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Compile Data Set for Download or QSAR

Found 81 hits Enz. Inhib. hit(s) with all data for entry = 50028392   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257624
PNG
(7-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H17NO2S/c18-20(19,15-4-2-1-3-5-15)16-7-6-13-8-10-17-11-9-14(13)12-16/h1-7,12,17H,8-11H2
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6n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257613
PNG
(CHEMBL493951 | N-(cyclopropylmethyl)-N-methyl-2,3,...)
Show SMILES CN(CC1CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C15H22N2O2S/c1-17(11-12-2-3-12)20(18,19)15-5-4-13-6-8-16-9-7-14(13)10-15/h4-5,10,12,16H,2-3,6-9,11H2,1H3
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7n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257615
PNG
(7-(piperidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES O=S(=O)(N1CCCCC1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C15H22N2O2S/c18-20(19,17-10-2-1-3-11-17)15-5-4-13-6-8-16-9-7-14(13)12-15/h4-5,12,16H,1-3,6-11H2
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9n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257612
PNG
(CHEMBL493950 | N-benzyl-N-methyl-2,3,4,5-tetrahydr...)
Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C18H22N2O2S/c1-20(14-15-5-3-2-4-6-15)23(21,22)18-8-7-16-9-11-19-12-10-17(16)13-18/h2-8,13,19H,9-12,14H2,1H3
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10n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257621
PNG
(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Show SMILES Clc1ccccc1OC1CCN(CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C21H25ClN2O3S/c22-20-3-1-2-4-21(20)27-18-9-13-24(14-10-18)28(25,26)19-6-5-16-7-11-23-12-8-17(16)15-19/h1-6,15,18,23H,7-14H2
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13n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257620
PNG
(7-(4-(2-fluorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Show SMILES Fc1ccccc1OC1CCN(CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C21H25FN2O3S/c22-20-3-1-2-4-21(20)27-18-9-13-24(14-10-18)28(25,26)19-6-5-16-7-11-23-12-8-17(16)15-19/h1-6,15,18,23H,7-14H2
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15n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257563
PNG
(CHEMBL492349 | N-(2-chlorobenzyl)-2,3,4,5-tetrahyd...)
Show SMILES Clc1ccccc1CNS(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C17H19ClN2O2S/c18-17-4-2-1-3-15(17)12-20-23(21,22)16-6-5-13-7-9-19-10-8-14(13)11-16/h1-6,11,19-20H,7-10,12H2
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30n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257614
PNG
(7-(pyrrolidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-...)
Show SMILES O=S(=O)(N1CCCC1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C14H20N2O2S/c17-19(18,16-9-1-2-10-16)14-4-3-12-5-7-15-8-6-13(12)11-14/h3-4,11,15H,1-2,5-10H2
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51n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257617
PNG
(CHEMBL492556 | N-((2,3-dihydrobenzofuran-3-yl)meth...)
Show SMILES CN(CC1COc2ccccc12)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C20H24N2O3S/c1-22(13-17-14-25-20-5-3-2-4-19(17)20)26(23,24)18-7-6-15-8-10-21-11-9-16(15)12-18/h2-7,12,17,21H,8-11,13-14H2,1H3
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58n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257565
PNG
(CHEMBL492949 | N,N-dimethyl-2,3,4,5-tetrahydro-1H-...)
Show SMILES CN(C)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C12H18N2O2S/c1-14(2)17(15,16)12-4-3-10-5-7-13-8-6-11(10)9-12/h3-4,9,13H,5-8H2,1-2H3
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87n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257611
PNG
(CHEMBL522349 | N-(2-fluorophenyl)-2,3,4,5-tetrahyd...)
Show SMILES Fc1ccccc1NS(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H17FN2O2S/c17-15-3-1-2-4-16(15)19-22(20,21)14-6-5-12-7-9-18-10-8-13(12)11-14/h1-6,11,18-19H,7-10H2
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133n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257562
PNG
(CHEMBL492348 | N-(2-chlorophenyl)-2,3,4,5-tetrahyd...)
Show SMILES Clc1ccccc1NS(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H17ClN2O2S/c17-15-3-1-2-4-16(15)19-22(20,21)14-6-5-12-7-9-18-10-8-13(12)11-14/h1-6,11,18-19H,7-10H2
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156n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257616
PNG
(4-(2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylsulfon...)
Show SMILES O=S(=O)(N1CCOCC1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C14H20N2O3S/c17-20(18,16-7-9-19-10-8-16)14-2-1-12-3-5-15-6-4-13(12)11-14/h1-2,11,15H,3-10H2
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196n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257564
PNG
(CHEMBL511044 | N-(cyclopropylmethyl)-2,3,4,5-tetra...)
Show SMILES O=S(=O)(NCC1CC1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C14H20N2O2S/c17-19(18,16-10-11-1-2-11)14-4-3-12-5-7-15-8-6-13(12)9-14/h3-4,9,11,15-16H,1-2,5-8,10H2
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235n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257610
PNG
(CHEMBL493152 | N-phenyl-2,3,4,5-tetrahydro-1H-benz...)
Show SMILES O=S(=O)(Nc1ccccc1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H18N2O2S/c19-21(20,18-15-4-2-1-3-5-15)16-7-6-13-8-10-17-11-9-14(13)12-16/h1-7,12,17-18H,8-11H2
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382n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257609
PNG
(CHEMBL493151 | N-propyl-2,3,4,5-tetrahydro-1H-benz...)
Show SMILES CCCNS(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C13H20N2O2S/c1-2-7-15-18(16,17)13-4-3-11-5-8-14-9-6-12(11)10-13/h3-4,10,14-15H,2,5-9H2,1H3
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531n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257566
PNG
(CHEMBL492950 | N-methyl-N-phenyl-2,3,4,5-tetrahydr...)
Show SMILES CN(c1ccccc1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C17H20N2O2S/c1-19(16-5-3-2-4-6-16)22(20,21)17-8-7-14-9-11-18-12-10-15(14)13-17/h2-8,13,18H,9-12H2,1H3
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1.20E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]mesulergine form human recombinant 5HT2C receptor expressed in mouse Swiss 3T3 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257570
PNG
(7-(3-(4-chlorophenoxy)azetidin-1-ylsulfonyl)-2,3,4...)
Show SMILES Clc1ccc(OC2CN(C2)S(=O)(=O)c2ccc3CCNCCc3c2)cc1
Show InChI InChI=1S/C19H21ClN2O3S/c20-16-2-4-17(5-3-16)25-18-12-22(13-18)26(23,24)19-6-1-14-7-9-21-10-8-15(14)11-19/h1-6,11,18,21H,7-10,12-13H2
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2.09E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257621
PNG
(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Show SMILES Clc1ccccc1OC1CCN(CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C21H25ClN2O3S/c22-20-3-1-2-4-21(20)27-18-9-13-24(14-10-18)28(25,26)19-6-5-16-7-11-23-12-8-17(16)15-19/h1-6,15,18,23H,7-14H2
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2.90E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257617
PNG
(CHEMBL492556 | N-((2,3-dihydrobenzofuran-3-yl)meth...)
Show SMILES CN(CC1COc2ccccc12)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C20H24N2O3S/c1-22(13-17-14-25-20-5-3-2-4-19(17)20)26(23,24)18-7-6-15-8-10-21-11-9-16(15)12-18/h2-7,12,17,21H,8-11,13-14H2,1H3
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2.99E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257568
PNG
(7-(3-(2-chlorophenoxy)azetidin-1-ylsulfonyl)-2,3,4...)
Show SMILES Clc1ccccc1OC1CN(C1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C19H21ClN2O3S/c20-18-3-1-2-4-19(18)25-16-12-22(13-16)26(23,24)17-6-5-14-7-9-21-10-8-15(14)11-17/h1-6,11,16,21H,7-10,12-13H2
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3.41E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257571
PNG
((R)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...)
Show SMILES Clc1ccccc1O[C@@H]1CCN(C1)S(=O)(=O)c1ccc2CCNCCc2c1 |r|
Show InChI InChI=1S/C20H23ClN2O3S/c21-19-3-1-2-4-20(19)26-17-9-12-23(14-17)27(24,25)18-6-5-15-7-10-22-11-8-16(15)13-18/h1-6,13,17,22H,7-12,14H2/t17-/m1/s1
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3.43E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257569
PNG
(7-(3-(3-chlorophenoxy)azetidin-1-ylsulfonyl)-2,3,4...)
Show SMILES Clc1cccc(OC2CN(C2)S(=O)(=O)c2ccc3CCNCCc3c2)c1
Show InChI InChI=1S/C19H21ClN2O3S/c20-16-2-1-3-17(11-16)25-18-12-22(13-18)26(23,24)19-5-4-14-6-8-21-9-7-15(14)10-19/h1-5,10-11,18,21H,6-9,12-13H2
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3.69E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257618
PNG
((S)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...)
Show SMILES Clc1ccccc1O[C@H]1CCN(C1)S(=O)(=O)c1ccc2CCNCCc2c1 |r|
Show InChI InChI=1S/C20H23ClN2O3S/c21-19-3-1-2-4-20(19)26-17-9-12-23(14-17)27(24,25)18-6-5-15-7-10-22-11-8-16(15)13-18/h1-6,13,17,22H,7-12,14H2/t17-/m0/s1
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5.24E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50257624
PNG
(7-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H17NO2S/c18-20(19,15-4-2-1-3-5-15)16-7-6-13-8-10-17-11-9-14(13)12-16/h1-7,12,17H,8-11H2
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>7.20E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM50257621
PNG
(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Show SMILES Clc1ccccc1OC1CCN(CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C21H25ClN2O3S/c22-20-3-1-2-4-21(20)27-18-9-13-24(14-10-18)28(25,26)19-6-5-16-7-11-23-12-8-17(16)15-19/h1-6,15,18,23H,7-14H2
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n/an/an/an/a 32n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT2A receptor expressed in mouse Swiss 3T3 cells by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257625
PNG
(7-(2-fluorophenylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES Fc1ccccc1S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H16FNO2S/c17-15-3-1-2-4-16(15)21(19,20)14-6-5-12-7-9-18-10-8-13(12)11-14/h1-6,11,18H,7-10H2
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n/an/an/an/a 7n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257624
PNG
(7-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H17NO2S/c18-20(19,15-4-2-1-3-5-15)16-7-6-13-8-10-17-11-9-14(13)12-16/h1-7,12,17H,8-11H2
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n/an/an/an/a 9n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257626
PNG
(7-(3-fluorophenylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H16FNO2S/c17-14-2-1-3-15(11-14)21(19,20)16-5-4-12-6-8-18-9-7-13(12)10-16/h1-5,10-11,18H,6-9H2
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n/an/an/an/a 9n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257569
PNG
(7-(3-(3-chlorophenoxy)azetidin-1-ylsulfonyl)-2,3,4...)
Show SMILES Clc1cccc(OC2CN(C2)S(=O)(=O)c2ccc3CCNCCc3c2)c1
Show InChI InChI=1S/C19H21ClN2O3S/c20-16-2-1-3-17(11-16)25-18-12-22(13-18)26(23,24)19-5-4-14-6-8-21-9-7-15(14)10-19/h1-5,10-11,18,21H,6-9,12-13H2
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n/an/an/an/a 12n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257571
PNG
((R)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...)
Show SMILES Clc1ccccc1O[C@@H]1CCN(C1)S(=O)(=O)c1ccc2CCNCCc2c1 |r|
Show InChI InChI=1S/C20H23ClN2O3S/c21-19-3-1-2-4-20(19)26-17-9-12-23(14-17)27(24,25)18-6-5-15-7-10-22-11-8-16(15)13-18/h1-6,13,17,22H,7-12,14H2/t17-/m1/s1
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n/an/an/an/a 14n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257627
PNG
(7-(4-fluorophenylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H16FNO2S/c17-14-2-5-15(6-3-14)21(19,20)16-4-1-12-7-9-18-10-8-13(12)11-16/h1-6,11,18H,7-10H2
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n/an/an/an/a 15n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257613
PNG
(CHEMBL493951 | N-(cyclopropylmethyl)-N-methyl-2,3,...)
Show SMILES CN(CC1CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C15H22N2O2S/c1-17(11-12-2-3-12)20(18,19)15-5-4-13-6-8-16-9-7-14(13)10-15/h4-5,10,12,16H,2-3,6-9,11H2,1H3
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n/an/an/an/a 17n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257624
PNG
(7-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H17NO2S/c18-20(19,15-4-2-1-3-5-15)16-7-6-13-8-10-17-11-9-14(13)12-16/h1-7,12,17H,8-11H2
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n/an/an/an/a 18n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257625
PNG
(7-(2-fluorophenylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES Fc1ccccc1S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H16FNO2S/c17-15-3-1-2-4-16(15)21(19,20)14-6-5-12-7-9-18-10-8-13(12)11-14/h1-6,11,18H,7-10H2
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n/an/an/an/a 18n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257570
PNG
(7-(3-(4-chlorophenoxy)azetidin-1-ylsulfonyl)-2,3,4...)
Show SMILES Clc1ccc(OC2CN(C2)S(=O)(=O)c2ccc3CCNCCc3c2)cc1
Show InChI InChI=1S/C19H21ClN2O3S/c20-16-2-4-17(5-3-16)25-18-12-22(13-18)26(23,24)19-6-1-14-7-9-21-10-8-15(14)11-19/h1-6,11,18,21H,7-10,12-13H2
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n/an/an/an/a 28n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257568
PNG
(7-(3-(2-chlorophenoxy)azetidin-1-ylsulfonyl)-2,3,4...)
Show SMILES Clc1ccccc1OC1CN(C1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C19H21ClN2O3S/c20-18-3-1-2-4-19(18)25-16-12-22(13-16)26(23,24)17-6-5-14-7-9-21-10-8-15(14)11-17/h1-6,11,16,21H,7-10,12-13H2
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n/an/an/an/a 31n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257618
PNG
((S)-7-(3-(2-chlorophenoxy)pyrrolidin-1-ylsulfonyl)...)
Show SMILES Clc1ccccc1O[C@H]1CCN(C1)S(=O)(=O)c1ccc2CCNCCc2c1 |r|
Show InChI InChI=1S/C20H23ClN2O3S/c21-19-3-1-2-4-20(19)26-17-9-12-23(14-17)27(24,25)18-6-5-15-7-10-22-11-8-16(15)13-18/h1-6,13,17,22H,7-12,14H2/t17-/m0/s1
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n/an/an/an/a 31n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257621
PNG
(7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,...)
Show SMILES Clc1ccccc1OC1CCN(CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C21H25ClN2O3S/c22-20-3-1-2-4-21(20)27-18-9-13-24(14-10-18)28(25,26)19-6-5-16-7-11-23-12-8-17(16)15-19/h1-6,15,18,23H,7-14H2
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n/an/an/an/a 31n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257626
PNG
(7-(3-fluorophenylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H16FNO2S/c17-14-2-1-3-15(11-14)21(19,20)16-5-4-12-6-8-18-9-7-13(12)10-16/h1-5,10-11,18H,6-9H2
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n/an/an/an/a 33n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257615
PNG
(7-(piperidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES O=S(=O)(N1CCCCC1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C15H22N2O2S/c18-20(19,17-10-2-1-3-11-17)15-5-4-13-6-8-16-9-7-14(13)12-15/h4-5,12,16H,1-3,6-11H2
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n/an/an/an/a 34n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257617
PNG
(CHEMBL492556 | N-((2,3-dihydrobenzofuran-3-yl)meth...)
Show SMILES CN(CC1COc2ccccc12)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C20H24N2O3S/c1-22(13-17-14-25-20-5-3-2-4-19(17)20)26(23,24)18-7-6-15-8-10-21-11-9-16(15)12-18/h2-7,12,17,21H,8-11,13-14H2,1H3
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n/an/an/an/a 41n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257563
PNG
(CHEMBL492349 | N-(2-chlorobenzyl)-2,3,4,5-tetrahyd...)
Show SMILES Clc1ccccc1CNS(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C17H19ClN2O2S/c18-17-4-2-1-3-15(17)12-20-23(21,22)16-6-5-13-7-9-19-10-8-14(13)11-16/h1-6,11,19-20H,7-10,12H2
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n/an/an/an/a 46n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257565
PNG
(CHEMBL492949 | N,N-dimethyl-2,3,4,5-tetrahydro-1H-...)
Show SMILES CN(C)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C12H18N2O2S/c1-14(2)17(15,16)12-4-3-10-5-7-13-8-6-11(10)9-12/h3-4,9,13H,5-8H2,1-2H3
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n/an/an/an/a 47n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257614
PNG
(7-(pyrrolidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-...)
Show SMILES O=S(=O)(N1CCCC1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C14H20N2O2S/c17-19(18,16-9-1-2-10-16)14-4-3-12-5-7-15-8-6-13(12)11-14/h3-4,11,15H,1-2,5-10H2
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n/an/an/an/a 50n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257610
PNG
(CHEMBL493152 | N-phenyl-2,3,4,5-tetrahydro-1H-benz...)
Show SMILES O=S(=O)(Nc1ccccc1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H18N2O2S/c19-21(20,18-15-4-2-1-3-5-15)16-7-6-13-8-10-17-11-9-14(13)12-16/h1-7,12,17-18H,8-11H2
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n/an/an/an/a 69n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257613
PNG
(CHEMBL493951 | N-(cyclopropylmethyl)-N-methyl-2,3,...)
Show SMILES CN(CC1CC1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C15H22N2O2S/c1-17(11-12-2-3-12)20(18,19)15-5-4-13-6-8-16-9-7-14(13)10-15/h4-5,10,12,16H,2-3,6-9,11H2,1H3
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n/an/an/an/a 71n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (Human))
BDBM50257611
PNG
(CHEMBL522349 | N-(2-fluorophenyl)-2,3,4,5-tetrahyd...)
Show SMILES Fc1ccccc1NS(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H17FN2O2S/c17-15-3-1-2-4-16(15)19-22(20,21)14-6-5-12-7-9-18-10-8-13(12)11-14/h1-6,11,18-19H,7-10H2
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n/an/an/an/a 75n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2B receptor by cell-based system


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257627
PNG
(7-(4-fluorophenylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C16H16FNO2S/c17-14-2-5-15(6-3-14)21(19,20)16-4-1-12-7-9-18-10-8-13(12)11-16/h1-6,11,18H,7-10H2
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n/an/an/an/a 80n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM50257615
PNG
(7-(piperidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-b...)
Show SMILES O=S(=O)(N1CCCCC1)c1ccc2CCNCCc2c1
Show InChI InChI=1S/C15H22N2O2S/c18-20(19,17-10-2-1-3-11-17)15-5-4-13-6-8-16-9-7-14(13)12-15/h4-5,12,16H,1-3,6-11H2
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n/an/an/an/a 84n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant 5HT2C receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 19: 1871-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.071
BindingDB Entry DOI: 10.7270/Q2GB23XH
More data for this
Ligand-Target Pair
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