Found 40 hits Enz. Inhib. hit(s) with all data for entry = 50013586 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132222
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-18-24-23(17-25(26)35-2)27(30-19-29-24)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132206
(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)Show SMILES CCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-17-23-24(18-25(26)35-2)29-19-30-27(23)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115301
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50118826
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132229
(4-(7-Methyl-quinazolin-4-yl)-piperazine-1-carboxyl...)Show SMILES Cc1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H25N5O2/c1-19-7-12-23-24(17-19)27-18-28-25(23)30-13-15-31(16-14-30)26(32)29-20-8-10-22(11-9-20)33-21-5-3-2-4-6-21/h2-12,17-18H,13-16H2,1H3,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132227
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC Show InChI InChI=1S/C23H27N5O2S/c1-3-30-21-14-19-18(13-20(21)29-2)22(26-16-25-19)27-9-11-28(12-10-27)23(31)24-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,24,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132210
(4-(6-Amino-7-chloro-quinazolin-4-yl)-piperazine-1-...)Show SMILES Nc1cc2c(ncnc2cc1Cl)N1CCN(CC1)C(=S)NCc1ccccc1 Show InChI InChI=1S/C20H21ClN6S/c21-16-11-18-15(10-17(16)22)19(25-13-24-18)26-6-8-27(9-7-26)20(28)23-12-14-4-2-1-3-5-14/h1-5,10-11,13H,6-9,12,22H2,(H,23,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132211
(4-(7-Ethylamino-6-nitro-quinazolin-4-yl)-piperazin...)Show SMILES CCNc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1[N+]([O-])=O Show InChI InChI=1S/C27H27N7O4/c1-2-28-24-17-23-22(16-25(24)34(36)37)26(30-18-29-23)32-12-14-33(15-13-32)27(35)31-19-8-10-21(11-9-19)38-20-6-4-3-5-7-20/h3-11,16-18,28H,2,12-15H2,1H3,(H,31,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132215
(4-(6-Fluoro-quinazolin-4-yl)-piperazine-1-carboxyl...)Show SMILES Fc1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C25H22FN5O2/c26-18-6-11-23-22(16-18)24(28-17-27-23)30-12-14-31(15-13-30)25(32)29-19-7-9-21(10-8-19)33-20-4-2-1-3-5-20/h1-11,16-17H,12-15H2,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132232
(4-Quinazolin-4-yl-piperazine-1-carboxylic acid (4-...)Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2ccccc12 Show InChI InChI=1S/C25H23N5O2/c31-25(28-19-10-12-21(13-11-19)32-20-6-2-1-3-7-20)30-16-14-29(15-17-30)24-22-8-4-5-9-23(22)26-18-27-24/h1-13,18H,14-17H2,(H,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132213
(4-(6-Methoxy-quinazolin-4-yl)-piperazine-1-carboxy...)Show SMILES COc1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C26H25N5O3/c1-33-22-11-12-24-23(17-22)25(28-18-27-24)30-13-15-31(16-14-30)26(32)29-19-7-9-21(10-8-19)34-20-5-3-2-4-6-20/h2-12,17-18H,13-16H2,1H3,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132224
(4-(6-Methyl-quinazolin-4-yl)-piperazine-1-carboxyl...)Show SMILES Cc1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-19-7-12-24-23(17-19)25(28-18-27-24)30-13-15-31(16-14-30)26(32)29-20-8-10-22(11-9-20)33-21-5-3-2-4-6-21/h2-12,17-18H,13-16H2,1H3,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50118831
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132220
(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)Show SMILES CCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=S)NCc1ccccc1 Show InChI InChI=1S/C23H27N5O2S/c1-3-30-21-13-18-19(14-20(21)29-2)25-16-26-22(18)27-9-11-28(12-10-27)23(31)24-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,24,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50115295
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132202
(4-[4-(4-Phenoxy-phenylcarbamoyl)-piperazin-1-yl]-q...)Show SMILES COC(=O)c1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C27H25N5O4/c1-35-26(33)19-7-12-23-24(17-19)28-18-29-25(23)31-13-15-32(16-14-31)27(34)30-20-8-10-22(11-9-20)36-21-5-3-2-4-6-21/h2-12,17-18H,13-16H2,1H3,(H,30,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >750 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132225
(4-(7-Methoxy-quinazolin-4-yl)-piperazine-1-carboxy...)Show SMILES COc1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H25N5O3/c1-33-22-11-12-23-24(17-22)27-18-28-25(23)30-13-15-31(16-14-30)26(32)29-19-7-9-21(10-8-19)34-20-5-3-2-4-6-20/h2-12,17-18H,13-16H2,1H3,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132212
(4-(6,7-Difluoro-quinazolin-4-yl)-piperazine-1-carb...)Show SMILES Fc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1F Show InChI InChI=1S/C25H21F2N5O2/c26-21-14-20-23(15-22(21)27)28-16-29-24(20)31-10-12-32(13-11-31)25(33)30-17-6-8-19(9-7-17)34-18-4-2-1-3-5-18/h1-9,14-16H,10-13H2,(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132234
(CHEMBL103599 | N-[4-(4-Benzylthiocarbamoyl-piperaz...)Show SMILES CC(=O)Nc1cc2c(ncnc2cc1Cl)N1CCN(CC1)C(=S)NCc1ccccc1 Show InChI InChI=1S/C22H23ClN6OS/c1-15(30)27-20-11-17-19(12-18(20)23)25-14-26-21(17)28-7-9-29(10-8-28)22(31)24-13-16-5-3-2-4-6-16/h2-6,11-12,14H,7-10,13H2,1H3,(H,24,31)(H,27,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132201
(4-(7-Isopropoxy-quinazolin-4-yl)-piperazine-1-carb...)Show SMILES CC(C)Oc1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-20(2)35-24-12-13-25-26(18-24)29-19-30-27(25)32-14-16-33(17-15-32)28(34)31-21-8-10-23(11-9-21)36-22-6-4-3-5-7-22/h3-13,18-20H,14-17H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132221
(4-(7-Amino-6-nitro-quinazolin-4-yl)-piperazine-1-c...)Show SMILES Nc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1[N+]([O-])=O Show InChI InChI=1S/C25H23N7O4/c26-21-15-22-20(14-23(21)32(34)35)24(28-16-27-22)30-10-12-31(13-11-30)25(33)29-17-6-8-19(9-7-17)36-18-4-2-1-3-5-18/h1-9,14-16H,10-13,26H2,(H,29,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132226
(4-(7-Chloro-6-nitro-quinazolin-4-yl)-piperazine-1-...)Show SMILES [O-][N+](=O)c1cc2c(ncnc2cc1Cl)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H21ClN6O4/c26-21-15-22-20(14-23(21)32(34)35)24(28-16-27-22)30-10-12-31(13-11-30)25(33)29-17-6-8-19(9-7-17)36-18-4-2-1-3-5-18/h1-9,14-16H,10-13H2,(H,29,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132219
(4-(6-Bromo-quinazolin-4-yl)-piperazine-1-carboxyli...)Show SMILES Brc1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C25H22BrN5O2/c26-18-6-11-23-22(16-18)24(28-17-27-23)30-12-14-31(15-13-30)25(32)29-19-7-9-21(10-8-19)33-20-4-2-1-3-5-20/h1-11,16-17H,12-15H2,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132208
(4-(6-Amino-7-ethylamino-quinazolin-4-yl)-piperazin...)Show SMILES CCNc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1N Show InChI InChI=1S/C22H27N7S/c1-2-24-20-13-19-17(12-18(20)23)21(27-15-26-19)28-8-10-29(11-9-28)22(30)25-14-16-6-4-3-5-7-16/h3-7,12-13,15,24H,2,8-11,14,23H2,1H3,(H,25,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132209
(4-(7-Nitro-quinazolin-4-yl)-piperazine-1-carboxyli...)Show SMILES [O-][N+](=O)c1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H22N6O4/c32-25(28-18-6-9-21(10-7-18)35-20-4-2-1-3-5-20)30-14-12-29(13-15-30)24-22-11-8-19(31(33)34)16-23(22)26-17-27-24/h1-11,16-17H,12-15H2,(H,28,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132231
(4-(7-Chloro-quinazolin-4-yl)-piperazine-1-carbothi...)Show SMILES Clc1ccc2c(ncnc2c1)N1CCN(CC1)C(=S)NCc1ccccc1 Show InChI InChI=1S/C20H20ClN5S/c21-16-6-7-17-18(12-16)23-14-24-19(17)25-8-10-26(11-9-25)20(27)22-13-15-4-2-1-3-5-15/h1-7,12,14H,8-11,13H2,(H,22,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132228
(4-(6-Iodo-quinazolin-4-yl)-piperazine-1-carboxylic...)Show SMILES Ic1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C25H22IN5O2/c26-18-6-11-23-22(16-18)24(28-17-27-23)30-12-14-31(15-13-30)25(32)29-19-7-9-21(10-8-19)33-20-4-2-1-3-5-20/h1-11,16-17H,12-15H2,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132236
(4-(5-Methyl-quinazolin-4-yl)-piperazine-1-carboxyl...)Show SMILES Cc1cccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c12 Show InChI InChI=1S/C26H25N5O2/c1-19-6-5-9-23-24(19)25(28-18-27-23)30-14-16-31(17-15-30)26(32)29-20-10-12-22(13-11-20)33-21-7-3-2-4-8-21/h2-13,18H,14-17H2,1H3,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132216
(4-(8-Methoxy-quinazolin-4-yl)-piperazine-1-carboxy...)Show SMILES COc1cccc2c(ncnc12)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H25N5O3/c1-33-23-9-5-8-22-24(23)27-18-28-25(22)30-14-16-31(17-15-30)26(32)29-19-10-12-21(13-11-19)34-20-6-3-2-4-7-20/h2-13,18H,14-17H2,1H3,(H,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132214
(4-(6,8-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc(OC)c2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C27H27N5O4/c1-34-22-16-23-25(24(17-22)35-2)28-18-29-26(23)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132207
(4-(6-Nitro-quinazolin-4-yl)-piperazine-1-carboxyli...)Show SMILES [O-][N+](=O)c1ccc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 Show InChI InChI=1S/C25H22N6O4/c32-25(28-18-6-9-21(10-7-18)35-20-4-2-1-3-5-20)30-14-12-29(13-15-30)24-22-16-19(31(33)34)8-11-23(22)26-17-27-24/h1-11,16-17H,12-15H2,(H,28,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132233
(4-(7-Chloro-6-nitro-quinazolin-4-yl)-piperazine-1-...)Show SMILES [O-][N+](=O)c1cc2c(ncnc2cc1Cl)N1CCN(CC1)C(=[SH+])[N-]Cc1ccccc1 Show InChI InChI=1S/C20H19ClN6O2S/c21-16-11-17-15(10-18(16)27(28)29)19(24-13-23-17)25-6-8-26(9-7-25)20(30)22-12-14-4-2-1-3-5-14/h1-5,10-11,13H,6-9,12H2,(H,22,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132205
(4-[4-(4-Phenoxy-phenylcarbamoyl)-piperazin-1-yl]-q...)Show SMILES OC(=O)c1ccc2c(ncnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H23N5O4/c32-25(33)18-6-11-22-23(16-18)27-17-28-24(22)30-12-14-31(15-13-30)26(34)29-19-7-9-21(10-8-19)35-20-4-2-1-3-5-20/h1-11,16-17H,12-15H2,(H,29,34)(H,32,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132235
(4-Quinazolin-4-yl-piperazine-1-carbothioic acid be...)Show InChI InChI=1S/C20H21N5S/c26-20(21-14-16-6-2-1-3-7-16)25-12-10-24(11-13-25)19-17-8-4-5-9-18(17)22-15-23-19/h1-9,15H,10-14H2,(H,21,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132217
(4-(7-Ethylamino-6-nitro-quinazolin-4-yl)-piperazin...)Show SMILES CCNc1cc2ncnc(N3CCN(CC3)C(=[SH+])[N-]Cc3ccccc3)c2cc1[N+]([O-])=O Show InChI InChI=1S/C22H25N7O2S/c1-2-23-19-13-18-17(12-20(19)29(30)31)21(26-15-25-18)27-8-10-28(11-9-27)22(32)24-14-16-6-4-3-5-7-16/h3-7,12-13,15H,2,8-11,14H2,1H3,(H2,23,24,25,26,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132218
(4-(6,7-Dimethoxy-2-methyl-quinazolin-4-yl)-piperaz...)Show SMILES COc1cc2nc(C)nc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C28H29N5O4/c1-19-29-24-18-26(36-3)25(35-2)17-23(24)27(30-19)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-18H,13-16H2,1-3H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132203
(4-(2-Chloro-6,7-dimethoxy-quinazolin-4-yl)-piperaz...)Show SMILES COc1cc2nc(Cl)nc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H26ClN5O4/c1-35-23-16-21-22(17-24(23)36-2)30-26(28)31-25(21)32-12-14-33(15-13-32)27(34)29-18-8-10-20(11-9-18)37-19-6-4-3-5-7-19/h3-11,16-17H,12-15H2,1-2H3,(H,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132204
(4-(7,8-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1ccc2c(ncnc2c1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C27H27N5O4/c1-34-23-13-12-22-24(25(23)35-2)28-18-29-26(22)31-14-16-32(17-15-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-13,18H,14-17H2,1-2H3,(H,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132223
(4-(6,7-Dimethoxy-2-morpholin-4-yl-quinazolin-4-yl)...)Show SMILES COc1cc2nc(nc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC)N1CCOCC1 Show InChI InChI=1S/C31H34N6O5/c1-39-27-20-25-26(21-28(27)40-2)33-30(36-16-18-41-19-17-36)34-29(25)35-12-14-37(15-13-35)31(38)32-22-8-10-24(11-9-22)42-23-6-4-3-5-7-23/h3-11,20-21H,12-19H2,1-2H3,(H,32,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50132230
(4-(6,7,8-Trimethoxy-quinazolin-4-yl)-piperazine-1-...)Show SMILES COc1cc2c(ncnc2c(OC)c1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O5/c1-35-23-17-22-24(26(37-3)25(23)36-2)29-18-30-27(22)32-13-15-33(16-14-32)28(34)31-19-9-11-21(12-10-19)38-20-7-5-4-6-8-20/h4-12,17-18H,13-16H2,1-3H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells |
Bioorg Med Chem Lett 13: 3001-4 (2003)
BindingDB Entry DOI: 10.7270/Q2668CKR |
More data for this
Ligand-Target Pair | |
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