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Compile Data Set for Download or QSAR

Found 20 hits Enz. Inhib. hit(s) with all data for entry = 50032908   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin L2


(Homo sapiens (Human))
BDBM50336482
PNG
(CHEMBL1668599 | citibrasine)
Show SMILES COc1c(OC)c(OC)c2n(C)c3c(O)cccc3c(=O)c2c1O
Show InChI InChI=1S/C17H17NO6/c1-18-11-8(6-5-7-9(11)19)13(20)10-12(18)15(22-2)17(24-4)16(23-3)14(10)21/h5-7,19,21H,1-4H3
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200n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336477
PNG
(1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-met...)
Show SMILES [#6]-[#8]-c1c(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6])c(-[#8])c2c1n(-[#6])c1c(-[#8])ccc(-[#6]\[#6]=[#6](\[#6])-[#6])c1c2=O
Show InChI InChI=1S/C25H29NO5/c1-13(2)7-9-15-10-12-17(27)20-18(15)24(30)19-21(26(20)5)25(31-6)23(29)16(22(19)28)11-8-14(3)4/h7-8,10,12,27-29H,9,11H2,1-6H3
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500n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336481
PNG
(CHEMBL451705 | citrusinine I | citrusinine-I)
Show SMILES COc1cc(O)c2c(c1OC)n(C)c1c(O)cccc1c2=O
Show InChI InChI=1S/C16H15NO5/c1-17-13-8(5-4-6-9(13)18)15(20)12-10(19)7-11(21-2)16(22-3)14(12)17/h4-7,18-19H,1-3H3
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1.00E+3n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336478
PNG
(1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-...)
Show SMILES [#6]-[#8]-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c2c1n(-[#6])c1c(-[#8])cccc1c2=O
Show InChI InChI=1S/C20H21NO5/c1-10(2)8-9-12-18(24)14-16(20(26-4)19(12)25)21(3)15-11(17(14)23)6-5-7-13(15)22/h5-8,22,24-25H,9H2,1-4H3
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1.10E+3n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336476
PNG
(1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-me...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc2n(-[#6])c3c(-[#8])ccc(-[#6]\[#6]=[#6](\[#6])-[#6])c3c(=O)c2c1-[#8]
Show InChI InChI=1S/C24H27NO4/c1-13(2)6-8-15-9-11-18(26)22-20(15)24(29)21-17(25(22)5)12-19(27)16(23(21)28)10-7-14(3)4/h6-7,9,11-12,26-28H,8,10H2,1-5H3
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1.20E+3n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336486
PNG
(3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trime...)
Show SMILES COc1c(O)c2CC(O)C(C)(C)Oc2c2c1n(C)c1c(O)cccc1c2=O
Show InChI InChI=1S/C20H21NO6/c1-20(2)12(23)8-10-17(25)19(26-4)15-13(18(10)27-20)16(24)9-6-5-7-11(22)14(9)21(15)3/h5-7,12,22-23,25H,8H2,1-4H3
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1.70E+3n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336480
PNG
(1,3,5-trihydroxy-4-methoxy-10-methylacridone | CHE...)
Show SMILES COc1c(O)cc(O)c2c1n(C)c1c(O)cccc1c2=O
Show InChI InChI=1S/C15H13NO5/c1-16-12-7(4-3-5-8(12)17)14(20)11-9(18)6-10(19)15(21-2)13(11)16/h3-6,17-19H,1-2H3
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4.20E+3n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336485
PNG
(2,3-dihydro-4,9-dihydroxy-2-(2-hydroxy-propan-2-yl...)
Show SMILES COc1c2OC(Cc2c(O)c2c1n(C)c1c(O)cccc1c2=O)C(C)(C)O
Show InChI InChI=1S/C20H21NO6/c1-20(2,25)12-8-10-17(24)13-15(19(26-4)18(10)27-12)21(3)14-9(16(13)23)6-5-7-11(14)22/h5-7,12,22,24-25H,8H2,1-4H3
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4.40E+3n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336479
PNG
(CHEMBL1668598 | glycocitrine-I)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2c1n(-[#6])c1c(-[#8])cccc1c2=O
Show InChI InChI=1S/C19H19NO4/c1-10(2)7-8-11-14(22)9-15(23)16-18(11)20(3)17-12(19(16)24)5-4-6-13(17)21/h4-7,9,21-23H,8H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336482
PNG
(CHEMBL1668599 | citibrasine)
Show SMILES COc1c(OC)c(OC)c2n(C)c3c(O)cccc3c(=O)c2c1O
Show InChI InChI=1S/C17H17NO6/c1-18-11-8(6-5-7-9(11)19)13(20)10-12(18)15(22-2)17(24-4)16(23-3)14(10)21/h5-7,19,21H,1-4H3
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PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336478
PNG
(1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-...)
Show SMILES [#6]-[#8]-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c2c1n(-[#6])c1c(-[#8])cccc1c2=O
Show InChI InChI=1S/C20H21NO5/c1-10(2)8-9-12-18(24)14-16(20(26-4)19(12)25)21(3)15-11(17(14)23)6-5-7-13(15)22/h5-8,22,24-25H,9H2,1-4H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336481
PNG
(CHEMBL451705 | citrusinine I | citrusinine-I)
Show SMILES COc1cc(O)c2c(c1OC)n(C)c1c(O)cccc1c2=O
Show InChI InChI=1S/C16H15NO5/c1-17-13-8(5-4-6-9(13)18)15(20)12-10(19)7-11(21-2)16(22-3)14(12)17/h4-7,18-19H,1-3H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336477
PNG
(1,3,5-trihydroxy-4-methoxy-10-methyl-2,8-bis(3-met...)
Show SMILES [#6]-[#8]-c1c(-[#8])c(-[#6]\[#6]=[#6](/[#6])-[#6])c(-[#8])c2c1n(-[#6])c1c(-[#8])ccc(-[#6]\[#6]=[#6](\[#6])-[#6])c1c2=O
Show InChI InChI=1S/C25H29NO5/c1-13(2)7-9-15-10-12-17(27)20-18(15)24(30)19-21(26(20)5)25(31-6)23(29)16(22(19)28)11-8-14(3)4/h7-8,10,12,27-29H,9,11H2,1-6H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336486
PNG
(3,4-dihydro-3,5,8-trihydroxy-6-methoxy-2,2,7-trime...)
Show SMILES COc1c(O)c2CC(O)C(C)(C)Oc2c2c1n(C)c1c(O)cccc1c2=O
Show InChI InChI=1S/C20H21NO6/c1-20(2)12(23)8-10-17(25)19(26-4)15-13(18(10)27-20)16(24)9-6-5-7-11(22)14(9)21(15)3/h5-7,12,22-23,25H,8H2,1-4H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336476
PNG
(1,3,5-trihydroxy-2,8-bis(3-methylbut-2-enyl)-10-me...)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc2n(-[#6])c3c(-[#8])ccc(-[#6]\[#6]=[#6](\[#6])-[#6])c3c(=O)c2c1-[#8]
Show InChI InChI=1S/C24H27NO4/c1-13(2)6-8-15-9-11-18(26)22-20(15)24(29)21-17(25(22)5)12-19(27)16(23(21)28)10-7-14(3)4/h6-7,9,11-12,26-28H,8,10H2,1-5H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336485
PNG
(2,3-dihydro-4,9-dihydroxy-2-(2-hydroxy-propan-2-yl...)
Show SMILES COc1c2OC(Cc2c(O)c2c1n(C)c1c(O)cccc1c2=O)C(C)(C)O
Show InChI InChI=1S/C20H21NO6/c1-20(2,25)12-8-10-17(24)13-15(19(26-4)18(10)27-12)21(3)14-9(16(13)23)6-5-7-11(14)22/h5-7,12,22,24-25H,8H2,1-4H3
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n/an/a 5.20E+3n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336480
PNG
(1,3,5-trihydroxy-4-methoxy-10-methylacridone | CHE...)
Show SMILES COc1c(O)cc(O)c2c1n(C)c1c(O)cccc1c2=O
Show InChI InChI=1S/C15H13NO5/c1-16-12-7(4-3-5-8(12)17)14(20)11-9(18)6-10(19)15(21-2)13(11)16/h3-6,17-19H,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336479
PNG
(CHEMBL1668598 | glycocitrine-I)
Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2c1n(-[#6])c1c(-[#8])cccc1c2=O
Show InChI InChI=1S/C19H19NO4/c1-10(2)7-8-11-14(22)9-15(23)16-18(11)20(3)17-12(19(16)24)5-4-6-13(17)21/h4-7,9,21-23H,8H2,1-3H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336484
PNG
(CHEMBL1668600 | pyranofoline)
Show SMILES COc1c2OC(C)(C)C=Cc2c(O)c2c1n(C)c1c(O)cccc1c2=O |c:8|
Show InChI InChI=1S/C20H19NO5/c1-20(2)9-8-11-17(24)13-15(19(25-4)18(11)26-20)21(3)14-10(16(13)23)6-5-7-12(14)22/h5-9,22,24H,1-4H3
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Article
PubMed
n/an/a 4.40E+4n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair
Cathepsin L2


(Homo sapiens (Human))
BDBM50336483
PNG
(5-hydroxynoracronycine | CHEMBL447169)
Show SMILES Cn1c2c(O)cccc2c(=O)c2c(O)cc3OC(C)(C)C=Cc3c12 |c:21|
Show InChI InChI=1S/C19H17NO4/c1-19(2)8-7-10-14(24-19)9-13(22)15-17(10)20(3)16-11(18(15)23)5-4-6-12(16)21/h4-9,21-22H,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.80E+4n/an/an/an/an/an/a



Universidade Federal de S£o Carlos

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cathepsin V expressed in Pichia pastoris


Bioorg Med Chem 19: 1477-81 (2011)


Article DOI: 10.1016/j.bmc.2010.12.056
BindingDB Entry DOI: 10.7270/Q2QJ7HK4
More data for this
Ligand-Target Pair