Compile Data Set for Download or QSAR

Found 72 hits Enz. Inhib. hit(s) with all data for entry = 3083   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27793 (2-{[2-({5-[2-(dimethylamino)acetamido]-2-methoxy-4...) Show SMILES COc1cc(C)c(NC(=O)CN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H27FN8O3/c1-13-10-19(37-4)18(11-17(13)29-20(35)12-34(2)3)31-25-32-23-14(8-9-28-23)24(33-25)30-16-7-5-6-15(26)21(16)22(27)36/h5-11H,12H2,1-4H3,(H2,27,36)(H,29,35)(H3,28,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27799 (2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...) Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C26H27FN8O3/c1-34(2)13-21(36)35-10-8-14-11-20(38-3)18(12-19(14)35)31-26-32-24-15(7-9-29-24)25(33-26)30-17-6-4-5-16(27)22(17)23(28)37/h4-7,9,11-12H,8,10,13H2,1-3H3,(H2,28,37)(H3,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27815 (2-fluoro-6-{[2-({6-methoxy-1-[2-(piperidin-1-yl)ac...) Show SMILES COc1cc2CCCN(C(=O)CN3CCCCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C30H33FN8O3/c1-42-24-15-18-7-6-14-39(25(40)17-38-12-3-2-4-13-38)23(18)16-22(24)35-30-36-28-19(10-11-33-28)29(37-30)34-21-9-5-8-20(31)26(21)27(32)41/h5,8-11,15-16H,2-4,6-7,12-14,17H2,1H3,(H2,32,41)(H3,33,34,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27804 (2-{[2-({1-[2-(azetidin-1-yl)acetyl]-5-methoxy-2,3-...) Show SMILES COc1cc2CCN(C(=O)CN3CCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C27H27FN8O3/c1-39-21-12-15-7-11-36(22(37)14-35-9-3-10-35)20(15)13-19(21)32-27-33-25-16(6-8-30-25)26(34-27)31-18-5-2-4-17(28)23(18)24(29)38/h2,4-6,8,12-13H,3,7,9-11,14H2,1H3,(H2,29,38)(H3,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27814 (2-{[2-({1-[2-(dimethylamino)acetyl]-6-methoxy-1,2,...) Show SMILES COc1cc2CCCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C27H29FN8O3/c1-35(2)14-22(37)36-11-5-6-15-12-21(39-3)19(13-20(15)36)32-27-33-25-16(9-10-30-25)26(34-27)31-18-8-4-7-17(28)23(18)24(29)38/h4,7-10,12-13H,5-6,11,14H2,1-3H3,(H2,29,38)(H3,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27792 (2-{[2-({5-[2-(dimethylamino)acetamido]-2-methoxyph...) Show SMILES COc1ccc(NC(=O)CN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C24H25FN8O3/c1-33(2)12-19(34)28-13-7-8-18(36-3)17(11-13)30-24-31-22-14(9-10-27-22)23(32-24)29-16-6-4-5-15(25)20(16)21(26)35/h4-11H,12H2,1-3H3,(H2,26,35)(H,28,34)(H3,27,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27803 (2-fluoro-6-{[2-({5-methoxy-1-[2-(pyrrolidin-1-yl)a...) Show SMILES COc1cc2CCN(C(=O)CN3CCCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C28H29FN8O3/c1-40-22-13-16-8-12-37(23(38)15-36-10-2-3-11-36)21(16)14-20(22)33-28-34-26-17(7-9-31-26)27(35-28)32-19-6-4-5-18(29)24(19)25(30)39/h4-7,9,13-14H,2-3,8,10-12,15H2,1H3,(H2,30,39)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27783 (2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piper...) Show SMILES COc1cc(ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-20(22(15-17)38-3)32-27-33-25-18(9-10-30-25)26(34-27)31-21-6-4-5-19(28)23(21)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27798 (2-fluoro-6-{[2-({5-methoxy-1-[2-(methylamino)acety...) Show SMILES CNCC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc12 Show InChI InChI=1S/C25H25FN8O3/c1-28-12-20(35)34-9-7-13-10-19(37-2)17(11-18(13)34)31-25-32-23-14(6-8-29-23)24(33-25)30-16-5-3-4-15(26)21(16)22(27)36/h3-6,8,10-11,28H,7,9,12H2,1-2H3,(H2,27,36)(H3,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27802 (2-{[2-({1-[2-(diethylamino)acetyl]-5-methoxy-2,3-d...) Show SMILES CCN(CC)CC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc12 Show InChI InChI=1S/C28H31FN8O3/c1-4-36(5-2)15-23(38)37-12-10-16-13-22(40-3)20(14-21(16)37)33-28-34-26-17(9-11-31-26)27(35-28)32-19-8-6-7-18(29)24(19)25(30)39/h6-9,11,13-14H,4-5,10,12,15H2,1-3H3,(H2,30,39)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27817 (2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...) Show SMILES CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 Show InChI InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27800 (2-({2-[(1-{2-[ethyl(methyl)amino]acetyl}-5-methoxy...) Show SMILES CCN(C)CC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc12 Show InChI InChI=1S/C27H29FN8O3/c1-4-35(2)14-22(37)36-11-9-15-12-21(39-3)19(13-20(15)36)32-27-33-25-16(8-10-30-25)26(34-27)31-18-7-5-6-17(28)23(18)24(29)38/h5-8,10,12-13H,4,9,11,14H2,1-3H3,(H2,29,38)(H3,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27784 (2-fluoro-6-{[2-({2-methoxy-5-[4-(propan-2-yl)piper...) Show SMILES COc1ccc(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-22(38-3)21(15-17)32-27-33-25-18(9-10-30-25)26(34-27)31-20-6-4-5-19(28)23(20)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27811 (2-fluoro-6-({2-[(5-methoxy-1-{3-[4-(propan-2-yl)pi...) Show SMILES COc1cc2CCN(C(=O)CCN3CCN(CC3)C(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C32H38FN9O3/c1-19(2)41-15-13-40(14-16-41)11-9-27(43)42-12-8-20-17-26(45-3)24(18-25(20)42)37-32-38-30-21(7-10-35-30)31(39-32)36-23-6-4-5-22(33)28(23)29(34)44/h4-7,10,17-19H,8-9,11-16H2,1-3H3,(H2,34,44)(H3,35,36,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27797 (2-[(2-{[1-(2-aminoacetyl)-5-methoxy-2,3-dihydro-1H...) Show SMILES COc1cc2CCN(C(=O)CN)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C24H23FN8O3/c1-36-18-9-12-6-8-33(19(34)11-26)17(12)10-16(18)30-24-31-22-13(5-7-28-22)23(32-24)29-15-4-2-3-14(25)20(15)21(27)35/h2-5,7,9-10H,6,8,11,26H2,1H3,(H2,27,35)(H3,28,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27810 (2-fluoro-6-{[2-({5-methoxy-1-[3-(morpholin-4-yl)pr...) Show SMILES COc1cc2CCN(C(=O)CCN3CCOCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C29H31FN8O4/c1-41-23-15-17-6-10-38(24(39)7-9-37-11-13-42-14-12-37)22(17)16-21(23)34-29-35-27-18(5-8-32-27)28(36-29)33-20-4-2-3-19(30)25(20)26(31)40/h2-5,8,15-16H,6-7,9-14H2,1H3,(H2,31,40)(H3,32,33,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27796 (2-({2-[(1-acetyl-5-methoxy-2,3-dihydro-1H-indol-6-...) Show SMILES COc1cc2CCN(C(C)=O)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C24H22FN7O3/c1-12(33)32-9-7-13-10-19(35-2)17(11-18(13)32)29-24-30-22-14(6-8-27-22)23(31-24)28-16-5-3-4-15(25)20(16)21(26)34/h3-6,8,10-11H,7,9H2,1-2H3,(H2,26,34)(H3,27,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27790 (2-fluoro-6-{[2-({2-methoxy-5-[(1-propylpiperidin-4...) Show SMILES CCCN1CCC(CC1)Oc1ccc(OC)c(Nc2nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n2)c1 Show InChI InChI=1S/C28H32FN7O3/c1-3-13-36-14-10-17(11-15-36)39-18-7-8-23(38-2)22(16-18)33-28-34-26-19(9-12-31-26)27(35-28)32-21-6-4-5-20(29)24(21)25(30)37/h4-9,12,16-17H,3,10-11,13-15H2,1-2H3,(H2,30,37)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27786 (2-{[2-({5-[3-(dimethylamino)propoxy]-2-methoxyphen...) Show SMILES COc1ccc(OCCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H28FN7O3/c1-33(2)12-5-13-36-15-8-9-20(35-3)19(14-15)30-25-31-23-16(10-11-28-23)24(32-25)29-18-7-4-6-17(26)21(18)22(27)34/h4,6-11,14H,5,12-13H2,1-3H3,(H2,27,34)(H3,28,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27809 (2-{[2-({1-[3-(dimethylamino)propanoyl]-5-methoxy-2...) Show SMILES COc1cc2CCN(C(=O)CCN(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C27H29FN8O3/c1-35(2)11-9-22(37)36-12-8-15-13-21(39-3)19(14-20(15)36)32-27-33-25-16(7-10-30-25)26(34-27)31-18-6-4-5-17(28)23(18)24(29)38/h4-7,10,13-14H,8-9,11-12H2,1-3H3,(H2,29,38)(H3,30,31,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27816 (2-{[2-({1-[3-(dimethylamino)propanoyl]-6-methoxy-1...) Show SMILES COc1cc2CCCN(C(=O)CCN(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C28H31FN8O3/c1-36(2)13-10-23(38)37-12-5-6-16-14-22(40-3)20(15-21(16)37)33-28-34-26-17(9-11-31-26)27(35-28)32-19-8-4-7-18(29)24(19)25(30)39/h4,7-9,11,14-15H,5-6,10,12-13H2,1-3H3,(H2,30,39)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27788 (2-{[2-({5-[3-(dimethylamino)propyl]-2-methoxypheny...) Show SMILES COc1ccc(CCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H28FN7O2/c1-33(2)13-5-6-15-9-10-20(35-3)19(14-15)30-25-31-23-16(11-12-28-23)24(32-25)29-18-8-4-7-17(26)21(18)22(27)34/h4,7-12,14H,5-6,13H2,1-3H3,(H2,27,34)(H3,28,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27787 (2-{[2-({4-chloro-5-[3-(dimethylamino)propoxy]-2-me...) Show SMILES COc1cc(Cl)c(OCCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H27ClFN7O3/c1-34(2)10-5-11-37-19-13-18(20(36-3)12-15(19)26)31-25-32-23-14(8-9-29-23)24(33-25)30-17-7-4-6-16(27)21(17)22(28)35/h4,6-9,12-13H,5,10-11H2,1-3H3,(H2,28,35)(H3,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27806 (2-fluoro-6-{[2-({5-methoxy-1-[2-(morpholin-4-yl)ac...) Show SMILES COc1cc2CCN(C(=O)CN3CCOCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C28H29FN8O4/c1-40-22-13-16-6-8-37(23(38)15-36-9-11-41-12-10-36)21(16)14-20(22)33-28-34-26-17(5-7-31-26)27(35-28)32-19-4-2-3-18(29)24(19)25(30)39/h2-5,7,13-14H,6,8-12,15H2,1H3,(H2,30,39)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27783 (2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piper...) Show SMILES COc1cc(ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-20(22(15-17)38-3)32-27-33-25-18(9-10-30-25)26(34-27)31-21-6-4-5-19(28)23(21)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27789 (2-{[2-({5-[3-(dimethylamino)propyl]-2-methoxy-4-me...) Show SMILES COc1cc(C)c(CCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C26H30FN7O2/c1-15-13-21(36-4)20(14-16(15)7-6-12-34(2)3)31-26-32-24-17(10-11-29-24)25(33-26)30-19-9-5-8-18(27)22(19)23(28)35/h5,8-11,13-14H,6-7,12H2,1-4H3,(H2,28,35)(H3,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27785 (2-fluoro-6-{[2-({2-methoxy-4-methyl-5-[4-(propan-2...) Show SMILES COc1cc(C)c(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C28H33FN8O2/c1-16(2)36-10-12-37(13-11-36)22-15-21(23(39-4)14-17(22)3)33-28-34-26-18(8-9-31-26)27(35-28)32-20-7-5-6-19(29)24(20)25(30)38/h5-9,14-16H,10-13H2,1-4H3,(H2,30,38)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27813 (2-({2-[(1-acetyl-6-methoxy-1,2,3,4-tetrahydroquino...) Show SMILES COc1cc2CCCN(C(C)=O)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H24FN7O3/c1-13(34)33-10-4-5-14-11-20(36-2)18(12-19(14)33)30-25-31-23-15(8-9-28-23)24(32-25)29-17-7-3-6-16(26)21(17)22(27)35/h3,6-9,11-12H,4-5,10H2,1-2H3,(H2,27,35)(H3,28,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27791 (2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...) Show SMILES CCCN1CCC(CC1)Oc1cc(Nc2nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n2)c(OC)cc1Cl Show InChI InChI=1S/C28H31ClFN7O3/c1-3-11-37-12-8-16(9-13-37)40-22-15-21(23(39-2)14-18(22)29)34-28-35-26-17(7-10-32-26)27(36-28)33-20-6-4-5-19(30)24(20)25(31)38/h4-7,10,14-16H,3,8-9,11-13H2,1-2H3,(H2,31,38)(H3,32,33,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27808 (2-fluoro-6-({2-[(5-methoxy-1-{2-[4-(propan-2-yl)pi...) Show SMILES COc1cc2CCN(C(=O)CN3CCN(CC3)C(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C31H36FN9O3/c1-18(2)40-13-11-39(12-14-40)17-26(42)41-10-8-19-15-25(44-3)23(16-24(19)41)36-31-37-29-20(7-9-34-29)30(38-31)35-22-6-4-5-21(32)27(22)28(33)43/h4-7,9,15-16,18H,8,10-14,17H2,1-3H3,(H2,33,43)(H3,34,35,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27805 (2-fluoro-6-{[2-({1-[2-(1H-imidazol-1-yl)acetyl]-5-...) Show SMILES COc1cc2CCN(C(=O)Cn3ccnc3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C27H24FN9O3/c1-40-21-11-15-6-9-37(22(38)13-36-10-8-30-14-36)20(15)12-19(21)33-27-34-25-16(5-7-31-25)26(35-27)32-18-4-2-3-17(28)23(18)24(29)39/h2-5,7-8,10-12,14H,6,9,13H2,1H3,(H2,29,39)(H3,31,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27812 (2-{[2-({1-[2-(dimethylamino)ethyl]-5-methoxy-2,3-d...) Show SMILES COc1cc2CCN(CCN(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C26H29FN8O2/c1-34(2)11-12-35-10-8-15-13-21(37-3)19(14-20(15)35)31-26-32-24-16(7-9-29-24)25(33-26)30-18-6-4-5-17(27)22(18)23(28)36/h4-7,9,13-14H,8,10-12H2,1-3H3,(H2,28,36)(H3,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27794 (2-{[2-({5-[2-(dimethylamino)-N-methylacetamido]-2-...) Show SMILES COc1ccc(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N(C)C(=O)CN(C)C Show InChI InChI=1S/C25H27FN8O3/c1-33(2)13-20(35)34(3)14-8-9-19(37-4)18(12-14)30-25-31-23-15(10-11-28-23)24(32-25)29-17-7-5-6-16(26)21(17)22(27)36/h5-12H,13H2,1-4H3,(H2,27,36)(H3,28,29,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27801 (2-fluoro-6-({2-[(5-methoxy-1-{2-[methoxy(methyl)am...) Show SMILES CON(C)CC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc12 Show InChI InChI=1S/C26H27FN8O4/c1-34(39-3)13-21(36)35-10-8-14-11-20(38-2)18(12-19(14)35)31-26-32-24-15(7-9-29-24)25(33-26)30-17-6-4-5-16(27)22(17)23(28)37/h4-7,9,11-12H,8,10,13H2,1-3H3,(H2,28,37)(H3,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM27795 (2-{[2-({5-[2-(dimethylamino)-N-methylacetamido]-2-...) Show SMILES COc1cc(C)c(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N(C)C(=O)CN(C)C Show InChI InChI=1S/C26H29FN8O3/c1-14-11-20(38-5)18(12-19(14)35(4)21(36)13-34(2)3)31-26-32-24-15(9-10-29-24)25(33-26)30-17-8-6-7-16(27)22(17)23(28)37/h6-12H,13H2,1-5H3,(H2,28,37)(H3,29,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM27783 (2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piper...) Show SMILES COc1cc(ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-20(22(15-17)38-3)32-27-33-25-18(9-10-30-25)26(34-27)31-21-6-4-5-19(28)23(21)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	7.5	22
GSK					Assay Description Inhibitor binding to JNK3 was assessed by a fluorescence anisotropy competitive binding assay. The reaction mixture (JNK3 and fluorescently labelled ...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27812 (2-{[2-({1-[2-(dimethylamino)ethyl]-5-methoxy-2,3-d...) Show SMILES COc1cc2CCN(CCN(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C26H29FN8O2/c1-34(2)11-12-35-10-8-15-13-21(37-3)19(14-20(15)35)31-26-32-24-16(7-9-29-24)25(33-26)30-18-6-4-5-17(27)22(18)23(28)36/h4-7,9,13-14H,8,10-12H2,1-3H3,(H2,28,36)(H3,29,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27796 (2-({2-[(1-acetyl-5-methoxy-2,3-dihydro-1H-indol-6-...) Show SMILES COc1cc2CCN(C(C)=O)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C24H22FN7O3/c1-12(33)32-9-7-13-10-19(35-2)17(11-18(13)32)29-24-30-22-14(6-8-27-22)23(31-24)28-16-5-3-4-15(25)20(16)21(26)34/h3-6,8,10-11H,7,9H2,1-2H3,(H2,26,34)(H3,27,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27806 (2-fluoro-6-{[2-({5-methoxy-1-[2-(morpholin-4-yl)ac...) Show SMILES COc1cc2CCN(C(=O)CN3CCOCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C28H29FN8O4/c1-40-22-13-16-6-8-37(23(38)15-36-9-11-41-12-10-36)21(16)14-20(22)33-28-34-26-17(5-7-31-26)27(35-28)32-19-4-2-3-18(29)24(19)25(30)39/h2-5,7,13-14H,6,8-12,15H2,1H3,(H2,30,39)(H3,31,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27810 (2-fluoro-6-{[2-({5-methoxy-1-[3-(morpholin-4-yl)pr...) Show SMILES COc1cc2CCN(C(=O)CCN3CCOCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C29H31FN8O4/c1-41-23-15-17-6-10-38(24(39)7-9-37-11-13-42-14-12-37)22(17)16-21(23)34-29-35-27-18(5-8-32-27)28(36-29)33-20-4-2-3-19(30)25(20)26(31)40/h2-5,8,15-16H,6-7,9-14H2,1H3,(H2,31,40)(H3,32,33,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27789 (2-{[2-({5-[3-(dimethylamino)propyl]-2-methoxy-4-me...) Show SMILES COc1cc(C)c(CCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C26H30FN7O2/c1-15-13-21(36-4)20(14-16(15)7-6-12-34(2)3)31-26-32-24-17(10-11-29-24)25(33-26)30-19-9-5-8-18(27)22(19)23(28)35/h5,8-11,13-14H,6-7,12H2,1-4H3,(H2,28,35)(H3,29,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27805 (2-fluoro-6-{[2-({1-[2-(1H-imidazol-1-yl)acetyl]-5-...) Show SMILES COc1cc2CCN(C(=O)Cn3ccnc3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C27H24FN9O3/c1-40-21-11-15-6-9-37(22(38)13-36-10-8-30-14-36)20(15)12-19(21)33-27-34-25-16(5-7-31-25)26(35-27)32-18-4-2-3-17(28)23(18)24(29)39/h2-5,7-8,10-12,14H,6,9,13H2,1H3,(H2,29,39)(H3,31,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27786 (2-{[2-({5-[3-(dimethylamino)propoxy]-2-methoxyphen...) Show SMILES COc1ccc(OCCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H28FN7O3/c1-33(2)12-5-13-36-15-8-9-20(35-3)19(14-15)30-25-31-23-16(10-11-28-23)24(32-25)29-18-7-4-6-17(26)21(18)22(27)34/h4,6-11,14H,5,12-13H2,1-3H3,(H2,27,34)(H3,28,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27809 (2-{[2-({1-[3-(dimethylamino)propanoyl]-5-methoxy-2...) Show SMILES COc1cc2CCN(C(=O)CCN(C)C)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C27H29FN8O3/c1-35(2)11-9-22(37)36-12-8-15-13-21(39-3)19(14-20(15)36)32-27-33-25-16(7-10-30-25)26(34-27)31-18-6-4-5-17(28)23(18)24(29)38/h4-7,10,13-14H,8-9,11-12H2,1-3H3,(H2,29,38)(H3,30,31,32,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27801 (2-fluoro-6-({2-[(5-methoxy-1-{2-[methoxy(methyl)am...) Show SMILES CON(C)CC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc12 Show InChI InChI=1S/C26H27FN8O4/c1-34(39-3)13-21(36)35-10-8-14-11-20(38-2)18(12-19(14)35)31-26-32-24-15(7-9-29-24)25(33-26)30-17-6-4-5-16(27)22(17)23(28)37/h4-7,9,11-12H,8,10,13H2,1-3H3,(H2,28,37)(H3,29,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27797 (2-[(2-{[1-(2-aminoacetyl)-5-methoxy-2,3-dihydro-1H...) Show SMILES COc1cc2CCN(C(=O)CN)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C24H23FN8O3/c1-36-18-9-12-6-8-33(19(34)11-26)17(12)10-16(18)30-24-31-22-13(5-7-28-22)23(32-24)29-15-4-2-3-14(25)20(15)21(27)35/h2-5,7,9-10H,6,8,11,26H2,1H3,(H2,27,35)(H3,28,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27802 (2-{[2-({1-[2-(diethylamino)acetyl]-5-methoxy-2,3-d...) Show SMILES CCN(CC)CC(=O)N1CCc2cc(OC)c(Nc3nc(Nc4cccc(F)c4C(N)=O)c4cc[nH]c4n3)cc12 Show InChI InChI=1S/C28H31FN8O3/c1-4-36(5-2)15-23(38)37-12-10-16-13-22(40-3)20(14-21(16)37)33-28-34-26-17(9-11-31-26)27(35-28)32-19-8-6-7-18(29)24(19)25(30)39/h6-9,11,13-14H,4-5,10,12,15H2,1-3H3,(H2,30,39)(H3,31,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27790 (2-fluoro-6-{[2-({2-methoxy-5-[(1-propylpiperidin-4...) Show SMILES CCCN1CCC(CC1)Oc1ccc(OC)c(Nc2nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n2)c1 Show InChI InChI=1S/C28H32FN7O3/c1-3-13-36-14-10-17(11-15-36)39-18-7-8-23(38-2)22(16-18)33-28-34-26-19(9-12-31-26)27(35-28)32-21-6-4-5-20(29)24(21)25(30)37/h4-9,12,16-17H,3,10-11,13-15H2,1-2H3,(H2,30,37)(H3,31,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27787 (2-{[2-({4-chloro-5-[3-(dimethylamino)propoxy]-2-me...) Show SMILES COc1cc(Cl)c(OCCCN(C)C)cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C25H27ClFN7O3/c1-34(2)10-5-11-37-19-13-18(20(36-3)12-15(19)26)31-25-32-23-14(8-9-29-23)24(33-25)30-17-7-4-6-16(27)21(17)22(28)35/h4,6-9,12-13H,5,10-11H2,1-3H3,(H2,28,35)(H3,29,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM27803 (2-fluoro-6-{[2-({5-methoxy-1-[2-(pyrrolidin-1-yl)a...) Show SMILES COc1cc2CCN(C(=O)CN3CCCC3)c2cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 Show InChI InChI=1S/C28H29FN8O3/c1-40-22-13-16-8-12-37(23(38)15-36-10-2-3-11-36)21(16)14-20(22)33-28-34-26-17(7-9-31-26)27(35-28)32-19-6-4-5-18(29)24(19)25(30)39/h4-7,9,13-14H,2-3,8,10-12,15H2,1H3,(H2,30,39)(H3,31,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing substrate GST-biotin-C-JUN, ATP, and purified activated JNK1alpha1 i...				Bioorg Med Chem Lett 19: 360-4 (2009) Article DOI: 10.1016/j.bmcl.2008.11.077 BindingDB Entry DOI: 10.7270/Q2NZ85ZT
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 72 total )  |  Next  |  Last  >>

Jump to: