Found 116 hits Enz. Inhib. hit(s) with all data for entry = 50012146 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115351
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccc(C)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H29N5O4/c1-19-4-8-21(9-5-19)37-22-10-6-20(7-11-22)31-28(34)33-14-12-32(13-15-33)27-23-16-25(35-2)26(36-3)17-24(23)29-18-30-27/h4-11,16-18H,12-15H2,1-3H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115335
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccc(Cl)cc4)cc3)c2cc1OC Show InChI InChI=1S/C27H26ClN5O4/c1-35-24-15-22-23(16-25(24)36-2)29-17-30-26(22)32-11-13-33(14-12-32)27(34)31-19-5-9-21(10-6-19)37-20-7-3-18(28)4-8-20/h3-10,15-17H,11-14H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115302
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)C)c2cc1OC Show InChI InChI=1S/C24H29N5O3/c1-16(2)17-5-7-18(8-6-17)27-24(30)29-11-9-28(10-12-29)23-19-13-21(31-3)22(32-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115347
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)(C)C)c2cc1OC Show InChI InChI=1S/C25H31N5O3/c1-25(2,3)17-6-8-18(9-7-17)28-24(31)30-12-10-29(11-13-30)23-19-14-21(32-4)22(33-5)15-20(19)26-16-27-23/h6-9,14-16H,10-13H2,1-5H3,(H,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50115302
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)C)c2cc1OC Show InChI InChI=1S/C24H29N5O3/c1-16(2)17-5-7-18(8-6-17)27-24(30)29-11-9-28(10-12-29)23-19-13-21(31-3)22(32-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Flt3 kinase |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50115302
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)C)c2cc1OC Show InChI InChI=1S/C24H29N5O3/c1-16(2)17-5-7-18(8-6-17)27-24(30)29-11-9-28(10-12-29)23-19-13-21(31-3)22(32-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50115301
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115299
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4cccc5ccccc45)cc3)c2cc1OC Show InChI InChI=1S/C31H29N5O4/c1-38-28-18-25-26(19-29(28)39-2)32-20-33-30(25)35-14-16-36(17-15-35)31(37)34-22-10-12-23(13-11-22)40-27-9-5-7-21-6-3-4-8-24(21)27/h3-13,18-20H,14-17H2,1-2H3,(H,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50115301
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor alpha |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115331
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Cc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C28H29N5O3/c1-35-25-17-23-24(18-26(25)36-2)29-19-30-27(23)32-12-14-33(15-13-32)28(34)31-22-10-8-21(9-11-22)16-20-6-4-3-5-7-20/h3-11,17-19H,12-16H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115302
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)C)c2cc1OC Show InChI InChI=1S/C24H29N5O3/c1-16(2)17-5-7-18(8-6-17)27-24(30)29-11-9-28(10-12-29)23-19-13-21(31-3)22(32-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115301
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115319
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Nc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H28N6O3/c1-35-24-16-22-23(17-25(24)36-2)28-18-29-26(22)32-12-14-33(15-13-32)27(34)31-21-10-8-20(9-11-21)30-19-6-4-3-5-7-19/h3-11,16-18,30H,12-15H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50115302
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)C)c2cc1OC Show InChI InChI=1S/C24H29N5O3/c1-16(2)17-5-7-18(8-6-17)27-24(30)29-11-9-28(10-12-29)23-19-13-21(31-3)22(32-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor alpha |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115354
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(Br)c(Cl)c3)c2cc1OC Show InChI InChI=1S/C21H21BrClN5O2S/c1-29-18-10-14-17(11-19(18)30-2)24-12-25-20(14)27-5-7-28(8-6-27)21(31)26-13-3-4-15(22)16(23)9-13/h3-4,9-12H,5-8H2,1-2H3,(H,26,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115308
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1ccccc1Oc1ccc(NC(=O)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C28H29N5O5/c1-35-23-6-4-5-7-24(23)38-20-10-8-19(9-11-20)31-28(34)33-14-12-32(13-15-33)27-21-16-25(36-2)26(37-3)17-22(21)29-18-30-27/h4-11,16-18H,12-15H2,1-3H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115306
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES CCCc1ccc(NC(=O)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C24H29N5O3/c1-4-5-17-6-8-18(9-7-17)27-24(30)29-12-10-28(11-13-29)23-19-14-21(31-2)22(32-3)15-20(19)25-16-26-23/h6-9,14-16H,4-5,10-13H2,1-3H3,(H,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50115298
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Br)cc3)c2cc1OC Show InChI InChI=1S/C21H22BrN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115301
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115327
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccc(N)cc4)cc3)c2cc1OC Show InChI InChI=1S/C27H28N6O4/c1-35-24-15-22-23(16-25(24)36-2)29-17-30-26(22)32-11-13-33(14-12-32)27(34)31-19-5-9-21(10-6-19)37-20-7-3-18(28)4-8-20/h3-10,15-17H,11-14,28H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115334
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=[SH+])[N-]c3ccc(Cl)c(c3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H21ClN6O4S/c1-31-18-10-14-16(11-19(18)32-2)23-12-24-20(14)26-5-7-27(8-6-26)21(33)25-13-3-4-15(22)17(9-13)28(29)30/h3-4,9-12H,5-8H2,1-2H3,(H,25,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115311
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=[SH+])[N-]c3cccc(c3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H22N6O4S/c1-30-18-11-16-17(12-19(18)31-2)22-13-23-20(16)25-6-8-26(9-7-25)21(32)24-14-4-3-5-15(10-14)27(28)29/h3-5,10-13H,6-9H2,1-2H3,(H,24,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115344
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES CCCCc1ccc(NC(=O)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C25H31N5O3/c1-4-5-6-18-7-9-19(10-8-18)28-25(31)30-13-11-29(12-14-30)24-20-15-22(32-2)23(33-3)16-21(20)26-17-27-24/h7-10,15-17H,4-6,11-14H2,1-3H3,(H,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115326
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(Br)cc3)c2cc1OC Show InChI InChI=1S/C21H22BrN5O2S/c1-28-18-11-16-17(12-19(18)29-2)23-13-24-20(16)26-7-9-27(10-8-26)21(30)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115350
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(OC(C)C)cc3)c2cc1OC Show InChI InChI=1S/C24H29N5O4/c1-16(2)33-18-7-5-17(6-8-18)27-24(30)29-11-9-28(10-12-29)23-19-13-21(31-3)22(32-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50115301
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Flt3 kinase |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115295
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115337
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)-c3ccccc3)c2cc1OC Show InChI InChI=1S/C27H27N5O3/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-21-10-8-20(9-11-21)19-6-4-3-5-7-19/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115298
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Br)cc3)c2cc1OC Show InChI InChI=1S/C21H22BrN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115342
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(OCc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C28H29N5O4/c1-35-25-16-23-24(17-26(25)36-2)29-19-30-27(23)32-12-14-33(15-13-32)28(34)31-21-8-10-22(11-9-21)37-18-20-6-4-3-5-7-20/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115325
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(I)cc3)c2cc1OC Show InChI InChI=1S/C21H22IN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115338
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(cc3)C(C)(C)C)c2cc1OC Show InChI InChI=1S/C25H31N5O2S/c1-25(2,3)17-6-8-18(9-7-17)28-24(33)30-12-10-29(11-13-30)23-19-14-21(31-4)22(32-5)15-20(19)26-16-27-23/h6-9,14-16H,10-13H2,1-5H3,(H,28,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115346
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=[SH+])[N-]c3ccc(cc3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H22N6O4S/c1-30-18-11-16-17(12-19(18)31-2)22-13-23-20(16)25-7-9-26(10-8-25)21(32)24-14-3-5-15(6-4-14)27(28)29/h3-6,11-13H,7-10H2,1-2H3,(H,24,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115329
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H27N5O3S/c1-33-24-16-22-23(17-25(24)34-2)28-18-29-26(22)31-12-14-32(15-13-31)27(36)30-19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50115295
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115357
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(SC)cc3)c2cc1OC Show InChI InChI=1S/C22H25N5O2S2/c1-28-19-12-17-18(13-20(19)29-2)23-14-24-21(17)26-8-10-27(11-9-26)22(30)25-15-4-6-16(31-3)7-5-15/h4-7,12-14H,8-11H2,1-3H3,(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115343
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(I)cc3)c2cc1OC Show InChI InChI=1S/C21H22IN5O2S/c1-28-18-11-16-17(12-19(18)29-2)23-13-24-20(16)26-7-9-27(10-8-26)21(30)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115353
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3cccc(Cl)c3)c2cc1OC Show InChI InChI=1S/C21H22ClN5O2S/c1-28-18-11-16-17(12-19(18)29-2)23-13-24-20(16)26-6-8-27(9-7-26)21(30)25-15-5-3-4-14(22)10-15/h3-5,10-13H,6-9H2,1-2H3,(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115297
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OC Show InChI InChI=1S/C22H22N6O3/c1-30-19-11-17-18(12-20(19)31-2)24-14-25-21(17)27-7-9-28(10-8-27)22(29)26-16-5-3-15(13-23)4-6-16/h3-6,11-12,14H,7-10H2,1-2H3,(H,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50115297
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OC Show InChI InChI=1S/C22H22N6O3/c1-30-19-11-17-18(12-20(19)31-2)24-14-25-21(17)27-7-9-28(10-8-27)22(29)26-16-5-3-15(13-23)4-6-16/h3-6,11-12,14H,7-10H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115304
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(SC)cc3)c2cc1OC Show InChI InChI=1S/C22H25N5O3S/c1-29-19-12-17-18(13-20(19)30-2)23-14-24-21(17)26-8-10-27(11-9-26)22(28)25-15-4-6-16(31-3)7-5-15/h4-7,12-14H,8-11H2,1-3H3,(H,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115333
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES CCCCc1ccc(NC(=S)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C25H31N5O2S/c1-4-5-6-18-7-9-19(10-8-18)28-25(33)30-13-11-29(12-14-30)24-20-15-22(31-2)23(32-3)16-21(20)26-17-27-24/h7-10,15-17H,4-6,11-14H2,1-3H3,(H,28,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115298
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Br)cc3)c2cc1OC Show InChI InChI=1S/C21H22BrN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115295
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50115298
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Br)cc3)c2cc1OC Show InChI InChI=1S/C21H22BrN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor alpha |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115359
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(cc3)C(C)C)c2cc1OC Show InChI InChI=1S/C24H29N5O2S/c1-16(2)17-5-7-18(8-6-17)27-24(32)29-11-9-28(10-12-29)23-19-13-21(30-3)22(31-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115341
(4-{[4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1...)Show SMILES CCOC(=O)c1ccc(NC(=O)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1 Show InChI InChI=1S/C24H27N5O5/c1-4-34-23(30)16-5-7-17(8-6-16)27-24(31)29-11-9-28(10-12-29)22-18-13-20(32-2)21(33-3)14-19(18)25-15-26-22/h5-8,13-15H,4,9-12H2,1-3H3,(H,27,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50115297
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OC Show InChI InChI=1S/C22H22N6O3/c1-30-19-11-17-18(12-20(19)31-2)24-14-25-21(17)27-7-9-28(10-8-27)22(29)26-16-5-3-15(13-23)4-6-16/h3-6,11-12,14H,7-10H2,1-2H3,(H,26,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor alpha |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115332
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(Cl)cc3)c2cc1OC Show InChI InChI=1S/C21H22ClN5O2S/c1-28-18-11-16-17(12-19(18)29-2)23-13-24-20(16)26-7-9-27(10-8-26)21(30)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115297
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OC Show InChI InChI=1S/C22H22N6O3/c1-30-19-11-17-18(12-20(19)31-2)24-14-25-21(17)27-7-9-28(10-8-27)22(29)26-16-5-3-15(13-23)4-6-16/h3-6,11-12,14H,7-10H2,1-2H3,(H,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Platelet-derived growth factor receptor beta phosphorylation |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
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