BindingDB PrimarySearch

Found 16 hits Enz. Inhib. hit(s) with all data for entry = 50018619
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neprilysin (Rattus norvegicus (Rat))	BDBM50197517 ((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat NEP				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Oryctolagus cuniculus (rabbit))	BDBM50197517 ((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rabbit NEP				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197517 ((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.0	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197513 ((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	7.0	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197519 ((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	7.0	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197517 ((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant NEP				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197507 ((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	7.0	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197513 ((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7.4				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Oryctolagus cuniculus (rabbit))	BDBM50190746 ((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rabbit NEP				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197517 ((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.5	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7.4				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197519 ((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12.6	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7.4				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197507 ((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.8	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7.4				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50190746 ((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of rat NEP				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50190746 ((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18.9	n/a	n/a	n/a	n/a	7.0	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50190746 ((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant NEP				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50190746 ((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31.8	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7.4				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair