Compile Data Set for Download or QSAR

Found 18 hits Enz. Inhib. hit(s) with all data for entry = 50033198   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50341234 (4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...) Show SMILES Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C24H20ClN5O/c1-16-4-9-20(28-23(31)18-7-5-17(14-25)6-8-18)13-22(16)30-24-27-12-10-21(29-24)19-3-2-11-26-15-19/h2-13,15H,14H2,1H3,(H,28,31)(H,27,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50341234 (4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...) Show SMILES Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C24H20ClN5O/c1-16-4-9-20(28-23(31)18-7-5-17(14-25)6-8-18)13-22(16)30-24-27-12-10-21(29-24)19-3-2-11-26-15-19/h2-13,15H,14H2,1H3,(H,28,31)(H,27,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50341235 (4-(aminomethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyr...) Show SMILES Cc1ccc(NC(=O)c2ccc(CN)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C24H22N6O/c1-16-4-9-20(28-23(31)18-7-5-17(14-25)6-8-18)13-22(16)30-24-27-12-10-21(29-24)19-3-2-11-26-15-19/h2-13,15H,14,25H2,1H3,(H,28,31)(H,27,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	788	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50341236 (4-((2-chloroacetamido)methyl)-N-(4-methyl-3-(4-(py...) Show SMILES Cc1ccc(NC(=O)c2ccc(CNC(=O)CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C26H23ClN6O2/c1-17-4-9-21(31-25(35)19-7-5-18(6-8-19)15-30-24(34)14-27)13-23(17)33-26-29-12-10-22(32-26)20-3-2-11-28-16-20/h2-13,16H,14-15H2,1H3,(H,30,34)(H,31,35)(H,29,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	788	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50341236 (4-((2-chloroacetamido)methyl)-N-(4-methyl-3-(4-(py...) Show SMILES Cc1ccc(NC(=O)c2ccc(CNC(=O)CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C26H23ClN6O2/c1-17-4-9-21(31-25(35)19-7-5-18(6-8-19)15-30-24(34)14-27)13-23(17)33-26-29-12-10-22(32-26)20-3-2-11-28-16-20/h2-13,16H,14-15H2,1H3,(H,30,34)(H,31,35)(H,29,32,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50341235 (4-(aminomethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyr...) Show SMILES Cc1ccc(NC(=O)c2ccc(CN)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C24H22N6O/c1-16-4-9-20(28-23(31)18-7-5-17(14-25)6-8-18)13-22(16)30-24-27-12-10-21(29-24)19-3-2-11-26-15-19/h2-13,15H,14,25H2,1H3,(H,28,31)(H,27,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50341238 (4-(methacrylamidomethyl)-N-(4-methyl-3-(4-(pyridin...) Show SMILES CC(=C)C(=O)NCc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 Show InChI InChI=1S/C28H26N6O2/c1-18(2)26(35)31-16-20-7-9-21(10-8-20)27(36)32-23-11-6-19(3)25(15-23)34-28-30-14-12-24(33-28)22-5-4-13-29-17-22/h4-15,17H,1,16H2,2-3H3,(H,31,35)(H,32,36)(H,30,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50341238 (4-(methacrylamidomethyl)-N-(4-methyl-3-(4-(pyridin...) Show SMILES CC(=C)C(=O)NCc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 Show InChI InChI=1S/C28H26N6O2/c1-18(2)26(35)31-16-20-7-9-21(10-8-20)27(36)32-23-11-6-19(3)25(15-23)34-28-30-14-12-24(33-28)22-5-4-13-29-17-22/h4-15,17H,1,16H2,2-3H3,(H,31,35)(H,32,36)(H,30,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.11E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50341237 (4-(but-2-enamidomethyl)-N-(4-methyl-3-(4-(pyridin-...) Show SMILES C\C=C\C(=O)NCc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 Show InChI InChI=1S/C28H26N6O2/c1-3-5-26(35)31-17-20-8-10-21(11-9-20)27(36)32-23-12-7-19(2)25(16-23)34-28-30-15-13-24(33-28)22-6-4-14-29-18-22/h3-16,18H,17H2,1-2H3,(H,31,35)(H,32,36)(H,30,33,34)/b5-3+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50341237 (4-(but-2-enamidomethyl)-N-(4-methyl-3-(4-(pyridin-...) Show SMILES C\C=C\C(=O)NCc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 Show InChI InChI=1S/C28H26N6O2/c1-3-5-26(35)31-17-20-8-10-21(11-9-20)27(36)32-23-12-7-19(2)25(16-23)34-28-30-15-13-24(33-28)22-6-4-14-29-18-22/h3-16,18H,17H2,1-2H3,(H,31,35)(H,32,36)(H,30,33,34)/b5-3+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type PDGFRalpha assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation count...				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50341234 (4-(chloromethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)py...) Show SMILES Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C24H20ClN5O/c1-16-4-9-20(28-23(31)18-7-5-17(14-25)6-8-18)13-22(16)30-24-27-12-10-21(29-24)19-3-2-11-26-15-19/h2-13,15H,14H2,1H3,(H,28,31)(H,27,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50341237 (4-(but-2-enamidomethyl)-N-(4-methyl-3-(4-(pyridin-...) Show SMILES C\C=C\C(=O)NCc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 Show InChI InChI=1S/C28H26N6O2/c1-3-5-26(35)31-17-20-8-10-21(11-9-20)27(36)32-23-12-7-19(2)25(16-23)34-28-30-15-13-24(33-28)22-6-4-14-29-18-22/h3-16,18H,17H2,1-2H3,(H,31,35)(H,32,36)(H,30,33,34)/b5-3+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50341236 (4-((2-chloroacetamido)methyl)-N-(4-methyl-3-(4-(py...) Show SMILES Cc1ccc(NC(=O)c2ccc(CNC(=O)CCl)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C26H23ClN6O2/c1-17-4-9-21(31-25(35)19-7-5-18(6-8-19)15-30-24(34)14-27)13-23(17)33-26-29-12-10-22(32-26)20-3-2-11-28-16-20/h2-13,16H,14-15H2,1H3,(H,30,34)(H,31,35)(H,29,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50341235 (4-(aminomethyl)-N-(4-methyl-3-(4-(pyridin-3-yl)pyr...) Show SMILES Cc1ccc(NC(=O)c2ccc(CN)cc2)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C24H22N6O/c1-16-4-9-20(28-23(31)18-7-5-17(14-25)6-8-18)13-22(16)30-24-27-12-10-21(29-24)19-3-2-11-26-15-19/h2-13,15H,14,25H2,1H3,(H,28,31)(H,27,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50341238 (4-(methacrylamidomethyl)-N-(4-methyl-3-(4-(pyridin...) Show SMILES CC(=C)C(=O)NCc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 Show InChI InChI=1S/C28H26N6O2/c1-18(2)26(35)31-16-20-7-9-21(10-8-20)27(36)32-23-11-6-19(3)25(15-23)34-28-30-14-12-24(33-28)22-5-4-13-29-17-22/h4-15,17H,1,16H2,2-3H3,(H,31,35)(H,32,36)(H,30,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into polyAlaGluLsTyr after 60 mins by microplate scintillation counting				J Med Chem 54: 1347-55 (2011) Article DOI: 10.1021/jm101396q BindingDB Entry DOI: 10.7270/Q2NC61J5
					More data for this Ligand-Target Pair