BindingDB PrimarySearch

Found 26 hits Enz. Inhib. hit(s) with all data for entry = 50010919
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100131 (5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100135 ((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100135 ((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100131 (5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant of compound on ligand binding to aggregates of Amyloid beta was measured by comparing with [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100130 (4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(I)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100130 (4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(I)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100132 (6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100132 (6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100133 (CHEMBL55401 \| [4-(6-Bromo-benzothiazol-2-yl)-pheny...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100133 (CHEMBL55401 \| [4-(6-Bromo-benzothiazol-2-yl)-pheny...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100136 (6-Iodo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-benz...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ccc(I)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100136 (6-Iodo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-benz...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ccc(I)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100134 (2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...) Show SMILES CN(C)c1ccc(cc1)-c1sc2cc(C)ccc2[n+]1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	116	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100134 (2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...) Show SMILES CN(C)c1ccc(cc1)-c1sc2cc(C)ccc2[n+]1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	116	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100135 ((E,E)-1-iodo-2,5-bis-(3-hydroxycarbonyl-4-methoxy)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100131 (5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for amyloid beta compared to [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100136 (6-Iodo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-benz...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ccc(I)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100132 (6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100131 (5-(Biphenyl-4-ylazo)-bis (2-hydroxy-benzoic acid)(...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant of compound on ligand binding to aggregates of Amyloid beta was measured by comparing with [125I]-TZDM				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100130 (4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(I)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100133 (CHEMBL55401 \| [4-(6-Bromo-benzothiazol-2-yl)-pheny...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100130 (4-(6-Iodobenzo[d]thiazol-2-yl)-N,N-dimethylaniline...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(I)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100132 (6-Bromo-2-[4-(4-methyl-piperazin-1-yl)-phenyl]-ben...) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100133 (CHEMBL55401 \| [4-(6-Bromo-benzothiazol-2-yl)-pheny...) Show SMILES CN(C)c1ccc(cc1)-c1nc2ccc(Br)cc2s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100134 (2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...) Show SMILES CN(C)c1ccc(cc1)-c1sc2cc(C)ccc2[n+]1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50100134 (2-(4-Dimethylamino-phenyl)-3,6-dimethyl-benzothiaz...) Show SMILES CN(C)c1ccc(cc1)-c1sc2cc(C)ccc2[n+]1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Pennsylvania Curated by ChEMBL					Assay Description Inhibition constant for aggregates of amyloid beta compared to [125I]-IMSB				J Med Chem 44: 1905-14 (2001) BindingDB Entry DOI: 10.7270/Q2V69HV8
University of Pennsylvania Curated by ChEMBL					More data for this Ligand-Target Pair