Found 64 hits Enz. Inhib. hit(s) with all data for entry = 50046614 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121379
(CHEMBL3622134)Show SMILES CCn1c(cc2c1nc(Nc1nccs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C21H23N7OS/c1-3-27-15(20(29)28(12-4-5-12)13-6-7-13)10-14-17-16(23-11-26(17)2)18(24-19(14)27)25-21-22-8-9-30-21/h8-13H,3-7H2,1-2H3,(H,22,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121378
(CHEMBL3622135)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)cs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(23-11-27(18)3)19(25-20(15)28)26-22-24-12(2)10-31-22/h9-11,13-14H,4-8H2,1-3H3,(H,24,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121377
(CHEMBL3622136)Show SMILES CCn1c(cc2c1nc(Nc1ncc(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(24-11-27(18)3)19(25-20(15)28)26-22-23-10-12(2)31-22/h9-11,13-14H,4-8H2,1-3H3,(H,23,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121391
(CHEMBL3622137)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)c(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C23H27N7OS/c1-5-29-17(22(31)30(14-6-7-14)15-8-9-15)10-16-19-18(24-11-28(19)4)20(26-21(16)29)27-23-25-12(2)13(3)32-23/h10-11,14-15H,5-9H2,1-4H3,(H,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121383
(CHEMBL3622130)Show SMILES CCn1c(cc2c1nc(NC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C19H24N6O/c1-4-24-14(19(26)25(11-5-6-11)12-7-8-12)9-13-16-15(21-10-23(16)3)17(20-2)22-18(13)24/h9-12H,4-8H2,1-3H3,(H,20,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121385
(CHEMBL3622128)Show SMILES CNc1nc2n(CCCO)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C20H26N6O2/c1-21-18-16-17(24(2)11-22-16)14-10-15(25(8-3-9-27)19(14)23-18)20(28)26(12-4-5-12)13-6-7-13/h10-13,27H,3-9H2,1-2H3,(H,21,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121390
(CHEMBL3622138)Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)-c1nnnn1C1CC1 |r| Show InChI InChI=1S/C17H21N9O2/c1-18-15-13-14(24(2)8-19-13)11-5-12(17-21-22-23-26(17)9-3-4-9)25(16(11)20-15)6-10(28)7-27/h5,8-10,27-28H,3-4,6-7H2,1-2H3,(H,18,20)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121386
(CHEMBL3622127)Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 |r| Show InChI InChI=1S/C20H26N6O3/c1-21-18-16-17(24(2)10-22-16)14-7-15(25(19(14)23-18)8-13(28)9-27)20(29)26(11-3-4-11)12-5-6-12/h7,10-13,27-28H,3-6,8-9H2,1-2H3,(H,21,23)/t13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase Fyn
(Homo sapiens (Human)) | BDBM50121391
(CHEMBL3622137)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)c(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C23H27N7OS/c1-5-29-17(22(31)30(14-6-7-14)15-8-9-15)10-16-19-18(24-11-28(19)4)20(26-21(16)29)27-23-25-12(2)13(3)32-23/h10-11,14-15H,5-9H2,1-4H3,(H,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Fyn (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121380
(CHEMBL3622133)Show SMILES CCn1c(cc2c1nc(NC(=O)NCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H29N7O3/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)11-15-18-17(24-12-27(18)2)19(25-20(15)28)26-22(31)23-9-10-32-3/h11-14H,4-10H2,1-3H3,(H2,23,25,26,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121384
(CHEMBL3622129)Show SMILES CNc1nc2n(C[C@@H](C)O)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 |r| Show InChI InChI=1S/C20H26N6O2/c1-11(27)9-25-15(20(28)26(12-4-5-12)13-6-7-13)8-14-17-16(22-10-24(17)3)18(21-2)23-19(14)25/h8,10-13,27H,4-7,9H2,1-3H3,(H,21,23)/t11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121379
(CHEMBL3622134)Show SMILES CCn1c(cc2c1nc(Nc1nccs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C21H23N7OS/c1-3-27-15(20(29)28(12-4-5-12)13-6-7-13)10-14-17-16(23-11-26(17)2)18(24-19(14)27)25-21-22-8-9-30-21/h8-13H,3-7H2,1-2H3,(H,22,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121378
(CHEMBL3622135)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)cs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(23-11-27(18)3)19(25-20(15)28)26-22-24-12(2)10-31-22/h9-11,13-14H,4-8H2,1-3H3,(H,24,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121381
(CHEMBL3622132)Show SMILES CCn1c(cc2c1nc(NC(=O)OCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H28N6O4/c1-4-27-16(21(29)28(13-5-6-13)14-7-8-14)11-15-18-17(23-12-26(18)2)19(24-20(15)27)25-22(30)32-10-9-31-3/h11-14H,4-10H2,1-3H3,(H,24,25,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121377
(CHEMBL3622136)Show SMILES CCn1c(cc2c1nc(Nc1ncc(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(24-11-27(18)3)19(25-20(15)28)26-22-23-10-12(2)31-22/h9-11,13-14H,4-8H2,1-3H3,(H,23,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50121379
(CHEMBL3622134)Show SMILES CCn1c(cc2c1nc(Nc1nccs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C21H23N7OS/c1-3-27-15(20(29)28(12-4-5-12)13-6-7-13)10-14-17-16(23-11-26(17)2)18(24-19(14)27)25-21-22-8-9-30-21/h8-13H,3-7H2,1-2H3,(H,22,24,25) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121382
(CHEMBL3622131)Show SMILES CCn1c(cc2c1nc(NCCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H30N6O2/c1-4-27-17(22(29)28(14-6-7-14)15-8-9-15)12-16-19-18(24-13-26(19)2)20(25-21(16)27)23-10-5-11-30-3/h12-15H,4-11H2,1-3H3,(H,23,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50121379
(CHEMBL3622134)Show SMILES CCn1c(cc2c1nc(Nc1nccs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C21H23N7OS/c1-3-27-15(20(29)28(12-4-5-12)13-6-7-13)10-14-17-16(23-11-26(17)2)18(24-19(14)27)25-21-22-8-9-30-21/h8-13H,3-7H2,1-2H3,(H,22,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121388
(CHEMBL3622140)Show SMILES CCN(C(C)C)C(=O)c1cc2c(nc(NC)c3ncn(C)c23)n1C[C@H](O)CO |r| Show InChI InChI=1S/C19H28N6O3/c1-6-24(11(2)3)19(28)14-7-13-16-15(21-10-23(16)5)17(20-4)22-18(13)25(14)8-12(27)9-26/h7,10-12,26-27H,6,8-9H2,1-5H3,(H,20,22)/t12-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50121378
(CHEMBL3622135)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)cs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(23-11-27(18)3)19(25-20(15)28)26-22-24-12(2)10-31-22/h9-11,13-14H,4-8H2,1-3H3,(H,24,25,26) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50121377
(CHEMBL3622136)Show SMILES CCn1c(cc2c1nc(Nc1ncc(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(24-11-27(18)3)19(25-20(15)28)26-22-23-10-12(2)31-22/h9-11,13-14H,4-8H2,1-3H3,(H,23,25,26) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50121378
(CHEMBL3622135)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)cs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(23-11-27(18)3)19(25-20(15)28)26-22-24-12(2)10-31-22/h9-11,13-14H,4-8H2,1-3H3,(H,24,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50121377
(CHEMBL3622136)Show SMILES CCn1c(cc2c1nc(Nc1ncc(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(24-11-27(18)3)19(25-20(15)28)26-22-23-10-12(2)31-22/h9-11,13-14H,4-8H2,1-3H3,(H,23,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121379
(CHEMBL3622134)Show SMILES CCn1c(cc2c1nc(Nc1nccs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C21H23N7OS/c1-3-27-15(20(29)28(12-4-5-12)13-6-7-13)10-14-17-16(23-11-26(17)2)18(24-19(14)27)25-21-22-8-9-30-21/h8-13H,3-7H2,1-2H3,(H,22,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121391
(CHEMBL3622137)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)c(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C23H27N7OS/c1-5-29-17(22(31)30(14-6-7-14)15-8-9-15)10-16-19-18(24-11-28(19)4)20(26-21(16)29)27-23-25-12(2)13(3)32-23/h10-11,14-15H,5-9H2,1-4H3,(H,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50121383
(CHEMBL3622130)Show SMILES CCn1c(cc2c1nc(NC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C19H24N6O/c1-4-24-14(19(26)25(11-5-6-11)12-7-8-12)9-13-16-15(21-10-23(16)3)17(20-2)22-18(13)24/h9-12H,4-8H2,1-3H3,(H,20,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50121383
(CHEMBL3622130)Show SMILES CCn1c(cc2c1nc(NC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C19H24N6O/c1-4-24-14(19(26)25(11-5-6-11)12-7-8-12)9-13-16-15(21-10-23(16)3)17(20-2)22-18(13)24/h9-12H,4-8H2,1-3H3,(H,20,22) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121378
(CHEMBL3622135)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)cs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(23-11-27(18)3)19(25-20(15)28)26-22-24-12(2)10-31-22/h9-11,13-14H,4-8H2,1-3H3,(H,24,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121377
(CHEMBL3622136)Show SMILES CCn1c(cc2c1nc(Nc1ncc(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H25N7OS/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)9-15-18-17(24-11-27(18)3)19(25-20(15)28)26-22-23-10-12(2)31-22/h9-11,13-14H,4-8H2,1-3H3,(H,23,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50121391
(CHEMBL3622137)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)c(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C23H27N7OS/c1-5-29-17(22(31)30(14-6-7-14)15-8-9-15)10-16-19-18(24-11-28(19)4)20(26-21(16)29)27-23-25-12(2)13(3)32-23/h10-11,14-15H,5-9H2,1-4H3,(H,25,26,27) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121385
(CHEMBL3622128)Show SMILES CNc1nc2n(CCCO)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C20H26N6O2/c1-21-18-16-17(24(2)11-22-16)14-10-15(25(8-3-9-27)19(14)23-18)20(28)26(12-4-5-12)13-6-7-13/h10-13,27H,3-9H2,1-2H3,(H,21,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121391
(CHEMBL3622137)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)c(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C23H27N7OS/c1-5-29-17(22(31)30(14-6-7-14)15-8-9-15)10-16-19-18(24-11-28(19)4)20(26-21(16)29)27-23-25-12(2)13(3)32-23/h10-11,14-15H,5-9H2,1-4H3,(H,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121383
(CHEMBL3622130)Show SMILES CCn1c(cc2c1nc(NC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C19H24N6O/c1-4-24-14(19(26)25(11-5-6-11)12-7-8-12)9-13-16-15(21-10-23(16)3)17(20-2)22-18(13)24/h9-12H,4-8H2,1-3H3,(H,20,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121390
(CHEMBL3622138)Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)-c1nnnn1C1CC1 |r| Show InChI InChI=1S/C17H21N9O2/c1-18-15-13-14(24(2)8-19-13)11-5-12(17-21-22-23-26(17)9-3-4-9)25(16(11)20-15)6-10(28)7-27/h5,8-10,27-28H,3-4,6-7H2,1-2H3,(H,18,20)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121380
(CHEMBL3622133)Show SMILES CCn1c(cc2c1nc(NC(=O)NCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H29N7O3/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)11-15-18-17(24-12-27(18)2)19(25-20(15)28)26-22(31)23-9-10-32-3/h11-14H,4-10H2,1-3H3,(H2,23,25,26,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50121380
(CHEMBL3622133)Show SMILES CCn1c(cc2c1nc(NC(=O)NCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H29N7O3/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)11-15-18-17(24-12-27(18)2)19(25-20(15)28)26-22(31)23-9-10-32-3/h11-14H,4-10H2,1-3H3,(H2,23,25,26,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121386
(CHEMBL3622127)Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 |r| Show InChI InChI=1S/C20H26N6O3/c1-21-18-16-17(24(2)10-22-16)14-7-15(25(19(14)23-18)8-13(28)9-27)20(29)26(11-3-4-11)12-5-6-12/h7,10-13,27-28H,3-6,8-9H2,1-2H3,(H,21,23)/t13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50121391
(CHEMBL3622137)Show SMILES CCn1c(cc2c1nc(Nc1nc(C)c(C)s1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C23H27N7OS/c1-5-29-17(22(31)30(14-6-7-14)15-8-9-15)10-16-19-18(24-11-28(19)4)20(26-21(16)29)27-23-25-12(2)13(3)32-23/h10-11,14-15H,5-9H2,1-4H3,(H,25,26,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50121380
(CHEMBL3622133)Show SMILES CCn1c(cc2c1nc(NC(=O)NCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H29N7O3/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)11-15-18-17(24-12-27(18)2)19(25-20(15)28)26-22(31)23-9-10-32-3/h11-14H,4-10H2,1-3H3,(H2,23,25,26,31) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121383
(CHEMBL3622130)Show SMILES CCn1c(cc2c1nc(NC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C19H24N6O/c1-4-24-14(19(26)25(11-5-6-11)12-7-8-12)9-13-16-15(21-10-23(16)3)17(20-2)22-18(13)24/h9-12H,4-8H2,1-3H3,(H,20,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121384
(CHEMBL3622129)Show SMILES CNc1nc2n(C[C@@H](C)O)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 |r| Show InChI InChI=1S/C20H26N6O2/c1-11(27)9-25-15(20(28)26(12-4-5-12)13-6-7-13)8-14-17-16(22-10-24(17)3)18(21-2)23-19(14)25/h8,10-13,27H,4-7,9H2,1-3H3,(H,21,23)/t11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121385
(CHEMBL3622128)Show SMILES CNc1nc2n(CCCO)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C20H26N6O2/c1-21-18-16-17(24(2)11-22-16)14-10-15(25(8-3-9-27)19(14)23-18)20(28)26(12-4-5-12)13-6-7-13/h10-13,27H,3-9H2,1-2H3,(H,21,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121387
(CHEMBL3622141)Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)N(C)C1CC1 |r| Show InChI InChI=1S/C18H24N6O3/c1-19-16-14-15(22(2)9-20-14)12-6-13(18(27)23(3)10-4-5-10)24(17(12)21-16)7-11(26)8-25/h6,9-11,25-26H,4-5,7-8H2,1-3H3,(H,19,21)/t11-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121380
(CHEMBL3622133)Show SMILES CCn1c(cc2c1nc(NC(=O)NCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H29N7O3/c1-4-28-16(21(30)29(13-5-6-13)14-7-8-14)11-15-18-17(24-12-27(18)2)19(25-20(15)28)26-22(31)23-9-10-32-3/h11-14H,4-10H2,1-3H3,(H2,23,25,26,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121384
(CHEMBL3622129)Show SMILES CNc1nc2n(C[C@@H](C)O)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 |r| Show InChI InChI=1S/C20H26N6O2/c1-11(27)9-25-15(20(28)26(12-4-5-12)13-6-7-13)8-14-17-16(22-10-24(17)3)18(21-2)23-19(14)25/h8,10-13,27H,4-7,9H2,1-3H3,(H,21,23)/t11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121389
(CHEMBL3622139)Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)NC1CC1 |r| Show InChI InChI=1S/C17H22N6O3/c1-18-15-13-14(22(2)8-19-13)11-5-12(17(26)20-9-3-4-9)23(16(11)21-15)6-10(25)7-24/h5,8-10,24-25H,3-4,6-7H2,1-2H3,(H,18,21)(H,20,26)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121381
(CHEMBL3622132)Show SMILES CCn1c(cc2c1nc(NC(=O)OCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H28N6O4/c1-4-27-16(21(29)28(13-5-6-13)14-7-8-14)11-15-18-17(23-12-26(18)2)19(24-20(15)27)25-22(30)32-10-9-31-3/h11-14H,4-10H2,1-3H3,(H,24,25,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121388
(CHEMBL3622140)Show SMILES CCN(C(C)C)C(=O)c1cc2c(nc(NC)c3ncn(C)c23)n1C[C@H](O)CO |r| Show InChI InChI=1S/C19H28N6O3/c1-6-24(11(2)3)19(28)14-7-13-16-15(21-10-23(16)5)17(20-4)22-18(13)25(14)8-12(27)9-26/h7,10-12,26-27H,6,8-9H2,1-5H3,(H,20,22)/t12-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50121382
(CHEMBL3622131)Show SMILES CCn1c(cc2c1nc(NCCCOC)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1 Show InChI InChI=1S/C22H30N6O2/c1-4-27-17(22(29)28(14-6-7-14)15-8-9-15)12-16-19-18(24-13-26(19)2)20(25-21(16)27)23-10-5-11-30-3/h12-15H,4-11H2,1-3H3,(H,23,25) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50121386
(CHEMBL3622127)Show SMILES CNc1nc2n(C[C@H](O)CO)c(cc2c2n(C)cnc12)C(=O)N(C1CC1)C1CC1 |r| Show InChI InChI=1S/C20H26N6O3/c1-21-18-16-17(24(2)10-22-16)14-7-15(25(19(14)23-18)8-13(28)9-27)20(29)26(11-3-4-11)12-5-6-12/h7,10-13,27-28H,3-6,8-9H2,1-2H3,(H,21,23)/t13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assay |
ACS Med Chem Lett 6: 845-9 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00225 BindingDB Entry DOI: 10.7270/Q2Q2421M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |