Found 93 hits Enz. Inhib. hit(s) with all data for entry = 50038306 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374627
(CHEMBL270692)Show SMILES COc1cc(Nc2ncnc(n2)-n2c(Nc3c(C)cccc3C)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C27H27N7O3/c1-16-9-8-10-17(2)23(16)32-27-31-19-11-6-7-12-20(19)34(27)26-29-15-28-25(33-26)30-18-13-21(35-3)24(37-5)22(14-18)36-4/h6-15H,1-5H3,(H,31,32)(H,28,29,30,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50374627
(CHEMBL270692)Show SMILES COc1cc(Nc2ncnc(n2)-n2c(Nc3c(C)cccc3C)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C27H27N7O3/c1-16-9-8-10-17(2)23(16)32-27-31-19-11-6-7-12-20(19)34(27)26-29-15-28-25(33-26)30-18-13-21(35-3)24(37-5)22(14-18)36-4/h6-15H,1-5H3,(H,31,32)(H,28,29,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374625
(CHEMBL403522)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1N1CCN(C)CC1 |(-2.95,-19.43,;-4.29,-20.2,;-4.29,-21.74,;-2.96,-22.51,;-2.97,-24.05,;-1.64,-24.82,;-.3,-24.05,;-.3,-22.51,;1.02,-21.74,;2.36,-22.5,;2.36,-24.05,;1.03,-24.83,;3.7,-24.82,;4.02,-26.32,;3.11,-27.55,;3.73,-28.96,;5.26,-29.13,;6.16,-27.89,;5.55,-26.49,;6.18,-25.09,;5.04,-24.05,;5.04,-22.5,;6.37,-21.74,;6.37,-20.2,;5.03,-19.44,;7.7,-19.43,;9.04,-20.2,;9.03,-21.75,;7.7,-22.51,;7.69,-24.05,;3.7,-21.73,;3.7,-20.19,;-4.29,-24.82,;-5.62,-24.05,;-5.63,-22.51,;-6.96,-21.74,;-6.95,-20.2,;-8.28,-19.43,;-9.62,-20.19,;-10.95,-19.42,;-9.62,-21.73,;-8.29,-22.51,)| Show InChI InChI=1S/C32H32N8O2/c1-20-8-7-9-21(2)28(20)40-30(41)23-19-33-31(36-29(23)39-25-11-6-5-10-24(25)35-32(39)40)34-22-12-13-26(27(18-22)42-4)38-16-14-37(3)15-17-38/h5-13,18-19H,14-17H2,1-4H3,(H,33,34,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374628
(CHEMBL271131)Show SMILES COc1cc(Nc2ncnc(n2)-n2c(Nc3ccccc3)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C25H23N7O3/c1-33-20-13-17(14-21(34-2)22(20)35-3)28-23-26-15-27-24(31-23)32-19-12-8-7-11-18(19)30-25(32)29-16-9-5-4-6-10-16/h4-15H,1-3H3,(H,29,30)(H,26,27,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374621
(CHEMBL260956)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc(OC)c1OCCN1CCN(C)CC1 |(-2.05,-47.19,;-3.39,-47.96,;-3.39,-49.5,;-2.06,-50.27,;-2.07,-51.81,;-.74,-52.59,;.59,-51.82,;.6,-50.27,;1.92,-49.5,;3.26,-50.27,;3.26,-51.81,;1.92,-52.59,;4.6,-52.58,;4.92,-54.08,;4.01,-55.32,;4.62,-56.73,;6.16,-56.89,;7.06,-55.66,;6.44,-54.26,;7.08,-52.85,;5.93,-51.82,;5.94,-50.27,;7.27,-49.5,;7.27,-47.97,;5.93,-47.2,;8.59,-47.2,;9.94,-47.97,;9.93,-49.51,;8.6,-50.28,;8.59,-51.82,;4.59,-49.49,;4.59,-47.95,;-3.39,-52.58,;-4.73,-51.82,;-6.06,-52.59,;-7.39,-51.82,;-4.73,-50.27,;-6.06,-49.5,;-7.4,-50.27,;-8.73,-49.5,;-8.74,-47.96,;-7.41,-47.18,;-7.42,-45.65,;-8.75,-44.88,;-8.76,-43.34,;-10.08,-45.66,;-10.07,-47.2,)| Show InChI InChI=1S/C35H38N8O4/c1-22-9-8-10-23(2)30(22)43-33(44)25-21-36-34(39-32(25)42-27-12-7-6-11-26(27)38-35(42)43)37-24-19-28(45-4)31(29(20-24)46-5)47-18-17-41-15-13-40(3)14-16-41/h6-12,19-21H,13-18H2,1-5H3,(H,36,37,39) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374616
(CHEMBL260306)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc(OC)c1OCCCN1CCN(C)CC1 |(22.25,-6.46,;20.92,-7.23,;20.91,-8.77,;22.24,-9.54,;22.23,-11.08,;23.56,-11.85,;24.9,-11.08,;24.9,-9.54,;26.23,-8.77,;27.57,-9.53,;27.57,-11.08,;26.23,-11.85,;28.9,-11.85,;29.22,-13.35,;28.31,-14.58,;28.93,-15.99,;30.46,-16.16,;31.37,-14.92,;30.75,-13.52,;31.38,-12.12,;30.24,-11.08,;30.24,-9.53,;31.58,-8.77,;31.57,-7.23,;30.24,-6.47,;32.9,-6.46,;34.24,-7.23,;34.24,-8.78,;32.9,-9.54,;32.9,-11.08,;28.9,-8.76,;28.9,-7.22,;20.91,-11.85,;19.58,-11.08,;18.25,-11.86,;18.25,-13.4,;19.58,-9.54,;18.24,-8.77,;16.91,-9.54,;15.58,-8.77,;15.58,-7.23,;16.91,-6.46,;18.24,-7.24,;19.57,-6.47,;19.58,-4.93,;20.92,-4.17,;18.25,-4.16,;16.91,-4.92,)| Show InChI InChI=1S/C36H40N8O4/c1-23-10-8-11-24(2)31(23)44-34(45)26-22-37-35(40-33(26)43-28-13-7-6-12-27(28)39-36(43)44)38-25-20-29(46-4)32(30(21-25)47-5)48-19-9-14-42-17-15-41(3)16-18-42/h6-8,10-13,20-22H,9,14-19H2,1-5H3,(H,37,38,40) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50374628
(CHEMBL271131)Show SMILES COc1cc(Nc2ncnc(n2)-n2c(Nc3ccccc3)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C25H23N7O3/c1-33-20-13-17(14-21(34-2)22(20)35-3)28-23-26-15-27-24(31-23)32-19-12-8-7-11-18(19)30-25(32)29-16-9-5-4-6-10-16/h4-15H,1-3H3,(H,29,30)(H,26,27,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374614
(CHEMBL254674)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(Cl)cc(Cl)cc2Cl)c3=O)cc1 |(13.38,-19.23,;14.71,-20,;16.05,-19.24,;17.38,-20.01,;17.37,-21.55,;16.04,-22.32,;14.71,-21.55,;18.7,-22.32,;20.04,-21.55,;21.37,-22.32,;21.36,-23.86,;22.69,-24.63,;24.03,-23.87,;24.03,-22.32,;25.35,-21.55,;26.7,-22.31,;26.69,-23.86,;25.36,-24.64,;28.03,-24.63,;28.35,-26.13,;27.44,-27.37,;28.06,-28.77,;29.59,-28.94,;30.49,-27.7,;29.88,-26.3,;30.51,-24.9,;29.37,-23.86,;29.37,-22.32,;30.7,-21.55,;30.7,-20.01,;29.36,-19.25,;32.03,-19.24,;33.37,-20.02,;34.7,-19.25,;33.37,-21.56,;32.03,-22.32,;32.03,-23.86,;28.03,-21.54,;28.03,-20,;20.04,-24.63,;18.71,-23.87,)| Show InChI InChI=1S/C29H23Cl3N8O/c1-37-10-12-38(13-11-37)19-8-6-18(7-9-19)34-28-33-16-20-26(36-28)39-24-5-3-2-4-23(24)35-29(39)40(27(20)41)25-21(31)14-17(30)15-22(25)32/h2-9,14-16H,10-13H2,1H3,(H,33,34,36) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374619
(CHEMBL406804)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc(OC)c1OCCN1CCOCC1 |(-1.93,5.11,;-3.27,4.34,;-3.27,2.8,;-1.94,2.03,;-1.95,.49,;-.62,-.29,;.71,.48,;.72,2.03,;2.04,2.8,;3.38,2.04,;3.38,.49,;2.04,-.29,;4.72,-.28,;5.04,-1.78,;4.13,-3.02,;4.74,-4.42,;6.28,-4.59,;7.18,-3.35,;6.56,-1.95,;7.19,-.55,;6.05,.48,;6.06,2.03,;7.39,2.8,;7.39,4.34,;6.05,5.1,;8.71,5.11,;10.06,4.33,;10.05,2.79,;8.72,2.03,;8.71,.49,;4.71,2.81,;4.71,4.35,;-3.27,-.28,;-4.61,.48,;-5.94,-.29,;-7.27,.48,;-4.61,2.03,;-5.94,2.8,;-7.28,2.03,;-8.61,2.8,;-8.62,4.35,;-7.29,5.12,;-7.3,6.65,;-8.63,7.42,;-9.96,6.64,;-9.95,5.1,)| Show InChI InChI=1S/C34H35N7O5/c1-21-8-7-9-22(2)29(21)41-32(42)24-20-35-33(38-31(24)40-26-11-6-5-10-25(26)37-34(40)41)36-23-18-27(43-3)30(28(19-23)44-4)46-17-14-39-12-15-45-16-13-39/h5-11,18-20H,12-17H2,1-4H3,(H,35,36,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374615
(CHEMBL406661)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(Cl)cccc2Cl)c3=O)cc1 |(-12.03,-20.12,;-10.7,-20.89,;-9.36,-20.13,;-8.03,-20.9,;-8.04,-22.44,;-9.37,-23.21,;-10.7,-22.44,;-6.71,-23.21,;-5.37,-22.44,;-4.04,-23.21,;-4.05,-24.75,;-2.72,-25.52,;-1.38,-24.76,;-1.38,-23.21,;-.06,-22.44,;1.29,-23.2,;1.28,-24.75,;-.05,-25.53,;2.62,-25.52,;2.94,-27.02,;2.03,-28.26,;2.65,-29.66,;4.18,-29.83,;5.08,-28.59,;4.47,-27.19,;5.1,-25.79,;3.96,-24.75,;3.96,-23.21,;5.29,-22.44,;5.29,-20.9,;3.95,-20.14,;6.62,-20.13,;7.96,-20.91,;7.96,-22.45,;6.62,-23.21,;6.62,-24.75,;2.62,-22.43,;2.62,-20.89,;-5.37,-25.52,;-6.7,-24.76,)| Show InChI InChI=1S/C29H24Cl2N8O/c1-36-13-15-37(16-14-36)19-11-9-18(10-12-19)33-28-32-17-20-26(35-28)38-24-8-3-2-7-23(24)34-29(38)39(27(20)40)25-21(30)5-4-6-22(25)31/h2-12,17H,13-16H2,1H3,(H,32,33,35) | PDB
UniProtKB/SwissProt
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PC cid
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374618
(CHEMBL408030)Show SMILES Cc1cccc(C)c1-n1c2nc3ccccc3n2c2nc(Nc3ccc(OCCCN4CCCCC4)cc3)ncc2c1=O |(29.92,5.51,;31.26,4.75,;32.58,5.52,;33.93,4.74,;33.92,3.2,;32.59,2.44,;32.58,.9,;31.26,3.21,;29.93,2.44,;29.92,.9,;31.06,-.14,;30.43,-1.54,;31.05,-2.94,;30.15,-4.18,;28.61,-4.01,;28,-2.61,;28.91,-1.37,;28.59,.13,;27.25,.9,;25.91,.12,;24.58,.89,;23.25,.13,;21.92,.9,;21.93,2.44,;20.6,3.21,;19.26,2.44,;17.93,3.21,;16.59,2.44,;15.26,3.21,;15.26,4.75,;16.59,5.52,;17.93,4.74,;19.26,5.51,;19.27,7.05,;17.93,7.82,;16.59,7.05,;19.26,.89,;20.6,.13,;24.59,2.44,;25.91,3.21,;27.25,2.45,;28.58,3.22,;28.58,4.76,)| Show InChI InChI=1S/C34H35N7O2/c1-23-10-8-11-24(2)30(23)41-32(42)27-22-35-33(38-31(27)40-29-13-5-4-12-28(29)37-34(40)41)36-25-14-16-26(17-15-25)43-21-9-20-39-18-6-3-7-19-39/h4-5,8,10-17,22H,3,6-7,9,18-21H2,1-2H3,(H,35,36,38) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374617
(CHEMBL405430)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1OCCCN1CCN(C)CC1 |(-3.89,-6.67,;-5.23,-7.43,;-5.23,-8.97,;-3.9,-9.74,;-3.91,-11.29,;-2.58,-12.06,;-1.25,-11.29,;-1.24,-9.74,;.08,-8.97,;1.42,-9.74,;1.42,-11.28,;.08,-12.06,;2.76,-12.05,;3.08,-13.56,;2.17,-14.79,;2.79,-16.2,;4.32,-16.36,;5.22,-15.13,;4.6,-13.73,;5.24,-12.32,;4.09,-11.29,;4.1,-9.74,;5.43,-8.97,;5.43,-7.44,;4.09,-6.67,;6.75,-6.67,;8.1,-7.44,;8.09,-8.98,;6.76,-9.75,;6.75,-11.29,;2.76,-8.96,;2.76,-7.42,;-5.23,-12.05,;-6.57,-11.29,;-6.57,-9.74,;-7.9,-8.97,;-9.24,-9.74,;-10.57,-8.97,;-10.57,-7.43,;-9.24,-6.66,;-7.9,-7.44,;-6.57,-6.68,;-6.56,-5.14,;-5.23,-4.37,;-7.9,-4.36,;-9.24,-5.13,)| Show InChI InChI=1S/C35H38N8O3/c1-23-9-7-10-24(2)31(23)43-33(44)26-22-36-34(39-32(26)42-28-12-6-5-11-27(28)38-35(42)43)37-25-13-14-29(30(21-25)45-4)46-20-8-15-41-18-16-40(3)17-19-41/h5-7,9-14,21-22H,8,15-20H2,1-4H3,(H,36,37,39) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374622
(CHEMBL407279)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1OCCN1CCN(C)CC1 |(21.28,-33.67,;19.94,-34.43,;19.94,-35.97,;21.27,-36.75,;21.26,-38.29,;22.59,-39.06,;23.92,-38.29,;23.93,-36.75,;25.25,-35.98,;26.59,-36.74,;26.59,-38.29,;25.26,-39.06,;27.93,-39.06,;28.25,-40.56,;27.34,-41.79,;27.96,-43.2,;29.49,-43.36,;30.39,-42.13,;29.78,-40.73,;30.41,-39.32,;29.27,-38.29,;29.27,-36.74,;30.6,-35.97,;30.6,-34.44,;29.26,-33.67,;31.93,-33.67,;33.27,-34.44,;33.26,-35.98,;31.93,-36.75,;31.92,-38.29,;27.93,-35.96,;27.93,-34.42,;19.94,-39.06,;18.6,-38.29,;18.6,-36.74,;17.27,-35.97,;15.93,-36.74,;14.6,-35.97,;14.6,-34.43,;15.92,-33.65,;15.91,-32.12,;14.58,-31.36,;14.57,-29.82,;13.25,-32.14,;13.26,-33.68,)| Show InChI InChI=1S/C34H36N8O3/c1-22-8-7-9-23(2)30(22)42-32(43)25-21-35-33(38-31(25)41-27-11-6-5-10-26(27)37-34(41)42)36-24-12-13-28(29(20-24)44-4)45-19-18-40-16-14-39(3)15-17-40/h5-13,20-21H,14-19H2,1-4H3,(H,35,36,38) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374623
(CHEMBL261174)Show SMILES CN(C)CCCOc1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc1 |(-10.01,-30.27,;-10.01,-31.81,;-11.34,-32.58,;-8.68,-32.58,;-8.68,-34.12,;-7.35,-34.89,;-7.35,-36.43,;-6.01,-37.2,;-4.68,-36.43,;-3.34,-37.2,;-3.36,-38.74,;-2.02,-39.51,;-.69,-38.74,;-.69,-37.2,;.64,-36.43,;1.98,-37.19,;1.98,-38.74,;.64,-39.52,;3.31,-39.51,;3.63,-41.01,;2.73,-42.24,;3.34,-43.65,;4.87,-43.82,;5.78,-42.58,;5.16,-41.18,;5.79,-39.78,;4.65,-38.74,;4.65,-37.19,;5.99,-36.43,;5.98,-34.89,;4.65,-34.13,;7.31,-34.12,;8.65,-34.89,;8.65,-36.44,;7.31,-37.2,;7.31,-38.74,;3.31,-36.42,;3.31,-34.88,;-4.68,-39.51,;-6.01,-38.74,)| Show InChI InChI=1S/C31H31N7O2/c1-20-9-7-10-21(2)27(20)38-29(39)24-19-32-30(33-22-13-15-23(16-14-22)40-18-8-17-36(3)4)35-28(24)37-26-12-6-5-11-25(26)34-31(37)38/h5-7,9-16,19H,8,17-18H2,1-4H3,(H,32,33,35) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lyn by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374611
(CHEMBL406684)Show SMILES COc1ccc(Cl)cc1-n1c2nc3ccccc3n2c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O |(29.7,-42.87,;29.7,-44.41,;31.04,-45.18,;32.37,-44.41,;33.71,-45.18,;33.7,-46.72,;35.03,-47.5,;32.37,-47.49,;31.04,-46.72,;29.71,-47.48,;29.7,-49.03,;30.85,-50.07,;30.21,-51.47,;30.83,-52.87,;29.93,-54.11,;28.39,-53.94,;27.78,-52.53,;28.69,-51.3,;28.37,-49.8,;27.03,-49.03,;25.69,-49.8,;24.36,-49.03,;23.03,-49.8,;21.7,-49.03,;21.71,-47.49,;20.38,-46.72,;19.04,-47.48,;19.04,-49.03,;20.38,-49.8,;17.71,-46.71,;17.71,-45.18,;16.39,-44.41,;15.05,-45.17,;13.72,-44.4,;15.04,-46.71,;16.38,-47.49,;24.37,-47.49,;25.69,-46.72,;27.03,-47.48,;28.37,-46.7,;28.36,-45.16,)| Show InChI InChI=1S/C30H27ClN8O2/c1-36-13-15-37(16-14-36)21-10-8-20(9-11-21)33-29-32-18-22-27(35-29)38-24-6-4-3-5-23(24)34-30(38)39(28(22)40)25-17-19(31)7-12-26(25)41-2/h3-12,17-18H,13-16H2,1-2H3,(H,32,33,35) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374620
(CHEMBL407516)Show SMILES CN1CCN(CCOc2ccc(Nc3ncc4c(n3)n3c5ccccc5nc3n(-c3c(C)cccc3C)c4=O)cc2F)CC1 |(15.66,-43.08,;15.65,-44.62,;16.98,-45.4,;16.98,-46.93,;15.64,-47.69,;15.64,-49.23,;16.98,-50,;18.31,-49.23,;19.65,-50,;19.65,-51.55,;20.98,-52.32,;22.3,-51.55,;23.63,-52.32,;24.97,-51.55,;24.97,-50.01,;26.3,-49.24,;27.64,-50,;27.63,-51.55,;26.3,-52.32,;28.97,-52.32,;29.29,-53.82,;28.38,-55.05,;29,-56.46,;30.53,-56.62,;31.43,-55.39,;30.82,-53.99,;31.45,-52.58,;30.31,-51.55,;30.31,-50,;31.65,-49.24,;31.64,-47.7,;30.3,-46.93,;32.97,-46.93,;34.31,-47.7,;34.31,-49.24,;32.97,-50.01,;32.97,-51.55,;28.97,-49.22,;28.97,-47.68,;22.31,-50.01,;20.98,-49.24,;20.99,-47.7,;14.31,-46.93,;14.32,-45.39,)| Show InChI InChI=1S/C33H33FN8O2/c1-21-7-6-8-22(2)29(21)42-31(43)24-20-35-32(38-30(24)41-27-10-5-4-9-26(27)37-33(41)42)36-23-11-12-28(25(34)19-23)44-18-17-40-15-13-39(3)14-16-40/h4-12,19-20H,13-18H2,1-3H3,(H,35,36,38) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374609
(CHEMBL270777)Show SMILES COc1cc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc(OC)c1OC |(-10.47,-11.17,;-9.13,-11.93,;-7.8,-11.16,;-6.47,-11.93,;-5.15,-11.16,;-3.81,-11.93,;-2.48,-11.16,;-2.48,-9.62,;-1.15,-8.85,;.19,-9.61,;.19,-11.16,;-1.15,-11.93,;1.53,-11.93,;2.86,-11.16,;4,-12.19,;3.37,-13.6,;3.99,-15,;3.09,-16.23,;1.55,-16.07,;.94,-14.66,;1.85,-13.43,;2.86,-9.61,;4.2,-8.84,;4.19,-7.31,;2.86,-6.54,;5.52,-6.54,;6.86,-7.31,;6.86,-8.85,;5.53,-9.62,;5.52,-11.16,;1.52,-8.83,;1.52,-7.29,;-5.13,-9.62,;-6.46,-8.84,;-6.46,-7.3,;-5.13,-6.54,;-7.8,-9.61,;-9.13,-8.84,;-10.47,-9.61,)| Show InChI InChI=1S/C29H26N6O4/c1-16-9-8-10-17(2)24(16)35-27(36)19-15-30-28(31-18-13-22(37-3)25(39-5)23(14-18)38-4)33-26(19)34-21-12-7-6-11-20(21)32-29(34)35/h6-15H,1-5H3,(H,30,31,33) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374624
(CHEMBL410892)Show SMILES CN(C)CCOc1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc1 |(11.02,-18.02,;12.35,-18.79,;13.68,-18.02,;12.35,-20.33,;13.68,-21.1,;15.02,-20.33,;16.35,-21.1,;17.69,-20.33,;19.02,-21.11,;19.01,-22.65,;20.34,-23.42,;21.67,-22.65,;21.68,-21.11,;23,-20.34,;24.34,-21.1,;24.34,-22.65,;23.01,-23.42,;25.68,-23.42,;26,-24.92,;25.09,-26.15,;25.71,-27.56,;27.24,-27.72,;28.14,-26.49,;27.52,-25.09,;28.16,-23.68,;27.01,-22.65,;27.02,-21.1,;28.35,-20.33,;28.35,-18.8,;27.01,-18.03,;29.68,-18.03,;31.02,-18.8,;31.01,-20.34,;29.68,-21.11,;29.67,-22.65,;25.68,-20.32,;25.68,-18.78,;17.69,-23.42,;16.35,-22.65,)| Show InChI InChI=1S/C30H29N7O2/c1-19-8-7-9-20(2)26(19)37-28(38)23-18-31-29(32-21-12-14-22(15-13-21)39-17-16-35(3)4)34-27(23)36-25-11-6-5-10-24(25)33-30(36)37/h5-15,18H,16-17H2,1-4H3,(H,31,32,34) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374614
(CHEMBL254674)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(Cl)cc(Cl)cc2Cl)c3=O)cc1 |(13.38,-19.23,;14.71,-20,;16.05,-19.24,;17.38,-20.01,;17.37,-21.55,;16.04,-22.32,;14.71,-21.55,;18.7,-22.32,;20.04,-21.55,;21.37,-22.32,;21.36,-23.86,;22.69,-24.63,;24.03,-23.87,;24.03,-22.32,;25.35,-21.55,;26.7,-22.31,;26.69,-23.86,;25.36,-24.64,;28.03,-24.63,;28.35,-26.13,;27.44,-27.37,;28.06,-28.77,;29.59,-28.94,;30.49,-27.7,;29.88,-26.3,;30.51,-24.9,;29.37,-23.86,;29.37,-22.32,;30.7,-21.55,;30.7,-20.01,;29.36,-19.25,;32.03,-19.24,;33.37,-20.02,;34.7,-19.25,;33.37,-21.56,;32.03,-22.32,;32.03,-23.86,;28.03,-21.54,;28.03,-20,;20.04,-24.63,;18.71,-23.87,)| Show InChI InChI=1S/C29H23Cl3N8O/c1-37-10-12-38(13-11-37)19-8-6-18(7-9-19)34-28-33-16-20-26(36-28)39-24-5-3-2-4-23(24)35-29(39)40(27(20)41)25-21(31)14-17(30)15-22(25)32/h2-9,14-16H,10-13H2,1H3,(H,33,34,36) | PDB
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Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374619
(CHEMBL406804)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc(OC)c1OCCN1CCOCC1 |(-1.93,5.11,;-3.27,4.34,;-3.27,2.8,;-1.94,2.03,;-1.95,.49,;-.62,-.29,;.71,.48,;.72,2.03,;2.04,2.8,;3.38,2.04,;3.38,.49,;2.04,-.29,;4.72,-.28,;5.04,-1.78,;4.13,-3.02,;4.74,-4.42,;6.28,-4.59,;7.18,-3.35,;6.56,-1.95,;7.19,-.55,;6.05,.48,;6.06,2.03,;7.39,2.8,;7.39,4.34,;6.05,5.1,;8.71,5.11,;10.06,4.33,;10.05,2.79,;8.72,2.03,;8.71,.49,;4.71,2.81,;4.71,4.35,;-3.27,-.28,;-4.61,.48,;-5.94,-.29,;-7.27,.48,;-4.61,2.03,;-5.94,2.8,;-7.28,2.03,;-8.61,2.8,;-8.62,4.35,;-7.29,5.12,;-7.3,6.65,;-8.63,7.42,;-9.96,6.64,;-9.95,5.1,)| Show InChI InChI=1S/C34H35N7O5/c1-21-8-7-9-22(2)29(21)41-32(42)24-20-35-33(38-31(24)40-26-11-6-5-10-25(26)37-34(40)41)36-23-18-27(43-3)30(28(19-23)44-4)46-17-14-39-12-15-45-16-13-39/h5-11,18-20H,12-17H2,1-4H3,(H,35,36,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374615
(CHEMBL406661)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(Cl)cccc2Cl)c3=O)cc1 |(-12.03,-20.12,;-10.7,-20.89,;-9.36,-20.13,;-8.03,-20.9,;-8.04,-22.44,;-9.37,-23.21,;-10.7,-22.44,;-6.71,-23.21,;-5.37,-22.44,;-4.04,-23.21,;-4.05,-24.75,;-2.72,-25.52,;-1.38,-24.76,;-1.38,-23.21,;-.06,-22.44,;1.29,-23.2,;1.28,-24.75,;-.05,-25.53,;2.62,-25.52,;2.94,-27.02,;2.03,-28.26,;2.65,-29.66,;4.18,-29.83,;5.08,-28.59,;4.47,-27.19,;5.1,-25.79,;3.96,-24.75,;3.96,-23.21,;5.29,-22.44,;5.29,-20.9,;3.95,-20.14,;6.62,-20.13,;7.96,-20.91,;7.96,-22.45,;6.62,-23.21,;6.62,-24.75,;2.62,-22.43,;2.62,-20.89,;-5.37,-25.52,;-6.7,-24.76,)| Show InChI InChI=1S/C29H24Cl2N8O/c1-36-13-15-37(16-14-36)19-11-9-18(10-12-19)33-28-32-17-20-26(35-28)38-24-8-3-2-7-23(24)34-29(38)39(27(20)40)25-21(30)5-4-6-22(25)31/h2-12,17H,13-16H2,1H3,(H,32,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
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PC sid
UniChem
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PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374616
(CHEMBL260306)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc(OC)c1OCCCN1CCN(C)CC1 |(22.25,-6.46,;20.92,-7.23,;20.91,-8.77,;22.24,-9.54,;22.23,-11.08,;23.56,-11.85,;24.9,-11.08,;24.9,-9.54,;26.23,-8.77,;27.57,-9.53,;27.57,-11.08,;26.23,-11.85,;28.9,-11.85,;29.22,-13.35,;28.31,-14.58,;28.93,-15.99,;30.46,-16.16,;31.37,-14.92,;30.75,-13.52,;31.38,-12.12,;30.24,-11.08,;30.24,-9.53,;31.58,-8.77,;31.57,-7.23,;30.24,-6.47,;32.9,-6.46,;34.24,-7.23,;34.24,-8.78,;32.9,-9.54,;32.9,-11.08,;28.9,-8.76,;28.9,-7.22,;20.91,-11.85,;19.58,-11.08,;18.25,-11.86,;18.25,-13.4,;19.58,-9.54,;18.24,-8.77,;16.91,-9.54,;15.58,-8.77,;15.58,-7.23,;16.91,-6.46,;18.24,-7.24,;19.57,-6.47,;19.58,-4.93,;20.92,-4.17,;18.25,-4.16,;16.91,-4.92,)| Show InChI InChI=1S/C36H40N8O4/c1-23-10-8-11-24(2)31(23)44-34(45)26-22-37-35(40-33(26)43-28-13-7-6-12-27(28)39-36(43)44)38-25-20-29(46-4)32(30(21-25)47-5)48-19-9-14-42-17-15-41(3)16-18-42/h6-8,10-13,20-22H,9,14-19H2,1-5H3,(H,37,38,40) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374621
(CHEMBL260956)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc(OC)c1OCCN1CCN(C)CC1 |(-2.05,-47.19,;-3.39,-47.96,;-3.39,-49.5,;-2.06,-50.27,;-2.07,-51.81,;-.74,-52.59,;.59,-51.82,;.6,-50.27,;1.92,-49.5,;3.26,-50.27,;3.26,-51.81,;1.92,-52.59,;4.6,-52.58,;4.92,-54.08,;4.01,-55.32,;4.62,-56.73,;6.16,-56.89,;7.06,-55.66,;6.44,-54.26,;7.08,-52.85,;5.93,-51.82,;5.94,-50.27,;7.27,-49.5,;7.27,-47.97,;5.93,-47.2,;8.59,-47.2,;9.94,-47.97,;9.93,-49.51,;8.6,-50.28,;8.59,-51.82,;4.59,-49.49,;4.59,-47.95,;-3.39,-52.58,;-4.73,-51.82,;-6.06,-52.59,;-7.39,-51.82,;-4.73,-50.27,;-6.06,-49.5,;-7.4,-50.27,;-8.73,-49.5,;-8.74,-47.96,;-7.41,-47.18,;-7.42,-45.65,;-8.75,-44.88,;-8.76,-43.34,;-10.08,-45.66,;-10.07,-47.2,)| Show InChI InChI=1S/C35H38N8O4/c1-22-9-8-10-23(2)30(22)43-33(44)25-21-36-34(39-32(25)42-27-12-7-6-11-26(27)38-35(42)43)37-24-19-28(45-4)31(29(20-24)46-5)47-18-17-41-15-13-40(3)14-16-41/h6-12,19-21H,13-18H2,1-5H3,(H,36,37,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50374627
(CHEMBL270692)Show SMILES COc1cc(Nc2ncnc(n2)-n2c(Nc3c(C)cccc3C)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C27H27N7O3/c1-16-9-8-10-17(2)23(16)32-27-31-19-11-6-7-12-20(19)34(27)26-29-15-28-25(33-26)30-18-13-21(35-3)24(37-5)22(14-18)36-4/h6-15H,1-5H3,(H,31,32)(H,28,29,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38-alpha by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374612
(CHEMBL409447)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2cccc(C)c2)c3=O)cc1 Show InChI InChI=1S/C30H28N8O/c1-20-6-5-7-23(18-20)37-28(39)24-19-31-29(34-27(24)38-26-9-4-3-8-25(26)33-30(37)38)32-21-10-12-22(13-11-21)36-16-14-35(2)15-17-36/h3-13,18-19H,14-17H2,1-2H3,(H,31,32,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374625
(CHEMBL403522)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1N1CCN(C)CC1 |(-2.95,-19.43,;-4.29,-20.2,;-4.29,-21.74,;-2.96,-22.51,;-2.97,-24.05,;-1.64,-24.82,;-.3,-24.05,;-.3,-22.51,;1.02,-21.74,;2.36,-22.5,;2.36,-24.05,;1.03,-24.83,;3.7,-24.82,;4.02,-26.32,;3.11,-27.55,;3.73,-28.96,;5.26,-29.13,;6.16,-27.89,;5.55,-26.49,;6.18,-25.09,;5.04,-24.05,;5.04,-22.5,;6.37,-21.74,;6.37,-20.2,;5.03,-19.44,;7.7,-19.43,;9.04,-20.2,;9.03,-21.75,;7.7,-22.51,;7.69,-24.05,;3.7,-21.73,;3.7,-20.19,;-4.29,-24.82,;-5.62,-24.05,;-5.63,-22.51,;-6.96,-21.74,;-6.95,-20.2,;-8.28,-19.43,;-9.62,-20.19,;-10.95,-19.42,;-9.62,-21.73,;-8.29,-22.51,)| Show InChI InChI=1S/C32H32N8O2/c1-20-8-7-9-21(2)28(20)40-30(41)23-19-33-31(36-29(23)39-25-11-6-5-10-24(25)35-32(39)40)34-22-12-13-26(27(18-22)42-4)38-16-14-37(3)15-17-38/h5-13,18-19H,14-17H2,1-4H3,(H,33,34,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374620
(CHEMBL407516)Show SMILES CN1CCN(CCOc2ccc(Nc3ncc4c(n3)n3c5ccccc5nc3n(-c3c(C)cccc3C)c4=O)cc2F)CC1 |(15.66,-43.08,;15.65,-44.62,;16.98,-45.4,;16.98,-46.93,;15.64,-47.69,;15.64,-49.23,;16.98,-50,;18.31,-49.23,;19.65,-50,;19.65,-51.55,;20.98,-52.32,;22.3,-51.55,;23.63,-52.32,;24.97,-51.55,;24.97,-50.01,;26.3,-49.24,;27.64,-50,;27.63,-51.55,;26.3,-52.32,;28.97,-52.32,;29.29,-53.82,;28.38,-55.05,;29,-56.46,;30.53,-56.62,;31.43,-55.39,;30.82,-53.99,;31.45,-52.58,;30.31,-51.55,;30.31,-50,;31.65,-49.24,;31.64,-47.7,;30.3,-46.93,;32.97,-46.93,;34.31,-47.7,;34.31,-49.24,;32.97,-50.01,;32.97,-51.55,;28.97,-49.22,;28.97,-47.68,;22.31,-50.01,;20.98,-49.24,;20.99,-47.7,;14.31,-46.93,;14.32,-45.39,)| Show InChI InChI=1S/C33H33FN8O2/c1-21-7-6-8-22(2)29(21)42-31(43)24-20-35-32(38-30(24)41-27-10-5-4-9-26(27)37-33(41)42)36-23-11-12-28(25(34)19-23)44-18-17-40-15-13-39(3)14-16-40/h4-12,19-20H,13-18H2,1-3H3,(H,35,36,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374618
(CHEMBL408030)Show SMILES Cc1cccc(C)c1-n1c2nc3ccccc3n2c2nc(Nc3ccc(OCCCN4CCCCC4)cc3)ncc2c1=O |(29.92,5.51,;31.26,4.75,;32.58,5.52,;33.93,4.74,;33.92,3.2,;32.59,2.44,;32.58,.9,;31.26,3.21,;29.93,2.44,;29.92,.9,;31.06,-.14,;30.43,-1.54,;31.05,-2.94,;30.15,-4.18,;28.61,-4.01,;28,-2.61,;28.91,-1.37,;28.59,.13,;27.25,.9,;25.91,.12,;24.58,.89,;23.25,.13,;21.92,.9,;21.93,2.44,;20.6,3.21,;19.26,2.44,;17.93,3.21,;16.59,2.44,;15.26,3.21,;15.26,4.75,;16.59,5.52,;17.93,4.74,;19.26,5.51,;19.27,7.05,;17.93,7.82,;16.59,7.05,;19.26,.89,;20.6,.13,;24.59,2.44,;25.91,3.21,;27.25,2.45,;28.58,3.22,;28.58,4.76,)| Show InChI InChI=1S/C34H35N7O2/c1-23-10-8-11-24(2)30(23)41-32(42)27-22-35-33(38-31(27)40-29-13-5-4-12-28(29)37-34(40)41)36-25-14-16-26(17-15-25)43-21-9-20-39-18-6-3-7-19-39/h4-5,8,10-17,22H,3,6-7,9,18-21H2,1-2H3,(H,35,36,38) | PDB
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374617
(CHEMBL405430)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1OCCCN1CCN(C)CC1 |(-3.89,-6.67,;-5.23,-7.43,;-5.23,-8.97,;-3.9,-9.74,;-3.91,-11.29,;-2.58,-12.06,;-1.25,-11.29,;-1.24,-9.74,;.08,-8.97,;1.42,-9.74,;1.42,-11.28,;.08,-12.06,;2.76,-12.05,;3.08,-13.56,;2.17,-14.79,;2.79,-16.2,;4.32,-16.36,;5.22,-15.13,;4.6,-13.73,;5.24,-12.32,;4.09,-11.29,;4.1,-9.74,;5.43,-8.97,;5.43,-7.44,;4.09,-6.67,;6.75,-6.67,;8.1,-7.44,;8.09,-8.98,;6.76,-9.75,;6.75,-11.29,;2.76,-8.96,;2.76,-7.42,;-5.23,-12.05,;-6.57,-11.29,;-6.57,-9.74,;-7.9,-8.97,;-9.24,-9.74,;-10.57,-8.97,;-10.57,-7.43,;-9.24,-6.66,;-7.9,-7.44,;-6.57,-6.68,;-6.56,-5.14,;-5.23,-4.37,;-7.9,-4.36,;-9.24,-5.13,)| Show InChI InChI=1S/C35H38N8O3/c1-23-9-7-10-24(2)31(23)43-33(44)26-22-36-34(39-32(26)42-28-12-6-5-11-27(28)38-35(42)43)37-25-13-14-29(30(21-25)45-4)46-20-8-15-41-18-16-40(3)17-19-41/h5-7,9-14,21-22H,8,15-20H2,1-4H3,(H,36,37,39) | PDB
MMDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374626
(CHEMBL260963)Show SMILES COc1cccc(c1)-n1c2nc3ccccc3n2c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O Show InChI InChI=1S/C30H28N8O2/c1-35-14-16-36(17-15-35)21-12-10-20(11-13-21)32-29-31-19-24-27(34-29)38-26-9-4-3-8-25(26)33-30(38)37(28(24)39)22-6-5-7-23(18-22)40-2/h3-13,18-19H,14-17H2,1-2H3,(H,31,32,34) | PDB
UniProtKB/SwissProt
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PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
MMDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Syk by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374609
(CHEMBL270777)Show SMILES COc1cc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc(OC)c1OC |(-10.47,-11.17,;-9.13,-11.93,;-7.8,-11.16,;-6.47,-11.93,;-5.15,-11.16,;-3.81,-11.93,;-2.48,-11.16,;-2.48,-9.62,;-1.15,-8.85,;.19,-9.61,;.19,-11.16,;-1.15,-11.93,;1.53,-11.93,;2.86,-11.16,;4,-12.19,;3.37,-13.6,;3.99,-15,;3.09,-16.23,;1.55,-16.07,;.94,-14.66,;1.85,-13.43,;2.86,-9.61,;4.2,-8.84,;4.19,-7.31,;2.86,-6.54,;5.52,-6.54,;6.86,-7.31,;6.86,-8.85,;5.53,-9.62,;5.52,-11.16,;1.52,-8.83,;1.52,-7.29,;-5.13,-9.62,;-6.46,-8.84,;-6.46,-7.3,;-5.13,-6.54,;-7.8,-9.61,;-9.13,-8.84,;-10.47,-9.61,)| Show InChI InChI=1S/C29H26N6O4/c1-16-9-8-10-17(2)24(16)35-27(36)19-15-30-28(31-18-13-22(37-3)25(39-5)23(14-18)38-4)33-26(19)34-21-12-7-6-11-20(21)32-29(34)35/h6-15H,1-5H3,(H,30,31,33) | PDB
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PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374622
(CHEMBL407279)Show SMILES COc1cc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)ccc1OCCN1CCN(C)CC1 |(21.28,-33.67,;19.94,-34.43,;19.94,-35.97,;21.27,-36.75,;21.26,-38.29,;22.59,-39.06,;23.92,-38.29,;23.93,-36.75,;25.25,-35.98,;26.59,-36.74,;26.59,-38.29,;25.26,-39.06,;27.93,-39.06,;28.25,-40.56,;27.34,-41.79,;27.96,-43.2,;29.49,-43.36,;30.39,-42.13,;29.78,-40.73,;30.41,-39.32,;29.27,-38.29,;29.27,-36.74,;30.6,-35.97,;30.6,-34.44,;29.26,-33.67,;31.93,-33.67,;33.27,-34.44,;33.26,-35.98,;31.93,-36.75,;31.92,-38.29,;27.93,-35.96,;27.93,-34.42,;19.94,-39.06,;18.6,-38.29,;18.6,-36.74,;17.27,-35.97,;15.93,-36.74,;14.6,-35.97,;14.6,-34.43,;15.92,-33.65,;15.91,-32.12,;14.58,-31.36,;14.57,-29.82,;13.25,-32.14,;13.26,-33.68,)| Show InChI InChI=1S/C34H36N8O3/c1-22-8-7-9-23(2)30(22)42-32(43)25-21-35-33(38-31(25)41-27-11-6-5-10-26(27)37-34(41)42)36-24-12-13-28(29(20-24)44-4)45-19-18-40-16-14-39(3)15-17-40/h5-13,20-21H,14-19H2,1-4H3,(H,35,36,38) | PDB
MMDB
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antibodypedia
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PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50374613
(CHEMBL270085)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2ccc(C)cc2)c3=O)cc1 Show InChI InChI=1S/C30H28N8O/c1-20-7-11-23(12-8-20)37-28(39)24-19-31-29(34-27(24)38-26-6-4-3-5-25(26)33-30(37)38)32-21-9-13-22(14-10-21)36-17-15-35(2)16-18-36/h3-14,19H,15-18H2,1-2H3,(H,31,32,34) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Lck by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374623
(CHEMBL261174)Show SMILES CN(C)CCCOc1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc1 |(-10.01,-30.27,;-10.01,-31.81,;-11.34,-32.58,;-8.68,-32.58,;-8.68,-34.12,;-7.35,-34.89,;-7.35,-36.43,;-6.01,-37.2,;-4.68,-36.43,;-3.34,-37.2,;-3.36,-38.74,;-2.02,-39.51,;-.69,-38.74,;-.69,-37.2,;.64,-36.43,;1.98,-37.19,;1.98,-38.74,;.64,-39.52,;3.31,-39.51,;3.63,-41.01,;2.73,-42.24,;3.34,-43.65,;4.87,-43.82,;5.78,-42.58,;5.16,-41.18,;5.79,-39.78,;4.65,-38.74,;4.65,-37.19,;5.99,-36.43,;5.98,-34.89,;4.65,-34.13,;7.31,-34.12,;8.65,-34.89,;8.65,-36.44,;7.31,-37.2,;7.31,-38.74,;3.31,-36.42,;3.31,-34.88,;-4.68,-39.51,;-6.01,-38.74,)| Show InChI InChI=1S/C31H31N7O2/c1-20-9-7-10-21(2)27(20)38-29(39)24-19-32-30(33-22-13-15-23(16-14-22)40-18-8-17-36(3)4)35-28(24)37-26-12-6-5-11-25(26)34-31(37)38/h5-7,9-16,19H,8,17-18H2,1-4H3,(H,32,33,35) | PDB
MMDB
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DrugBank
antibodypedia
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PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Btk by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374624
(CHEMBL410892)Show SMILES CN(C)CCOc1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(C)cccc2C)c3=O)cc1 |(11.02,-18.02,;12.35,-18.79,;13.68,-18.02,;12.35,-20.33,;13.68,-21.1,;15.02,-20.33,;16.35,-21.1,;17.69,-20.33,;19.02,-21.11,;19.01,-22.65,;20.34,-23.42,;21.67,-22.65,;21.68,-21.11,;23,-20.34,;24.34,-21.1,;24.34,-22.65,;23.01,-23.42,;25.68,-23.42,;26,-24.92,;25.09,-26.15,;25.71,-27.56,;27.24,-27.72,;28.14,-26.49,;27.52,-25.09,;28.16,-23.68,;27.01,-22.65,;27.02,-21.1,;28.35,-20.33,;28.35,-18.8,;27.01,-18.03,;29.68,-18.03,;31.02,-18.8,;31.01,-20.34,;29.68,-21.11,;29.67,-22.65,;25.68,-20.32,;25.68,-18.78,;17.69,-23.42,;16.35,-22.65,)| Show InChI InChI=1S/C30H29N7O2/c1-19-8-7-9-20(2)26(19)37-28(38)23-18-31-29(32-21-12-14-22(15-13-21)39-17-16-35(3)4)34-27(23)36-25-11-6-5-10-24(25)33-30(36)37/h5-15,18H,16-17H2,1-4H3,(H,31,32,34) | PDB
MMDB
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antibodypedia
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PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50374628
(CHEMBL271131)Show SMILES COc1cc(Nc2ncnc(n2)-n2c(Nc3ccccc3)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C25H23N7O3/c1-33-20-13-17(14-21(34-2)22(20)35-3)28-23-26-15-27-24(31-23)32-19-12-8-7-11-18(19)30-25(32)29-16-9-5-4-6-10-16/h4-15H,1-3H3,(H,29,30)(H,26,27,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 463 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38-alpha by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50374614
(CHEMBL254674)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(Cl)cc(Cl)cc2Cl)c3=O)cc1 |(13.38,-19.23,;14.71,-20,;16.05,-19.24,;17.38,-20.01,;17.37,-21.55,;16.04,-22.32,;14.71,-21.55,;18.7,-22.32,;20.04,-21.55,;21.37,-22.32,;21.36,-23.86,;22.69,-24.63,;24.03,-23.87,;24.03,-22.32,;25.35,-21.55,;26.7,-22.31,;26.69,-23.86,;25.36,-24.64,;28.03,-24.63,;28.35,-26.13,;27.44,-27.37,;28.06,-28.77,;29.59,-28.94,;30.49,-27.7,;29.88,-26.3,;30.51,-24.9,;29.37,-23.86,;29.37,-22.32,;30.7,-21.55,;30.7,-20.01,;29.36,-19.25,;32.03,-19.24,;33.37,-20.02,;34.7,-19.25,;33.37,-21.56,;32.03,-22.32,;32.03,-23.86,;28.03,-21.54,;28.03,-20,;20.04,-24.63,;18.71,-23.87,)| Show InChI InChI=1S/C29H23Cl3N8O/c1-37-10-12-38(13-11-37)19-8-6-18(7-9-19)34-28-33-16-20-26(36-28)39-24-5-3-2-4-23(24)35-29(39)40(27(20)41)25-21(31)14-17(30)15-22(25)32/h2-9,14-16H,10-13H2,1H3,(H,33,34,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50374615
(CHEMBL406661)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c4ccccc4nc2n(-c2c(Cl)cccc2Cl)c3=O)cc1 |(-12.03,-20.12,;-10.7,-20.89,;-9.36,-20.13,;-8.03,-20.9,;-8.04,-22.44,;-9.37,-23.21,;-10.7,-22.44,;-6.71,-23.21,;-5.37,-22.44,;-4.04,-23.21,;-4.05,-24.75,;-2.72,-25.52,;-1.38,-24.76,;-1.38,-23.21,;-.06,-22.44,;1.29,-23.2,;1.28,-24.75,;-.05,-25.53,;2.62,-25.52,;2.94,-27.02,;2.03,-28.26,;2.65,-29.66,;4.18,-29.83,;5.08,-28.59,;4.47,-27.19,;5.1,-25.79,;3.96,-24.75,;3.96,-23.21,;5.29,-22.44,;5.29,-20.9,;3.95,-20.14,;6.62,-20.13,;7.96,-20.91,;7.96,-22.45,;6.62,-23.21,;6.62,-24.75,;2.62,-22.43,;2.62,-20.89,;-5.37,-25.52,;-6.7,-24.76,)| Show InChI InChI=1S/C29H24Cl2N8O/c1-36-13-15-37(16-14-36)19-11-9-18(10-12-19)33-28-32-17-20-26(35-28)38-24-8-3-2-7-23(24)34-29(38)39(27(20)40)25-21(30)5-4-6-22(25)31/h2-12,17H,13-16H2,1H3,(H,32,33,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of b-Raf by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Kit by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374612
(CHEMBL409447)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2cccc(C)c2)c3=O)cc1 Show InChI InChI=1S/C30H28N8O/c1-20-6-5-7-23(18-20)37-28(39)24-19-31-29(34-27(24)38-26-9-4-3-8-25(26)33-30(37)38)32-21-10-12-22(13-11-21)36-16-14-35(2)15-17-36/h3-13,18-19H,14-17H2,1-2H3,(H,31,32,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50374608
(CHEMBL410295)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 |(-5.07,-9.29,;-3.87,-8.32,;-4.12,-6.8,;-2.92,-5.83,;-1.48,-6.38,;-1.24,-7.9,;-2.43,-8.87,;-.29,-5.41,;1.15,-5.96,;2.35,-4.99,;2.11,-3.47,;3.3,-2.5,;3.06,-.98,;4.25,-.01,;4.01,1.51,;2.57,2.06,;1.38,1.09,;1.62,-.43,;-.06,1.64,;-.3,3.16,;-1.82,3.4,;-2.52,2.03,;-4.01,1.63,;-4.41,.14,;-3.32,-.95,;-1.83,-.55,;-1.43,.94,;.89,4.13,;.65,5.65,;-.79,6.2,;-1.98,5.23,;-1.03,7.72,;.17,8.7,;1.6,8.15,;1.85,6.62,;3.28,6.07,;2.33,3.58,;3.53,4.55,;.67,-2.92,;-.53,-3.89,)| Show InChI InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tyk2 by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50374611
(CHEMBL406684)Show SMILES COc1ccc(Cl)cc1-n1c2nc3ccccc3n2c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O |(29.7,-42.87,;29.7,-44.41,;31.04,-45.18,;32.37,-44.41,;33.71,-45.18,;33.7,-46.72,;35.03,-47.5,;32.37,-47.49,;31.04,-46.72,;29.71,-47.48,;29.7,-49.03,;30.85,-50.07,;30.21,-51.47,;30.83,-52.87,;29.93,-54.11,;28.39,-53.94,;27.78,-52.53,;28.69,-51.3,;28.37,-49.8,;27.03,-49.03,;25.69,-49.8,;24.36,-49.03,;23.03,-49.8,;21.7,-49.03,;21.71,-47.49,;20.38,-46.72,;19.04,-47.48,;19.04,-49.03,;20.38,-49.8,;17.71,-46.71,;17.71,-45.18,;16.39,-44.41,;15.05,-45.17,;13.72,-44.4,;15.04,-46.71,;16.38,-47.49,;24.37,-47.49,;25.69,-46.72,;27.03,-47.48,;28.37,-46.7,;28.36,-45.16,)| Show InChI InChI=1S/C30H27ClN8O2/c1-36-13-15-37(16-14-36)21-10-8-20(9-11-21)33-29-32-18-22-27(35-29)38-24-6-4-3-5-23(24)34-30(38)39(28(22)40)25-17-19(31)7-12-26(25)41-2/h3-12,17-18H,13-16H2,1-2H3,(H,32,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Src by HTRF assay |
J Med Chem 51: 1637-48 (2008)
Article DOI: 10.1021/jm701095m
BindingDB Entry DOI: 10.7270/Q23B6114 |
More data for this
Ligand-Target Pair | |
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