Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM215552 (US9296745, 109-A | US9296745, 109-B | US9296745, 1...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Inc. Curated by ChEMBL | Assay Description Inhibition of human DGAT2 assessed as reduction in synthesis of triglycerol in human hepatocyte using [14C]glycerol as substrate preincubated for 20 ... | J Med Chem 61: 1767-1773 (2018) Article DOI: 10.1021/acs.jmedchem.7b00762 BindingDB Entry DOI: 10.7270/Q2C53P79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM215552 (US9296745, 109-A | US9296745, 109-B | US9296745, 1...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Inc. Curated by ChEMBL | Assay Description Inhibition of human DGAT2 using [1-14C]decanoyl-CoA/1,2-didecanoyl-sn-glycerol as substrate preincubated for 120 mins followed by substrate addition ... | J Med Chem 61: 1767-1773 (2018) Article DOI: 10.1021/acs.jmedchem.7b00762 BindingDB Entry DOI: 10.7270/Q2C53P79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin D (Homo sapiens (Human)) | BDBM136570 (US8865706, 9) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Inc. Curated by ChEMBL | Assay Description Inhibition of cathepsin D (unknown origin) by cell based assay | J Med Chem 61: 1767-1773 (2018) Article DOI: 10.1021/acs.jmedchem.7b00762 BindingDB Entry DOI: 10.7270/Q2C53P79 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin D (Homo sapiens (Human)) | BDBM136570 (US8865706, 9) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant cathepsin D (unknown origin) | J Med Chem 61: 1767-1773 (2018) Article DOI: 10.1021/acs.jmedchem.7b00762 BindingDB Entry DOI: 10.7270/Q2C53P79 | |||||||||||
More data for this Ligand-Target Pair |