Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177615 ((R)-2-(5-(2,3-difluorobenzylthio)-2-aminothiazolo[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177611 (2-(5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177602 (2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177607 ((R)-2-(2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177604 (5-(2,3-difluorobenzylthio)-2-aminothiazolo[4,5-d]p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177613 ((R)-2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177606 (5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5-d]pyri...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177614 (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-o...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177612 ((S)-2-(5-(3-phenoxybenzylthio)-2-aminothiazolo[4,5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177605 ((S)-2-(2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177603 (2-(2-amino-5-(pentylthio)thiazolo[4,5-d]pyrimidin-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177610 (5-(benzylthio)thiazolo[4,5-d]pyrimidine-2,7-diamin...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177608 (2-amino-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-o...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50177609 (5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol | CHEM...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Charnwood Curated by ChEMBL | Assay Description Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | Bioorg Med Chem Lett 16: 960-3 (2006) Article DOI: 10.1016/j.bmcl.2005.10.091 BindingDB Entry DOI: 10.7270/Q2D79B09 | |||||||||||
More data for this Ligand-Target Pair |