Found 9 hits Enz. Inhib. hit(s) with all data for entry = 50048816 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228247
(CHEMBL38017 | LY-197055)Show SMILES CC1CC(=O)NN=C1c1ccc2NC(=O)C(C)(C)c2c1 |c:6| Show InChI InChI=1S/C15H17N3O2/c1-8-6-12(19)17-18-13(8)9-4-5-11-10(7-9)15(2,3)14(20)16-11/h4-5,7-8H,6H2,1-3H3,(H,16,20)(H,17,19) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228246
(Indolidan)Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C1=NNC(=O)CC1 |t:14| Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-7-8(3-4-11(9)15-13(14)19)10-5-6-12(18)17-16-10/h3-4,7H,5-6H2,1-2H3,(H,15,19)(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228245
(CHEMBL34945 | LY-186126)Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)C(C)(C)c2c1 |c:6| Show InChI InChI=1S/C16H19N3O2/c1-9-7-13(20)17-18-14(9)10-5-6-12-11(8-10)16(2,3)15(21)19(12)4/h5-6,8-9H,7H2,1-4H3,(H,17,20) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228248
(CHEMBL37981)Show InChI InChI=1S/C13H13N3O2/c1-16-13(18)5-4-11(15-16)8-2-3-10-9(6-8)7-12(17)14-10/h2-3,6H,4-5,7H2,1H3,(H,14,17) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 6.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228245
(CHEMBL34945 | LY-186126)Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)C(C)(C)c2c1 |c:6| Show InChI InChI=1S/C16H19N3O2/c1-9-7-13(20)17-18-14(9)10-5-6-12-11(8-10)16(2,3)15(21)19(12)4/h5-6,8-9H,7H2,1-4H3,(H,17,20) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of sarcoplasmic reticulum Phosphodiesterase 4 |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228246
(Indolidan)Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C1=NNC(=O)CC1 |t:14| Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-7-8(3-4-11(9)15-13(14)19)10-5-6-12(18)17-16-10/h3-4,7H,5-6H2,1-2H3,(H,15,19)(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of sarcoplasmic reticulum Phosphodiesterase 4 |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228249
(CHEMBL417501)Show SMILES CN1C(=O)C(C)(C)c2cc(ccc12)C1=NNC(=O)CC1 |t:15| Show InChI InChI=1S/C15H17N3O2/c1-15(2)10-8-9(11-5-7-13(19)17-16-11)4-6-12(10)18(3)14(15)20/h4,6,8H,5,7H2,1-3H3,(H,17,19) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of sarcoplasmic reticulum Phosphodiesterase 4 |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228245
(CHEMBL34945 | LY-186126)Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)C(C)(C)c2c1 |c:6| Show InChI InChI=1S/C16H19N3O2/c1-9-7-13(20)17-18-14(9)10-5-6-12-11(8-10)16(2,3)15(21)19(12)4/h5-6,8-9H,7H2,1-4H3,(H,17,20) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for sarcoplasmic reticulum phosphodiesterase 4 of canine ventricle |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50228245
(CHEMBL34945 | LY-186126)Show SMILES CC1CC(=O)NN=C1c1ccc2N(C)C(=O)C(C)(C)c2c1 |c:6| Show InChI InChI=1S/C16H19N3O2/c1-9-7-13(20)17-18-14(9)10-5-6-12-11(8-10)16(2,3)15(21)19(12)4/h5-6,8-9H,7H2,1-4H3,(H,17,20) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for Phosphodiesterase 4 of canine myocardial vesicles |
J Med Chem 32: 1476-80 (1989)
BindingDB Entry DOI: 10.7270/Q2P271B2 |
More data for this Ligand-Target Pair | |