BindingDB PrimarySearch

Found 24 hits Enz. Inhib. hit(s) with all data for entry = 50017629
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	5.5	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clamp				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184729 (2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	5.5	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clamp				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184738 (2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184730 (4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyrid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184730 (4-(trifluoromethyl)-N-(4-(3-(trifluoromethyl)pyrid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	5.5	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clamp				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184729 (2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184745 (CHEMBL209124 \| N-(4-(3-methylpyridin-2-yl)phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184731 (6-(2-methoxyphenyl)-2-(4-(trifluoromethyl)phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184735 (2-p-tolyl-6-(3-(trifluoromethyl)pyridin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184740 (6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phe...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50184729 (2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing rat TRPV1 assessed by patch clamp				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM50184729 (2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing rat TRPV1 assessed by patch clamp				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184742 (2-(4-tert-butylphenyl)-6-(3-(trifluoromethyl)pyrid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184734 (6-(3-methylpyridin-2-yl)-2-(4-(trifluoromethyl)phe...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184739 (2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184741 (2-(4-fluorophenyl)-6-(3-(trifluoromethyl)pyridin-2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184747 (2-(4-(trifluoromethyl)phenyl)-1,2-dihydroindazol-3...) Show SMILES FC(F)(F)c1ccc(cc1)-n1[nH]c2ccccc2c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184743 (2-(4-(trifluoromethyl)phenyl)-5-(3-(trifluoromethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184746 (4-tert-butyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184733 (CHEMBL210667 \| N-(4-(3-methylpyridin-2-yl)phenyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184732 (4-methyl-N-(4-(3-(trifluoromethyl)pyridin-2-yl)phe...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184744 (CHEMBL209112 \| N-(4-(pyridin-2-yl)phenyl)-4-(trifl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184736 (CHEMBL208870 \| N-(4-(3-(trifluoromethyl)pyridin-2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair