Compile Data Set for Download or QSAR

Found 25 hits Enz. Inhib. hit(s) with all data for entry = 50048116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to...				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.860	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 t...				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205145 (CHEMBL3947425) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5OC(F)(F)F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C35H35F4N7O6/c1-43-14-16-45(17-15-43)13-6-18-50-31-21-25-23(20-30(31)49-3)27(11-12-40-25)51-28-10-9-22(19-24(28)36)41-33(47)32-42-46(34(48)44(32)2)26-7-4-5-8-29(26)52-35(37,38)39/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,41,47)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of Ron (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to 4...				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205141 (CHEMBL3918992) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C35H36F2N6O5/c1-22-12-16-42(17-13-22)15-6-18-47-32-21-27-24(20-31(32)46-3)29(11-14-38-27)48-30-10-9-23(19-26(30)37)39-34(44)33-40-43(35(45)41(33)2)28-8-5-4-7-25(28)36/h4-5,7-11,14,19-22H,6,12-13,15-18H2,1-3H3,(H,39,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-Kit (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after...				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of FLT3 (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205139 (CHEMBL3911896) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5OC(F)(F)F)c(=O)n4C4CC4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C37H37F4N7O6/c1-45-15-17-46(18-16-45)14-5-19-52-33-22-27-25(21-32(33)51-2)29(12-13-42-27)53-30-11-8-23(20-26(30)38)43-35(49)34-44-48(36(50)47(34)24-9-10-24)28-6-3-4-7-31(28)54-37(39,40)41/h3-4,6-8,11-13,20-22,24H,5,9-10,14-19H2,1-2H3,(H,43,49)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205147 (CHEMBL3911762) Show SMILES CCn1c(nn(-c2ccccc2OC(F)(F)F)c1=O)C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1 Show InChI InChI=1S/C37H38F4N6O6/c1-4-46-34(44-47(36(46)49)28-8-5-6-9-31(28)53-37(39,40)41)35(48)43-24-10-11-30(26(38)20-24)52-29-12-15-42-27-22-33(32(50-3)21-25(27)29)51-19-7-16-45-17-13-23(2)14-18-45/h5-6,8-12,15,20-23H,4,7,13-14,16-19H2,1-3H3,(H,43,48)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205148 (CHEMBL3938747) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5Cl)c(=O)n4C4CC4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C36H37ClFN7O5/c1-42-15-17-43(18-16-42)14-5-19-49-33-22-28-25(21-32(33)48-2)30(12-13-39-28)50-31-11-8-23(20-27(31)38)40-35(46)34-41-45(29-7-4-3-6-26(29)37)36(47)44(34)24-9-10-24/h3-4,6-8,11-13,20-22,24H,5,9-10,14-19H2,1-2H3,(H,40,46)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-Kit (unknown origin) using biotinylated-poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measur...				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of FLT3 (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205142 (CHEMBL3954957) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(OC(F)F)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C36H37F3N6O6/c1-22-12-16-44(17-13-22)15-4-18-49-32-21-28-26(20-31(32)48-3)29(11-14-40-28)51-30-10-5-23(19-27(30)37)41-34(46)33-42-45(36(47)43(33)2)24-6-8-25(9-7-24)50-35(38)39/h5-11,14,19-22,35H,4,12-13,15-18H2,1-3H3,(H,41,46)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50399540 (FORETINIB | US10464902, Foretinib | US10882853, Co...) Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.60	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after ...				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205144 (CHEMBL3945791) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5cccc(F)c5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-13-15-42(16-14-40)12-5-17-47-31-21-27-25(20-30(31)46-3)28(10-11-37-27)48-29-9-8-23(19-26(29)36)38-33(44)32-39-43(34(45)41(32)2)24-7-4-6-22(35)18-24/h4,6-11,18-21H,5,12-17H2,1-3H3,(H,38,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205143 (CHEMBL3937387) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C35H36F2N6O5/c1-22-12-16-42(17-13-22)15-4-18-47-32-21-28-26(20-31(32)46-3)29(11-14-38-28)48-30-10-7-24(19-27(30)37)39-34(44)33-40-43(35(45)41(33)2)25-8-5-23(36)6-9-25/h5-11,14,19-22H,4,12-13,15-18H2,1-3H3,(H,39,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205146 (CHEMBL3956129) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(Cl)cc5Cl)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 Show InChI InChI=1S/C35H35Cl2FN6O5/c1-21-10-14-43(15-11-21)13-4-16-48-32-20-27-24(19-31(32)47-3)29(9-12-39-27)49-30-8-6-23(18-26(30)38)40-34(45)33-41-44(35(46)42(33)2)28-7-5-22(36)17-25(28)37/h5-9,12,17-21H,4,10-11,13-16H2,1-3H3,(H,40,45)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50204947 (CHEMBL3946271) Show SMILES COc1ccc(cc1)-n1nc(C(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCCCC5)c(OC)cc34)c(F)c2)n(C)c1=O Show InChI InChI=1S/C35H37FN6O6/c1-40-33(39-42(35(40)44)24-9-11-25(45-2)12-10-24)34(43)38-23-8-13-30(27(36)20-23)48-29-14-15-37-28-22-32(31(46-3)21-26(28)29)47-19-7-18-41-16-5-4-6-17-41/h8-15,20-22H,4-7,16-19H2,1-3H3,(H,38,43)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	141	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of Ron (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50205140 (CHEMBL3946811) Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 Show InChI InChI=1S/C34H35F2N7O5/c1-40-14-16-42(17-15-40)13-6-18-47-31-21-26-23(20-30(31)46-3)28(11-12-37-26)48-29-10-9-22(19-25(29)36)38-33(44)32-39-43(34(45)41(32)2)27-8-5-4-7-24(27)35/h4-5,7-12,19-21H,6,13-18H2,1-3H3,(H,38,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin) after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair