Found 42 hits Enz. Inhib. hit(s) with all data for entry = 50036299 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18224
(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18268
(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50031871
(5-Chloro-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)Show InChI InChI=1S/C18H20ClN5O3/c1-25-12-6-10(7-13(26-2)16(12)27-3)22-8-9-4-5-11-14(15(9)19)17(20)24-18(21)23-11/h4-7,22H,8H2,1-3H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50031871
(5-Chloro-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)Show InChI InChI=1S/C18H20ClN5O3/c1-25-12-6-10(7-13(26-2)16(12)27-3)22-8-9-4-5-11-14(15(9)19)17(20)24-18(21)23-11/h4-7,22H,8H2,1-3H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50035481
(5-Chloro-N*6*-(3,4,5-trimethoxy-benzyl)-quinazolin...)Show InChI InChI=1S/C18H20ClN5O3/c1-25-12-6-9(7-13(26-2)16(12)27-3)8-22-11-5-4-10-14(15(11)19)17(20)24-18(21)23-10/h4-7,22H,8H2,1-3H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50031865
(5-Chloro-6-{[methyl-(3,4,5-trimethoxy-phenyl)-amin...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2c1Cl Show InChI InChI=1S/C19H22ClN5O3/c1-25(11-7-13(26-2)17(28-4)14(8-11)27-3)9-10-5-6-12-15(16(10)20)18(21)24-19(22)23-12/h5-8H,9H2,1-4H3,(H4,21,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50035481
(5-Chloro-N*6*-(3,4,5-trimethoxy-benzyl)-quinazolin...)Show InChI InChI=1S/C18H20ClN5O3/c1-25-12-6-9(7-13(26-2)16(12)27-3)8-22-11-5-4-10-14(15(11)19)17(20)24-18(21)23-10/h4-7,22H,8H2,1-3H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM18268
(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50031865
(5-Chloro-6-{[methyl-(3,4,5-trimethoxy-phenyl)-amin...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2c1Cl Show InChI InChI=1S/C19H22ClN5O3/c1-25(11-7-13(26-2)17(28-4)14(8-11)27-3)9-10-5-6-12-15(16(10)20)18(21)24-19(22)23-12/h5-8H,9H2,1-4H3,(H4,21,22,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50031865
(5-Chloro-6-{[methyl-(3,4,5-trimethoxy-phenyl)-amin...)Show SMILES COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2c1Cl Show InChI InChI=1S/C19H22ClN5O3/c1-25(11-7-13(26-2)17(28-4)14(8-11)27-3)9-10-5-6-12-15(16(10)20)18(21)24-19(22)23-12/h5-8H,9H2,1-4H3,(H4,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50035484
(5-Chloro-N*6*-methyl-N*6*-(3,4,5-trimethoxy-benzyl...)Show SMILES COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C19H22ClN5O3/c1-25(9-10-7-13(26-2)17(28-4)14(8-10)27-3)12-6-5-11-15(16(12)20)18(21)24-19(22)23-11/h5-8H,9H2,1-4H3,(H4,21,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM18224
(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50035483
(5-Chloro-N*6*-(2,5-dimethoxy-benzyl)-quinazoline-2...)Show InChI InChI=1S/C17H18ClN5O2/c1-24-10-3-6-13(25-2)9(7-10)8-21-12-5-4-11-14(15(12)18)16(19)23-17(20)22-11/h3-7,21H,8H2,1-2H3,(H4,19,20,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50035483
(5-Chloro-N*6*-(2,5-dimethoxy-benzyl)-quinazoline-2...)Show InChI InChI=1S/C17H18ClN5O2/c1-24-10-3-6-13(25-2)9(7-10)8-21-12-5-4-11-14(15(12)18)16(19)23-17(20)22-11/h3-7,21H,8H2,1-2H3,(H4,19,20,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50031873
(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)Show InChI InChI=1S/C17H18ClN5O2/c1-24-10-4-6-13(25-2)12(7-10)21-8-9-3-5-11-14(15(9)18)16(19)23-17(20)22-11/h3-7,21H,8H2,1-2H3,(H4,19,20,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM18224
(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)Show InChI InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50035481
(5-Chloro-N*6*-(3,4,5-trimethoxy-benzyl)-quinazolin...)Show InChI InChI=1S/C18H20ClN5O3/c1-25-12-6-9(7-13(26-2)16(12)27-3)8-22-11-5-4-10-14(15(11)19)17(20)24-18(21)23-10/h4-7,22H,8H2,1-3H3,(H4,20,21,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50031871
(5-Chloro-6-[(3,4,5-trimethoxy-phenylamino)-methyl]...)Show InChI InChI=1S/C18H20ClN5O3/c1-25-12-6-10(7-13(26-2)16(12)27-3)22-8-9-4-5-11-14(15(9)19)17(20)24-18(21)23-11/h4-7,22H,8H2,1-3H3,(H4,20,21,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50035484
(5-Chloro-N*6*-methyl-N*6*-(3,4,5-trimethoxy-benzyl...)Show SMILES COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C19H22ClN5O3/c1-25(9-10-7-13(26-2)17(28-4)14(8-10)27-3)12-6-5-11-15(16(12)20)18(21)24-19(22)23-11/h5-8H,9H2,1-4H3,(H4,21,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM18268
(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50031873
(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)Show InChI InChI=1S/C17H18ClN5O2/c1-24-10-4-6-13(25-2)12(7-10)21-8-9-3-5-11-14(15(9)18)16(19)23-17(20)22-11/h3-7,21H,8H2,1-2H3,(H4,19,20,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50031873
(5-Chloro-6-[(2,5-dimethoxy-phenylamino)-methyl]-qu...)Show InChI InChI=1S/C17H18ClN5O2/c1-24-10-4-6-13(25-2)12(7-10)21-8-9-3-5-11-14(15(9)18)16(19)23-17(20)22-11/h3-7,21H,8H2,1-2H3,(H4,19,20,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50035483
(5-Chloro-N*6*-(2,5-dimethoxy-benzyl)-quinazoline-2...)Show InChI InChI=1S/C17H18ClN5O2/c1-24-10-3-6-13(25-2)9(7-10)8-21-12-5-4-11-14(15(12)18)16(19)23-17(20)22-11/h3-7,21H,8H2,1-2H3,(H4,19,20,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50035484
(5-Chloro-N*6*-methyl-N*6*-(3,4,5-trimethoxy-benzyl...)Show SMILES COc1cc(CN(C)c2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C19H22ClN5O3/c1-25(9-10-7-13(26-2)17(28-4)14(8-10)27-3)12-6-5-11-15(16(12)20)18(21)24-19(22)23-11/h5-8H,9H2,1-4H3,(H4,21,22,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM18512
(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)Show InChI InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50035478
(5-Chloro-N*6*-[2-(2,5-dimethoxy-phenyl)-ethyl]-qui...)Show InChI InChI=1S/C18H20ClN5O2/c1-25-11-3-6-14(26-2)10(9-11)7-8-22-13-5-4-12-15(16(13)19)17(20)24-18(21)23-12/h3-6,9,22H,7-8H2,1-2H3,(H4,20,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50035479
(5-Chloro-N*6*-[3-(2,5-dimethoxy-phenyl)-propyl]-qu...)Show InChI InChI=1S/C19H22ClN5O2/c1-26-12-5-8-15(27-2)11(10-12)4-3-9-23-14-7-6-13-16(17(14)20)18(21)25-19(22)24-13/h5-8,10,23H,3-4,9H2,1-2H3,(H4,21,22,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50035479
(5-Chloro-N*6*-[3-(2,5-dimethoxy-phenyl)-propyl]-qu...)Show InChI InChI=1S/C19H22ClN5O2/c1-26-12-5-8-15(27-2)11(10-12)4-3-9-23-14-7-6-13-16(17(14)20)18(21)25-19(22)24-13/h5-8,10,23H,3-4,9H2,1-2H3,(H4,21,22,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50035478
(5-Chloro-N*6*-[2-(2,5-dimethoxy-phenyl)-ethyl]-qui...)Show InChI InChI=1S/C18H20ClN5O2/c1-25-11-3-6-14(26-2)10(9-11)7-8-22-13-5-4-12-15(16(13)19)17(20)24-18(21)23-12/h3-6,9,22H,7-8H2,1-2H3,(H4,20,21,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18512
(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)Show InChI InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50035482
(5-Chloro-N*6*-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-...)Show SMILES COc1cc(CCNc2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C19H22ClN5O3/c1-26-13-8-10(9-14(27-2)17(13)28-3)6-7-23-12-5-4-11-15(16(12)20)18(21)25-19(22)24-11/h4-5,8-9,23H,6-7H2,1-3H3,(H4,21,22,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM18069
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM18512
(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)Show InChI InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50035482
(5-Chloro-N*6*-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-...)Show SMILES COc1cc(CCNc2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C19H22ClN5O3/c1-26-13-8-10(9-14(27-2)17(13)28-3)6-7-23-12-5-4-11-15(16(12)20)18(21)25-19(22)24-11/h4-5,8-9,23H,6-7H2,1-3H3,(H4,21,22,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM18069
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50035478
(5-Chloro-N*6*-[2-(2,5-dimethoxy-phenyl)-ethyl]-qui...)Show InChI InChI=1S/C18H20ClN5O2/c1-25-11-3-6-14(26-2)10(9-11)7-8-22-13-5-4-12-15(16(13)19)17(20)24-18(21)23-12/h3-6,9,22H,7-8H2,1-2H3,(H4,20,21,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Bifunctional dihydrofolate reductase-thymidylate synthase
(Toxoplasma gondii) | BDBM50035480
(5-Chloro-N*6*-[3-(3,4,5-trimethoxy-phenyl)-propyl]...)Show SMILES COc1cc(CCCNc2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C20H24ClN5O3/c1-27-14-9-11(10-15(28-2)18(14)29-3)5-4-8-24-13-7-6-12-16(17(13)21)19(22)26-20(23)25-12/h6-7,9-10,24H,4-5,8H2,1-3H3,(H4,22,23,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Toxoplasma gondii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM50035480
(5-Chloro-N*6*-[3-(3,4,5-trimethoxy-phenyl)-propyl]...)Show SMILES COc1cc(CCCNc2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C20H24ClN5O3/c1-27-14-9-11(10-15(28-2)18(14)29-3)5-4-8-24-13-7-6-12-16(17(13)21)19(22)26-20(23)25-12/h6-7,9-10,24H,4-5,8H2,1-3H3,(H4,22,23,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50035479
(5-Chloro-N*6*-[3-(2,5-dimethoxy-phenyl)-propyl]-qu...)Show InChI InChI=1S/C19H22ClN5O2/c1-26-12-5-8-15(27-2)11(10-12)4-3-9-23-14-7-6-13-16(17(14)20)18(21)25-19(22)24-13/h5-8,10,23H,3-4,9H2,1-2H3,(H4,21,22,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50035482
(5-Chloro-N*6*-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-...)Show SMILES COc1cc(CCNc2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C19H22ClN5O3/c1-26-13-8-10(9-14(27-2)17(13)28-3)6-7-23-12-5-4-11-15(16(12)20)18(21)25-19(22)24-11/h4-5,8-9,23H,6-7H2,1-3H3,(H4,21,22,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Pneumocystis carinii) | BDBM50035480
(5-Chloro-N*6*-[3-(3,4,5-trimethoxy-phenyl)-propyl]...)Show SMILES COc1cc(CCCNc2ccc3nc(N)nc(N)c3c2Cl)cc(OC)c1OC Show InChI InChI=1S/C20H24ClN5O3/c1-27-14-9-11(10-15(28-2)18(14)29-3)5-4-8-24-13-7-6-12-16(17(13)21)19(22)26-20(23)25-12/h6-7,9-10,24H,4-5,8H2,1-3H3,(H4,22,23,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase of Pneumocystis carinii |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | |
Dihydrofolate reductase
(Rattus norvegicus (rat)) | BDBM18069
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 1.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Inhibition of Dihydrofolate reductase (DHFR) of in rat liver |
J Med Chem 37: 4522-8 (1995)
BindingDB Entry DOI: 10.7270/Q2DF6RVD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |