Found 54 hits Enz. Inhib. hit(s) with all data for entry = 50038175 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM14949
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372706
(CHEMBL257858)Show SMILES COc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C32H31F4N7O3/c1-19-7-8-20(28(44)39-25-6-4-5-24(27(25)33)32(34,35)36)17-26(19)40-29(45)23-18-37-31(41-30(23)46-3)38-21-9-11-22(12-10-21)43-15-13-42(2)14-16-43/h4-12,17-18H,13-16H2,1-3H3,(H,39,44)(H,40,45)(H,37,38,41) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM14949
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM14949
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50372708
(CHEMBL269936)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(NC)n1 Show InChI InChI=1S/C22H20F4N6O2/c1-11-7-8-12(19(33)30-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)31-20(34)13-10-29-21(28-3)32-18(13)27-2/h4-10H,1-3H3,(H,30,33)(H,31,34)(H2,27,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM14949
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372710
(CHEMBL255533)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H19F4N5O3/c1-11-7-8-12(18(32)29-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)30-19(33)13-10-28-21(27-2)31-20(13)34-3/h4-10H,1-3H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372714
(CHEMBL255989)Show SMILES COc1nc(NCCCN2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C30H36F3N7O3/c1-19-9-10-21(26(41)36-24-8-5-7-23(20(24)2)30(31,32)33)17-25(19)37-27(42)22-18-35-29(38-28(22)43-4)34-11-6-12-40-15-13-39(3)14-16-40/h5,7-10,17-18H,6,11-16H2,1-4H3,(H,36,41)(H,37,42)(H,34,35,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM14949
(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)Show SMILES Cc1ccc(cc1-c1ccc2nc(N)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O/c1-13-5-6-15(21(31)29-18-4-2-3-17(11-18)23(24,25)26)10-19(13)14-7-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372711
(CHEMBL270793)Show SMILES COc1nc(NCCN2CCOCC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C27H29F3N6O4/c1-17-6-7-18(23(37)33-20-5-3-4-19(15-20)27(28,29)30)14-22(17)34-24(38)21-16-32-26(35-25(21)39-2)31-8-9-36-10-12-40-13-11-36/h3-7,14-16H,8-13H2,1-2H3,(H,33,37)(H,34,38)(H,31,32,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372712
(CHEMBL271099)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(Oc2ccccc2)n1 Show InChI InChI=1S/C27H22F3N5O3/c1-16-11-12-17(23(36)33-19-8-6-7-18(14-19)27(28,29)30)13-22(16)34-24(37)21-15-32-26(31-2)35-25(21)38-20-9-4-3-5-10-20/h3-15H,1-2H3,(H,33,36)(H,34,37)(H,31,32,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372707
(CHEMBL408292)Show SMILES Cc1ccc(cc1NC(=O)c1cnc(NCCN2CCOCC2)nc1Oc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C32H31F3N6O4/c1-21-10-11-22(28(42)38-24-7-5-6-23(19-24)32(33,34)35)18-27(21)39-29(43)26-20-37-31(36-12-13-41-14-16-44-17-15-41)40-30(26)45-25-8-3-2-4-9-25/h2-11,18-20H,12-17H2,1H3,(H,38,42)(H,39,43)(H,36,37,40) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372715
(CHEMBL271101)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2C)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C23H22F3N5O3/c1-12-8-9-14(19(32)29-17-7-5-6-16(13(17)2)23(24,25)26)10-18(12)30-20(33)15-11-28-22(27-3)31-21(15)34-4/h5-11H,1-4H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372713
(CHEMBL255132)Show SMILES COc1nc(NCCCCN(C)C)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C28H33F3N6O3/c1-17-11-12-19(24(38)34-22-10-8-9-21(18(22)2)28(29,30)31)15-23(17)35-25(39)20-16-33-27(36-26(20)40-5)32-13-6-7-14-37(3)4/h8-12,15-16H,6-7,13-14H2,1-5H3,(H,34,38)(H,35,39)(H,32,33,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372716
(CHEMBL271018)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H20F3N5O3/c1-12-7-8-13(18(31)28-15-6-4-5-14(10-15)22(23,24)25)9-17(12)29-19(32)16-11-27-21(26-2)30-20(16)33-3/h4-11H,1-3H3,(H,28,31)(H,29,32)(H,26,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372708
(CHEMBL269936)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(NC)n1 Show InChI InChI=1S/C22H20F4N6O2/c1-11-7-8-12(19(33)30-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)31-20(34)13-10-29-21(28-3)32-18(13)27-2/h4-10H,1-3H3,(H,30,33)(H,31,34)(H2,27,28,29,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50372709
(CHEMBL271650)Show SMILES COc1nc(NC2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C27H29F3N6O3/c1-16-7-8-17(23(37)32-20-6-4-5-18(14-20)27(28,29)30)13-22(16)34-24(38)21-15-31-26(35-25(21)39-3)33-19-9-11-36(2)12-10-19/h4-8,13-15,19H,9-12H2,1-3H3,(H,32,37)(H,34,38)(H,31,33,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Lck by HTRF assay |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50372710
(CHEMBL255533)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H19F4N5O3/c1-11-7-8-12(18(32)29-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)30-19(33)13-10-28-21(27-2)31-20(13)34-3/h4-10H,1-3H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 254 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372706
(CHEMBL257858)Show SMILES COc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C32H31F4N7O3/c1-19-7-8-20(28(44)39-25-6-4-5-24(27(25)33)32(34,35)36)17-26(19)40-29(45)23-18-37-31(41-30(23)46-3)38-21-9-11-22(12-10-21)43-15-13-42(2)14-16-43/h4-12,17-18H,13-16H2,1-3H3,(H,39,44)(H,40,45)(H,37,38,41) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 255 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372706
(CHEMBL257858)Show SMILES COc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C32H31F4N7O3/c1-19-7-8-20(28(44)39-25-6-4-5-24(27(25)33)32(34,35)36)17-26(19)40-29(45)23-18-37-31(41-30(23)46-3)38-21-9-11-22(12-10-21)43-15-13-42(2)14-16-43/h4-12,17-18H,13-16H2,1-3H3,(H,39,44)(H,40,45)(H,37,38,41) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50372706
(CHEMBL257858)Show SMILES COc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C32H31F4N7O3/c1-19-7-8-20(28(44)39-25-6-4-5-24(27(25)33)32(34,35)36)17-26(19)40-29(45)23-18-37-31(41-30(23)46-3)38-21-9-11-22(12-10-21)43-15-13-42(2)14-16-43/h4-12,17-18H,13-16H2,1-3H3,(H,39,44)(H,40,45)(H,37,38,41) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 856 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372711
(CHEMBL270793)Show SMILES COc1nc(NCCN2CCOCC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C27H29F3N6O4/c1-17-6-7-18(23(37)33-20-5-3-4-19(15-20)27(28,29)30)14-22(17)34-24(38)21-16-32-26(35-25(21)39-2)31-8-9-36-10-12-40-13-11-36/h3-7,14-16H,8-13H2,1-2H3,(H,33,37)(H,34,38)(H,31,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50372716
(CHEMBL271018)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H20F3N5O3/c1-12-7-8-13(18(31)28-15-6-4-5-14(10-15)22(23,24)25)9-17(12)29-19(32)16-11-27-21(26-2)30-20(16)33-3/h4-11H,1-3H3,(H,28,31)(H,29,32)(H,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372706
(CHEMBL257858)Show SMILES COc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1F)C(F)(F)F Show InChI InChI=1S/C32H31F4N7O3/c1-19-7-8-20(28(44)39-25-6-4-5-24(27(25)33)32(34,35)36)17-26(19)40-29(45)23-18-37-31(41-30(23)46-3)38-21-9-11-22(12-10-21)43-15-13-42(2)14-16-43/h4-12,17-18H,13-16H2,1-3H3,(H,39,44)(H,40,45)(H,37,38,41) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372708
(CHEMBL269936)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(NC)n1 Show InChI InChI=1S/C22H20F4N6O2/c1-11-7-8-12(19(33)30-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)31-20(34)13-10-29-21(28-3)32-18(13)27-2/h4-10H,1-3H3,(H,30,33)(H,31,34)(H2,27,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372716
(CHEMBL271018)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H20F3N5O3/c1-12-7-8-13(18(31)28-15-6-4-5-14(10-15)22(23,24)25)9-17(12)29-19(32)16-11-27-21(26-2)30-20(16)33-3/h4-11H,1-3H3,(H,28,31)(H,29,32)(H,26,27,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50372715
(CHEMBL271101)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2C)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C23H22F3N5O3/c1-12-8-9-14(19(32)29-17-7-5-6-16(13(17)2)23(24,25)26)10-18(12)30-20(33)15-11-28-22(27-3)31-21(15)34-4/h5-11H,1-4H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372710
(CHEMBL255533)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H19F4N5O3/c1-11-7-8-12(18(32)29-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)30-19(33)13-10-28-21(27-2)31-20(13)34-3/h4-10H,1-3H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372715
(CHEMBL271101)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2C)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C23H22F3N5O3/c1-12-8-9-14(19(32)29-17-7-5-6-16(13(17)2)23(24,25)26)10-18(12)30-20(33)15-11-28-22(27-3)31-21(15)34-4/h5-11H,1-4H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372707
(CHEMBL408292)Show SMILES Cc1ccc(cc1NC(=O)c1cnc(NCCN2CCOCC2)nc1Oc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C32H31F3N6O4/c1-21-10-11-22(28(42)38-24-7-5-6-23(19-24)32(33,34)35)18-27(21)39-29(43)26-20-37-31(36-12-13-41-14-16-44-17-15-41)40-30(26)45-25-8-3-2-4-9-25/h2-11,18-20H,12-17H2,1H3,(H,38,42)(H,39,43)(H,36,37,40) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372709
(CHEMBL271650)Show SMILES COc1nc(NC2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C27H29F3N6O3/c1-16-7-8-17(23(37)32-20-6-4-5-18(14-20)27(28,29)30)13-22(16)34-24(38)21-15-31-26(35-25(21)39-3)33-19-9-11-36(2)12-10-19/h4-8,13-15,19H,9-12H2,1-3H3,(H,32,37)(H,34,38)(H,31,33,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372714
(CHEMBL255989)Show SMILES COc1nc(NCCCN2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C30H36F3N7O3/c1-19-9-10-21(26(41)36-24-8-5-7-23(20(24)2)30(31,32)33)17-25(19)37-27(42)22-18-35-29(38-28(22)43-4)34-11-6-12-40-15-13-39(3)14-16-40/h5,7-10,17-18H,6,11-16H2,1-4H3,(H,36,41)(H,37,42)(H,34,35,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372713
(CHEMBL255132)Show SMILES COc1nc(NCCCCN(C)C)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C28H33F3N6O3/c1-17-11-12-19(24(38)34-22-10-8-9-21(18(22)2)28(29,30)31)15-23(17)35-25(39)20-16-33-27(36-26(20)40-5)32-13-6-7-14-37(3)4/h8-12,15-16H,6-7,13-14H2,1-5H3,(H,34,38)(H,35,39)(H,32,33,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372708
(CHEMBL269936)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(NC)n1 Show InChI InChI=1S/C22H20F4N6O2/c1-11-7-8-12(19(33)30-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)31-20(34)13-10-29-21(28-3)32-18(13)27-2/h4-10H,1-3H3,(H,30,33)(H,31,34)(H2,27,28,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372715
(CHEMBL271101)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2C)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C23H22F3N5O3/c1-12-8-9-14(19(32)29-17-7-5-6-16(13(17)2)23(24,25)26)10-18(12)30-20(33)15-11-28-22(27-3)31-21(15)34-4/h5-11H,1-4H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372712
(CHEMBL271099)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(Oc2ccccc2)n1 Show InChI InChI=1S/C27H22F3N5O3/c1-16-11-12-17(23(36)33-19-8-6-7-18(14-19)27(28,29)30)13-22(16)34-24(37)21-15-32-26(31-2)35-25(21)38-20-9-4-3-5-10-20/h3-15H,1-2H3,(H,33,36)(H,34,37)(H,31,32,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372707
(CHEMBL408292)Show SMILES Cc1ccc(cc1NC(=O)c1cnc(NCCN2CCOCC2)nc1Oc1ccccc1)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C32H31F3N6O4/c1-21-10-11-22(28(42)38-24-7-5-6-23(19-24)32(33,34)35)18-27(21)39-29(43)26-20-37-31(36-12-13-41-14-16-44-17-15-41)40-30(26)45-25-8-3-2-4-9-25/h2-11,18-20H,12-17H2,1H3,(H,38,42)(H,39,43)(H,36,37,40) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372711
(CHEMBL270793)Show SMILES COc1nc(NCCN2CCOCC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C27H29F3N6O4/c1-17-6-7-18(23(37)33-20-5-3-4-19(15-20)27(28,29)30)14-22(17)34-24(38)21-16-32-26(35-25(21)39-2)31-8-9-36-10-12-40-13-11-36/h3-7,14-16H,8-13H2,1-2H3,(H,33,37)(H,34,38)(H,31,32,35) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372714
(CHEMBL255989)Show SMILES COc1nc(NCCCN2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C30H36F3N7O3/c1-19-9-10-21(26(41)36-24-8-5-7-23(20(24)2)30(31,32)33)17-25(19)37-27(42)22-18-35-29(38-28(22)43-4)34-11-6-12-40-15-13-39(3)14-16-40/h5,7-10,17-18H,6,11-16H2,1-4H3,(H,36,41)(H,37,42)(H,34,35,38) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372713
(CHEMBL255132)Show SMILES COc1nc(NCCCCN(C)C)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C28H33F3N6O3/c1-17-11-12-19(24(38)34-22-10-8-9-21(18(22)2)28(29,30)31)15-23(17)35-25(39)20-16-33-27(36-26(20)40-5)32-13-6-7-14-37(3)4/h8-12,15-16H,6-7,13-14H2,1-5H3,(H,34,38)(H,35,39)(H,32,33,36) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372715
(CHEMBL271101)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2C)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C23H22F3N5O3/c1-12-8-9-14(19(32)29-17-7-5-6-16(13(17)2)23(24,25)26)10-18(12)30-20(33)15-11-28-22(27-3)31-21(15)34-4/h5-11H,1-4H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372712
(CHEMBL271099)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(Oc2ccccc2)n1 Show InChI InChI=1S/C27H22F3N5O3/c1-16-11-12-17(23(36)33-19-8-6-7-18(14-19)27(28,29)30)13-22(16)34-24(37)21-15-32-26(31-2)35-25(21)38-20-9-4-3-5-10-20/h3-15H,1-2H3,(H,33,36)(H,34,37)(H,31,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372709
(CHEMBL271650)Show SMILES COc1nc(NC2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C27H29F3N6O3/c1-16-7-8-17(23(37)32-20-6-4-5-18(14-20)27(28,29)30)13-22(16)34-24(38)21-15-31-26(35-25(21)39-3)33-19-9-11-36(2)12-10-19/h4-8,13-15,19H,9-12H2,1-3H3,(H,32,37)(H,34,38)(H,31,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372714
(CHEMBL255989)Show SMILES COc1nc(NCCCN2CCN(C)CC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C30H36F3N7O3/c1-19-9-10-21(26(41)36-24-8-5-7-23(20(24)2)30(31,32)33)17-25(19)37-27(42)22-18-35-29(38-28(22)43-4)34-11-6-12-40-15-13-39(3)14-16-40/h5,7-10,17-18H,6,11-16H2,1-4H3,(H,36,41)(H,37,42)(H,34,35,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372713
(CHEMBL255132)Show SMILES COc1nc(NCCCCN(C)C)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1C)C(F)(F)F Show InChI InChI=1S/C28H33F3N6O3/c1-17-11-12-19(24(38)34-22-10-8-9-21(18(22)2)28(29,30)31)15-23(17)35-25(39)20-16-33-27(36-26(20)40-5)32-13-6-7-14-37(3)4/h8-12,15-16H,6-7,13-14H2,1-5H3,(H,34,38)(H,35,39)(H,32,33,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372716
(CHEMBL271018)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H20F3N5O3/c1-12-7-8-13(18(31)28-15-6-4-5-14(10-15)22(23,24)25)9-17(12)29-19(32)16-11-27-21(26-2)30-20(16)33-3/h4-11H,1-3H3,(H,28,31)(H,29,32)(H,26,27,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50372716
(CHEMBL271018)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H20F3N5O3/c1-12-7-8-13(18(31)28-15-6-4-5-14(10-15)22(23,24)25)9-17(12)29-19(32)16-11-27-21(26-2)30-20(16)33-3/h4-11H,1-3H3,(H,28,31)(H,29,32)(H,26,27,30) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Jak3 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50372710
(CHEMBL255533)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2F)C(F)(F)F)c(OC)n1 Show InChI InChI=1S/C22H19F4N5O3/c1-11-7-8-12(18(32)29-15-6-4-5-14(17(15)23)22(24,25)26)9-16(11)30-19(33)13-10-28-21(27-2)31-20(13)34-3/h4-10H,1-3H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372712
(CHEMBL271099)Show SMILES CNc1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)c(Oc2ccccc2)n1 Show InChI InChI=1S/C27H22F3N5O3/c1-16-11-12-17(23(36)33-19-8-6-7-18(14-19)27(28,29)30)13-22(16)34-24(37)21-15-32-26(31-2)35-25(21)38-20-9-4-3-5-10-20/h3-15H,1-2H3,(H,33,36)(H,34,37)(H,31,32,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50372711
(CHEMBL270793)Show SMILES COc1nc(NCCN2CCOCC2)ncc1C(=O)Nc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C27H29F3N6O4/c1-17-6-7-18(23(37)33-20-5-3-4-19(15-20)27(28,29)30)14-22(17)34-24(38)21-16-32-26(35-25(21)39-2)31-8-9-36-10-12-40-13-11-36/h3-7,14-16H,8-13H2,1-2H3,(H,33,37)(H,34,38)(H,31,32,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Tie2 |
Bioorg Med Chem Lett 18: 1172-6 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.123 BindingDB Entry DOI: 10.7270/Q2WD41FK |
More data for this Ligand-Target Pair | |