylmet...)Show InChI InChI=1S/C12H18N2O2/c1-14-6-2-3-11(14)9-16-12-5-4-10(8-15)13-7-12/h4-5,7,11,15H,2-3,6,8-9H2,1H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069831
(2-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-7-3-4-9(14)8-15-10-5-2-6-13-11(10)12/h2,5-6,9H,3-4,7-8H2,1H3/t9-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 451 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069845
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-2-methylsu...)Show InChI InChI=1S/C12H18N2OS/c1-14-8-4-5-10(14)9-15-11-6-3-7-13-12(11)16-2/h3,6-7,10H,4-5,8-9H2,1-2H3/t10-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 559 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069853
(2-Iodo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyr...)Show InChI InChI=1S/C11H15IN2O/c1-14-7-3-4-9(14)8-15-10-5-2-6-13-11(10)12/h2,5-6,9H,3-4,7-8H2,1H3/t9-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 606 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069854
(CHEMBL310893 | N,N-Diethyl-3-((S)-1-methyl-pyrroli...)Show InChI InChI=1S/C16H25N3O2/c1-4-19(5-2)16(20)14-8-9-17-11-15(14)21-12-13-7-6-10-18(13)3/h8-9,11,13H,4-7,10,12H2,1-3H3/t13-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 2.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50069842
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-2-nitro-py...)Show InChI InChI=1S/C11H15N3O3/c1-13-7-3-4-9(13)8-17-10-5-2-6-12-11(10)14(15)16/h2,5-6,9H,3-4,7-8H2,1H3/t9-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069846
(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C15H24N2O/c1-3-4-6-13-9-15(11-16-10-13)18-12-14-7-5-8-17(14)2/h9-11,14H,3-8,12H2,1-2H3/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibitory concentration to antagonise cation efflux in nAChR subtype human alpha3betaX, expressed in IMR-32 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069833
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)Show InChI InChI=1S/C14H22N2O/c1-3-5-12-8-14(10-15-9-12)17-11-13-6-4-7-16(13)2/h8-10,13H,3-7,11H2,1-2H3/t13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069833
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)Show InChI InChI=1S/C14H22N2O/c1-3-5-12-8-14(10-15-9-12)17-11-13-6-4-7-16(13)2/h8-10,13H,3-7,11H2,1-2H3/t13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069846
(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C15H24N2O/c1-3-4-6-13-9-15(11-16-10-13)18-12-14-7-5-8-17(14)2/h9-11,14H,3-8,12H2,1-2H3/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Inhibition of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid PDB UniChem
Similars
| PDB PubMed
| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069831
(2-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-7-3-4-9(14)8-15-10-5-2-6-13-11(10)12/h2,5-6,9H,3-4,7-8H2,1H3/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069826
(2-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-5-6-12(8-13-10)15-9-11-4-3-7-14(11)2/h5-6,8,11H,3-4,7,9H2,1-2H3/t11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50056148
(2-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-12(6-3-7-13-10)15-9-11-5-4-8-14(11)2/h3,6-7,11H,4-5,8-9H2,1-2H3/t11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069833
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-propyl-p...)Show InChI InChI=1S/C14H22N2O/c1-3-5-12-8-14(10-15-9-12)17-11-13-6-4-7-16(13)2/h8-10,13H,3-7,11H2,1-2H3/t13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069827
(3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-4-2-3-10(14)8-15-11-5-9(12)6-13-7-11/h5-7,10H,2-4,8H2,1H3/t10-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 5.95E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069835
(4-Bromo-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-6-2-3-9(14)8-15-11-7-13-5-4-10(11)12/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069846
(3-Butyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C15H24N2O/c1-3-4-6-13-9-15(11-16-10-13)18-12-14-7-5-8-17(14)2/h9-11,14H,3-8,12H2,1-2H3/t14-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069828
(4-Methyl-3-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-5-6-13-8-12(10)15-9-11-4-3-7-14(11)2/h5-6,8,11H,3-4,7,9H2,1-2H3/t11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069837
(3-Ethyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C13H20N2O/c1-3-11-7-13(9-14-8-11)16-10-12-5-4-6-15(12)2/h7-9,12H,3-6,10H2,1-2H3/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50049756
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)Show InChI InChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069843
(2-Chloro-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C11H15ClN2O/c1-14-6-2-3-9(14)8-15-10-4-5-11(12)13-7-10/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Stimulation of cation efflux in human nAChR alpha4-beta2 expressing K177 cells |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069840
(2-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-py...)Show InChI InChI=1S/C11H15BrN2O/c1-14-6-2-3-9(14)8-15-10-4-5-11(12)13-7-10/h4-5,7,9H,2-3,6,8H2,1H3/t9-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50069839
(3-Methyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-p...)Show InChI InChI=1S/C12H18N2O/c1-10-6-12(8-13-7-10)15-9-11-4-3-5-14(11)2/h6-8,11H,3-5,9H2,1-2H3/t11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. |
Bioorg Med Chem Lett 8: 249-54 (1999)
BindingDB Entry DOI: 10.7270/Q2P26X90 |
More data for this Ligand-Target Pair | |