Found 11 hits Enz. Inhib. hit(s) with all data for entry = 50016698 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50140541
((S)-2-Amino-2-cyclohexyl-1-(3,3-difluoro-pyrrolidi...)Show InChI InChI=1S/C12H20F2N2O/c13-12(14)6-7-16(8-12)11(17)10(15)9-4-2-1-3-5-9/h9-10H,1-8,15H2/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50140527
((S)-2-Amino-2-cyclohexyl-1-((S)-3-fluoro-pyrrolidi...)Show InChI InChI=1S/C12H21FN2O/c13-10-6-7-15(8-10)12(16)11(14)9-4-2-1-3-5-9/h9-11H,1-8,14H2/t10-,11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50172141
((S)-2-Amino-2-cyclohexyl-1-(3,4-difluoro-pyrrolidi...)Show InChI InChI=1S/C12H20F2N2O/c13-9-6-16(7-10(9)14)12(17)11(15)8-4-2-1-3-5-8/h8-11H,1-7,15H2/t9?,10?,11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV calculated from IC50 from standard dose inhibition curve using cheng-Prussoff equation; range=61+/... |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50172144
((S)-2-Amino-2-cyclohexyl-1-(2,3,4,5-tetrafluoro-py...)Show InChI InChI=1S/C12H18F4N2O/c13-7-8(14)11(16)18(10(7)15)12(19)9(17)6-4-2-1-3-5-6/h6-11H,1-5,17H2/t7?,8?,9-,10?,11?/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 81 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50172143
((S)-2-Amino-2-cyclohexyl-1-(3-fluoro-azetidin-1-yl...)Show InChI InChI=1S/C11H19FN2O/c12-9-6-14(7-9)11(15)10(13)8-4-2-1-3-5-8/h8-10H,1-7,13H2/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 109 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50172139
((S)-2-Amino-2-cyclohexyl-1-(3,3-difluoro-azetidin-...)Show InChI InChI=1S/C11H18F2N2O/c12-11(13)6-15(7-11)10(16)9(14)8-4-2-1-3-5-8/h8-9H,1-7,14H2/t9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM12191
((2S)-2-amino-2-cyclohexyl-1-(pyrrolidin-1-yl)ethan...)Show InChI InChI=1S/C12H22N2O/c13-11(10-6-2-1-3-7-10)12(15)14-8-4-5-9-14/h10-11H,1-9,13H2/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 121 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50140539
((S)-2-Amino-2-cyclohexyl-1-((R)-3-fluoro-pyrrolidi...)Show InChI InChI=1S/C12H21FN2O/c13-10-6-7-15(8-10)12(16)11(14)9-4-2-1-3-5-9/h9-11H,1-8,14H2/t10-,11+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 128 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50172145
((S)-2-Amino-2-cyclohexyl-1-((3R,4R)-3,4-difluoro-p...)Show SMILES N[C@@H](C1CCCCC1)C(=O)N1C[C@@H](F)[C@H](F)C1 Show InChI InChI=1S/C12H20F2N2O/c13-9-6-16(7-10(9)14)12(17)11(15)8-4-2-1-3-5-8/h8-11H,1-7,15H2/t9-,10-,11+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 504 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50172140
((S)-2-Amino-2-cyclohexyl-1-((3S,4S)-3,4-difluoro-p...)Show SMILES N[C@@H](C1CCCCC1)C(=O)N1C[C@H](F)[C@@H](F)C1 Show InChI InChI=1S/C12H20F2N2O/c13-9-6-16(7-10(9)14)12(17)11(15)8-4-2-1-3-5-8/h8-11H,1-7,15H2/t9-,10-,11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50172142
((S)-2-Amino-1-azetidin-1-yl-2-cyclohexyl-ethanone ...)Show InChI InChI=1S/C11H20N2O/c12-10(9-5-2-1-3-6-9)11(14)13-7-4-8-13/h9-10H,1-8,12H2/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibitory constant against Dipeptidylpeptidase IV activity |
Bioorg Med Chem Lett 15: 4770-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.07.026 BindingDB Entry DOI: 10.7270/Q28K78M0 |
More data for this Ligand-Target Pair | |