Found 16 hits Enz. Inhib. hit(s) with all data for entry = 50013747 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134315
(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)Show SMILES CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3 |r,c:8,t:6,THB:12:13:1.2:19.20,15:14:1.2:19.20| Show InChI InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134315
(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)Show SMILES CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3 |r,c:8,t:6,THB:12:13:1.2:19.20,15:14:1.2:19.20| Show InChI InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134312
(CHEMBL120863 | Thioacetic acid S-(9-methoxy-2-meth...)Show InChI InChI=1S/C15H14N2O4S/c1-8(18)22-15-14(20)17-10-5-4-6-12(21-3)9(10)7-11(17)13(19)16(15)2/h4-7,15H,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134310
(9-Methoxy-2-methyl-2,3,10,10a-tetrahydro-pyrazino[...)Show InChI InChI=1S/C13H14N2O3/c1-14-7-12(16)15-9-4-3-5-11(18-2)8(9)6-10(15)13(14)17/h3-5,10H,6-7H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134313
(2-Methyl-2,3-dihydro-pyrazino[1,2-a]indole-1,4-dio...)Show InChI InChI=1S/C12H10N2O2/c1-13-7-11(15)14-9-5-3-2-4-8(9)6-10(14)12(13)16/h2-6H,7H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134311
(3-Benzyldisulfanyl-9-methoxy-2-methyl-2,3-dihydro-...)Show SMILES COc1cccc2n3c(cc12)C(=O)N(C)C(SSCc1ccccc1)C3=O Show InChI InChI=1S/C20H18N2O3S2/c1-21-18(23)16-11-14-15(9-6-10-17(14)25-2)22(16)19(24)20(21)27-26-12-13-7-4-3-5-8-13/h3-11,20H,12H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134310
(9-Methoxy-2-methyl-2,3,10,10a-tetrahydro-pyrazino[...)Show InChI InChI=1S/C13H14N2O3/c1-14-7-12(16)15-9-4-3-5-11(18-2)8(9)6-10(15)13(14)17/h3-5,10H,6-7H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134311
(3-Benzyldisulfanyl-9-methoxy-2-methyl-2,3-dihydro-...)Show SMILES COc1cccc2n3c(cc12)C(=O)N(C)C(SSCc1ccccc1)C3=O Show InChI InChI=1S/C20H18N2O3S2/c1-21-18(23)16-11-14-15(9-6-10-17(14)25-2)22(16)19(24)20(21)27-26-12-13-7-4-3-5-8-13/h3-11,20H,12H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134314
(9-Methoxy-2-methyl-2,3-dihydro-pyrazino[1,2-a]indo...)Show InChI InChI=1S/C13H12N2O3/c1-14-7-12(16)15-9-4-3-5-11(18-2)8(9)6-10(15)13(14)17/h3-6H,7H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134313
(2-Methyl-2,3-dihydro-pyrazino[1,2-a]indole-1,4-dio...)Show InChI InChI=1S/C12H10N2O2/c1-13-7-11(15)14-9-5-3-2-4-8(9)6-10(14)12(13)16/h2-6H,7H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134308
(3-Benzyldisulfanyl-2-methyl-2,3-dihydro-pyrazino[1...)Show InChI InChI=1S/C19H16N2O2S2/c1-20-17(22)16-11-14-9-5-6-10-15(14)21(16)18(23)19(20)25-24-12-13-7-3-2-4-8-13/h2-11,19H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134314
(9-Methoxy-2-methyl-2,3-dihydro-pyrazino[1,2-a]indo...)Show InChI InChI=1S/C13H12N2O3/c1-14-7-12(16)15-9-4-3-5-11(18-2)8(9)6-10(15)13(14)17/h3-6H,7H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134309
(2-Methyl-2,3,10,10a-tetrahydro-pyrazino[1,2-a]indo...)Show InChI InChI=1S/C12H12N2O2/c1-13-7-11(15)14-9-5-3-2-4-8(9)6-10(14)12(13)16/h2-5,10H,6-7H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134308
(3-Benzyldisulfanyl-2-methyl-2,3-dihydro-pyrazino[1...)Show InChI InChI=1S/C19H16N2O2S2/c1-20-17(22)16-11-14-9-5-6-10-15(14)21(16)18(23)19(20)25-24-12-13-7-3-2-4-8-13/h2-11,19H,12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type I |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134309
(2-Methyl-2,3,10,10a-tetrahydro-pyrazino[1,2-a]indo...)Show InChI InChI=1S/C12H12N2O2/c1-13-7-11(15)14-9-5-3-2-4-8(9)6-10(14)12(13)16/h2-5,10H,6-7H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134312
(CHEMBL120863 | Thioacetic acid S-(9-methoxy-2-meth...)Show InChI InChI=1S/C15H14N2O4S/c1-8(18)22-15-14(20)17-10-5-4-6-12(21-3)9(10)7-11(17)13(19)16(15)2/h4-7,15H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.48E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College of Science
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferase |
Bioorg Med Chem Lett 13: 3661-3 (2003)
BindingDB Entry DOI: 10.7270/Q2CF9PHX |
More data for this
Ligand-Target Pair | |
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