Compile Data Set for Download or QSAR

Found 62 hits Enz. Inhib. hit(s) with all data for entry = 50031006   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305149 (2-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...) Show SMILES Oc1ccc(cc1F)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H14FN3O/c21-15-9-11(5-6-17(15)25)19-14-10-23-20-18(14)13(7-8-22-20)12-3-1-2-4-16(12)24-19/h1-10,19,24-25H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305150 (3-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...) Show SMILES Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C20H14FN3O/c21-16-9-11(25)5-6-14(16)19-15-10-23-20-18(15)13(7-8-22-20)12-3-1-2-4-17(12)24-19/h1-10,19,24-25H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305157 (3-chloro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...) Show SMILES Oc1ccc(c(Cl)c1)-c1nc2ccccc2c2ncnc3[nH]cc1c23 Show InChI InChI=1S/C19H11ClN4O/c20-14-7-10(25)5-6-11(14)17-13-8-21-19-16(13)18(22-9-23-19)12-3-1-2-4-15(12)24-17/h1-9,25H,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305156 (2-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...) Show SMILES Oc1ccc(cc1F)C1Nc2ccccc2-c2ncnc3[nH]cc1c23 Show InChI InChI=1S/C19H13FN4O/c20-13-7-10(5-6-15(13)25)17-12-8-21-19-16(12)18(22-9-23-19)11-3-1-2-4-14(11)24-17/h1-9,17,24-25H,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305155 (3-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...) Show SMILES Oc1ccc(C2Nc3ccccc3-c3ncnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C19H13FN4O/c20-14-7-10(25)5-6-11(14)17-13-8-21-19-16(13)18(22-9-23-19)12-3-1-2-4-15(12)24-17/h1-9,17,24-25H,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305148 (4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...) Show SMILES Oc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H15N3O/c24-13-7-5-12(6-8-13)19-16-11-22-20-18(16)15(9-10-21-20)14-3-1-2-4-17(14)23-19/h1-11,19,23-24H,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305153 (2-bromo-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}....) Show SMILES Oc1ccc(cc1Br)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H14BrN3O/c21-15-9-11(5-6-17(15)25)19-14-10-23-20-18(14)13(7-8-22-20)12-3-1-2-4-16(12)24-19/h1-10,19,24-25H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305154 ((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...) Show SMILES OCc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C21H17N3O/c25-12-13-5-7-14(8-6-13)20-17-11-23-21-19(17)16(9-10-22-21)15-3-1-2-4-18(15)24-20/h1-11,20,24-25H,12H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305152 (3-chloro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...) Show SMILES Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(Cl)c1 Show InChI InChI=1S/C20H14ClN3O/c21-16-9-11(25)5-6-14(16)19-15-10-23-20-18(15)13(7-8-22-20)12-3-1-2-4-17(12)24-19/h1-10,19,24-25H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305151 ((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...) Show SMILES OB(O)c1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H16BN3O2/c25-21(26)13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24-26H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305193 (CHEMBL589387 | Methyl 9-(3-fluoro-4-hydroxyphenyl)...) Show SMILES COC(=O)C1(Nc2ccccc2-c2ccnc3[nH]cc1c23)c1ccc(O)c(F)c1 Show InChI InChI=1S/C22H16FN3O3/c1-29-21(28)22(12-6-7-18(27)16(23)10-12)15-11-25-20-19(15)14(8-9-24-20)13-4-2-3-5-17(13)26-22/h2-11,26-27H,1H3,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305196 (10-(2-fluoro-4-hydroxyphenyl)-9,13,15-triazatetrac...) Show SMILES Oc1ccc(C2NC(=O)c3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C21H14FN3O2/c22-17-9-11(26)5-6-15(17)19-16-10-24-20-18(16)13(7-8-23-20)12-3-1-2-4-14(12)21(27)25-19/h1-10,19,26H,(H,23,24)(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305178 (9-(4-methoxyphenyl)-8,12,14-triazatetracyclo[8.6.1...) Show SMILES COc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C21H17N3O/c1-25-14-8-6-13(7-9-14)20-17-12-23-21-19(17)16(10-11-22-21)15-4-2-3-5-18(15)24-20/h2-12,20,24H,1H3,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305175 (9-(2,3,6-trifluorophenyl)-8,12,14-triazatetracyclo...) Show SMILES Fc1ccc(F)c(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c1F Show InChI InChI=1S/C20H12F3N3/c21-13-5-6-14(22)18(23)17(13)19-12-9-25-20-16(12)11(7-8-24-20)10-3-1-2-4-15(10)26-19/h1-9,19,26H,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305179 (4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...) Show SMILES Nc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H16N4/c21-13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24H,21H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	71	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305173 (9-(2,6-difluorophenyl)-8,12,14-triazatetracyclo[8....) Show SMILES Fc1cccc(F)c1C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H13F2N3/c21-14-5-3-6-15(22)18(14)19-13-10-24-20-17(13)12(8-9-23-20)11-4-1-2-7-16(11)25-19/h1-10,19,25H,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305171 (9-(3-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....) Show SMILES Fc1cccc(c1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H14FN3/c21-13-5-3-4-12(10-13)19-16-11-23-20-18(16)15(8-9-22-20)14-6-1-2-7-17(14)24-19/h1-11,19,24H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305174 (9-(2,4-difluorophenyl)-8,12,14-triazatetracyclo[8....) Show SMILES Fc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C20H13F2N3/c21-11-5-6-14(16(22)9-11)19-15-10-24-20-18(15)13(7-8-23-20)12-3-1-2-4-17(12)25-19/h1-10,19,25H,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305192 (CHEMBL602648 | Methyl 9-(4-nitrophenyl)-8,12,14-tr...) Show SMILES COC(=O)C1(Nc2ccccc2-c2ccnc3[nH]cc1c23)c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C22H16N4O4/c1-30-21(27)22(13-6-8-14(9-7-13)26(28)29)17-12-24-20-19(17)16(10-11-23-20)15-4-2-3-5-18(15)25-22/h2-12,25H,1H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305194 (CHEMBL589632 | Methyl 9-(4-hydroxyphenyl)-8,12,14-...) Show SMILES COC(=O)C1(Nc2ccccc2-c2ccnc3[nH]cc1c23)c1ccc(O)cc1 Show InChI InChI=1S/C22H17N3O3/c1-28-21(27)22(13-6-8-14(26)9-7-13)17-12-24-20-19(17)16(10-11-23-20)15-4-2-3-5-18(15)25-22/h2-12,25-26H,1H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305170 (9-(2-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....) Show SMILES Fc1ccccc1C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H14FN3/c21-16-7-3-1-6-14(16)19-15-11-23-20-18(15)13(9-10-22-20)12-5-2-4-8-17(12)24-19/h1-11,19,24H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50300198 (5-chloro-3-phenyl-1H-pyrrolo[2,3-b]pyridine | CHEM...) Show SMILES Clc1cnc2[nH]cc(-c3ccccc3)c2c1 Show InChI InChI=1S/C13H9ClN2/c14-10-6-11-12(8-16-13(11)15-7-10)9-4-2-1-3-5-9/h1-8H,(H,15,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305176 (9-(2,3,4-trifluorophenyl)-8,12,14-triazatetracyclo...) Show SMILES Fc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1F Show InChI InChI=1S/C20H12F3N3/c21-14-6-5-12(17(22)18(14)23)19-13-9-25-20-16(13)11(7-8-24-20)10-3-1-2-4-15(10)26-19/h1-9,19,26H,(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305169 (9-phenyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^...) Show SMILES N1C(c2c[nH]c3nccc(-c4ccccc14)c23)c1ccccc1 Show InChI InChI=1S/C20H15N3/c1-2-6-13(7-3-1)19-16-12-22-20-18(16)15(10-11-21-20)14-8-4-5-9-17(14)23-19/h1-12,19,23H,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305188 (4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^{2,7}.0^{...) Show SMILES OCCCCc1[nH]c2ccccc2c2ncnc3ncc1c23 Show InChI InChI=1S/C17H16N4O/c22-8-4-3-7-14-12-9-18-17-15(12)16(19-10-20-17)11-5-1-2-6-13(11)21-14/h1-2,5-6,9-10,21-22H,3-4,7-8H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305162 (CHEMBL595397 | Methyl 2-{8,12,14-triazatetracyclo[...) Show SMILES COC(=O)CC1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C17H15N3O2/c1-22-15(21)8-14-12-9-19-17-16(12)11(6-7-18-17)10-4-2-3-5-13(10)20-14/h2-7,9,14,20H,8H2,1H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50300197 (4-phenyl-7H-pyrrolo[2,3-d]pyrimidine | CHEMBL57897...) Show SMILES c1cc2c(ncnc2[nH]1)-c1ccccc1 Show InChI InChI=1S/C12H9N3/c1-2-4-9(5-3-1)11-10-6-7-13-12(10)15-8-14-11/h1-8H,(H,13,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	486	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305172 (9-(4-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....) Show SMILES Fc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H14FN3/c21-13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305195 (CHEMBL602100 | Ethyl 9-(4-hydroxyphenyl)-8,12,14,1...) Show SMILES CCOC(=O)C1(Nc2ccccc2-c2ncnc3[nH]cc1c23)c1ccc(O)cc1 Show InChI InChI=1S/C22H18N4O3/c1-2-29-21(28)22(13-7-9-14(27)10-8-13)16-11-23-20-18(16)19(24-12-25-20)15-5-3-4-6-17(15)26-22/h3-12,26-27H,2H2,1H3,(H,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305163 (8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17}]h...) Show SMILES C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C14H11N3/c1-2-4-12-10(3-1)11-5-6-15-14-13(11)9(7-16-12)8-17-14/h1-6,8,16H,7H2,(H,15,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	750	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305166 (9-benzyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^...) Show SMILES C(C1Nc2ccccc2-c2ccnc3[nH]cc1c23)c1ccccc1 Show InChI InChI=1S/C21H17N3/c1-2-6-14(7-3-1)12-19-17-13-23-21-20(17)16(10-11-22-21)15-8-4-5-9-18(15)24-19/h1-11,13,19,24H,12H2,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305177 (2-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...) Show SMILES Oc1ccccc1C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H15N3O/c24-17-8-4-2-6-14(17)19-15-11-22-20-18(15)13(9-10-21-20)12-5-1-3-7-16(12)23-19/h1-11,19,23-24H,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305183 (9-(pyridin-4-yl)-8,12,14-triazatetracyclo[8.6.1.0^...) Show SMILES N1C(c2c[nH]c3nccc(-c4ccccc14)c23)c1ccncc1 Show InChI InChI=1S/C19H14N4/c1-2-4-16-13(3-1)14-7-10-21-19-17(14)15(11-22-19)18(23-16)12-5-8-20-9-6-12/h1-11,18,23H,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305187 (9-(3-fluorophenyl)-8,12,14,16-tetraazatetracyclo[8...) Show SMILES Fc1cccc(c1)C1Nc2ccccc2-c2ncnc3[nH]cc1c23 Show InChI InChI=1S/C19H13FN4/c20-12-5-3-4-11(8-12)17-14-9-21-19-16(14)18(22-10-23-19)13-6-1-2-7-15(13)24-17/h1-10,17,24H,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305158 (9-ethyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{...) Show SMILES CCC1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C16H15N3/c1-2-13-12-9-18-16-15(12)11(7-8-17-16)10-5-3-4-6-14(10)19-13/h3-9,13,19H,2H2,1H3,(H,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305165 (9-[(benzyloxy)methyl]-8,12,14-triazatetracyclo[8.6...) Show SMILES C(OCc1ccccc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C22H19N3O/c1-2-6-15(7-3-1)13-26-14-20-18-12-24-22-21(18)17(10-11-23-22)16-8-4-5-9-19(16)25-20/h1-12,20,25H,13-14H2,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305160 (9-(propan-2-yl)-8,12,14-triazatetracyclo[8.6.1.0^{...) Show SMILES CC(C)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C17H17N3/c1-10(2)16-13-9-19-17-15(13)12(7-8-18-17)11-5-3-4-6-14(11)20-16/h3-10,16,20H,1-2H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305180 (CHEMBL604246 | N-(4-{8,12,14-triazatetracyclo[8.6....) Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C21H18N4O2S/c1-28(26,27)25-14-8-6-13(7-9-14)20-17-12-23-21-19(17)16(10-11-22-21)15-4-2-3-5-18(15)24-20/h2-12,20,24-25H,1H3,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305161 (9-tert-butyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7...) Show SMILES CC(C)(C)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C18H19N3/c1-18(2,3)16-13-10-20-17-15(13)12(8-9-19-17)11-6-4-5-7-14(11)21-16/h4-10,16,21H,1-3H3,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305167 (4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...) Show SMILES OCCCCC1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C18H19N3O/c22-10-4-3-7-16-14-11-20-18-17(14)13(8-9-19-18)12-5-1-2-6-15(12)21-16/h1-2,5-6,8-9,11,16,21-22H,3-4,7,10H2,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305168 (3-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...) Show SMILES OCCCC1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C17H17N3O/c21-9-3-6-15-13-10-19-17-16(13)12(7-8-18-17)11-4-1-2-5-14(11)20-15/h1-2,4-5,7-8,10,15,20-21H,3,6,9H2,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305164 (9-cyclohexyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7...) Show SMILES C1CCC(CC1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H21N3/c1-2-6-13(7-3-1)19-16-12-22-20-18(16)15(10-11-21-20)14-8-4-5-9-17(14)23-19/h4-5,8-13,19,23H,1-3,6-7H2,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305181 (4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...) Show SMILES OC(=O)c1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C21H15N3O2/c25-21(26)13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24H,(H,22,23)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305159 (9-(2-methylpropyl)-8,12,14-triazatetracyclo[8.6.1....) Show SMILES CC(C)CC1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C18H19N3/c1-11(2)9-16-14-10-20-18-17(14)13(7-8-19-18)12-5-3-4-6-15(12)21-16/h3-8,10-11,16,21H,9H2,1-2H3,(H,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305197 (10-(4-methoxyphenyl)-9,13,15-triazatetracyclo[9.6....) Show SMILES COc1ccc(cc1)C1NC(=O)c2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C22H17N3O2/c1-27-14-8-6-13(7-9-14)20-18-12-24-21-19(18)16(10-11-23-21)15-4-2-3-5-17(15)22(26)25-20/h2-12,20H,1H3,(H,23,24)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305186 (9-phenyl-8,12,14,16-tetraazatetracyclo[8.6.1.0^{2,...) Show SMILES N1C(c2c[nH]c3ncnc(-c4ccccc14)c23)c1ccccc1 Show InChI InChI=1S/C19H14N4/c1-2-6-12(7-3-1)17-14-10-20-19-16(14)18(21-11-22-19)13-8-4-5-9-15(13)23-17/h1-11,17,23H,(H,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305182 (CHEMBL592269 | N-methyl-4-{8,12,14-triazatetracycl...) Show SMILES CNC(=O)c1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C22H18N4O/c1-23-22(27)14-8-6-13(7-9-14)20-17-12-25-21-19(17)16(10-11-24-21)15-4-2-3-5-18(15)26-20/h2-12,20,26H,1H3,(H,23,27)(H,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305189 (10,20,22-triazahexacyclo[15.6.1.0^{2,10}.0^{3,8}.0...) Show SMILES O=C1N2C(c3ccccc13)c1c[nH]c3nccc(-c4ccccc24)c13 Show InChI InChI=1S/C21H13N3O/c25-21-15-7-2-1-6-14(15)19-16-11-23-20-18(16)13(9-10-22-20)12-5-3-4-8-17(12)24(19)21/h1-11,19H,(H,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305185 (9-[(benzyloxy)methyl]-8,12,14,16-tetraazatetracycl...) Show SMILES C(OCc1ccccc1)C1Nc2ccccc2-c2ncnc3[nH]cc1c23 Show InChI InChI=1S/C21H18N4O/c1-2-6-14(7-3-1)11-26-12-18-16-10-22-21-19(16)20(23-13-24-21)15-8-4-5-9-17(15)25-18/h1-10,13,18,25H,11-12H2,(H,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50305191 (4-methylbenzene-1-sulfonic acid; N-{dispiro[adaman...) Show SMILES O=C1N2C(c3ccccc13)c1c[nH]c3ncnc(-c4ccccc24)c13 Show InChI InChI=1S/C20H12N4O/c25-20-12-6-2-1-5-11(12)18-14-9-21-19-16(14)17(22-10-23-19)13-7-3-4-8-15(13)24(18)20/h1-10,18H,(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 by radiometric assay				Bioorg Med Chem Lett 20: 153-6 (2010) Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ
					More data for this Ligand-Target Pair

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