Compile Data Set for Download or QSAR

Found 65 hits Enz. Inhib. hit(s) with all data for entry = 50048206   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208187 (CHEMBL3897116) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O/c1-12-8-9-27-16(12)20(29)28(14-6-4-3-5-7-14)19(26-27)13(2)25-18-15(10-21)17(22)23-11-24-18/h3-9,11,13H,1-2H3,(H3,22,23,24,25)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208168 (CHEMBL3924058) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(F)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H15FN8O/c1-11(25-17-13(9-21)16(22)23-10-24-17)18-26-27-8-7-14(20)15(27)19(29)28(18)12-5-3-2-4-6-12/h2-8,10-11H,1H3,(H3,22,23,24,25)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208187 (CHEMBL3897116) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O/c1-12-8-9-27-16(12)20(29)28(14-6-4-3-5-7-14)19(26-27)13(2)25-18-15(10-21)17(22)23-11-24-18/h3-9,11,13H,1-2H3,(H3,22,23,24,25)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208165 (CHEMBL3910904) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C#N)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-28-8-7-13(9-21)16(28)20(30)29(19)14-5-3-2-4-6-14/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208173 (CHEMBL3980944) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(c2c(=O)n1-c1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C20H15F3N8O/c1-11(28-17-13(9-24)16(25)26-10-27-17)18-29-30-8-7-14(20(21,22)23)15(30)19(32)31(18)12-5-3-2-4-6-12/h2-8,10-11H,1H3,(H3,25,26,27,28)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208173 (CHEMBL3980944) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(c2c(=O)n1-c1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C20H15F3N8O/c1-11(28-17-13(9-24)16(25)26-10-27-17)18-29-30-8-7-14(20(21,22)23)15(30)19(32)31(18)12-5-3-2-4-6-12/h2-8,10-11H,1H3,(H3,25,26,27,28)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208188 (CHEMBL3985833) Show SMILES C[C@H](Nc1nc(N)nc2[nH]cnc12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H17N9O/c1-11(23-16-14-15(22-10-21-14)24-19(20)25-16)17-26-27-9-5-8-13(27)18(29)28(17)12-6-3-2-4-7-12/h2-11H,1H3,(H4,20,21,22,23,24,25)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208168 (CHEMBL3924058) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(F)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H15FN8O/c1-11(25-17-13(9-21)16(22)23-10-24-17)18-26-27-8-7-14(20)15(27)19(29)28(18)12-5-3-2-4-6-12/h2-8,10-11H,1H3,(H3,22,23,24,25)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208164 (CHEMBL3928750) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2c(ccc2c(=O)n1-c1ccccc1)C#N |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-29-14(9-21)7-8-16(29)20(30)28(19)13-5-3-2-4-6-13/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208172 (CHEMBL3901256) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(CO)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O2/c1-12(25-18-15(9-21)17(22)23-11-24-18)19-26-27-8-7-13(10-29)16(27)20(30)28(19)14-5-3-2-4-6-14/h2-8,11-12,29H,10H2,1H3,(H3,22,23,24,25)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208166 (CHEMBL3901527) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H16N8O/c1-12(24-17-14(10-20)16(21)22-11-23-17)18-25-26-9-5-8-15(26)19(28)27(18)13-6-3-2-4-7-13/h2-9,11-12H,1H3,(H3,21,22,23,24)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208165 (CHEMBL3910904) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C#N)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-28-8-7-13(9-21)16(28)20(30)29(19)14-5-3-2-4-6-14/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208176 (CHEMBL3976777) Show SMILES Nc1ncnc(N2CCC[C@H]2c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C21H18N8O/c22-12-15-18(23)24-13-25-19(15)27-10-4-8-16(27)20-26-28-11-5-9-17(28)21(30)29(20)14-6-2-1-3-7-14/h1-3,5-7,9,11,13,16H,4,8,10H2,(H2,23,24,25)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208166 (CHEMBL3901527) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H16N8O/c1-12(24-17-14(10-20)16(21)22-11-23-17)18-25-26-9-5-8-15(26)19(28)27(18)13-6-3-2-4-7-13/h2-9,11-12H,1H3,(H3,21,22,23,24)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208167 (CHEMBL3985921) Show SMILES Nc1ncnc(N[C@@H](CCO)c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C20H18N8O2/c21-11-14-17(22)23-12-24-18(14)25-15(8-10-29)19-26-27-9-4-7-16(27)20(30)28(19)13-5-2-1-3-6-13/h1-7,9,12,15,29H,8,10H2,(H3,22,23,24,25)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208188 (CHEMBL3985833) Show SMILES C[C@H](Nc1nc(N)nc2[nH]cnc12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H17N9O/c1-11(23-16-14-15(22-10-21-14)24-19(20)25-16)17-26-27-9-5-8-13(27)18(29)28(17)12-6-3-2-4-7-12/h2-11H,1H3,(H4,20,21,22,23,24,25)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208176 (CHEMBL3976777) Show SMILES Nc1ncnc(N2CCC[C@H]2c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C21H18N8O/c22-12-15-18(23)24-13-25-19(15)27-10-4-8-16(27)20-26-28-11-5-9-17(28)21(30)29(20)14-6-2-1-3-7-14/h1-3,5-7,9,11,13,16H,4,8,10H2,(H2,23,24,25)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208192 (CHEMBL3957154) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H16N8O/c1-12(24-17-15-16(21-10-20-15)22-11-23-17)18-25-26-9-5-8-14(26)19(28)27(18)13-6-3-2-4-7-13/h2-12H,1H3,(H2,20,21,22,23,24)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208165 (CHEMBL3910904) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C#N)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-28-8-7-13(9-21)16(28)20(30)29(19)14-5-3-2-4-6-14/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208181 (CHEMBL3963227) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2c(C)ccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O/c1-12-8-9-16-20(29)27(14-6-4-3-5-7-14)19(26-28(12)16)13(2)25-18-15(10-21)17(22)23-11-24-18/h3-9,11,13H,1-2H3,(H3,22,23,24,25)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208170 (CHEMBL3902629) Show SMILES C[C@H](Nc1ncnc2[nH]cc(F)c12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H16FN7O/c1-12(25-18-16-14(21)10-22-17(16)23-11-24-18)19-26-27-9-5-8-15(27)20(29)28(19)13-6-3-2-4-7-13/h2-12H,1H3,(H2,22,23,24,25)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208192 (CHEMBL3957154) Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H16N8O/c1-12(24-17-15-16(21-10-20-15)22-11-23-17)18-25-26-9-5-8-14(26)19(28)27(18)13-6-3-2-4-7-13/h2-12H,1H3,(H2,20,21,22,23,24)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208181 (CHEMBL3963227) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2c(C)ccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O/c1-12-8-9-16-20(29)27(14-6-4-3-5-7-14)19(26-28(12)16)13(2)25-18-15(10-21)17(22)23-11-24-18/h3-9,11,13H,1-2H3,(H3,22,23,24,25)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208186 (CHEMBL3957244) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O/c1-2-15(25-18-14(11-21)17(22)23-12-24-18)19-26-27-10-6-9-16(27)20(29)28(19)13-7-4-3-5-8-13/h3-10,12,15H,2H2,1H3,(H3,22,23,24,25)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208164 (CHEMBL3928750) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2c(ccc2c(=O)n1-c1ccccc1)C#N |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-29-14(9-21)7-8-16(29)20(30)28(19)13-5-3-2-4-6-13/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208180 (CHEMBL3934713) Show SMILES C[C@H](Nc1ncnc(N)c1C(F)(F)F)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C19H16F3N7O/c1-11(26-16-14(19(20,21)22)15(23)24-10-25-16)17-27-28-9-5-8-13(28)18(30)29(17)12-6-3-2-4-7-12/h2-11H,1H3,(H3,23,24,25,26)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208171 (CHEMBL3898391) Show SMILES Nc1ncnc(N[C@@H](CO)c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C19H16N8O2/c20-9-13-16(21)22-11-23-17(13)24-14(10-28)18-25-26-8-4-7-15(26)19(29)27(18)12-5-2-1-3-6-12/h1-8,11,14,28H,10H2,(H3,21,22,23,24)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208167 (CHEMBL3985921) Show SMILES Nc1ncnc(N[C@@H](CCO)c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C20H18N8O2/c21-11-14-17(22)23-12-24-18(14)25-15(8-10-29)19-26-27-9-4-7-16(27)20(30)28(19)13-5-2-1-3-6-13/h1-7,9,12,15,29H,8,10H2,(H3,22,23,24,25)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208178 (CHEMBL3925368) Show SMILES Nc1ncnc(NC(CC(F)(F)F)c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N Show InChI InChI=1S/C20H15F3N8O/c21-20(22,23)9-14(28-17-13(10-24)16(25)26-11-27-17)18-29-30-8-4-7-15(30)19(32)31(18)12-5-2-1-3-6-12/h1-8,11,14H,9H2,(H3,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208186 (CHEMBL3957244) Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O/c1-2-15(25-18-14(11-21)17(22)23-12-24-18)19-26-27-10-6-9-16(27)20(29)28(19)13-7-4-3-5-8-13/h3-10,12,15H,2H2,1H3,(H3,22,23,24,25)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208163 (CHEMBL3899628) Show SMILES CC[C@H](Nc1ncnc2[nH]cnc12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O/c1-2-14(25-18-16-17(22-11-21-16)23-12-24-18)19-26-27-10-6-9-15(27)20(29)28(19)13-7-4-3-5-8-13/h3-12,14H,2H2,1H3,(H2,21,22,23,24,25)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208185 (CHEMBL3906055) Show SMILES Nc1ncnc(N2CC(F)(F)C[C@H]2c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C21H16F2N8O/c22-21(23)9-16(29(11-21)18-14(10-24)17(25)26-12-27-18)19-28-30-8-4-7-15(30)20(32)31(19)13-5-2-1-3-6-13/h1-8,12,16H,9,11H2,(H2,25,26,27)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208172 (CHEMBL3901256) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(CO)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H18N8O2/c1-12(25-18-15(9-21)17(22)23-11-24-18)19-26-27-8-7-13(10-29)16(27)20(30)28(19)14-5-3-2-4-6-14/h2-8,11-12,29H,10H2,1H3,(H3,22,23,24,25)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208170 (CHEMBL3902629) Show SMILES C[C@H](Nc1ncnc2[nH]cc(F)c12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H16FN7O/c1-12(25-18-16-14(21)10-22-17(16)23-11-24-18)19-26-27-9-5-8-15(27)20(29)28(19)13-6-3-2-4-7-13/h2-12H,1H3,(H2,22,23,24,25)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208165 (CHEMBL3910904) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C#N)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-28-8-7-13(9-21)16(28)20(30)29(19)14-5-3-2-4-6-14/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgD-mediated B-cell activation by measuring decrease in CD19+ cells expres...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208171 (CHEMBL3898391) Show SMILES Nc1ncnc(N[C@@H](CO)c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N |r| Show InChI InChI=1S/C19H16N8O2/c20-9-13-16(21)22-11-23-17(13)24-14(10-28)18-25-26-8-4-7-15(26)19(29)27(18)12-5-2-1-3-6-12/h1-8,11,14,28H,10H2,(H3,21,22,23,24)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208178 (CHEMBL3925368) Show SMILES Nc1ncnc(NC(CC(F)(F)F)c2nn3cccc3c(=O)n2-c2ccccc2)c1C#N Show InChI InChI=1S/C20H15F3N8O/c21-20(22,23)9-14(28-17-13(10-24)16(25)26-11-27-17)18-29-30-8-4-7-15(30)19(32)31(18)12-5-2-1-3-6-12/h1-8,11,14H,9H2,(H3,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208175 (CHEMBL3981636) Show SMILES C[C@H](Nc1ncnc2[nH]ccc12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H17N7O/c1-13(24-18-15-9-10-21-17(15)22-12-23-18)19-25-26-11-5-8-16(26)20(28)27(19)14-6-3-2-4-7-14/h2-13H,1H3,(H2,21,22,23,24)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208169 (CHEMBL3986289) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccnc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C18H15N9O/c1-11(24-15-13(9-19)14(20)22-10-23-15)16-25-26-8-7-21-17(26)18(28)27(16)12-5-3-2-4-6-12/h2-8,10-11H,1H3,(H3,20,22,23,24)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208190 (CHEMBL3911640) Show SMILES C[C@H](Nc1ccnc2ccnn12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H17N7O/c1-14(23-18-9-11-21-17-10-12-22-27(17)18)19-24-25-13-5-8-16(25)20(28)26(19)15-6-3-2-4-7-15/h2-14,23H,1H3/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208182 (CHEMBL3900775) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2c(ccc2c(=O)n1-c1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C20H15F3N8O/c1-11(28-17-13(9-24)16(25)26-10-27-17)18-29-31-14(7-8-15(31)20(21,22)23)19(32)30(18)12-5-3-2-4-6-12/h2-8,10-11H,1H3,(H3,25,26,27,28)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50208165 (CHEMBL3910904) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C#N)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-28-8-7-13(9-21)16(28)20(30)29(19)14-5-3-2-4-6-14/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged full length recombinant human PI3K p110gamma expressed in baculovirus expression system using PIP2 as substrate p...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208177 (CHEMBL3973614) Show SMILES C[C@H](Nc1ncnc(N)c1F)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C18H16FN7O/c1-11(23-16-14(19)15(20)21-10-22-16)17-24-25-9-5-8-13(25)18(27)26(17)12-6-3-2-4-7-12/h2-11H,1H3,(H3,20,21,22,23)/t11-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208174 (CHEMBL3918777) Show SMILES CC(c1nn2ccc(C)c2c(=O)n1-c1ccccc1)n1cnc2c(N)ncnc12 Show InChI InChI=1S/C20H18N8O/c1-12-8-9-27-16(12)20(29)28(14-6-4-3-5-7-14)18(25-27)13(2)26-11-24-15-17(21)22-10-23-19(15)26/h3-11,13H,1-2H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208191 (CHEMBL3920579) Show SMILES C[C@H](Nc1nc(N)nc(N)n1)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C17H17N9O/c1-10(20-17-22-15(18)21-16(19)23-17)13-24-25-9-5-8-12(25)14(27)26(13)11-6-3-2-4-7-11/h2-10H,1H3,(H5,18,19,20,21,22,23)/t10-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208191 (CHEMBL3920579) Show SMILES C[C@H](Nc1nc(N)nc(N)n1)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C17H17N9O/c1-10(20-17-22-15(18)21-16(19)23-17)13-24-25-9-5-8-12(25)14(27)26(13)11-6-3-2-4-7-11/h2-10H,1H3,(H5,18,19,20,21,22,23)/t10-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50208165 (CHEMBL3910904) Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C#N)c2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H15N9O/c1-12(26-18-15(10-22)17(23)24-11-25-18)19-27-28-8-7-13(9-21)16(28)20(30)29(19)14-5-3-2-4-6-14/h2-8,11-12H,1H3,(H3,23,24,25,26)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal Hi6s-tagged PI3K p110beta/full length human p85alpha expressed in baculovirus infected Sf21 in...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208184 (CHEMBL3946603) Show SMILES Cc1ccn2nc(Cn3cnc4c(N)ncnc34)n(-c3ccccc3C)c(=O)c12 |(26.2,-30.31,;26.69,-31.77,;25.78,-33.03,;26.7,-34.29,;28.17,-33.8,;29.5,-34.56,;30.83,-33.79,;32.16,-34.56,;32.16,-36.1,;30.92,-37,;31.39,-38.47,;32.94,-38.46,;33.96,-39.6,;33.48,-41.07,;35.46,-39.29,;35.94,-37.82,;34.91,-36.69,;33.42,-37,;30.84,-32.25,;32.17,-31.49,;32.17,-29.95,;33.51,-29.19,;34.85,-29.96,;34.84,-31.5,;33.5,-32.27,;33.49,-33.81,;29.51,-31.48,;29.52,-29.94,;28.17,-32.25,)| Show InChI InChI=1S/C20H18N8O/c1-12-5-3-4-6-14(12)28-15(25-27-8-7-13(2)17(27)20(28)29)9-26-11-24-16-18(21)22-10-23-19(16)26/h3-8,10-11H,9H2,1-2H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50323726 (2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tol...) Show SMILES Cc1ccccc1-n1c(Cn2cnc3c(N)ncnc23)nc2cccc(C)c2c1=O |(5.33,-1.02,;5.32,.52,;6.65,1.29,;6.64,2.84,;5.29,3.6,;3.97,2.82,;3.98,1.28,;2.65,.51,;2.67,-1.03,;4.01,-1.8,;4.01,-3.34,;2.77,-4.26,;3.24,-5.72,;4.78,-5.71,;5.82,-6.85,;5.34,-8.31,;7.31,-6.53,;7.78,-5.06,;6.75,-3.93,;5.26,-4.25,;1.33,-1.82,;-.01,-1.04,;-1.35,-1.83,;-2.67,-1.05,;-2.67,.49,;-1.35,1.26,;-1.35,2.8,;-.01,.5,;1.31,1.27,;1.31,2.81,)| Show InChI InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using P...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50208175 (CHEMBL3981636) Show SMILES C[C@H](Nc1ncnc2[nH]ccc12)c1nn2cccc2c(=O)n1-c1ccccc1 |r| Show InChI InChI=1S/C20H17N7O/c1-13(24-18-15-9-10-21-17(15)22-12-23-18)19-25-26-11-5-8-16(26)20(28)27(19)14-6-3-2-4-7-14/h2-13H,1H3,(H2,21,22,23,24)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...				ACS Med Chem Lett 8: 118-123 (2017) Article DOI: 10.1021/acsmedchemlett.6b00438 BindingDB Entry DOI: 10.7270/Q2ZC84WF
					More data for this Ligand-Target Pair

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