Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM23165 (CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sphingosine 1-phosphate receptor 4 (Homo sapiens (Human)) | BDBM23165 (CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 2 (Homo sapiens (Human)) | BDBM23165 (CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at human S1P2 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 3 (Homo sapiens (Human)) | BDBM23165 (CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at human S1P3 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM50360522 (CHEMBL1935662) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 mins | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM50360521 (CHEMBL1935666) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 mins | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM50360520 (CHEMBL1935665) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.63E+3 | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 mins | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM50360519 (CHEMBL1935664) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 mins | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM50158336 (2-(4-octylphenethyl)-2-aminopropane-1,3-diol | 2-A...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 mins | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM50360518 (CHEMBL1935663) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.84E+3 | n/a | n/a | n/a | n/a |
Institute of Pharmacology& Toxicology Curated by ChEMBL | Assay Description Agonist activity at EGFP-tagged S1P1 receptor expressed in human UOS2 cells assessed as receptor internalization in endosomes after 60 mins | Bioorg Med Chem Lett 22: 553-7 (2011) Article DOI: 10.1016/j.bmcl.2011.10.088 BindingDB Entry DOI: 10.7270/Q2154HGN | |||||||||||
More data for this Ligand-Target Pair |