Found 45 hits Enz. Inhib. hit(s) with all data for entry = 50046651 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123580
(CHEMBL3622208)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2ncsc12)-c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C20H21N3O4S/c1-11(13-7-18(24)21-9-13)27-20-19-15(22-10-28-19)8-14(23-20)12-4-5-16(25-2)17(6-12)26-3/h4-6,8,10-11,13H,7,9H2,1-3H3,(H,21,24)/t11-,13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123570
(CHEMBL3622698)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50400047
(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1 |r| Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123573
(CHEMBL3622697)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C16H14F2N4O3S/c1-8(14-5-19-16(23)25-14)24-13-3-9(2-12-11(13)7-26-21-12)10-4-20-22(6-10)15(17)18/h2-4,6-8,14-15H,5H2,1H3,(H,19,23)/t8-,14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123578
(CHEMBL3622209)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H16N4O3S/c1-9(15-6-17-16(21)23-15)22-14-4-10(11-5-18-20(2)7-11)3-13-12(14)8-24-19-13/h3-5,7-9,15H,6H2,1-2H3,(H,17,21)/t9-,15-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123584
(CHEMBL3622205)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-14(22)17-5-10)23-16-15-13(18-8-24-15)4-12(20-16)11-6-19-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123586
(CHEMBL3622204)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-16(22)18-6-12)23-15-4-11(13-7-20-21(2)8-13)3-14-17(15)24-9-19-14/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50076185
(CHEMBL3416026 | US9290481, 1.1)Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123568
(CHEMBL3622203)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123581
(CHEMBL3622207)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123583
(CHEMBL3622206)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50123568
(CHEMBL3622203)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of aurora A kinase (unknown origin) by enzymatic assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123576
(CHEMBL3622210)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C17H16F2N4O2S/c1-9(11-4-16(24)20-5-11)25-15-3-10(2-14-13(15)8-26-22-14)12-6-21-23(7-12)17(18)19/h2-3,6-9,11,17H,4-5H2,1H3,(H,20,24)/t9-,11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123586
(CHEMBL3622204)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-16(22)18-6-12)23-15-4-11(13-7-20-21(2)8-13)3-14-17(15)24-9-19-14/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50076185
(CHEMBL3416026 | US9290481, 1.1)Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123570
(CHEMBL3622698)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50123568
(CHEMBL3622203)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of aurora B kinase (unknown origin) by cell based assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123580
(CHEMBL3622208)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2ncsc12)-c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C20H21N3O4S/c1-11(13-7-18(24)21-9-13)27-20-19-15(22-10-28-19)8-14(23-20)12-4-5-16(25-2)17(6-12)26-3/h4-6,8,10-11,13H,7,9H2,1-3H3,(H,21,24)/t11-,13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123583
(CHEMBL3622206)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 161 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123578
(CHEMBL3622209)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H16N4O3S/c1-9(15-6-17-16(21)23-15)22-14-4-10(11-5-18-20(2)7-11)3-13-12(14)8-24-19-13/h3-5,7-9,15H,6H2,1-2H3,(H,17,21)/t9-,15-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50400047
(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1 |r| Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 178 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123586
(CHEMBL3622204)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-16(22)18-6-12)23-15-4-11(13-7-20-21(2)8-13)3-14-17(15)24-9-19-14/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123573
(CHEMBL3622697)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C16H14F2N4O3S/c1-8(14-5-19-16(23)25-14)24-13-3-9(2-12-11(13)7-26-21-12)10-4-20-22(6-10)15(17)18/h2-4,6-8,14-15H,5H2,1H3,(H,19,23)/t8-,14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 197 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123570
(CHEMBL3622698)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123581
(CHEMBL3622207)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 247 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123584
(CHEMBL3622205)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-14(22)17-5-10)23-16-15-13(18-8-24-15)4-12(20-16)11-6-19-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123568
(CHEMBL3622203)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123581
(CHEMBL3622207)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123583
(CHEMBL3622206)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 298 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123573
(CHEMBL3622697)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C16H14F2N4O3S/c1-8(14-5-19-16(23)25-14)24-13-3-9(2-12-11(13)7-26-21-12)10-4-20-22(6-10)15(17)18/h2-4,6-8,14-15H,5H2,1H3,(H,19,23)/t8-,14-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 328 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123576
(CHEMBL3622210)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C17H16F2N4O2S/c1-9(11-4-16(24)20-5-11)25-15-3-10(2-14-13(15)8-26-22-14)12-6-21-23(7-12)17(18)19/h2-3,6-9,11,17H,4-5H2,1H3,(H,20,24)/t9-,11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50076185
(CHEMBL3416026 | US9290481, 1.1)Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 367 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123580
(CHEMBL3622208)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2ncsc12)-c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C20H21N3O4S/c1-11(13-7-18(24)21-9-13)27-20-19-15(22-10-28-19)8-14(23-20)12-4-5-16(25-2)17(6-12)26-3/h4-6,8,10-11,13H,7,9H2,1-3H3,(H,21,24)/t11-,13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 517 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123568
(CHEMBL3622203)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 522 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123584
(CHEMBL3622205)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-14(22)17-5-10)23-16-15-13(18-8-24-15)4-12(20-16)11-6-19-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 538 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50126443
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 552 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50123583
(CHEMBL3622206)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 576 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of aurora A kinase (unknown origin) by enzymatic assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123578
(CHEMBL3622209)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H16N4O3S/c1-9(15-6-17-16(21)23-15)22-14-4-10(11-5-18-20(2)7-11)3-13-12(14)8-24-19-13/h3-5,7-9,15H,6H2,1-2H3,(H,17,21)/t9-,15-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 737 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50123581
(CHEMBL3622207)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1nc(cc2nscc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of aurora A kinase (unknown origin) by enzymatic assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50126443
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 951 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50400047
(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1 |r| Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 952 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50123576
(CHEMBL3622210)Show SMILES [H][C@@]1(CNC(=O)C1)[C@@H](C)Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C17H16F2N4O2S/c1-9(11-4-16(24)20-5-11)25-15-3-10(2-14-13(15)8-26-22-14)12-6-21-23(7-12)17(18)19/h2-3,6-9,11,17H,4-5H2,1H3,(H,20,24)/t9-,11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi... |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50076185
(CHEMBL3416026 | US9290481, 1.1)Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human ERG by automated patch clamp assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50123568
(CHEMBL3622203)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human ERG by binding assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50123568
(CHEMBL3622203)Show SMILES [H][C@@]1(CNC(=O)O1)[C@@H](C)Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F |r| Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human ERG by automated patch clamp assay |
Bioorg Med Chem Lett 25: 4642-7 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.037 BindingDB Entry DOI: 10.7270/Q2XD13HG |
More data for this Ligand-Target Pair | |