Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM50342750 (CHEMBL1771484 | N,8-dihydroxy-8-(2-(4-(prop-2-ynyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human)) | BDBM50342750 (CHEMBL1771484 | N,8-dihydroxy-8-(2-(4-(prop-2-ynyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence... | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50342752 (3-(2-(3-(((R)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50342751 (CHEMBL1771485 | N-hydroxy-3-(2-(4-(prop-2-ynyloxy)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human)) | BDBM19149 (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence... | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50342749 (3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM19149 (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50342753 (3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50342750 (CHEMBL1771484 | N,8-dihydroxy-8-(2-(4-(prop-2-ynyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM19149 (CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM50342752 (3-(2-(3-(((R)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM50342753 (3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human)) | BDBM50342751 (CHEMBL1771485 | N-hydroxy-3-(2-(4-(prop-2-ynyloxy)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence... | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM50342751 (CHEMBL1771485 | N-hydroxy-3-(2-(4-(prop-2-ynyloxy)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human)) | BDBM50342752 (3-(2-(3-(((R)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence... | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human)) | BDBM50342753 (3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence... | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human)) | BDBM50342749 (3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence... | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM50342749 (3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute Curated by ChEMBL | Assay Description Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assay | Bioorg Med Chem Lett 21: 2601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.01.134 BindingDB Entry DOI: 10.7270/Q2ZC835M | |||||||||||
More data for this Ligand-Target Pair |