Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kallikrein-7 (Homo sapiens (Human)) | BDBM203865 (Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of KLK7 (unknown origin) | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM203865 (Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in Escherichia coli Rosetta using Z-Lys-thioben... | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM50236212 (CHEMBL4093577) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibitory constant for porcine pancreatic elastase | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM203865 (Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human thrombin | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM203865 (Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human coagulation factor 10a | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kallikrein-5 (Homo sapiens (Human)) | BDBM203865 (Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human kallikrein 5 | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM203865 (Methyl (S)-2-((2-((3-(trifluoromethoxy)phenyl)carb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human neutrophil elastase | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM50236211 (CHEMBL4065974) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of recombinant human complement factor D catalytic domain (G24 to A253 residues) expressed in Escherichia coli Rosetta using Z-Lys-thioben... | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM203867 (3-(((2-Carbamoyl-1H-indol-5-yl)oxy)methyl)benzoic ...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 1.60E+6 | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl... | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM50236213 (2-(3-Benzylureido)Benzoic Acid | CHEMBL561499) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl... | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Complement factor D (Homo sapiens (Human)) | BDBM50236214 (CHEMBL4089211) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Displacement of [19F]-Methyl (S)-2-((2-((3-(Trifluoromethoxy)phenyl)carbamoyl)-pyrrolidine-1-carboxamido)methyl)benzoate from recombinant human compl... | J Med Chem 60: 1946-1958 (2017) Article DOI: 10.1021/acs.jmedchem.6b01684 BindingDB Entry DOI: 10.7270/Q2ZG6VHG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |