Found 104 hits Enz. Inhib. hit(s) with all data for entry = 50034291 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360024
(CHEMBL1928541)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H14N6O4S/c1-12-3-4-15(23(24)25)8-17(12)28(26,27)21(2)19-10-14-11-20-22-6-5-13(9-18)7-16(14)22/h3-8,10-11H,1-2H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360040
(CHEMBL1928536)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C18H15N5O4S/c1-4-14-7-8-22-17(9-14)15(12-20-22)11-19-21(3)28(26,27)18-10-16(23(24)25)6-5-13(18)2/h1,5-12H,2-3H3/b19-11+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360037
(CHEMBL1928533)Show SMILES CN(\N=C\c1cnn2ccc(Cl)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14ClN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360028
(CHEMBL1928525)Show SMILES CN(\N=C\c1cnn2ccc(Br)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14BrN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360050
(CHEMBL1928547)Show SMILES CC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:2.2| Show InChI InChI=1S/C17H14N6O4S/c1-11-3-4-14(23(24)25)8-17(11)28(26,27)21-20-12(2)15-10-19-22-6-5-13(9-18)7-16(15)22/h3-8,10,21H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360051
(CHEMBL1928548)Show SMILES CCC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:3.3| Show InChI InChI=1S/C18H16N6O4S/c1-3-16(15-11-20-23-7-6-13(10-19)8-17(15)23)21-22-29(27,28)18-9-14(24(25)26)5-4-12(18)2/h4-9,11,22H,3H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360049
(CHEMBL1928546)Show SMILES Cc1ccc(cc1S(=O)(=O)NN=Cc1cnn2ccc(cc12)C#N)[N+]([O-])=O |w:12.13| Show InChI InChI=1S/C16H12N6O4S/c1-11-2-3-14(22(23)24)7-16(11)27(25,26)20-18-9-13-10-19-21-5-4-12(8-17)6-15(13)21/h2-7,9-10,20H,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50360024
(CHEMBL1928541)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H14N6O4S/c1-12-3-4-15(23(24)25)8-17(12)28(26,27)21(2)19-10-14-11-20-22-6-5-13(9-18)7-16(14)22/h3-8,10-11H,1-2H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of PI3K p110gamma |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360036
(CHEMBL1926704)Show SMILES CN(\N=C\c1cnn2ccc(I)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14IN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360053
(CHEMBL1928550)Show SMILES CC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(Br)cc12 |w:2.2| Show InChI InChI=1S/C16H14BrN5O4S/c1-10-3-4-13(22(23)24)8-16(10)27(25,26)20-19-11(2)14-9-18-21-6-5-12(17)7-15(14)21/h3-9,20H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360040
(CHEMBL1928536)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C18H15N5O4S/c1-4-14-7-8-22-17(9-14)15(12-20-22)11-19-21(3)28(26,27)18-10-16(23(24)25)6-5-13(18)2/h1,5-12H,2-3H3/b19-11+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360052
(CHEMBL1928549)Show SMILES CCCC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:4.4| Show InChI InChI=1S/C19H18N6O4S/c1-3-4-17(16-12-21-24-8-7-14(11-20)9-18(16)24)22-23-30(28,29)19-10-15(25(26)27)6-5-13(19)2/h5-10,12,23H,3-4H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360040
(CHEMBL1928536)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C18H15N5O4S/c1-4-14-7-8-22-17(9-14)15(12-20-22)11-19-21(3)28(26,27)18-10-16(23(24)25)6-5-13(18)2/h1,5-12H,2-3H3/b19-11+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360045
(CHEMBL1928542)Show SMILES CN(\N=C\c1cnn2cc(F)c(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H13FN6O4S/c1-11-3-4-14(24(25)26)6-17(11)29(27,28)22(2)20-8-13-9-21-23-10-15(18)12(7-19)5-16(13)23/h3-6,8-10H,1-2H3/b20-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360024
(CHEMBL1928541)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H14N6O4S/c1-12-3-4-15(23(24)25)8-17(12)28(26,27)21(2)19-10-14-11-20-22-6-5-13(9-18)7-16(14)22/h3-8,10-11H,1-2H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360024
(CHEMBL1928541)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H14N6O4S/c1-12-3-4-15(23(24)25)8-17(12)28(26,27)21(2)19-10-14-11-20-22-6-5-13(9-18)7-16(14)22/h3-8,10-11H,1-2H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360054
(CHEMBL1928551)Show SMILES CN(N=C(C)c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O |w:2.1| Show InChI InChI=1S/C18H16N6O4S/c1-12-4-5-15(24(25)26)9-18(12)29(27,28)22(3)21-13(2)16-11-20-23-7-6-14(10-19)8-17(16)23/h4-9,11H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360037
(CHEMBL1928533)Show SMILES CN(\N=C\c1cnn2ccc(Cl)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14ClN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360032
(CHEMBL1928529)Show SMILES CN(\N=C\c1cnn2ccc(C)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H17N5O4S/c1-12-6-7-21-16(8-12)14(11-19-21)10-18-20(3)27(25,26)17-9-15(22(23)24)5-4-13(17)2/h4-11H,1-3H3/b18-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360039
(CHEMBL1928535)Show SMILES CN(\N=C\c1cnn2ccc(C=C)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C18H17N5O4S/c1-4-14-7-8-22-17(9-14)15(12-20-22)11-19-21(3)28(26,27)18-10-16(23(24)25)6-5-13(18)2/h4-12H,1H2,2-3H3/b19-11+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360034
(CHEMBL1928531)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C(F)(F)F)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H14F3N5O4S/c1-11-3-4-14(25(26)27)8-16(11)30(28,29)23(2)21-9-12-10-22-24-6-5-13(7-15(12)24)17(18,19)20/h3-10H,1-2H3/b21-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360028
(CHEMBL1928525)Show SMILES CN(\N=C\c1cnn2ccc(Br)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14BrN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360036
(CHEMBL1926704)Show SMILES CN(\N=C\c1cnn2ccc(I)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14IN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360046
(CHEMBL1928543)Show SMILES COc1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2c1 Show InChI InChI=1S/C17H17N5O5S/c1-12-4-5-14(22(23)24)8-17(12)28(25,26)20(2)18-10-13-11-19-21-7-6-15(27-3)9-16(13)21/h4-11H,1-3H3/b18-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360053
(CHEMBL1928550)Show SMILES CC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(Br)cc12 |w:2.2| Show InChI InChI=1S/C16H14BrN5O4S/c1-10-3-4-13(22(23)24)8-16(10)27(25,26)20-19-11(2)14-9-18-21-6-5-12(17)7-15(14)21/h3-9,20H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360028
(CHEMBL1928525)Show SMILES CN(\N=C\c1cnn2ccc(Br)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14BrN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50360024
(CHEMBL1928541)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H14N6O4S/c1-12-3-4-15(23(24)25)8-17(12)28(26,27)21(2)19-10-14-11-20-22-6-5-13(9-18)7-16(14)22/h3-8,10-11H,1-2H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of mTOR |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360052
(CHEMBL1928549)Show SMILES CCCC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:4.4| Show InChI InChI=1S/C19H18N6O4S/c1-3-4-17(16-12-21-24-8-7-14(11-20)9-18(16)24)22-23-30(28,29)19-10-15(25(26)27)6-5-13(19)2/h5-10,12,23H,3-4H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360041
(CHEMBL1928537)Show SMILES COC(=O)c1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2c1 Show InChI InChI=1S/C18H17N5O6S/c1-12-4-5-15(23(25)26)9-17(12)30(27,28)21(2)19-10-14-11-20-22-7-6-13(8-16(14)22)18(24)29-3/h4-11H,1-3H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360036
(CHEMBL1926704)Show SMILES CN(\N=C\c1cnn2ccc(I)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14IN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360037
(CHEMBL1928533)Show SMILES CN(\N=C\c1cnn2ccc(Cl)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H14ClN5O4S/c1-11-3-4-14(22(23)24)8-16(11)27(25,26)20(2)18-9-12-10-19-21-6-5-13(17)7-15(12)21/h3-10H,1-2H3/b18-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360055
(CHEMBL1928552)Show SMILES CCC(=NN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:3.3| Show InChI InChI=1S/C19H18N6O4S/c1-4-17(16-12-21-24-8-7-14(11-20)9-18(16)24)22-23(3)30(28,29)19-10-15(25(26)27)6-5-13(19)2/h5-10,12H,4H2,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360050
(CHEMBL1928547)Show SMILES CC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:2.2| Show InChI InChI=1S/C17H14N6O4S/c1-11-3-4-14(23(24)25)8-17(11)28(26,27)21-20-12(2)15-10-19-22-6-5-13(9-18)7-16(15)22/h3-8,10,21H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360051
(CHEMBL1928548)Show SMILES CCC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:3.3| Show InChI InChI=1S/C18H16N6O4S/c1-3-16(15-11-20-23-7-6-13(10-19)8-17(15)23)21-22-29(27,28)18-9-14(24(25)26)5-4-12(18)2/h4-9,11,22H,3H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360053
(CHEMBL1928550)Show SMILES CC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(Br)cc12 |w:2.2| Show InChI InChI=1S/C16H14BrN5O4S/c1-10-3-4-13(22(23)24)8-16(10)27(25,26)20-19-11(2)14-9-18-21-6-5-12(17)7-15(14)21/h3-9,20H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360054
(CHEMBL1928551)Show SMILES CN(N=C(C)c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O |w:2.1| Show InChI InChI=1S/C18H16N6O4S/c1-12-4-5-15(24(25)26)9-18(12)29(27,28)22(3)21-13(2)16-11-20-23-7-6-14(10-19)8-17(16)23/h4-9,11H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360042
(CHEMBL1928538)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C(N)=O)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H16N6O5S/c1-11-3-4-14(23(25)26)8-16(11)29(27,28)21(2)19-9-13-10-20-22-6-5-12(17(18)24)7-15(13)22/h3-10H,1-2H3,(H2,18,24)/b19-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360049
(CHEMBL1928546)Show SMILES Cc1ccc(cc1S(=O)(=O)NN=Cc1cnn2ccc(cc12)C#N)[N+]([O-])=O |w:12.13| Show InChI InChI=1S/C16H12N6O4S/c1-11-2-3-14(22(23)24)7-16(11)27(25,26)20-18-9-13-10-19-21-5-4-12(8-17)6-15(13)21/h2-7,9-10,20H,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360054
(CHEMBL1928551)Show SMILES CN(N=C(C)c1cnn2ccc(cc12)C#N)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O |w:2.1| Show InChI InChI=1S/C18H16N6O4S/c1-12-4-5-15(24(25)26)9-18(12)29(27,28)22(3)21-13(2)16-11-20-23-7-6-14(10-19)8-17(16)23/h4-9,11H,1-3H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360056
(CHEMBL1928553)Show SMILES CCC\C(=N/N(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N Show InChI InChI=1S/C20H20N6O4S/c1-4-5-18(17-13-22-25-9-8-15(12-21)10-19(17)25)23-24(3)31(29,30)20-11-16(26(27)28)7-6-14(20)2/h6-11,13H,4-5H2,1-3H3/b23-18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360049
(CHEMBL1928546)Show SMILES Cc1ccc(cc1S(=O)(=O)NN=Cc1cnn2ccc(cc12)C#N)[N+]([O-])=O |w:12.13| Show InChI InChI=1S/C16H12N6O4S/c1-11-2-3-14(22(23)24)7-16(11)27(25,26)20-18-9-13-10-19-21-5-4-12(8-17)6-15(13)21/h2-7,9-10,20H,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360048
(CHEMBL1928545)Show SMILES CN(\N=C\c1cnn2ccc(OC(C)=O)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C18H17N5O6S/c1-12-4-5-15(23(25)26)8-18(12)30(27,28)21(3)19-10-14-11-20-22-7-6-16(9-17(14)22)29-13(2)24/h4-11H,1-3H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360041
(CHEMBL1928537)Show SMILES COC(=O)c1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2c1 Show InChI InChI=1S/C18H17N5O6S/c1-12-4-5-15(23(25)26)9-17(12)30(27,28)21(2)19-10-14-11-20-22-7-6-13(8-16(14)22)18(24)29-3/h4-11H,1-3H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360032
(CHEMBL1928529)Show SMILES CN(\N=C\c1cnn2ccc(C)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H17N5O4S/c1-12-6-7-21-16(8-12)14(11-19-21)10-18-20(3)27(25,26)17-9-15(22(23)24)5-4-13(17)2/h4-11H,1-3H3/b18-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360050
(CHEMBL1928547)Show SMILES CC(=NNS(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N |w:2.2| Show InChI InChI=1S/C17H14N6O4S/c1-11-3-4-14(23(24)25)8-17(11)28(26,27)21-20-12(2)15-10-19-22-6-5-13(9-18)7-16(15)22/h3-8,10,21H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50360025
(CHEMBL1928522)Show SMILES CN(\N=C\c1cnn2ccccc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C16H15N5O4S/c1-12-6-7-14(21(22)23)9-16(12)26(24,25)19(2)17-10-13-11-18-20-8-4-3-5-15(13)20/h3-11H,1-2H3/b17-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110alpha using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360056
(CHEMBL1928553)Show SMILES CCC\C(=N/N(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O)c1cnn2ccc(cc12)C#N Show InChI InChI=1S/C20H20N6O4S/c1-4-5-18(17-13-22-25-9-8-15(12-21)10-19(17)25)23-24(3)31(29,30)20-11-16(26(27)28)7-6-14(20)2/h6-11,13H,4-5H2,1-3H3/b23-18+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50360048
(CHEMBL1928545)Show SMILES CN(\N=C\c1cnn2ccc(OC(C)=O)cc12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C18H17N5O6S/c1-12-4-5-15(23(25)26)8-18(12)30(27,28)21(3)19-10-14-11-20-22-7-6-16(9-17(14)22)29-13(2)24/h4-11H,1-3H3/b19-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110delta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographi... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360042
(CHEMBL1928538)Show SMILES CN(\N=C\c1cnn2ccc(cc12)C(N)=O)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C17H16N6O5S/c1-11-3-4-14(23(25)26)8-16(11)29(27,28)21(2)19-9-13-10-20-22-6-5-12(17(18)24)7-15(13)22/h3-10H,1-2H3,(H2,18,24)/b19-9+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50360046
(CHEMBL1928543)Show SMILES COc1ccn2ncc(\C=N\N(C)S(=O)(=O)c3cc(ccc3C)[N+]([O-])=O)c2c1 Show InChI InChI=1S/C17H17N5O5S/c1-12-4-5-14(22(23)24)8-17(12)28(25,26)20(2)18-10-13-11-19-21-7-6-15(27-3)9-16(13)21/h4-11H,1-3H3/b18-10+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3K p110beta using L-alpha-phosphotidylinositol as substrate and [gamma33P]ATP after 60 mins by thin layer chromatographic... |
Bioorg Med Chem 20: 69-85 (2011)
Article DOI: 10.1016/j.bmc.2011.11.029 BindingDB Entry DOI: 10.7270/Q2513ZNR |
More data for this Ligand-Target Pair | |