Found 32 hits Enz. Inhib. hit(s) with all data for entry = 50048544 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219966
(CHEMBL23959)Show SMILES CC[C@H](C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C20H21Cl2N3/c1-3-17(12-5-6-12)25-18(4-2)24-19-15(9-10-23-20(19)25)14-8-7-13(21)11-16(14)22/h7-12,17H,3-6H2,1-2H3/t17-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219965
(CHEMBL430913)Show SMILES CC[C@@H](C1CC1)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C20H21Cl2N3/c1-3-17(12-5-6-12)25-18(4-2)24-19-15(9-10-23-20(19)25)14-8-7-13(21)11-16(14)22/h7-12,17H,3-6H2,1-2H3/t17-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220479
(CHEMBL23342)Show InChI InChI=1S/C19H21Cl2N3/c1-4-6-12(3)24-17(5-2)23-18-15(9-10-22-19(18)24)14-8-7-13(20)11-16(14)21/h7-12H,4-6H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219957
(CHEMBL3085294)Show SMILES CCc1nc2c(ccnc2n1[C@H](C)C1CC1)-c1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C19H19Cl2N3/c1-3-17-23-18-15(14-7-6-13(20)10-16(14)21)8-9-22-19(18)24(17)11(2)12-4-5-12/h6-12H,3-5H2,1-2H3/t11-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220478
(CHEMBL22622)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1cc(C)c(OC)cc1C Show InChI InChI=1S/C22H29N3O/c1-7-9-16(5)25-20(8-2)24-21-17(10-11-23-22(21)25)18-12-15(4)19(26-6)13-14(18)3/h10-13,16H,7-9H2,1-6H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219962
(CHEMBL431105)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)cc1C(F)(F)F Show InChI InChI=1S/C21H24F3N3O/c1-5-7-13(3)27-18(6-2)26-19-16(10-11-25-20(19)27)15-9-8-14(28-4)12-17(15)21(22,23)24/h8-13H,5-7H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219954
(CHEMBL283993)Show SMILES CCc1nc2c(ccnc2n1C(C)C1CCC1)-c1ccc(OC(F)F)cc1Cl Show InChI InChI=1S/C21H22ClF2N3O/c1-3-18-26-19-16(15-8-7-14(11-17(15)22)28-21(23)24)9-10-25-20(19)27(18)12(2)13-5-4-6-13/h7-13,21H,3-6H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219969
(CHEMBL23439)Show SMILES CCC(CCOC)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H23ClF3N3O/c1-4-14(9-11-29-3)28-18(5-2)27-19-16(8-10-26-20(19)28)15-7-6-13(12-17(15)22)21(23,24)25/h6-8,10,12,14H,4-5,9,11H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219962
(CHEMBL431105)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(OC)cc1C(F)(F)F Show InChI InChI=1S/C21H24F3N3O/c1-5-7-13(3)27-18(6-2)26-19-16(10-11-25-20(19)27)15-9-8-14(28-4)12-17(15)21(22,23)24/h8-13H,5-7H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220480
(CHEMBL22433)Show InChI InChI=1S/C21H27N3O/c1-6-8-15(4)24-19(7-2)23-20-18(11-12-22-21(20)24)17-10-9-16(25-5)13-14(17)3/h9-13,15H,6-8H2,1-5H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219961
(CHEMBL23483)Show InChI InChI=1S/C19H21Cl2N3/c1-4-13(5-2)24-17(6-3)23-18-15(9-10-22-19(18)24)14-8-7-12(20)11-16(14)21/h7-11,13H,4-6H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219967
(CHEMBL423475)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(C)=O Show InChI InChI=1S/C21H24ClN3O/c1-5-7-13(3)25-19(6-2)24-20-17(10-11-23-21(20)25)16-9-8-15(14(4)26)12-18(16)22/h8-13H,5-7H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220485
(CHEMBL23354)Show InChI InChI=1S/C20H21Cl2N3/c1-3-18-24-19-16(15-8-7-14(21)11-17(15)22)9-10-23-20(19)25(18)12(2)13-5-4-6-13/h7-13H,3-6H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219963
(CHEMBL276971)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H21ClF3N3/c1-4-6-12(3)27-17(5-2)26-18-15(9-10-25-19(18)27)14-8-7-13(11-16(14)21)20(22,23)24/h7-12H,4-6H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219963
(CHEMBL276971)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H21ClF3N3/c1-4-6-12(3)27-17(5-2)26-18-15(9-10-25-19(18)27)14-8-7-13(11-16(14)21)20(22,23)24/h7-12H,4-6H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219970
(CHEMBL23950)Show InChI InChI=1S/C18H19Cl2N3/c1-4-11(3)23-16(5-2)22-17-14(8-9-21-18(17)23)13-7-6-12(19)10-15(13)20/h6-11H,4-5H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219956
(CHEMBL282289)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(SC)cc1C(F)(F)F Show InChI InChI=1S/C21H24F3N3S/c1-5-7-13(3)27-18(6-2)26-19-16(10-11-25-20(19)27)15-9-8-14(28-4)12-17(15)21(22,23)24/h8-13H,5-7H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219971
(CHEMBL23291)Show SMILES CCc1nc2c(ccnc2n1C(CCOC)C1CC1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C21H23Cl2N3O/c1-3-19-25-20-16(15-7-6-14(22)12-17(15)23)8-10-24-21(20)26(19)18(9-11-27-2)13-4-5-13/h6-8,10,12-13,18H,3-5,9,11H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220483
(CHEMBL22213)Show SMILES CCc1nc2c(ncnc2n1C(C1CC1)C1CC1)-c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H20ClF3N4/c1-2-16-28-18-17(14-8-7-13(9-15(14)22)21(23,24)25)26-10-27-20(18)29(16)19(11-3-4-11)12-5-6-12/h7-12,19H,2-6H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220476
(CHEMBL280666)Show SMILES CCC(CCOC)n1c(OC)nc2c(ccnc12)-c1ccc(OC(F)(F)F)cc1Cl Show InChI InChI=1S/C20H21ClF3N3O3/c1-4-12(8-10-28-2)27-18-17(26-19(27)29-3)15(7-9-25-18)14-6-5-13(11-16(14)21)30-20(22,23)24/h5-7,9,11-12H,4,8,10H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220475
(CHEMBL431886)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(\C)=N/OC Show InChI InChI=1S/C22H27ClN4O/c1-6-8-14(3)27-20(7-2)25-21-18(11-12-24-22(21)27)17-10-9-16(13-19(17)23)15(4)26-28-5/h9-14H,6-8H2,1-5H3/b26-15- | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219964
(CHEMBL23105)Show SMILES CCc1nc2c(ccnc2n1C(CCOC)C1CCC1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C22H25Cl2N3O/c1-3-20-26-21-17(16-8-7-15(23)13-18(16)24)9-11-25-22(21)27(20)19(10-12-28-2)14-5-4-6-14/h7-9,11,13-14,19H,3-6,10,12H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220481
(CHEMBL23178)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1cc(F)c(F)cc1Cl Show InChI InChI=1S/C19H20ClF2N3/c1-4-6-11(3)25-17(5-2)24-18-12(7-8-23-19(18)25)13-9-15(21)16(22)10-14(13)20/h7-11H,4-6H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220477
(CHEMBL23669)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(C)OC Show InChI InChI=1S/C22H28ClN3O/c1-6-8-14(3)26-20(7-2)25-21-18(11-12-24-22(21)26)17-10-9-16(13-19(17)23)15(4)27-5/h9-15H,6-8H2,1-5H3 | PDB
MMDB
UniProtKB/SwissProt
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| CHEMBL
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UniChem
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| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219960
(CHEMBL23630)Show SMILES CCC(COC)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H21ClF3N3O/c1-4-13(11-28-3)27-17(5-2)26-18-15(8-9-25-19(18)27)14-7-6-12(10-16(14)21)20(22,23)24/h6-10,13H,4-5,11H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219955
(CHEMBL279734)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(C)O Show InChI InChI=1S/C21H26ClN3O/c1-5-7-13(3)25-19(6-2)24-20-17(10-11-23-21(20)25)16-9-8-15(14(4)26)12-18(16)22/h8-14,26H,5-7H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220486
(CHEMBL23898)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1C(F)(F)F)S(C)(=O)=O Show InChI InChI=1S/C21H24F3N3O2S/c1-5-7-13(3)27-18(6-2)26-19-16(10-11-25-20(19)27)15-9-8-14(30(4,28)29)12-17(15)21(22,23)24/h8-13H,5-7H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220482
(CHEMBL23788)Show SMILES CCCC(C)n1c(nc2c(ccnc12)-c1ccc(Cl)cc1Cl)C(F)F Show InChI InChI=1S/C18H17Cl2F2N3/c1-3-4-10(2)25-17-15(24-18(25)16(21)22)13(7-8-23-17)12-6-5-11(19)9-14(12)20/h5-10,16H,3-4H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
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UniChem
Similars
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219958
(CHEMBL23112)Show SMILES CCC(CCOC)n1c(nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F)C1CC1 Show InChI InChI=1S/C22H23ClF3N3O/c1-3-15(9-11-30-2)29-20(13-4-5-13)28-19-17(8-10-27-21(19)29)16-7-6-14(12-18(16)23)22(24,25)26/h6-8,10,12-13,15H,3-5,9,11H2,1-2H3 | PDB
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UniChem
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50220484
(CHEMBL444011)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(cc1Cl)C(C)(C)O Show InChI InChI=1S/C22H28ClN3O/c1-6-8-14(3)26-19(7-2)25-20-17(11-12-24-21(20)26)16-10-9-15(13-18(16)23)22(4,5)27/h9-14,27H,6-8H2,1-5H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
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UniChem
| PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219968
(CHEMBL280665)Show SMILES CCC(CCOC)n1c(COC)nc2c(ccnc12)-c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H23ClF3N3O2/c1-4-14(8-10-29-2)28-18(12-30-3)27-19-16(7-9-26-20(19)28)15-6-5-13(11-17(15)22)21(23,24)25/h5-7,9,11,14H,4,8,10,12H2,1-3H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
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UniChem
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| 83 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1/2
(Rattus norvegicus (rat)-RAT) | BDBM50219959
(CHEMBL23799)Show SMILES CCCC(C)n1c(CC)nc2c(ccnc12)-c1ccc(Cl)cc1C(C)=O Show InChI InChI=1S/C21H24ClN3O/c1-5-7-13(3)25-19(6-2)24-20-17(10-11-23-21(20)25)16-9-8-15(22)12-18(16)14(4)26/h8-13H,5-7H2,1-4H3 | PDB
MMDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
In vitro binding affinity to the CRF receptor in rat cortical homogenates |
Bioorg Med Chem Lett 13: 125-8 (2003)
BindingDB Entry DOI: 10.7270/Q2JM2CV9 |
More data for this
Ligand-Target Pair | |
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