Compile Data Set for Download or QSAR

Found 84 hits Enz. Inhib. hit(s) with all data for entry = 50030986   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304826 ((S)-7-(2-chlorophenoxy)-2-((R)-2-methylpiperazin-1...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](Oc3ccccc3Cl)c2n1 |r| Show InChI InChI=1S/C19H22ClN3O/c1-13-12-21-10-11-23(13)18-9-7-14-6-8-17(19(14)22-18)24-16-5-3-2-4-15(16)20/h2-5,7,9,13,17,21H,6,8,10-12H2,1H3/t13-,17+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]5HT from human 5HT2C receptor expressed in mouse 3T3 cells by scintillation counting				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304805 ((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...) Show SMILES Clc1ccccc1O[C@H]1CCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C18H20ClN3O/c19-14-3-1-2-4-15(14)23-16-7-5-13-6-8-17(21-18(13)16)22-11-9-20-10-12-22/h1-4,6,8,16,20H,5,7,9-12H2/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304802 ((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...) Show SMILES Clc1ccccc1O[C@H]1CCCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C19H22ClN3O/c20-15-5-1-2-6-16(15)24-17-7-3-4-14-8-9-18(22-19(14)17)23-12-10-21-11-13-23/h1-2,5-6,8-9,17,21H,3-4,7,10-13H2/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304804 (7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...) Show SMILES Clc1ccccc1OC1CCc2ccc(nc12)N1CCNCC1 Show InChI InChI=1S/C18H20ClN3O/c19-14-3-1-2-4-15(14)23-16-7-5-13-6-8-17(21-18(13)16)22-11-9-20-10-12-22/h1-4,6,8,16,20H,5,7,9-12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304805 ((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...) Show SMILES Clc1ccccc1O[C@H]1CCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C18H20ClN3O/c19-14-3-1-2-4-15(14)23-16-7-5-13-6-8-17(21-18(13)16)22-11-9-20-10-12-22/h1-4,6,8,16,20H,5,7,9-12H2/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304808 (4-chloro-2-(piperazin-1-yl)thieno[2,3-d]pyrimidine...) Show SMILES Clc1nc(nc2sccc12)N1CCNCC1 Show InChI InChI=1S/C10H11ClN4S/c11-8-7-1-6-16-9(7)14-10(13-8)15-4-2-12-3-5-15/h1,6,12H,2-5H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304802 ((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...) Show SMILES Clc1ccccc1O[C@H]1CCCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C19H22ClN3O/c20-15-5-1-2-6-16(15)24-17-7-3-4-14-8-9-18(22-19(14)17)23-12-10-21-11-13-23/h1-2,5-6,8-9,17,21H,3-4,7,10-13H2/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304803 ((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...) Show SMILES Clc1ccccc1O[C@@H]1CCCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C19H22ClN3O/c20-15-5-1-2-6-16(15)24-17-7-3-4-14-8-9-18(22-19(14)17)23-12-10-21-11-13-23/h1-2,5-6,8-9,17,21H,3-4,7,10-13H2/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304827 ((S)-7-(3-fluorophenoxy)-2-(piperazin-1-yl)-6,7-dih...) Show SMILES Fc1cccc(O[C@H]2CCc3ccc(nc23)N2CCNCC2)c1 |r| Show InChI InChI=1S/C18H20FN3O/c19-14-2-1-3-15(12-14)23-16-6-4-13-5-7-17(21-18(13)16)22-10-8-20-9-11-22/h1-3,5,7,12,16,20H,4,6,8-11H2/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [3H]5HT from human 5HT2C receptor expressed in mouse 3T3 cells by scintillation counting				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304804 (7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...) Show SMILES Clc1ccccc1OC1CCc2ccc(nc12)N1CCNCC1 Show InChI InChI=1S/C18H20ClN3O/c19-14-3-1-2-4-15(14)23-16-7-5-13-6-8-17(21-18(13)16)22-11-9-20-10-12-22/h1-4,6,8,16,20H,5,7,9-12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304809 (4-(3-chlorobenzyloxy)-2-(piperazin-1-yl)thieno[2,3...) Show SMILES Clc1cccc(COc2nc(nc3sccc23)N2CCNCC2)c1 Show InChI InChI=1S/C17H17ClN4OS/c18-13-3-1-2-12(10-13)11-23-15-14-4-9-24-16(14)21-17(20-15)22-7-5-19-6-8-22/h1-4,9-10,19H,5-8,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304801 ((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3F)c2n1 |r| Show InChI InChI=1S/C20H23F2N3O/c1-13-11-23-8-9-25(13)19-7-3-14-2-6-18(20(14)24-19)26-12-15-10-16(21)4-5-17(15)22/h3-5,7,10,13,18,23H,2,6,8-9,11-12H2,1H3/t13-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304803 ((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...) Show SMILES Clc1ccccc1O[C@@H]1CCCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C19H22ClN3O/c20-15-5-1-2-6-16(15)24-17-7-3-4-14-8-9-18(22-19(14)17)23-12-10-21-11-13-23/h1-2,5-6,8-9,17,21H,3-4,7,10-13H2/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50016970 (4-Piperazin-1-yl-thieno[3,2-c]pyridine; hydrochlor...) Show SMILES C1CN(CCN1)c1nccc2sccc12 Show InChI InChI=1S/C11H13N3S/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304800 ((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...) Show SMILES Fc1ccc(F)c(CO[C@H]2CCc3ccc(nc23)N2CCNCC2)c1 |r| Show InChI InChI=1S/C19H21F2N3O/c20-15-3-4-16(21)14(11-15)12-25-17-5-1-13-2-6-18(23-19(13)17)24-9-7-22-8-10-24/h2-4,6,11,17,22H,1,5,7-10,12H2/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304801 ((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3F)c2n1 |r| Show InChI InChI=1S/C20H23F2N3O/c1-13-11-23-8-9-25(13)19-7-3-14-2-6-18(20(14)24-19)26-12-15-10-16(21)4-5-17(15)22/h3-5,7,10,13,18,23H,2,6,8-9,11-12H2,1H3/t13-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304806 ((R)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...) Show SMILES Clc1ccccc1O[C@@H]1CCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C18H20ClN3O/c19-14-3-1-2-4-15(14)23-16-7-5-13-6-8-17(21-18(13)16)22-11-9-20-10-12-22/h1-4,6,8,16,20H,5,7,9-12H2/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304820 (2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline | C...) Show SMILES C1CCc2nc(ccc2C1)N1CCNCC1 Show InChI InChI=1S/C13H19N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h5-6,14H,1-4,7-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50016972 (4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...) Show SMILES C1CN(CCN1)c1nccc2occc12 Show InChI InChI=1S/C11H13N3O/c1-3-13-11(9-2-8-15-10(1)9)14-6-4-12-5-7-14/h1-3,8,12H,4-7H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304812 (4-methoxy-2-(piperazin-1-yl)-5,6,7,8-tetrahydroqui...) Show SMILES COc1nc(nc2CCCCc12)N1CCNCC1 Show InChI InChI=1S/C13H20N4O/c1-18-12-10-4-2-3-5-11(10)15-13(16-12)17-8-6-14-7-9-17/h14H,2-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304800 ((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...) Show SMILES Fc1ccc(F)c(CO[C@H]2CCc3ccc(nc23)N2CCNCC2)c1 |r| Show InChI InChI=1S/C19H21F2N3O/c20-15-3-4-16(21)14(11-15)12-25-17-5-1-13-2-6-18(23-19(13)17)24-9-7-22-8-10-24/h2-4,6,11,17,22H,1,5,7-10,12H2/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304818 (4-(3-chlorobenzyloxy)-2-(piperazin-1-yl)thieno[3,2...) Show SMILES Clc1cccc(COc2nc(nc3ccsc23)N2CCNCC2)c1 Show InChI InChI=1S/C17H17ClN4OS/c18-13-3-1-2-12(10-13)11-23-16-15-14(4-9-24-15)20-17(21-16)22-7-5-19-6-8-22/h1-4,9-10,19H,5-8,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50304806 ((R)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...) Show SMILES Clc1ccccc1O[C@@H]1CCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C18H20ClN3O/c19-14-3-1-2-4-15(14)23-16-7-5-13-6-8-17(21-18(13)16)22-11-9-20-10-12-22/h1-4,6,8,16,20H,5,7,9-12H2/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304820 (2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline | C...) Show SMILES C1CCc2nc(ccc2C1)N1CCNCC1 Show InChI InChI=1S/C13H19N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h5-6,14H,1-4,7-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50304801 ((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3F)c2n1 |r| Show InChI InChI=1S/C20H23F2N3O/c1-13-11-23-8-9-25(13)19-7-3-14-2-6-18(20(14)24-19)26-12-15-10-16(21)4-5-17(15)22/h3-5,7,10,13,18,23H,2,6,8-9,11-12H2,1H3/t13-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	83	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304815 (4-(piperazin-1-yl)thieno[3,2-d]pyrimidine | CHEMBL...) Show SMILES C1CN(CCN1)c1ncnc2ccsc12 Show InChI InChI=1S/C10H12N4S/c1-6-15-9-8(1)12-7-13-10(9)14-4-2-11-3-5-14/h1,6-7,11H,2-5H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	113	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304810 (4-(piperazin-1-yl)thieno[2,3-d]pyrimidine | CHEMBL...) Show SMILES C1CN(CCN1)c1ncnc2sccc12 Show InChI InChI=1S/C10H12N4S/c1-6-15-10-8(1)9(12-7-13-10)14-4-2-11-3-5-14/h1,6-7,11H,2-5H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	127	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50304800 ((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...) Show SMILES Fc1ccc(F)c(CO[C@H]2CCc3ccc(nc23)N2CCNCC2)c1 |r| Show InChI InChI=1S/C19H21F2N3O/c20-15-3-4-16(21)14(11-15)12-25-17-5-1-13-2-6-18(23-19(13)17)24-9-7-22-8-10-24/h2-4,6,11,17,22H,1,5,7-10,12H2/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	153	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304811 (6-methyl-4-(piperazin-1-yl)furo[2,3-d]pyrimidine |...) Show SMILES Cc1cc2c(ncnc2o1)N1CCNCC1 Show InChI InChI=1S/C11H14N4O/c1-8-6-9-10(13-7-14-11(9)16-8)15-4-2-12-3-5-15/h6-7,12H,2-5H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	156	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304813 (6-bromo-8-(piperazin-1-yl)imidazo[1,2-a]pyrazine |...) Show SMILES Brc1cn2ccnc2c(n1)N1CCNCC1 Show InChI InChI=1S/C10H12BrN5/c11-8-7-16-6-3-13-9(16)10(14-8)15-4-1-12-2-5-15/h3,6-7,12H,1-2,4-5H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	207	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304817 (6-(piperazin-1-yl)-9-propyl-9H-purine | CHEMBL5944...) Show SMILES CCCn1cnc2c(ncnc12)N1CCNCC1 Show InChI InChI=1S/C12H18N6/c1-2-5-18-9-16-10-11(14-8-15-12(10)18)17-6-3-13-4-7-17/h8-9,13H,2-7H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	378	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304821 (4-Piperazin-1-yl-benzo[4,5]thieno[3,2-d]pyrimidine...) Show SMILES C1CN(CCN1)c1ncnc2c3ccccc3sc12 Show InChI InChI=1S/C14H14N4S/c1-2-4-11-10(3-1)12-13(19-11)14(17-9-16-12)18-7-5-15-6-8-18/h1-4,9,15H,5-8H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304819 (4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | C...) Show SMILES C1CN(CCN1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C10H13N5/c1-2-12-9-8(1)10(14-7-13-9)15-5-3-11-4-6-15/h1-2,7,11H,3-6H2,(H,12,13,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	755	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by GTPgammaS binding				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304823 (1-(piperazin-1-yl)isoquinoline | CHEMBL595552) Show SMILES C1CN(CCN1)c1nccc2ccccc12 Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-15-13(12)16-9-7-14-8-10-16/h1-6,14H,7-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2A receptor by FLIPR assay relative to 5HT				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304825 (4-(3-chlorobenzyloxy)-7-methyl-2-(piperazin-1-yl)t...) Show SMILES Cc1csc2c(OCc3cccc(Cl)c3)nc(nc12)N1CCNCC1 Show InChI InChI=1S/C18H19ClN4OS/c1-12-11-25-16-15(12)21-18(23-7-5-20-6-8-23)22-17(16)24-10-13-3-2-4-14(19)9-13/h2-4,9,11,20H,5-8,10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304822 (6-(3-chlorobenzyloxy)-2-(piperazin-1-yl)-9H-purine...) Show SMILES Clc1cccc(COc2nc(nc3nc[nH]c23)N2CCNCC2)c1 Show InChI InChI=1S/C16H17ClN6O/c17-12-3-1-2-11(8-12)9-24-15-13-14(20-10-19-13)21-16(22-15)23-6-4-18-5-7-23/h1-3,8,10,18H,4-7,9H2,(H,19,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304829 (2-(benzyloxy)-7-methyl-6-(piperazin-1-yl)-7H-purin...) Show SMILES Cn1cnc2nc(OCc3ccccc3)nc(N3CCNCC3)c12 Show InChI InChI=1S/C17H20N6O/c1-22-12-19-15-14(22)16(23-9-7-18-8-10-23)21-17(20-15)24-11-13-5-3-2-4-6-13/h2-6,12,18H,7-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304824 (2-chloro-7-phenyl-4-(piperazin-1-yl)thieno[3,2-d]p...) Show SMILES Clc1nc(N2CCNCC2)c2scc(-c3ccccc3)c2n1 Show InChI InChI=1S/C16H15ClN4S/c17-16-19-13-12(11-4-2-1-3-5-11)10-22-14(13)15(20-16)21-8-6-18-7-9-21/h1-5,10,18H,6-9H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304828 (2-Chloro-4-piperazin-1-yl-5,6,7,8-tetrahydro-benzo...) Show SMILES Clc1nc(N2CCNCC2)c2c3CCCCc3sc2n1 Show InChI InChI=1S/C14H17ClN4S/c15-14-17-12(19-7-5-16-6-8-19)11-9-3-1-2-4-10(9)20-13(11)18-14/h16H,1-8H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human ERG channel				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304819 (4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine | C...) Show SMILES C1CN(CCN1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C10H13N5/c1-2-12-9-8(1)10(14-7-13-9)15-5-3-11-4-6-15/h1-2,7,11H,3-6H2,(H,12,13,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	755	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304803 ((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...) Show SMILES Clc1ccccc1O[C@@H]1CCCc2ccc(nc12)N1CCNCC1 |r| Show InChI InChI=1S/C19H22ClN3O/c20-15-5-1-2-6-16(15)24-17-7-3-4-14-8-9-18(22-19(14)17)23-12-10-21-11-13-23/h1-2,5-6,8-9,17,21H,3-4,7,10-13H2/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50304815 (4-(piperazin-1-yl)thieno[3,2-d]pyrimidine | CHEMBL...) Show SMILES C1CN(CCN1)c1ncnc2ccsc12 Show InChI InChI=1S/C10H12N4S/c1-6-15-9-8(1)12-7-13-10(9)14-4-2-11-3-5-14/h1,6-7,11H,2-5H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against human 5HT2C receptor by FLIPR assay				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50304807 ((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...) Show SMILES C[C@@H]1CNCCN1c1ccc2CC[C@H](OCc3cc(F)ccc3C)c2n1 |r| Show InChI InChI=1S/C21H26FN3O/c1-14-3-6-18(22)11-17(14)13-26-19-7-4-16-5-8-20(24-21(16)19)25-10-9-23-12-15(25)2/h3,5-6,8,11,15,19,23H,4,7,9-10,12-13H2,1-2H3/t15-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity against 5HT2B receptor assessed as inositol phosphate accumulation				Bioorg Med Chem Lett 20: 266-71 (2010) Article DOI: 10.1016/j.bmcl.2009.10.112 BindingDB Entry DOI: 10.7270/Q2154H5M
					More data for this Ligand-Target Pair

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