BindingDB PrimarySearch

Found 11 hits Enz. Inhib. hit(s) with all data for entry = 50047176
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inverse agonist activity at human RORgamma transfected in HEK293 cells after 24 hrs by beta galactosidase luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM50152147 (CHEMBL3781062) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inverse agonist activity at human RORgamma transfected in HEK293 cells after 24 hrs by beta galactosidase luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor ROR-alpha (Homo sapiens (Human))	BDBM50152147 (CHEMBL3781062) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inverse agonist activity at human RORalpha transfected in HEK293 cells after 24 hrs by beta galactosidase luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor ROR-beta (Homo sapiens (Human))	BDBM50152147 (CHEMBL3781062) Show SMILES Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inverse agonist activity at human RORbeta transfected in HEK293 cells after 24 hrs by beta galactosidase luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM50152147 (CHEMBL3781062) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	880	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human PXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Bile acid receptor (Homo sapiens (Human))	BDBM50152147 (CHEMBL3781062) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Partial agonist activity at human FXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human PXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bile acid receptor (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human FXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM19993 (CHEMBL62136 \| N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human))	BDBM50370232 (BA-41166E \| L-5103 \| RIFAMPIN \| Rifadin \| Rifampic...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Agonist activity at human PXR transfected in HEK293 cells after 24 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 26: 1817-20 (2016) Article DOI: 10.1016/j.bmcl.2016.02.031 BindingDB Entry DOI: 10.7270/Q2R2138B
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)