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Compile Data Set for Download or QSAR

Found 46 hits Enz. Inhib. hit(s) with all data for entry = 50015228   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153168
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CNCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H25N5O/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)16-31-17-26-18-32-20-33(26)19-22-8-6-21(14-29)7-9-22/h3-13,18,20,31H,2,16-17,19H2,1H3
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n/an/a 0.0100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153170
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(C)Cc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H27N5O/c1-3-35-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-33(2)20-27-17-32-21-34(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
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n/an/a 0.0300n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153169
PNG
(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...)
Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)cc1
Show InChI InChI=1S/C27H20N4O3/c28-11-19-1-3-20(4-2-19)14-31-17-30-13-24(31)16-32-15-23-6-5-21(12-29)9-25(23)22-7-8-26-27(10-22)34-18-33-26/h1-10,13,17H,14-16,18H2
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n/an/a 0.100n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153173
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)18-33-19-26-16-31-20-32(26)17-22-8-6-21(14-29)7-9-22/h3-13,16,20H,2,17-19H2,1H3
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n/an/a 0.270n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153164
PNG
(CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)C(C)=O)C#N
Show InChI InChI=1S/C30H27N5O2/c1-3-37-29-6-4-5-26(14-29)30-13-25(16-32)11-12-27(30)19-34(22(2)36)20-28-17-33-21-35(28)18-24-9-7-23(15-31)8-10-24/h4-14,17,21H,3,18-20H2,1-2H3
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n/an/a 0.310n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153176
PNG
(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3
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n/an/a 0.360n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153172
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2
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n/an/a 0.370n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153166
PNG
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2
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n/an/a 0.370n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50126041
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,1-2H3
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n/an/a 0.370n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153175
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H22N4O2/c1-32-26-4-2-3-23(12-26)27-11-22(14-29)9-10-24(27)17-33-18-25-15-30-19-31(25)16-21-7-5-20(13-28)6-8-21/h2-12,15,19H,16-18H2,1H3
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n/an/a 0.460n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153171
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-2-35-26-5-3-4-25(15-26)27-14-23(17-31)10-11-24(27)12-13-29(34)28-18-32-20-33(28)19-22-8-6-21(16-30)7-9-22/h3-11,14-15,18,20,29,34H,2,19H2,1H3
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n/an/a 0.600n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153174
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2
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n/an/a 0.620n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50126036
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-3-35-26-6-4-5-24(16-26)27-15-22(18-31)7-10-23(27)13-14-29(34,28-19-32-20-33(28)2)25-11-8-21(17-30)9-12-25/h4-12,15-16,19-20,34H,3H2,1-2H3
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n/an/a 0.730n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153167
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-34-25-4-2-3-24(14-25)26-13-22(16-30)9-10-23(26)11-12-28(33)27-17-31-19-32(27)18-21-7-5-20(15-29)6-8-21/h2-10,13-14,17,19,28,33H,18H2,1H3
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n/an/a 1.20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153165
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES CCOc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-11-9-24(10-12-27)28-13-23(15-30)7-8-25(28)18-33-19-26-16-31-20-32(26)17-22-5-3-21(14-29)4-6-22/h3-13,16,20H,2,17-19H2,1H3
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n/an/a 1.20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50153177
PNG
(CHEMBL187809 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)S(C)(=O)=O)C#N
Show InChI InChI=1S/C29H27N5O3S/c1-3-37-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-34(38(2,35)36)20-27-17-32-21-33(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
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n/an/a 2.10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras CVIM by human Farnesyltransferase


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153176
PNG
(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3
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n/an/a 870n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153172
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-3-1-2-22(11-25)26-10-21(13-32)8-9-23(26)16-35-17-24-14-33-18-34(24)15-20-6-4-19(12-31)5-7-20/h1-11,14,18H,15-17H2
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n/an/a 990n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153170
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(C)Cc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H27N5O/c1-3-35-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-33(2)20-27-17-32-21-34(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153174
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153165
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES CCOc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-11-9-24(10-12-27)28-13-23(15-30)7-8-25(28)18-33-19-26-16-31-20-32(26)17-22-5-3-21(14-29)4-6-22/h3-13,16,20H,2,17-19H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50126036
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-3-35-26-6-4-5-24(16-26)27-15-22(18-31)7-10-23(27)13-14-29(34,28-19-32-20-33(28)2)25-11-8-21(17-30)9-12-25/h4-12,15-16,19-20,34H,3H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153168
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CNCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H25N5O/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)16-31-17-26-18-32-20-33(26)19-22-8-6-21(14-29)7-9-22/h3-13,18,20,31H,2,16-17,19H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153169
PNG
(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...)
Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)cc1
Show InChI InChI=1S/C27H20N4O3/c28-11-19-1-3-20(4-2-19)14-31-17-30-13-24(31)16-32-15-23-6-5-21(12-29)9-25(23)22-7-8-26-27(10-22)34-18-33-26/h1-10,13,17H,14-16,18H2
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153173
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)18-33-19-26-16-31-20-32(26)17-22-8-6-21(14-29)7-9-22/h3-13,16,20H,2,17-19H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50126041
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,1-2H3
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n/an/a 4.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153171
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-2-35-26-5-3-4-25(15-26)27-14-23(17-31)10-11-24(27)12-13-29(34)28-18-32-20-33(28)19-22-8-6-21(16-30)7-9-22/h3-11,14-15,18,20,29,34H,2,19H2,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153166
PNG
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2
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n/an/a 6.80E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153164
PNG
(CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)C(C)=O)C#N
Show InChI InChI=1S/C30H27N5O2/c1-3-37-29-6-4-5-26(14-29)30-13-25(16-32)11-12-27(30)19-34(22(2)36)20-28-17-33-21-35(28)18-24-9-7-23(15-31)8-10-24/h4-14,17,21H,3,18-20H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153175
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H22N4O2/c1-32-26-4-2-3-23(12-26)27-11-22(14-29)9-10-24(27)17-33-18-25-15-30-19-31(25)16-21-7-5-20(13-28)6-8-21/h2-12,15,19H,16-18H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153177
PNG
(CHEMBL187809 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)S(C)(=O)=O)C#N
Show InChI InChI=1S/C29H27N5O3S/c1-3-37-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-34(38(2,35)36)20-27-17-32-21-33(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50153167
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-34-25-4-2-3-24(14-25)26-13-22(16-30)9-10-23(26)11-12-28(33)27-17-31-19-32(27)18-21-7-5-20(15-29)6-8-21/h2-10,13-14,17,19,28,33H,18H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153176
PNG
(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C30H28N4O/c1-30(2,3)27-12-10-25(11-13-27)29-14-24(16-32)8-9-26(29)19-35-20-28-17-33-21-34(28)18-23-6-4-22(15-31)5-7-23/h4-14,17,21H,18-20H2,1-3H3
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n/an/an/an/a>100n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153174
PNG
(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)36-25-9-7-22(8-10-25)26-11-21(13-32)5-6-23(26)16-35-17-24-14-33-18-34(24)15-20-3-1-19(12-31)2-4-20/h1-11,14,18H,15-17H2
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153167
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-34-25-4-2-3-24(14-25)26-13-22(16-30)9-10-23(26)11-12-28(33)27-17-31-19-32(27)18-21-7-5-20(15-29)6-8-21/h2-10,13-14,17,19,28,33H,18H2,1H3
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n/an/an/an/a 57.5n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153175
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES COc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C27H22N4O2/c1-32-26-4-2-3-23(12-26)27-11-22(14-29)9-10-24(27)17-33-18-25-15-30-19-31(25)16-21-7-5-20(13-28)6-8-21/h2-12,15,19H,16-18H2,1H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153171
PNG
(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)c1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-2-35-26-5-3-4-25(15-26)27-14-23(17-31)10-11-24(27)12-13-29(34)28-18-32-20-33(28)19-22-8-6-21(16-30)7-9-22/h3-11,14-15,18,20,29,34H,2,19H2,1H3
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n/an/an/an/a 16.7n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153166
PNG
(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Show SMILES Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C26H19ClN4O/c27-24-3-1-2-22(11-24)26-10-21(13-29)8-9-23(26)16-32-17-25-14-30-18-31(25)15-20-6-4-19(12-28)5-7-20/h1-11,14,18H,15-17H2
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n/an/an/an/a 7.70n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153177
PNG
(CHEMBL187809 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)S(C)(=O)=O)C#N
Show InChI InChI=1S/C29H27N5O3S/c1-3-37-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-34(38(2,35)36)20-27-17-32-21-33(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
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n/an/an/an/a 100n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126041
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES COc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H20N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,1-2H3
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n/an/an/an/a 2.74n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153164
PNG
(CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)C(C)=O)C#N
Show InChI InChI=1S/C30H27N5O2/c1-3-37-29-6-4-5-26(14-29)30-13-25(16-32)11-12-27(30)19-34(22(2)36)20-28-17-33-21-35(28)18-24-9-7-23(15-31)8-10-24/h4-14,17,21H,3,18-20H2,1-2H3
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n/an/an/an/a 16n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50126036
PNG
(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H22N4O2/c1-3-35-26-6-4-5-24(16-26)27-15-22(18-31)7-10-23(27)13-14-29(34,28-19-32-20-33(28)2)25-11-8-21(17-30)9-12-25/h4-12,15-16,19-20,34H,3H2,1-2H3
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n/an/an/an/a 0.100n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153170
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(C)Cc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C29H27N5O/c1-3-35-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-33(2)20-27-17-32-21-34(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
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n/an/an/an/a 1.57n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153173
PNG
(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H24N4O2/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)18-33-19-26-16-31-20-32(26)17-22-8-6-21(14-29)7-9-22/h3-13,16,20H,2,17-19H2,1H3
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n/an/an/an/a 21.9n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153169
PNG
(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...)
Show SMILES N#Cc1ccc(Cn2cncc2COCc2ccc(cc2-c2ccc3OCOc3c2)C#N)cc1
Show InChI InChI=1S/C27H20N4O3/c28-11-19-1-3-20(4-2-19)14-31-17-30-13-24(31)16-32-15-23-6-5-21(12-29)9-25(23)22-7-8-26-27(10-22)34-18-33-26/h1-10,13,17H,14-16,18H2
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n/an/an/an/a 1.65n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50153168
PNG
(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CNCc1cncn1Cc1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H25N5O/c1-2-34-27-5-3-4-24(13-27)28-12-23(15-30)10-11-25(28)16-31-17-26-18-32-20-33(26)19-22-8-6-21(14-29)7-9-22/h3-13,18,20,31H,2,16-17,19H2,1H3
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n/an/an/an/a 1.34n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Reduced farnesylation in H-Ras NIH3T3 cells


Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair