Found 20 hits Enz. Inhib. hit(s) with all data for entry = 50000337 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0280 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0880 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4B expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE7A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A2 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE7A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE8A1 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A2 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE3A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE1A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE8A1 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.56E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE1A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE2A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE9A2 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50246909
(CHEMBL4075951)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCS[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C31H31Cl2F2N3O8S2/c1-36(2)28(39)20-4-3-5-21(12-20)48(42,43)38-10-11-47-29(38)30(40)45-26(14-22-23(32)15-37(41)16-24(22)33)19-8-9-25(46-31(34)35)27(13-19)44-17-18-6-7-18/h3-5,8-9,12-13,15-16,18,26,29,31H,6-7,10-11,14,17H2,1-2H3/t26-,29-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE11A4 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE2A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE9A2 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE3A expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM50246908
(CHEMBL4093768)Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@H]1C(=O)O[C@@H](Cc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1 |r| Show InChI InChI=1S/C32H33Cl2F2N3O8S/c1-37(2)30(40)21-5-3-6-22(13-21)48(43,44)39-12-4-7-26(39)31(41)46-28(15-23-24(33)16-38(42)17-25(23)34)20-10-11-27(47-32(35)36)29(14-20)45-18-19-8-9-19/h3,5-6,10-11,13-14,16-17,19,26,28,32H,4,7-9,12,15,18H2,1-2H3/t26-,28-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE11A4 expressed insect sf9 cells by radiometric assay |
J Med Chem 60: 10026-10046 (2017)
Article DOI: 10.1021/acs.jmedchem.7b01044 BindingDB Entry DOI: 10.7270/Q25H7JN4 |
More data for this Ligand-Target Pair | |