Compile Data Set for Download or QSAR

Found 94 hits Enz. Inhib. hit(s) with all data for entry = 50001664   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017103 (9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...) Show SMILES COc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC Show InChI InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3/b25-22+	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair				3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017103 (9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethyl-phenyli...) Show SMILES COc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC Show InChI InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3/b25-22+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017102 (4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidin-2-one | C...) Show SMILES CCCCOc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-14-8-11(5-6-13(14)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017109 (CHEMBL36290 | N-Butyl-4-[2-methoxy-5-(5-oxo-pyrrol...) Show SMILES CCCCNC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C19H28N2O4/c1-3-4-9-20-18(22)6-5-10-25-17-11-14(7-8-16(17)24-2)15-12-19(23)21-13-15/h7-8,11,15H,3-6,9-10,12-13H2,1-2H3,(H,20,22)(H,21,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017107 (1-Benzyl-4-(3,4-dimethoxy-phenyl)-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CN(Cc2ccccc2)C(=O)C1 Show InChI InChI=1S/C19H21NO3/c1-22-17-9-8-15(10-18(17)23-2)16-11-19(21)20(13-16)12-14-6-4-3-5-7-14/h3-10,16H,11-13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017092 (4-(3-Isobutoxy-4-methoxy-phenyl)-pyrrolidin-2-one ...) Show SMILES COc1ccc(cc1OCC(C)C)C1CNC(=O)C1 Show InChI InChI=1S/C15H21NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,10,12H,7-9H2,1-3H3,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017113 (4-(3,4-Dimethoxy-phenyl)-1-phenyl-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CN(C(=O)C1)c1ccccc1 Show InChI InChI=1S/C18H19NO3/c1-21-16-9-8-13(10-17(16)22-2)14-11-18(20)19(12-14)15-6-4-3-5-7-15/h3-10,14H,11-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017108 (4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrrolidine-3-carbo...) Show SMILES CCOC(=O)C1C(CNC1=O)c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C15H19NO5/c1-4-21-15(18)13-10(8-16-14(13)17)9-5-6-11(19-2)12(7-9)20-3/h5-7,10,13H,4,8H2,1-3H3,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017093 (4-(3,4-Dimethoxy-phenyl)-3-methyl-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CNC(=O)C1C Show InChI InChI=1S/C13H17NO3/c1-8-10(7-14-13(8)15)9-4-5-11(16-2)12(6-9)17-3/h4-6,8,10H,7H2,1-3H3,(H,14,15)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017114 (4-[4-Methoxy-3-(2-methyl-allyloxy)-phenyl]-pyrroli...) Show SMILES COc1ccc(cc1OCC(C)=C)C1CNC(=O)C1 Show InChI InChI=1S/C15H19NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,12H,1,7-9H2,2-3H3,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017112 (1-Acetyl-4-(3,4-dimethoxy-phenyl)-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CN(C(C)=O)C(=O)C1 Show InChI InChI=1S/C14H17NO4/c1-9(16)15-8-11(7-14(15)17)10-4-5-12(18-2)13(6-10)19-3/h4-6,11H,7-8H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017117 (4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...) Show SMILES CCOC(=O)CCCOc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C17H23NO5/c1-3-22-17(20)5-4-8-23-15-9-12(6-7-14(15)21-2)13-10-16(19)18-11-13/h6-7,9,13H,3-5,8,10-11H2,1-2H3,(H,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017118 (4-(3-Allyloxy-4-methoxy-phenyl)-pyrrolidin-2-one |...) Show SMILES COc1ccc(cc1OCC=C)C1CNC(=O)C1 Show InChI InChI=1S/C14H17NO3/c1-3-6-18-13-7-10(4-5-12(13)17-2)11-8-14(16)15-9-11/h3-5,7,11H,1,6,8-9H2,2H3,(H,15,16)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017111 (4-(3,4-Dimethoxy-phenyl)-1-methyl-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CN(C)C(=O)C1 Show InChI InChI=1S/C13H17NO3/c1-14-8-10(7-13(14)15)9-4-5-11(16-2)12(6-9)17-3/h4-6,10H,7-8H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017120 (CHEMBL284512 | N-Cyclohexyl-4-[2-methoxy-5-(5-oxo-...) Show SMILES COc1ccc(cc1OCCCC(=O)N(C)C1CCCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C22H32N2O4/c1-24(18-7-4-3-5-8-18)22(26)9-6-12-28-20-13-16(10-11-19(20)27-2)17-14-21(25)23-15-17/h10-11,13,17-18H,3-9,12,14-15H2,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017115 (4-[4-Methoxy-3-(2-methyl-butoxy)-phenyl]-pyrrolidi...) Show SMILES CCC(C)COc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C16H23NO3/c1-4-11(2)10-20-15-7-12(5-6-14(15)19-3)13-8-16(18)17-9-13/h5-7,11,13H,4,8-10H2,1-3H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017099 (4-(3,4-Dimethoxy-phenyl)-pyrrolidin-2-one | CHEMBL...) Show SMILES COc1ccc(cc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C12H15NO3/c1-15-10-4-3-8(5-11(10)16-2)9-6-12(14)13-7-9/h3-5,9H,6-7H2,1-2H3,(H,13,14)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017097 (1-Benzoyl-4-(3,4-dimethoxy-phenyl)-pyrrolidin-2-on...) Show SMILES COc1ccc(cc1OC)C1CN(C(=O)c2ccccc2)C(=O)C1 Show InChI InChI=1S/C19H19NO4/c1-23-16-9-8-14(10-17(16)24-2)15-11-18(21)20(12-15)19(22)13-6-4-3-5-7-13/h3-10,15H,11-12H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017096 (4-(3-Benzyloxy-4-methoxy-phenyl)-pyrrolidin-2-one ...) Show SMILES COc1ccc(cc1OCc1ccccc1)C1CNC(=O)C1 Show InChI InChI=1S/C18H19NO3/c1-21-16-8-7-14(15-10-18(20)19-11-15)9-17(16)22-12-13-5-3-2-4-6-13/h2-9,15H,10-12H2,1H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017101 (7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoi...) Show SMILES COc1cc2CC[C@H]3[C@@H](CNC3=O)c2cc1OC Show InChI InChI=1S/C14H17NO3/c1-17-12-5-8-3-4-9-11(7-15-14(9)16)10(8)6-13(12)18-2/h5-6,9,11H,3-4,7H2,1-2H3,(H,15,16)/t9-,11+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017096 (4-(3-Benzyloxy-4-methoxy-phenyl)-pyrrolidin-2-one ...) Show SMILES COc1ccc(cc1OCc1ccccc1)C1CNC(=O)C1 Show InChI InChI=1S/C18H19NO3/c1-21-16-8-7-14(15-10-18(20)19-11-15)9-17(16)22-12-13-5-3-2-4-6-13/h2-9,15H,10-12H2,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.74E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017094 (4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidine-2-thione...) Show SMILES CCCCOc1cc(ccc1OC)C1CNC(=S)C1 Show InChI InChI=1S/C15H21NO2S/c1-3-4-7-18-14-8-11(5-6-13(14)17-2)12-9-15(19)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.95E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017115 (4-[4-Methoxy-3-(2-methyl-butoxy)-phenyl]-pyrrolidi...) Show SMILES CCC(C)COc1cc(ccc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C16H23NO3/c1-4-11(2)10-20-15-7-12(5-6-14(15)19-3)13-8-16(18)17-9-13/h5-7,11,13H,4,8-10H2,1-3H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017104 (7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoi...) Show SMILES COc1cc2CC[C@@H]3[C@@H](CNC3=O)c2cc1OC Show InChI InChI=1S/C14H17NO3/c1-17-12-5-8-3-4-9-11(7-15-14(9)16)10(8)6-13(12)18-2/h5-6,9,11H,3-4,7H2,1-2H3,(H,15,16)/t9-,11-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.46E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017095 (4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...) Show SMILES COc1ccc(cc1OCCCC(O)=O)C1CNC(=O)C1 Show InChI InChI=1S/C15H19NO5/c1-20-12-5-4-10(11-8-14(17)16-9-11)7-13(12)21-6-2-3-15(18)19/h4-5,7,11H,2-3,6,8-9H2,1H3,(H,16,17)(H,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017094 (4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidine-2-thione...) Show SMILES CCCCOc1cc(ccc1OC)C1CNC(=S)C1 Show InChI InChI=1S/C15H21NO2S/c1-3-4-7-18-14-8-11(5-6-13(14)17-2)12-9-15(19)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50017116 (5,6-Dimethoxy-3,3a,8,8a-tetrahydro-1H-1-aza-cyclop...) Show SMILES COc1cc2CC3NC(=O)C[C@@H]3c2cc1OC Show InChI InChI=1S/C13H15NO3/c1-16-11-4-7-3-10-9(6-13(15)14-10)8(7)5-12(11)17-2/h4-5,9-10H,3,6H2,1-2H3,(H,14,15)/t9-,10?/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B (Bos taurus-BOVINE)	BDBM50010981 ((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...) Show SMILES CCCCOc1cc(CC2CNC(=O)N2)ccc1OC Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	9.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP in the presence of calcium (10 uM) and calmodu...				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017095 (4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-bu...) Show SMILES COc1ccc(cc1OCCCC(O)=O)C1CNC(=O)C1 Show InChI InChI=1S/C15H19NO5/c1-20-12-5-4-10(11-8-14(17)16-9-11)7-13(12)21-6-2-3-15(18)19/h4-5,7,11H,2-3,6,8-9H2,1H3,(H,16,17)(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017099 (4-(3,4-Dimethoxy-phenyl)-pyrrolidin-2-one | CHEMBL...) Show SMILES COc1ccc(cc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C12H15NO3/c1-15-10-4-3-8(5-11(10)16-2)9-6-12(14)13-7-9/h3-5,9H,6-7H2,1-2H3,(H,13,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017106 (4-Phenyl-pyrrolidin-2-one | CHEMBL286419) Show SMILES O=C1CC(CN1)c1ccccc1 Show InChI InChI=1S/C10H11NO/c12-10-6-9(7-11-10)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017097 (1-Benzoyl-4-(3,4-dimethoxy-phenyl)-pyrrolidin-2-on...) Show SMILES COc1ccc(cc1OC)C1CN(C(=O)c2ccccc2)C(=O)C1 Show InChI InChI=1S/C19H19NO4/c1-23-16-9-8-14(10-17(16)24-2)15-11-18(21)20(12-15)19(22)13-6-4-3-5-7-13/h3-10,15H,11-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP (insignificant)				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017110 (4-(4-Butoxy-3-methoxy-phenyl)-pyrrolidin-2-one | C...) Show SMILES CCCCOc1ccc(cc1OC)C1CNC(=O)C1 Show InChI InChI=1S/C15H21NO3/c1-3-4-7-19-13-6-5-11(8-14(13)18-2)12-9-15(17)16-10-12/h5-6,8,12H,3-4,7,9-10H2,1-2H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017111 (4-(3,4-Dimethoxy-phenyl)-1-methyl-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CN(C)C(=O)C1 Show InChI InChI=1S/C13H17NO3/c1-14-8-10(7-13(14)15)9-4-5-11(16-2)12(6-9)17-3/h4-6,10H,7-8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017101 (7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoi...) Show SMILES COc1cc2CC[C@H]3[C@@H](CNC3=O)c2cc1OC Show InChI InChI=1S/C14H17NO3/c1-17-12-5-8-3-4-9-11(7-15-14(9)16)10(8)6-13(12)18-2/h5-6,9,11H,3-4,7H2,1-2H3,(H,15,16)/t9-,11+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP (insignificant)				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017092 (4-(3-Isobutoxy-4-methoxy-phenyl)-pyrrolidin-2-one ...) Show SMILES COc1ccc(cc1OCC(C)C)C1CNC(=O)C1 Show InChI InChI=1S/C15H21NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,10,12H,7-9H2,1-3H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017116 (5,6-Dimethoxy-3,3a,8,8a-tetrahydro-1H-1-aza-cyclop...) Show SMILES COc1cc2CC3NC(=O)C[C@@H]3c2cc1OC Show InChI InChI=1S/C13H15NO3/c1-16-11-4-7-3-10-9(6-13(15)14-10)8(7)5-12(11)17-2/h4-5,9-10H,3,6H2,1-2H3,(H,14,15)/t9-,10?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017118 (4-(3-Allyloxy-4-methoxy-phenyl)-pyrrolidin-2-one |...) Show SMILES COc1ccc(cc1OCC=C)C1CNC(=O)C1 Show InChI InChI=1S/C14H17NO3/c1-3-6-18-13-7-10(4-5-12(13)17-2)11-8-14(16)15-9-11/h3-5,7,11H,1,6,8-9H2,2H3,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017105 (4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrrolidine-3-carbo...) Show SMILES COc1ccc(cc1OC)C1CNC(=O)C1C(O)=O Show InChI InChI=1S/C13H15NO5/c1-18-9-4-3-7(5-10(9)19-2)8-6-14-12(15)11(8)13(16)17/h3-5,8,11H,6H2,1-2H3,(H,14,15)(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017093 (4-(3,4-Dimethoxy-phenyl)-3-methyl-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CNC(=O)C1C Show InChI InChI=1S/C13H17NO3/c1-8-10(7-14-13(8)15)9-4-5-11(16-2)12(6-9)17-3/h4-6,8,10H,7H2,1-3H3,(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017121 (4-(4-Butoxy-phenyl)-pyrrolidin-2-one | CHEMBL32597) Show SMILES CCCCOc1ccc(cc1)C1CNC(=O)C1 Show InChI InChI=1S/C14H19NO2/c1-2-3-8-17-13-6-4-11(5-7-13)12-9-14(16)15-10-12/h4-7,12H,2-3,8-10H2,1H3,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE;Compound is insignificant.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017100 (4-(3-Butoxy-phenyl)-pyrrolidin-2-one | CHEMBL32226) Show SMILES CCCCOc1cccc(c1)C1CNC(=O)C1 Show InChI InChI=1S/C14H19NO2/c1-2-3-7-17-13-6-4-5-11(8-13)12-9-14(16)15-10-12/h4-6,8,12H,2-3,7,9-10H2,1H3,(H,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017114 (4-[4-Methoxy-3-(2-methyl-allyloxy)-phenyl]-pyrroli...) Show SMILES COc1ccc(cc1OCC(C)=C)C1CNC(=O)C1 Show InChI InChI=1S/C15H19NO3/c1-10(2)9-19-14-6-11(4-5-13(14)18-3)12-7-15(17)16-8-12/h4-6,12H,1,7-9H2,2-3H3,(H,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017119 (4-(3-Hydroxy-4-methoxy-phenyl)-pyrrolidin-2-one | ...) Show SMILES COc1ccc(cc1O)C1CNC(=O)C1 Show InChI InChI=1S/C11H13NO3/c1-15-10-3-2-7(4-9(10)13)8-5-11(14)12-6-8/h2-4,8,13H,5-6H2,1H3,(H,12,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cGMP for cGMP-PDE.				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017113 (4-(3,4-Dimethoxy-phenyl)-1-phenyl-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CN(C(=O)C1)c1ccccc1 Show InChI InChI=1S/C18H19NO3/c1-21-16-9-8-13(10-17(16)22-2)14-11-18(20)19(12-14)15-6-4-3-5-7-15/h3-10,14H,11-12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP (insignificant)				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Bos taurus)	BDBM50017112 (1-Acetyl-4-(3,4-dimethoxy-phenyl)-pyrrolidin-2-one...) Show SMILES COc1ccc(cc1OC)C1CN(C(C)=O)C(=O)C1 Show InChI InChI=1S/C14H17NO4/c1-9(16)15-8-11(7-14(15)17)10-4-5-12(18-2)13(6-10)19-3/h4-6,11H,7-8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Neurochimie du CNRS Curated by ChEMBL					Assay Description Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP				J Med Chem 32: 1450-7 (1989) BindingDB Entry DOI: 10.7270/Q2DN441H
					More data for this Ligand-Target Pair

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