Found 30 hits Enz. Inhib. hit(s) with all data for entry = 50033983 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354983
(CHEMBL1836947)Show SMILES COc1cc(OC(F)F)ccc1-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 |(44.5,-44.78,;42.97,-44.81,;42.22,-46.16,;43.02,-47.47,;42.27,-48.83,;43.06,-50.15,;42.32,-51.49,;43.11,-52.81,;40.78,-51.52,;40.73,-48.85,;39.94,-47.53,;40.69,-46.19,;39.9,-44.87,;40.81,-43.62,;42.35,-43.62,;39.9,-42.36,;38.42,-42.84,;37.09,-42.08,;37.08,-40.54,;35.75,-39.77,;35.74,-38.23,;36.51,-36.91,;34.97,-36.91,;34.42,-40.55,;32.88,-40.55,;33.65,-41.88,;35.76,-42.85,;35.76,-44.39,;34.42,-45.16,;37.09,-45.16,;38.42,-44.39,)| Show InChI InChI=1S/C22H25F2N5O2/c1-11-25-20(28-18(13-4-5-13)14-6-7-14)19-21(26-11)29(12(2)27-19)16-9-8-15(31-22(23)24)10-17(16)30-3/h8-10,13-14,18,22H,4-7H2,1-3H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.291 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354981
(CHEMBL1836945)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC(F)F)cc1Cl |(10.94,-43.27,;9.4,-43.27,;8.49,-42.02,;7.02,-42.5,;5.68,-41.73,;5.68,-40.19,;4.34,-39.43,;4.34,-37.89,;5.1,-36.57,;3.56,-36.56,;3.01,-40.2,;1.47,-40.21,;2.24,-41.54,;4.35,-42.51,;4.35,-44.05,;3.02,-44.82,;5.69,-44.82,;7.02,-44.05,;8.49,-44.53,;9.28,-45.85,;8.53,-47.19,;9.32,-48.51,;10.86,-48.49,;11.66,-49.8,;10.91,-51.15,;11.7,-52.47,;9.37,-51.18,;11.61,-47.13,;10.82,-45.82,;11.56,-44.47,)| Show InChI InChI=1S/C21H22ClF2N5O/c1-10-25-19(28-17(12-3-4-12)13-5-6-13)18-20(26-10)29(11(2)27-18)16-8-7-14(9-15(16)22)30-21(23)24/h7-9,12-13,17,21H,3-6H2,1-2H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.373 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50087713
((1-Ethyl-propyl)-[3-(4-methoxy-2-methyl-phenyl)-2,...)Show SMILES CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C |(-4.03,1.25,;-2.68,.48,;-1.35,1.27,;-1.37,2.81,;-2.86,3.21,;-.02,.5,;-.02,-1.04,;-1.34,-1.81,;-1.34,-3.35,;-2.66,-4.12,;,-4.12,;1.33,-3.35,;2.8,-3.8,;3.7,-2.55,;5.24,-2.53,;2.77,-1.32,;1.33,-1.81,;3.3,-5.26,;2.28,-6.39,;2.77,-7.87,;4.28,-8.16,;4.78,-9.63,;3.76,-10.79,;5.3,-7,;4.79,-5.55,;5.82,-4.4,)| Show InChI InChI=1S/C21H28N4O/c1-7-16(8-2)23-19-12-14(4)22-21-20(15(5)24-25(19)21)18-10-9-17(26-6)11-13(18)3/h9-12,16,23H,7-8H2,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354980
(CHEMBL1836944)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C21H23F2N5O/c1-11-24-19(27-17(13-3-4-13)14-5-6-14)18-20(25-11)28(12(2)26-18)15-7-9-16(10-8-15)29-21(22)23/h7-10,13-14,17,21H,3-6H2,1-2H3,(H,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354984
(CHEMBL1836948)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC(F)F)cc1F |(42.35,-43.62,;40.81,-43.62,;39.9,-42.36,;38.42,-42.84,;37.09,-42.08,;37.08,-40.54,;35.75,-39.77,;35.74,-38.23,;36.51,-36.91,;34.97,-36.91,;34.42,-40.55,;32.88,-40.55,;33.65,-41.88,;35.76,-42.85,;35.76,-44.39,;34.42,-45.16,;37.09,-45.16,;38.42,-44.39,;39.9,-44.87,;40.69,-46.19,;39.94,-47.53,;40.73,-48.85,;42.27,-48.83,;43.06,-50.15,;42.32,-51.49,;43.11,-52.81,;40.78,-51.52,;43.02,-47.47,;42.22,-46.16,;42.97,-44.81,)| Show InChI InChI=1S/C21H22F3N5O/c1-10-25-19(28-17(12-3-4-12)13-5-6-13)18-20(26-10)29(11(2)27-18)16-8-7-14(9-15(16)22)30-21(23)24/h7-9,12-13,17,21H,3-6H2,1-2H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354979
(CHEMBL1836943)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C21H22F3N5O/c1-11-25-19(28-17(13-3-4-13)14-5-6-14)18-20(26-11)29(12(2)27-18)15-7-9-16(10-8-15)30-21(22,23)24/h7-10,13-14,17H,3-6H2,1-2H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354976
(CHEMBL1836940)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22ClN5/c1-11-22-19(25-17(13-3-4-13)14-5-6-14)18-20(23-11)26(12(2)24-18)16-9-7-15(21)8-10-16/h7-10,13-14,17H,3-6H2,1-2H3,(H,22,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354982
(CHEMBL1836946)Show SMILES COc1ccc(c(Cl)c1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 |(24.71,-51.72,;25.46,-50.37,;24.66,-49.05,;23.12,-49.08,;22.33,-47.76,;23.08,-46.42,;24.61,-46.38,;25.36,-45.03,;25.41,-47.7,;22.29,-45.1,;23.2,-43.84,;24.74,-43.84,;22.29,-42.59,;20.81,-43.07,;19.48,-42.3,;19.47,-40.76,;18.14,-40,;18.13,-38.46,;18.9,-37.13,;17.36,-37.13,;16.81,-40.77,;15.27,-40.77,;16.04,-42.11,;18.15,-43.07,;18.15,-44.62,;16.81,-45.39,;19.48,-45.39,;20.82,-44.62,)| Show InChI InChI=1S/C21H24ClN5O/c1-11-23-20(26-18(13-4-5-13)14-6-7-14)19-21(24-11)27(12(2)25-19)17-9-8-15(28-3)10-16(17)22/h8-10,13-14,18H,4-7H2,1-3H3,(H,23,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50116105
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50302593
(1-(4-methoxy-2-methylphenyl)-N-(2-methoxyethyl)-3,...)Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C Show InChI InChI=1S/C21H29N5O2/c1-7-10-25(11-12-27-5)20-19-15(3)24-26(21(19)23-16(4)22-20)18-9-8-17(28-6)13-14(18)2/h8-9,13H,7,10-12H2,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354968
(CHEMBL1836933)Show SMILES COc1ccc(c(C)c1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 |(20.29,-8.23,;21.04,-6.89,;20.24,-5.57,;18.7,-5.59,;17.91,-4.27,;18.66,-2.93,;20.2,-2.9,;20.94,-1.55,;20.99,-4.21,;17.87,-1.61,;18.78,-.36,;20.32,-.36,;17.87,.9,;16.4,.42,;15.06,1.18,;15.06,2.72,;13.72,3.49,;13.72,5.03,;14.48,6.35,;12.94,6.35,;12.39,2.71,;10.85,2.71,;11.62,1.38,;13.73,.41,;13.73,-1.13,;12.4,-1.9,;15.07,-1.9,;16.4,-1.13,)| Show InChI InChI=1S/C22H27N5O/c1-12-11-17(28-4)9-10-18(12)27-14(3)25-20-21(23-13(2)24-22(20)27)26-19(15-5-6-15)16-7-8-16/h9-11,15-16,19H,5-8H2,1-4H3,(H,23,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354967
(CHEMBL1836932)Show SMILES COc1ccc(cc1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 Show InChI InChI=1S/C21H25N5O/c1-12-22-20(25-18(14-4-5-14)15-6-7-15)19-21(23-12)26(13(2)24-19)16-8-10-17(27-3)11-9-16/h8-11,14-15,18H,4-7H2,1-3H3,(H,22,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354978
(CHEMBL1836942)Show SMILES CCOc1ccc(cc1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 Show InChI InChI=1S/C22H27N5O/c1-4-28-18-11-9-17(10-12-18)27-14(3)25-20-21(23-13(2)24-22(20)27)26-19(15-5-6-15)16-7-8-16/h9-12,15-16,19H,4-8H2,1-3H3,(H,23,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354965
(CHEMBL1836950)Show SMILES COc1ccc(c(C)c1)-n1ncc2c(NC(C3CC3)C3CC3)nc(C)nc12 Show InChI InChI=1S/C21H25N5O/c1-12-10-16(27-3)8-9-18(12)26-21-17(11-22-26)20(23-13(2)24-21)25-19(14-4-5-14)15-6-7-15/h8-11,14-15,19H,4-7H2,1-3H3,(H,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354966
(CHEMBL1836931)Show SMILES COc1ccc(c(C)c1)-n1cnc2c(NC(C3CC3)C3CC3)nc(C)nc12 Show InChI InChI=1S/C21H25N5O/c1-12-10-16(27-3)8-9-17(12)26-11-22-19-20(23-13(2)24-21(19)26)25-18(14-4-5-14)15-6-7-15/h8-11,14-15,18H,4-7H2,1-3H3,(H,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354974
(CHEMBL1836939)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(cc1)C#N Show InChI InChI=1S/C21H22N6/c1-12-23-20(26-18(15-5-6-15)16-7-8-16)19-21(24-12)27(13(2)25-19)17-9-3-14(11-22)4-10-17/h3-4,9-10,15-16,18H,5-8H2,1-2H3,(H,23,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354977
(CHEMBL1836941)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(F)cc1 Show InChI InChI=1S/C20H22FN5/c1-11-22-19(25-17(13-3-4-13)14-5-6-14)18-20(23-11)26(12(2)24-18)16-9-7-15(21)8-10-16/h7-10,13-14,17H,3-6H2,1-2H3,(H,22,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354975
(CHEMBL1834003)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C21H25N5O2S/c1-12-22-20(25-18(14-4-5-14)15-6-7-15)19-21(23-12)26(13(2)24-19)16-8-10-17(11-9-16)29(3,27)28/h8-11,14-15,18H,4-7H2,1-3H3,(H,22,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354969
(CHEMBL1836934)Show SMILES COCc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC)cc1 Show InChI InChI=1S/C22H27N5O2/c1-13-23-21(26-19(14-4-5-14)15-6-7-15)20-22(24-13)27(18(25-20)12-28-2)16-8-10-17(29-3)11-9-16/h8-11,14-15,19H,4-7,12H2,1-3H3,(H,23,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354973
(CHEMBL1836938)Show SMILES COc1ccc(cc1)-n1c(nc2c(NC(C3CC3)C3CC3)nc(C)nc12)C1CC(F)(F)C1 Show InChI InChI=1S/C24H27F2N5O/c1-13-27-21(29-19(14-3-4-14)15-5-6-15)20-23(28-13)31(17-7-9-18(32-2)10-8-17)22(30-20)16-11-24(25,26)12-16/h7-10,14-16,19H,3-6,11-12H2,1-2H3,(H,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 261 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354970
(CHEMBL1836935)Show SMILES COc1ccc(cc1)-n1c(CC2CC2)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 Show InChI InChI=1S/C24H29N5O/c1-14-25-23(28-21(16-5-6-16)17-7-8-17)22-24(26-14)29(20(27-22)13-15-3-4-15)18-9-11-19(30-2)12-10-18/h9-12,15-17,21H,3-8,13H2,1-2H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 308 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354971
(CHEMBL1836936)Show SMILES COc1ccc(cc1)-n1c(CC(C)C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 Show InChI InChI=1S/C24H31N5O/c1-14(2)13-20-27-22-23(28-21(16-5-6-16)17-7-8-17)25-15(3)26-24(22)29(20)18-9-11-19(30-4)12-10-18/h9-12,14,16-17,21H,5-8,13H2,1-4H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 607 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354972
(CHEMBL1836937)Show SMILES COc1ccc(cc1)-n1c(nc2c(NC(C3CC3)C3CC3)nc(C)nc12)C1CCCO1 Show InChI InChI=1S/C24H29N5O2/c1-14-25-22(27-20(15-5-6-15)16-7-8-16)21-24(26-14)29(17-9-11-18(30-2)12-10-17)23(28-21)19-4-3-13-31-19/h9-12,15-16,19-20H,3-8,13H2,1-2H3,(H,25,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 867 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP formation |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354983
(CHEMBL1836947)Show SMILES COc1cc(OC(F)F)ccc1-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 |(44.5,-44.78,;42.97,-44.81,;42.22,-46.16,;43.02,-47.47,;42.27,-48.83,;43.06,-50.15,;42.32,-51.49,;43.11,-52.81,;40.78,-51.52,;40.73,-48.85,;39.94,-47.53,;40.69,-46.19,;39.9,-44.87,;40.81,-43.62,;42.35,-43.62,;39.9,-42.36,;38.42,-42.84,;37.09,-42.08,;37.08,-40.54,;35.75,-39.77,;35.74,-38.23,;36.51,-36.91,;34.97,-36.91,;34.42,-40.55,;32.88,-40.55,;33.65,-41.88,;35.76,-42.85,;35.76,-44.39,;34.42,-45.16,;37.09,-45.16,;38.42,-44.39,)| Show InChI InChI=1S/C22H25F2N5O2/c1-11-25-20(28-18(13-4-5-13)14-6-7-14)19-21(26-11)29(12(2)27-19)16-9-8-15(31-22(23)24)10-17(16)30-3/h8-10,13-14,18,22H,4-7H2,1-3H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.291 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human CRF1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50087713
((1-Ethyl-propyl)-[3-(4-methoxy-2-methyl-phenyl)-2,...)Show SMILES CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C |(-4.03,1.25,;-2.68,.48,;-1.35,1.27,;-1.37,2.81,;-2.86,3.21,;-.02,.5,;-.02,-1.04,;-1.34,-1.81,;-1.34,-3.35,;-2.66,-4.12,;,-4.12,;1.33,-3.35,;2.8,-3.8,;3.7,-2.55,;5.24,-2.53,;2.77,-1.32,;1.33,-1.81,;3.3,-5.26,;2.28,-6.39,;2.77,-7.87,;4.28,-8.16,;4.78,-9.63,;3.76,-10.79,;5.3,-7,;4.79,-5.55,;5.82,-4.4,)| Show InChI InChI=1S/C21H28N4O/c1-7-16(8-2)23-19-12-14(4)22-21-20(15(5)24-25(19)21)18-10-9-17(26-6)11-13(18)3/h9-12,16,23H,7-8H2,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 0.279 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human CRF1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50116105
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 0.303 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human CRF1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354981
(CHEMBL1836945)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC(F)F)cc1Cl |(10.94,-43.27,;9.4,-43.27,;8.49,-42.02,;7.02,-42.5,;5.68,-41.73,;5.68,-40.19,;4.34,-39.43,;4.34,-37.89,;5.1,-36.57,;3.56,-36.56,;3.01,-40.2,;1.47,-40.21,;2.24,-41.54,;4.35,-42.51,;4.35,-44.05,;3.02,-44.82,;5.69,-44.82,;7.02,-44.05,;8.49,-44.53,;9.28,-45.85,;8.53,-47.19,;9.32,-48.51,;10.86,-48.49,;11.66,-49.8,;10.91,-51.15,;11.7,-52.47,;9.37,-51.18,;11.61,-47.13,;10.82,-45.82,;11.56,-44.47,)| Show InChI InChI=1S/C21H22ClF2N5O/c1-10-25-19(28-17(12-3-4-12)13-5-6-13)18-20(26-10)29(11(2)27-18)16-8-7-14(9-15(16)22)30-21(23)24/h7-9,12-13,17,21H,3-6H2,1-2H3,(H,25,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.373 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human CRF1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354967
(CHEMBL1836932)Show SMILES COc1ccc(cc1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 Show InChI InChI=1S/C21H25N5O/c1-12-22-20(25-18(14-4-5-14)15-6-7-15)19-21(23-12)26(13(2)24-19)16-8-10-17(27-3)11-9-16/h8-11,14-15,18H,4-7H2,1-3H3,(H,22,23,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human CRF1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50302593
(1-(4-methoxy-2-methylphenyl)-N-(2-methoxyethyl)-3,...)Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C Show InChI InChI=1S/C21H29N5O2/c1-7-10-25(11-12-27-5)20-19-15(3)24-26(21(19)23-16(4)22-20)18-9-8-17(28-6)13-14(18)2/h8-9,13H,7,10-12H2,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human CRF1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50354980
(CHEMBL1836944)Show SMILES Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C21H23F2N5O/c1-11-24-19(27-17(13-3-4-13)14-5-6-14)18-20(25-11)28(12(2)26-18)15-7-9-16(10-8-15)29-21(22)23/h7-10,13-14,17,21H,3-6H2,1-2H3,(H,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human CRF1 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6108-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.040 BindingDB Entry DOI: 10.7270/Q2F19046 |
More data for this Ligand-Target Pair | |