Found 60 hits Enz. Inhib. hit(s) with all data for entry = 50045611 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM21367
(6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) | PDB
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PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070614
(CHEMBL3409037)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C30H48N4O2/c1-25(2)26-13-7-8-14-27(26)32-23-21-31(22-24-32)17-9-4-3-6-16-29(35)34-20-12-15-28(34)30(36)33-18-10-5-11-19-33/h7-8,13-14,25,28H,3-6,9-12,15-24H2,1-2H3/t28-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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PC cid
PC sid
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PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50003915
(CHEMBL3235744)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C27H36N4O2S/c1-34-25-12-7-6-11-23(25)30-17-15-29(16-18-30)14-8-2-3-13-26(32)31-20-22-10-5-4-9-21(22)19-24(31)27(28)33/h4-7,9-12,24H,2-3,8,13-20H2,1H3,(H2,28,33)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070615
(CHEMBL3409039)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C31H42N4O2/c36-30(35-21-11-16-29(35)31(37)34-19-8-2-9-20-34)17-7-10-18-32-22-24-33(25-23-32)28-15-6-5-14-27(28)26-12-3-1-4-13-26/h1,3-6,12-15,29H,2,7-11,16-25H2/t29-/m0/s1 | PDB
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070613
(CHEMBL3409035)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C31H36N4O2/c32-31(37)29-22-25-12-4-5-13-26(25)23-35(29)30(36)16-8-9-17-33-18-20-34(21-19-33)28-15-7-6-14-27(28)24-10-2-1-3-11-24/h1-7,10-15,29H,8-9,16-23H2,(H2,32,37)/t29-/m0/s1 | PDB
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| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF ... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070651
(CHEMBL3409049)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C37H46N4O3/c42-36(41-29-32-15-8-7-14-31(32)28-35(41)37(43)40-24-26-44-27-25-40)18-6-1-2-11-19-38-20-22-39(23-21-38)34-17-10-9-16-33(34)30-12-4-3-5-13-30/h3-5,7-10,12-17,35H,1-2,6,11,18-29H2/t35-/m0/s1 | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070662
(CHEMBL3409046)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C35H42N4O3/c40-34(39-27-30-13-5-4-12-29(30)26-33(39)35(41)38-22-24-42-25-23-38)16-8-9-17-36-18-20-37(21-19-36)32-15-7-6-14-31(32)28-10-2-1-3-11-28/h1-7,10-15,33H,8-9,16-27H2/t33-/m0/s1 | PDB
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PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070612
(CHEMBL3409041)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C33H46N4O2/c38-32(37-23-13-18-31(37)33(39)36-21-11-4-12-22-36)19-7-1-2-10-20-34-24-26-35(27-25-34)30-17-9-8-16-29(30)28-14-5-3-6-15-28/h3,5-6,8-9,14-17,31H,1-2,4,7,10-13,18-27H2/t31-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070653
(CHEMBL3409047)Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C37H46N4O2/c42-36(41-29-32-17-8-7-16-31(32)28-35(41)37(43)40-22-12-3-13-23-40)20-6-2-11-21-38-24-26-39(27-25-38)34-19-10-9-18-33(34)30-14-4-1-5-15-30/h1,4-5,7-10,14-19,35H,2-3,6,11-13,20-29H2/t35-/m0/s1 | PDB
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PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070668
(CHEMBL3409045)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C36H44N4O2/c41-35(40-28-31-16-6-5-15-30(31)27-34(40)36(42)39-21-10-2-11-22-39)19-9-12-20-37-23-25-38(26-24-37)33-18-8-7-17-32(33)29-13-3-1-4-14-29/h1,3-8,13-18,34H,2,9-12,19-28H2/t34-/m0/s1 | PDB
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070620
(CHEMBL3409036)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C32H38N4O2/c33-32(38)30-23-26-13-6-7-14-27(26)24-36(30)31(37)17-5-2-10-18-34-19-21-35(22-20-34)29-16-9-8-15-28(29)25-11-3-1-4-12-25/h1,3-4,6-9,11-16,30H,2,5,10,17-24H2,(H2,33,38)/t30-/m0/s1 | PDB
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PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070618
(CHEMBL3407516)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C33H40N4O2/c34-33(39)31-24-27-14-7-8-15-28(27)25-37(31)32(38)18-6-1-2-11-19-35-20-22-36(23-21-35)30-17-10-9-16-29(30)26-12-4-3-5-13-26/h3-5,7-10,12-17,31H,1-2,6,11,18-25H2,(H2,34,39)/t31-/m0/s1 | PDB
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PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070613
(CHEMBL3409035)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C31H36N4O2/c32-31(37)29-22-25-12-4-5-13-26(25)23-35(29)30(36)16-8-9-17-33-18-20-34(21-19-33)28-15-7-6-14-27(28)24-10-2-1-3-11-24/h1-7,10-15,29H,8-9,16-23H2,(H2,32,37)/t29-/m0/s1 | PDB
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PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070652
(CHEMBL3409048)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C38H48N4O2/c43-37(42-30-33-18-9-8-17-32(33)29-36(42)38(44)41-23-13-4-14-24-41)21-7-1-2-12-22-39-25-27-40(28-26-39)35-20-11-10-19-34(35)31-15-5-3-6-16-31/h3,5-6,8-11,15-20,36H,1-2,4,7,12-14,21-30H2/t36-/m0/s1 | PDB
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PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070795
(CHEMBL3409044)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C35H50N4O2/c1-28(2)31-16-9-10-17-32(31)37-24-22-36(23-25-37)19-11-4-3-6-18-34(40)39-27-30-15-8-7-14-29(30)26-33(39)35(41)38-20-12-5-13-21-38/h7-10,14-17,28,33H,3-6,11-13,18-27H2,1-2H3/t33-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070612
(CHEMBL3409041)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C33H46N4O2/c38-32(37-23-13-18-31(37)33(39)36-21-11-4-12-22-36)19-7-1-2-10-20-34-24-26-35(27-25-34)30-17-9-8-16-29(30)28-14-5-3-6-15-28/h3,5-6,8-9,14-17,31H,1-2,4,7,10-13,18-27H2/t31-/m0/s1 | PDB
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070650
(CHEMBL3409031)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C25H40N4O2/c1-20(2)21-10-6-7-11-22(21)28-18-16-27(17-19-28)14-8-4-3-5-13-24(30)29-15-9-12-23(29)25(26)31/h6-7,10-11,20,23H,3-5,8-9,12-19H2,1-2H3,(H2,26,31)/t23-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070651
(CHEMBL3409049)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C37H46N4O3/c42-36(41-29-32-15-8-7-14-31(32)28-35(41)37(43)40-24-26-44-27-25-40)18-6-1-2-11-19-38-20-22-39(23-21-38)34-17-10-9-16-33(34)30-12-4-3-5-13-30/h3-5,7-10,12-17,35H,1-2,6,11,18-29H2/t35-/m0/s1 | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070796
(CHEMBL3409043)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C34H48N4O2/c1-27(2)30-15-8-9-16-31(30)36-23-21-35(22-24-36)18-10-3-5-17-33(39)38-26-29-14-7-6-13-28(29)25-32(38)34(40)37-19-11-4-12-20-37/h6-9,13-16,27,32H,3-5,10-12,17-26H2,1-2H3/t32-/m0/s1 | PDB
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UniChem
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PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070616
(CHEMBL3409040)Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C32H44N4O2/c37-31(36-22-12-17-30(36)32(38)35-20-10-3-11-21-35)18-6-2-9-19-33-23-25-34(26-24-33)29-16-8-7-15-28(29)27-13-4-1-5-14-27/h1,4-5,7-8,13-16,30H,2-3,6,9-12,17-26H2/t30-/m0/s1 | PDB
Reactome pathway
KEGG
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UniChem
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PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070617
(CHEMBL3409038)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCOCC2)CC1 |r| Show InChI InChI=1S/C29H46N4O3/c1-24(2)25-10-6-7-11-26(25)31-18-16-30(17-19-31)14-8-4-3-5-13-28(34)33-15-9-12-27(33)29(35)32-20-22-36-23-21-32/h6-7,10-11,24,27H,3-5,8-9,12-23H2,1-2H3/t27-/m0/s1 | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070616
(CHEMBL3409040)Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C32H44N4O2/c37-31(36-22-12-17-30(36)32(38)35-20-10-3-11-21-35)18-6-2-9-19-33-23-25-34(26-24-33)29-16-8-7-15-28(29)27-13-4-1-5-14-27/h1,4-5,7-8,13-16,30H,2-3,6,9-12,17-26H2/t30-/m0/s1 | PDB
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PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070649
(CHEMBL3409032)Show SMILES NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C28H38N4O2/c29-28(34)26-15-10-18-32(26)27(33)16-6-1-2-9-17-30-19-21-31(22-20-30)25-14-8-7-13-24(25)23-11-4-3-5-12-23/h3-5,7-8,11-14,26H,1-2,6,9-10,15-22H2,(H2,29,34)/t26-/m0/s1 | PDB
Reactome pathway
KEGG
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PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50003915
(CHEMBL3235744)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C27H36N4O2S/c1-34-25-12-7-6-11-23(25)30-17-15-29(16-18-30)14-8-2-3-13-26(32)31-20-22-10-5-4-9-21(22)19-24(31)27(28)33/h4-7,9-12,24H,2-3,8,13-20H2,1H3,(H2,28,33)/t24-/m0/s1 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Agonist activity at human 5HT1A receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070653
(CHEMBL3409047)Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C37H46N4O2/c42-36(41-29-32-17-8-7-16-31(32)28-35(41)37(43)40-22-12-3-13-23-40)20-6-2-11-21-38-24-26-39(27-25-38)34-19-10-9-18-33(34)30-14-4-1-5-15-30/h1,4-5,7-10,14-19,35H,2-3,6,11-13,20-29H2/t35-/m0/s1 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070621
(CHEMBL3409034)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C30H42N4O2/c1-23(2)26-13-8-9-14-27(26)33-19-17-32(18-20-33)16-10-4-3-5-15-29(35)34-22-25-12-7-6-11-24(25)21-28(34)30(31)36/h6-9,11-14,23,28H,3-5,10,15-22H2,1-2H3,(H2,31,36)/t28-/m0/s1 | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070615
(CHEMBL3409039)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C31H42N4O2/c36-30(35-21-11-16-29(35)31(37)34-19-8-2-9-20-34)17-7-10-18-32-22-24-33(25-23-32)28-15-6-5-14-27(28)26-12-3-1-4-13-26/h1,3-6,12-15,29H,2,7-11,16-25H2/t29-/m0/s1 | PDB
Reactome pathway
KEGG
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PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Agonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF ... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070795
(CHEMBL3409044)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C35H50N4O2/c1-28(2)31-16-9-10-17-32(31)37-24-22-36(23-25-37)19-11-4-3-6-18-34(40)39-27-30-15-8-7-14-29(30)26-33(39)35(41)38-20-12-5-13-21-38/h7-10,14-17,28,33H,3-6,11-13,18-27H2,1-2H3/t33-/m0/s1 | PDB
Reactome pathway
KEGG
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UniChem
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| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070620
(CHEMBL3409036)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C32H38N4O2/c33-32(38)30-23-26-13-6-7-14-27(26)24-36(30)31(37)17-5-2-10-18-34-19-21-35(22-20-34)29-16-9-8-15-28(29)25-11-3-1-4-12-25/h1,3-4,6-9,11-16,30H,2,5,10,17-24H2,(H2,33,38)/t30-/m0/s1 | PDB
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070614
(CHEMBL3409037)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C30H48N4O2/c1-25(2)26-13-7-8-14-27(26)32-23-21-31(22-24-32)17-9-4-3-6-16-29(35)34-20-12-15-28(34)30(36)33-18-10-5-11-19-33/h7-8,13-14,25,28H,3-6,9-12,15-24H2,1-2H3/t28-/m0/s1 | PDB
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Agonist activity at human 5HT1A receptor expressed in HEK293 cells assessed as cAMP concentration at 10'-6 M by adenylate cyclase activity based HTRF... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070648
(CHEMBL3409033)Show SMILES CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C28H38N4O2/c1-21(2)24-11-5-6-12-25(24)31-17-15-30(16-18-31)14-8-7-13-27(33)32-20-23-10-4-3-9-22(23)19-26(32)28(29)34/h3-6,9-12,21,26H,7-8,13-20H2,1-2H3,(H2,29,34)/t26-/m0/s1 | PDB
Reactome pathway
KEGG
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UniChem
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| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070611
(CHEMBL3409042)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C32H44N4O3/c37-31(36-18-10-15-30(36)32(38)35-23-25-39-26-24-35)16-6-1-2-9-17-33-19-21-34(22-20-33)29-14-8-7-13-28(29)27-11-4-3-5-12-27/h3-5,7-8,11-14,30H,1-2,6,9-10,15-26H2/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070648
(CHEMBL3409033)Show SMILES CC(C)c1ccccc1N1CCN(CCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C28H38N4O2/c1-21(2)24-11-5-6-12-25(24)31-17-15-30(16-18-31)14-8-7-13-27(33)32-20-23-10-4-3-9-22(23)19-26(32)28(29)34/h3-6,9-12,21,26H,7-8,13-20H2,1-2H3,(H2,29,34)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
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PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070611
(CHEMBL3409042)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C32H44N4O3/c37-31(36-18-10-15-30(36)32(38)35-23-25-39-26-24-35)16-6-1-2-9-17-33-19-21-34(22-20-33)29-14-8-7-13-28(29)27-11-4-3-5-12-27/h3-5,7-8,11-14,30H,1-2,6,9-10,15-26H2/t30-/m0/s1 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070615
(CHEMBL3409039)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C31H42N4O2/c36-30(35-21-11-16-29(35)31(37)34-19-8-2-9-20-34)17-7-10-18-32-22-24-33(25-23-32)28-15-6-5-14-27(28)26-12-3-1-4-13-26/h1,3-6,12-15,29H,2,7-11,16-25H2/t29-/m0/s1 | PDB
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070662
(CHEMBL3409046)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C35H42N4O3/c40-34(39-27-30-13-5-4-12-29(30)26-33(39)35(41)38-22-24-42-25-23-38)16-8-9-17-36-18-20-37(21-19-36)32-15-7-6-14-31(32)28-10-2-1-3-11-28/h1-7,10-15,33H,8-9,16-27H2/t33-/m0/s1 | PDB
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UniChem
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| Article
PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070652
(CHEMBL3409048)Show SMILES O=C(CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C38H48N4O2/c43-37(42-30-33-18-9-8-17-32(33)29-36(42)38(44)41-23-13-4-14-24-41)21-7-1-2-12-22-39-25-27-40(28-26-39)35-20-11-10-19-34(35)31-15-5-3-6-16-31/h3,5-6,8-11,15-20,36H,1-2,4,7,12-14,21-30H2/t36-/m0/s1 | PDB
UniProtKB/SwissProt
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UniChem
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| Article
PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070796
(CHEMBL3409043)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C34H48N4O2/c1-27(2)30-15-8-9-16-31(30)36-23-21-35(22-24-36)18-10-3-5-17-33(39)38-26-29-14-7-6-13-28(29)25-32(38)34(40)37-19-11-4-12-20-37/h6-9,13-16,27,32H,3-5,10-12,17-26H2,1-2H3/t32-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070621
(CHEMBL3409034)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C30H42N4O2/c1-23(2)26-13-8-9-14-27(26)33-19-17-32(18-20-33)16-10-4-3-5-15-29(35)34-22-25-12-7-6-11-24(25)21-28(34)30(31)36/h6-9,11-14,23,28H,3-5,10,15-22H2,1-2H3,(H2,31,36)/t28-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070668
(CHEMBL3409045)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1Cc2ccccc2C[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C36H44N4O2/c41-35(40-28-31-16-6-5-15-30(31)27-34(40)36(42)39-21-10-2-11-22-39)19-9-12-20-37-23-25-38(26-24-37)33-18-8-7-17-32(33)29-13-3-1-4-14-29/h1,3-8,13-18,34H,2,9-12,19-28H2/t34-/m0/s1 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM21367
(6-{4-[2-(methylsulfanyl)phenyl]piperazin-1-yl}-N-(...)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc23)CC1 Show InChI InChI=1S/C27H37N3OS/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31) | PDB
UniProtKB/SwissProt
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070649
(CHEMBL3409032)Show SMILES NC(=O)[C@@H]1CCCN1C(=O)CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C28H38N4O2/c29-28(34)26-15-10-18-32(26)27(33)16-6-1-2-9-17-30-19-21-31(22-20-30)25-14-8-7-13-24(25)23-11-4-3-5-12-23/h3-5,7-8,11-14,26H,1-2,6,9-10,15-22H2,(H2,29,34)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070618
(CHEMBL3407516)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C33H40N4O2/c34-33(39)31-24-27-14-7-8-15-28(27)25-37(31)32(38)18-6-1-2-11-19-35-20-22-36(23-21-35)30-17-10-9-16-29(30)26-12-4-3-5-13-26/h3-5,7-10,12-17,31H,1-2,6,11,18-25H2,(H2,34,39)/t31-/m0/s1 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070613
(CHEMBL3409035)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C31H36N4O2/c32-31(37)29-22-25-12-4-5-13-26(25)23-35(29)30(36)16-8-9-17-33-18-20-34(21-19-33)28-15-7-6-14-27(28)24-10-2-1-3-11-24/h1-7,10-15,29H,8-9,16-23H2,(H2,32,37)/t29-/m0/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070614
(CHEMBL3409037)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C30H48N4O2/c1-25(2)26-13-7-8-14-27(26)32-23-21-31(22-24-32)17-9-4-3-6-16-29(35)34-20-12-15-28(34)30(36)33-18-10-5-11-19-33/h7-8,13-14,25,28H,3-6,9-12,15-24H2,1-2H3/t28-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50003915
(CHEMBL3235744)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C27H36N4O2S/c1-34-25-12-7-6-11-23(25)30-17-15-29(16-18-30)14-8-2-3-13-26(32)31-20-22-10-5-4-9-21(22)19-24(31)27(28)33/h4-7,9-12,24H,2-3,8,13-20H2,1H3,(H2,28,33)/t24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070615
(CHEMBL3409039)Show SMILES O=C(CCCCN1CCN(CC1)c1ccccc1-c1ccccc1)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C31H42N4O2/c36-30(35-21-11-16-29(35)31(37)34-19-8-2-9-20-34)17-7-10-18-32-22-24-33(25-23-32)28-15-6-5-14-27(28)26-12-3-1-4-13-26/h1,3-6,12-15,29H,2,7-11,16-25H2/t29-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by ade... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50070613
(CHEMBL3409035)Show SMILES NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(CC1)c1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C31H36N4O2/c32-31(37)29-22-25-12-4-5-13-26(25)23-35(29)30(36)16-8-9-17-33-18-20-34(21-19-33)28-15-7-6-14-27(28)24-10-2-1-3-11-24/h1-7,10-15,29H,8-9,16-23H2,(H2,32,37)/t29-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Antagonist activity at human 5HT7 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by ade... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50003915
(CHEMBL3235744)Show SMILES CSc1ccccc1N1CCN(CCCCCC(=O)N2Cc3ccccc3C[C@H]2C(N)=O)CC1 |r| Show InChI InChI=1S/C27H36N4O2S/c1-34-25-12-7-6-11-23(25)30-17-15-29(16-18-30)14-8-2-3-13-26(32)31-20-22-10-5-4-9-21(22)19-24(31)27(28)33/h4-7,9-12,24H,2-3,8,13-20H2,1H3,(H2,28,33)/t24-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Antagonist activity at human 5HT1A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by ad... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50070614
(CHEMBL3409037)Show SMILES CC(C)c1ccccc1N1CCN(CCCCCCC(=O)N2CCC[C@H]2C(=O)N2CCCCC2)CC1 |r| Show InChI InChI=1S/C30H48N4O2/c1-25(2)26-13-7-8-14-27(26)32-23-21-31(22-24-32)17-9-4-3-6-16-29(35)34-20-12-15-28(34)30(36)33-18-10-5-11-19-33/h7-8,13-14,25,28H,3-6,9-12,15-24H2,1-2H3/t28-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Antagonist activity at human 5HT1A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP concentration at 10'-6 M by ad... |
Eur J Med Chem 92: 202-11 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.041
BindingDB Entry DOI: 10.7270/Q2TT4SNW |
More data for this
Ligand-Target Pair | |
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