Found 132 hits Enz. Inhib. hit(s) with all data for entry = 50021947 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM11868
(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccccc3)cc2)CCN(CC#C)CC1 Show InChI InChI=1S/C22H24N2O5S/c1-2-14-24-15-12-22(13-16-24,21(25)23-26)17-30(27,28)20-10-8-19(9-11-20)29-18-6-4-3-5-7-18/h1,3-11,26H,12-17H2,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM11868
(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccccc3)cc2)CCN(CC#C)CC1 Show InChI InChI=1S/C22H24N2O5S/c1-2-14-24-15-12-22(13-16-24,21(25)23-26)17-30(27,28)20-10-8-19(9-11-20)29-18-6-4-3-5-7-18/h1,3-11,26H,12-17H2,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP3 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM11868
(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)Show SMILES ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccccc3)cc2)CCN(CC#C)CC1 Show InChI InChI=1S/C22H24N2O5S/c1-2-14-24-15-12-22(13-16-24,21(25)23-26)17-30(27,28)20-10-8-19(9-11-20)29-18-6-4-3-5-7-18/h1,3-11,26H,12-17H2,(H,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP9 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50229639
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(=CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 |c:12| Show InChI InChI=1S/C23H31N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-6,20,29H,7-17H2,(H,24,27)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229655
(CHEMBL442432 | trans-2-hydroxycyclopentyl 4-(hydro...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1CCCC1O)C(=O)NO |w:26.28,30.34| Show InChI InChI=1S/C25H37N3O7S/c1-18-5-2-3-6-20(18)19-9-13-28(14-10-19)36(33,34)17-25(23(30)26-32)11-15-27(16-12-25)24(31)35-22-8-4-7-21(22)29/h2-3,5-6,19,21-22,29,32H,4,7-17H2,1H3,(H,26,30) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229651
((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@@H]1CCCN1)C(=O)NO)C#N Show InChI InChI=1S/C26H37N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-5,15,21-22,28,34H,2-3,6-14,17-18H2,1H3,(H,29,32)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229639
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(=CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 |c:12| Show InChI InChI=1S/C23H31N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-6,20,29H,7-17H2,(H,24,27)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229641
(CHEMBL400528 | pyrrolidin-3-yl 4-((4-(4-cyano-2-me...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1CCNC1)C(=O)NO)C#N |w:26.28| Show InChI InChI=1S/C25H35N5O6S/c1-18-14-19(15-26)2-3-22(18)20-5-10-30(11-6-20)37(34,35)17-25(23(31)28-33)7-12-29(13-8-25)24(32)36-21-4-9-27-16-21/h2-3,14,20-21,27,33H,4-13,16-17H2,1H3,(H,28,31) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50229634
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyanophenyl)pipe...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccc(cc2)C#N)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C24H32N4O7S/c25-15-18-1-3-19(4-2-18)20-5-10-28(11-6-20)36(32,33)17-24(22(29)26-31)8-12-27(13-9-24)23(30)35-21-7-14-34-16-21/h1-4,20-21,31H,5-14,16-17H2,(H,26,29)/t21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229651
((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@@H]1CCCN1)C(=O)NO)C#N Show InChI InChI=1S/C26H37N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-5,15,21-22,28,34H,2-3,6-14,17-18H2,1H3,(H,29,32)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229639
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(=CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 |c:12| Show InChI InChI=1S/C23H31N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-6,20,29H,7-17H2,(H,24,27)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229636
((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@H]1CCCN1)C(=O)NO)C#N Show InChI InChI=1S/C26H37N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-5,15,21-22,28,34H,2-3,6-14,17-18H2,1H3,(H,29,32)/t22-/m1/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229660
(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1(C)CCOC1)C(=O)NO |w:26.29| Show InChI InChI=1S/C25H37N3O7S/c1-19-5-3-4-6-21(19)20-7-12-28(13-8-20)36(32,33)18-25(22(29)26-31)9-14-27(15-10-25)23(30)35-24(2)11-16-34-17-24/h3-6,20,31H,7-18H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229643
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO)C#N Show InChI InChI=1S/C25H34N4O7S/c1-18-14-19(15-26)2-3-22(18)20-4-9-29(10-5-20)37(33,34)17-25(23(30)27-32)7-11-28(12-8-25)24(31)36-21-6-13-35-16-21/h2-3,14,20-21,32H,4-13,16-17H2,1H3,(H,27,30)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229657
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCN(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C22H32N4O7S/c27-20(23-29)22(7-9-25(10-8-22)21(28)33-19-6-15-32-16-19)17-34(30,31)26-13-11-24(12-14-26)18-4-2-1-3-5-18/h1-5,19,29H,6-17H2,(H,23,27)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50229657
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCN(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C22H32N4O7S/c27-20(23-29)22(7-9-25(10-8-22)21(28)33-19-6-15-32-16-19)17-34(30,31)26-13-11-24(12-14-26)18-4-2-1-3-5-18/h1-5,19,29H,6-17H2,(H,23,27)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229641
(CHEMBL400528 | pyrrolidin-3-yl 4-((4-(4-cyano-2-me...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1CCNC1)C(=O)NO)C#N |w:26.28| Show InChI InChI=1S/C25H35N5O6S/c1-18-14-19(15-26)2-3-22(18)20-5-10-30(11-6-20)37(34,35)17-25(23(31)28-33)7-12-29(13-8-25)24(32)36-21-4-9-27-16-21/h2-3,14,20-21,27,33H,4-13,16-17H2,1H3,(H,28,31) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229643
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO)C#N Show InChI InChI=1S/C25H34N4O7S/c1-18-14-19(15-26)2-3-22(18)20-4-9-29(10-5-20)37(33,34)17-25(23(30)27-32)7-11-28(12-8-25)24(31)36-21-6-13-35-16-21/h2-3,14,20-21,32H,4-13,16-17H2,1H3,(H,27,30)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229635
(4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbam...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1COCC1(C)C)C(=O)NO |w:26.28| Show InChI InChI=1S/C26H39N3O7S/c1-19-6-4-5-7-21(19)20-8-12-29(13-9-20)37(33,34)18-26(23(30)27-32)10-14-28(15-11-26)24(31)36-22-16-35-17-25(22,2)3/h4-7,20,22,32H,8-18H2,1-3H3,(H,27,30) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229657
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCN(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C22H32N4O7S/c27-20(23-29)22(7-9-25(10-8-22)21(28)33-19-6-15-32-16-19)17-34(30,31)26-13-11-24(12-14-26)18-4-2-1-3-5-18/h1-5,19,29H,6-17H2,(H,23,27)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229655
(CHEMBL442432 | trans-2-hydroxycyclopentyl 4-(hydro...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1CCCC1O)C(=O)NO |w:26.28,30.34| Show InChI InChI=1S/C25H37N3O7S/c1-18-5-2-3-6-20(18)19-9-13-28(14-10-19)36(33,34)17-25(23(30)26-32)11-15-27(16-12-25)24(31)35-22-8-4-7-21(22)29/h2-3,5-6,19,21-22,29,32H,4,7-17H2,1H3,(H,26,30) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229656
(CHEMBL252612 | pyrrolidin-3-yl 4-(hydroxycarbamoyl...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1CCNC1)C(=O)NO |w:26.28| Show InChI InChI=1S/C24H36N4O6S/c1-18-4-2-3-5-21(18)19-7-12-28(13-8-19)35(32,33)17-24(22(29)26-31)9-14-27(15-10-24)23(30)34-20-6-11-25-16-20/h2-5,19-20,25,31H,6-17H2,1H3,(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229650
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C24H35N3O7S/c1-18-4-2-3-5-21(18)19-6-11-27(12-7-19)35(31,32)17-24(22(28)25-30)9-13-26(14-10-24)23(29)34-20-8-15-33-16-20/h2-5,19-20,30H,6-17H2,1H3,(H,25,28)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229640
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES Cc1ccccc1C1=CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO |t:8| Show InChI InChI=1S/C24H33N3O7S/c1-18-4-2-3-5-21(18)19-6-11-27(12-7-19)35(31,32)17-24(22(28)25-30)9-13-26(14-10-24)23(29)34-20-8-15-33-16-20/h2-6,20,30H,7-17H2,1H3,(H,25,28)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229656
(CHEMBL252612 | pyrrolidin-3-yl 4-(hydroxycarbamoyl...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1CCNC1)C(=O)NO |w:26.28| Show InChI InChI=1S/C24H36N4O6S/c1-18-4-2-3-5-21(18)19-7-12-28(13-8-19)35(32,33)17-24(22(29)26-31)9-14-27(15-10-24)23(30)34-20-6-11-25-16-20/h2-5,19-20,25,31H,6-17H2,1H3,(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50229644
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C23H33N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-5,19-20,29H,6-17H2,(H,24,27)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229647
((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1=CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@H]1CCCN1)C(=O)NO)C#N |t:8| Show InChI InChI=1S/C26H35N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-6,15,22,28,34H,2-3,7-14,17-18H2,1H3,(H,29,32)/t22-/m1/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229646
((R)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@H]1CCCN1)C(=O)NO Show InChI InChI=1S/C25H38N4O6S/c1-19-5-2-3-7-22(19)20-8-13-29(14-9-20)36(33,34)18-25(23(30)27-32)10-15-28(16-11-25)24(31)35-17-21-6-4-12-26-21/h2-3,5,7,20-21,26,32H,4,6,8-18H2,1H3,(H,27,30)/t21-/m1/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50229644
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C23H33N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-5,19-20,29H,6-17H2,(H,24,27)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP9 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229644
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C23H33N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-5,19-20,29H,6-17H2,(H,24,27)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229635
(4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbam...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1COCC1(C)C)C(=O)NO |w:26.28| Show InChI InChI=1S/C26H39N3O7S/c1-19-6-4-5-7-21(19)20-8-12-29(13-9-20)37(33,34)18-26(23(30)27-32)10-14-28(15-11-26)24(31)36-22-16-35-17-25(22,2)3/h4-7,20,22,32H,8-18H2,1-3H3,(H,27,30) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229636
((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@H]1CCCN1)C(=O)NO)C#N Show InChI InChI=1S/C26H37N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-5,15,21-22,28,34H,2-3,6-14,17-18H2,1H3,(H,29,32)/t22-/m1/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229661
((S)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@@H]1CCCN1)C(=O)NO Show InChI InChI=1S/C25H38N4O6S/c1-19-5-2-3-7-22(19)20-8-13-29(14-9-20)36(33,34)18-25(23(30)27-32)10-15-28(16-11-25)24(31)35-17-21-6-4-12-26-21/h2-3,5,7,20-21,26,32H,4,6,8-18H2,1H3,(H,27,30)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229647
((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1=CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@H]1CCCN1)C(=O)NO)C#N |t:8| Show InChI InChI=1S/C26H35N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-6,15,22,28,34H,2-3,7-14,17-18H2,1H3,(H,29,32)/t22-/m1/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50229639
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(=CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 |c:12| Show InChI InChI=1S/C23H31N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-6,20,29H,7-17H2,(H,24,27)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP9 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229654
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)Show SMILES Cc1cc(ccc1N1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO)C#N Show InChI InChI=1S/C24H33N5O7S/c1-18-14-19(15-25)2-3-21(18)27-9-11-29(12-10-27)37(33,34)17-24(22(30)26-32)5-7-28(8-6-24)23(31)36-20-4-13-35-16-20/h2-3,14,20,32H,4-13,16-17H2,1H3,(H,26,30)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229654
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)Show SMILES Cc1cc(ccc1N1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO)C#N Show InChI InChI=1S/C24H33N5O7S/c1-18-14-19(15-25)2-3-21(18)27-9-11-29(12-10-27)37(33,34)17-24(22(30)26-32)5-7-28(8-6-24)23(31)36-20-4-13-35-16-20/h2-3,14,20,32H,4-13,16-17H2,1H3,(H,26,30)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229645
((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1=CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@@H]1CCCN1)C(=O)NO)C#N |t:8| Show InChI InChI=1S/C26H35N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-6,15,22,28,34H,2-3,7-14,17-18H2,1H3,(H,29,32)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229644
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C23H33N3O7S/c27-21(24-29)23(9-13-25(14-10-23)22(28)33-20-8-15-32-16-20)17-34(30,31)26-11-6-19(7-12-26)18-4-2-1-3-5-18/h1-5,19-20,29H,6-17H2,(H,24,27)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229646
((R)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@H]1CCCN1)C(=O)NO Show InChI InChI=1S/C25H38N4O6S/c1-19-5-2-3-7-22(19)20-8-13-29(14-9-20)36(33,34)18-25(23(30)27-32)10-15-28(16-11-25)24(31)35-17-21-6-4-12-26-21/h2-3,5,7,20-21,26,32H,4,6,8-18H2,1H3,(H,27,30)/t21-/m1/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229645
((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)Show SMILES Cc1cc(ccc1C1=CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@@H]1CCCN1)C(=O)NO)C#N |t:8| Show InChI InChI=1S/C26H35N5O6S/c1-19-15-20(16-27)4-5-23(19)21-6-11-31(12-7-21)38(35,36)18-26(24(32)29-34)8-13-30(14-9-26)25(33)37-17-22-3-2-10-28-22/h4-6,15,22,28,34H,2-3,7-14,17-18H2,1H3,(H,29,32)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229661
((S)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC[C@@H]1CCCN1)C(=O)NO Show InChI InChI=1S/C25H38N4O6S/c1-19-5-2-3-7-22(19)20-8-13-29(14-9-20)36(33,34)18-25(23(30)27-32)10-15-28(16-11-25)24(31)35-17-21-6-4-12-26-21/h2-3,5,7,20-21,26,32H,4,6,8-18H2,1H3,(H,27,30)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229660
(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1(C)CCOC1)C(=O)NO |w:26.29| Show InChI InChI=1S/C25H37N3O7S/c1-19-5-3-4-6-21(19)20-7-12-28(13-8-20)36(32,33)18-25(22(29)26-31)9-14-27(15-10-25)23(30)35-24(2)11-16-34-17-24/h3-6,20,31H,7-18H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229634
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyanophenyl)pipe...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccc(cc2)C#N)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C24H32N4O7S/c25-15-18-1-3-19(4-2-18)20-5-10-28(11-6-20)36(32,33)17-24(22(29)26-31)8-12-27(13-9-24)23(30)35-21-7-14-34-16-21/h1-4,20-21,31H,5-14,16-17H2,(H,26,29)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229650
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C24H35N3O7S/c1-18-4-2-3-5-21(18)19-6-11-27(12-7-19)35(31,32)17-24(22(28)25-30)9-13-26(14-10-24)23(29)34-20-8-15-33-16-20/h2-5,19-20,30H,6-17H2,1H3,(H,25,28)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229642
((S)-tetrahydrofuran-3-yl 4-((4-(2-fluorophenyl)pip...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccccc2F)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C23H32FN3O7S/c24-20-4-2-1-3-19(20)17-5-10-27(11-6-17)35(31,32)16-23(21(28)25-30)8-12-26(13-9-23)22(29)34-18-7-14-33-15-18/h1-4,17-18,30H,5-16H2,(H,25,28)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229663
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)Show SMILES Cc1cc(ccc1C1=CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO)C#N |t:8| Show InChI InChI=1S/C25H32N4O7S/c1-18-14-19(15-26)2-3-22(18)20-4-9-29(10-5-20)37(33,34)17-25(23(30)27-32)7-11-28(12-8-25)24(31)36-21-6-13-35-16-21/h2-4,14,21,32H,5-13,16-17H2,1H3,(H,27,30)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50229659
((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CC=C(C2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 |c:11| Show InChI InChI=1S/C22H29N3O7S/c26-20(23-28)22(8-11-24(12-9-22)21(27)32-19-7-13-31-15-19)16-33(29,30)25-10-6-18(14-25)17-4-2-1-3-5-17/h1-6,19,28H,7-16H2,(H,23,26)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229648
((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-3,5-dimeth...)Show SMILES Cc1cc(cc(C)c1C#N)C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)O[C@H]1CCOC1)C(=O)NO Show InChI InChI=1S/C26H36N4O7S/c1-18-13-21(14-19(2)23(18)15-27)20-3-8-30(9-4-20)38(34,35)17-26(24(31)28-33)6-10-29(11-7-26)25(32)37-22-5-12-36-16-22/h13-14,20,22,33H,3-12,16-17H2,1-2H3,(H,28,31)/t22-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of ADAM10 |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50229642
((S)-tetrahydrofuran-3-yl 4-((4-(2-fluorophenyl)pip...)Show SMILES ONC(=O)C1(CS(=O)(=O)N2CCC(CC2)c2ccccc2F)CCN(CC1)C(=O)O[C@H]1CCOC1 Show InChI InChI=1S/C23H32FN3O7S/c24-20-4-2-1-3-19(20)17-5-10-27(11-6-17)35(31,32)16-23(21(28)25-30)8-12-26(13-9-23)22(29)34-18-7-14-33-15-18/h1-4,17-18,30H,5-16H2,(H,25,28)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 sheddase in human BT474 cells |
Bioorg Med Chem Lett 18: 560-4 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.086 BindingDB Entry DOI: 10.7270/Q2CN73MJ |
More data for this Ligand-Target Pair | |