Found 33 hits Enz. Inhib. hit(s) with all data for entry = 50038651 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272695
(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)Show SMILES CCC(CC)c1cc(C)nn2c(c(C)nc12)-c1sc(nc1Cl)N1CCOCC1 |(8.98,-11.26,;8.98,-12.8,;7.65,-13.58,;6.32,-12.81,;4.99,-13.59,;7.66,-15.12,;6.34,-15.89,;6.33,-17.43,;5,-18.2,;7.67,-18.2,;9.01,-17.43,;10.49,-17.9,;11.4,-16.64,;12.94,-16.63,;10.48,-15.39,;9,-15.88,;10.98,-19.36,;12.45,-19.83,;12.46,-21.37,;11,-21.85,;10.09,-20.61,;8.55,-20.62,;13.71,-22.26,;13.55,-23.79,;14.79,-24.69,;16.2,-24.06,;16.36,-22.53,;15.11,-21.62,)| Show InChI InChI=1S/C20H26ClN5OS/c1-5-14(6-2)15-11-12(3)24-26-16(13(4)22-19(15)26)17-18(21)23-20(28-17)25-7-9-27-10-8-25/h11,14H,5-10H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272638
(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)Show SMILES CCCN(CCC)c1c(C)nc(nc1OC)-c1c(OC)cc(Cl)cc1OC Show InChI InChI=1S/C20H28ClN3O3/c1-7-9-24(10-8-2)18-13(3)22-19(23-20(18)27-6)17-15(25-4)11-14(21)12-16(17)26-5/h11-12H,7-10H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50348828
(CHEMBL1628268 | SR-125543A)Show SMILES COc1cc(Cl)c(cc1C)-c1nc(sc1C)N(CC#C)[C@@H](CC1CC1)c1ccc(C)c(F)c1 |r| Show InChI InChI=1S/C27H28ClFN2OS/c1-6-11-31(24(13-19-8-9-19)20-10-7-16(2)23(29)14-20)27-30-26(18(4)33-27)21-12-17(3)25(32-5)15-22(21)28/h1,7,10,12,14-15,19,24H,8-9,11,13H2,2-5H3/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM29442
(CHEMBL524616 | Pyrazolo[1,5-a]-1,3,5-triazine, 12-...)Show SMILES COCC(COC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C |(2.32,11.47,;1.92,9.99,;.43,9.59,;-.06,8.13,;.95,6.97,;2.44,7.37,;3.53,6.28,;-1.57,7.83,;-2.07,6.37,;-3.58,6.06,;-4.07,4.61,;-5.58,4.3,;-3.05,3.45,;-1.54,3.75,;-.31,2.83,;.95,3.72,;2.41,3.23,;.49,5.19,;-1.05,5.21,;-.33,1.29,;-1.66,.52,;-1.66,-1.02,;-.33,-1.79,;-.33,-3.33,;1.01,-4.1,;1.01,-1.02,;1.01,.52,;2.34,1.29,)| Show InChI InChI=1S/C20H27N5O3/c1-12-9-16(28-6)7-8-17(12)18-13(2)24-25-19(18)21-14(3)22-20(25)23-15(10-26-4)11-27-5/h7-9,15H,10-11H2,1-6H3,(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50058163
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
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Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50116105
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272702
(4-methoxy-2-(2-methoxy-4,6-bis(trifluoromethyl)phe...)Show SMILES CCCN(CCC)c1c(C)nc(nc1OC)-c1c(OC)cc(cc1C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C21H25F6N3O2/c1-6-8-30(9-7-2)17-12(3)28-18(29-19(17)32-5)16-14(21(25,26)27)10-13(20(22,23)24)11-15(16)31-4/h10-11H,6-9H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50231921
(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)Show SMILES CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 |(18.7,-17.27,;20.04,-16.5,;21.37,-17.27,;22.7,-16.5,;22.7,-14.96,;21.37,-14.19,;21.37,-12.65,;24.04,-17.26,;25.36,-16.49,;25.36,-14.95,;26.7,-17.26,;26.71,-18.81,;28.04,-19.58,;28.04,-21.12,;26.71,-21.89,;29.37,-21.89,;30.71,-21.11,;32.04,-21.88,;30.7,-19.57,;29.37,-18.8,;29.36,-17.26,;30.69,-16.49,;25.37,-19.58,;25.37,-21.11,;24.05,-21.88,;22.71,-21.11,;22.71,-19.58,;24.04,-18.81,)| Show InChI InChI=1S/C25H32N2O/c1-7-13-27(14-8-2)25-19(5)26-24(20-11-9-10-12-21(20)25)23-18(4)15-17(3)16-22(23)28-6/h9-12,15-16H,7-8,13-14H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272703
(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)Show InChI InChI=1S/C20H28N2O3/c1-8-15(9-2)25-18-14(5)21-19(22-20(18)24-7)17-13(4)10-12(3)11-16(17)23-6/h10-11,15H,8-9H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272705
(2-(4-(difluoromethyl)-2,6-dimethoxyphenyl)-4-metho...)Show SMILES CCC(CC)Oc1c(C)nc(nc1OC)-c1c(OC)cc(cc1OC)C(F)F Show InChI InChI=1S/C20H26F2N2O4/c1-7-13(8-2)28-17-11(3)23-19(24-20(17)27-6)16-14(25-4)9-12(18(21)22)10-15(16)26-5/h9-10,13,18H,7-8H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272704
(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)Show InChI InChI=1S/C19H25ClN2O4/c1-7-13(8-2)26-17-11(3)21-18(22-19(17)25-6)16-14(23-4)9-12(20)10-15(16)24-5/h9-10,13H,7-8H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272750
(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)Show InChI InChI=1S/C21H31N3O2/c1-8-10-24(11-9-2)19-16(5)22-20(23-21(19)26-7)18-15(4)12-14(3)13-17(18)25-6/h12-13H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272753
(4-ethoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methyl...)Show InChI InChI=1S/C22H33N3O2/c1-8-11-25(12-9-2)20-17(6)23-21(24-22(20)27-10-3)19-16(5)13-15(4)14-18(19)26-7/h13-14H,8-12H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272636
(4-ethyl-6-methoxy-2-(2-methoxy-4,6-dimethylphenyl)...)Show InChI InChI=1S/C22H33N3O2/c1-8-11-25(12-9-2)20-17(10-3)23-21(24-22(20)27-7)19-16(5)13-15(4)14-18(19)26-6/h13-14H,8-12H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272751
(4-chloro-2-(2-methoxy-4,6-dimethylphenyl)-6-methyl...)Show InChI InChI=1S/C20H28ClN3O/c1-7-9-24(10-8-2)18-15(5)22-20(23-19(18)21)17-14(4)11-13(3)12-16(17)25-6/h11-12H,7-10H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272754
(2-(2-methoxy-4,6-dimethylphenyl)-4-methyl-6-propox...)Show SMILES CCCOc1nc(nc(C)c1N(CCC)CCC)-c1c(C)cc(C)cc1OC Show InChI InChI=1S/C23H35N3O2/c1-8-11-26(12-9-2)21-18(6)24-22(25-23(21)28-13-10-3)20-17(5)14-16(4)15-19(20)27-7/h14-15H,8-13H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272637
(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-N,N,6-t...)Show SMILES CCCN(CCC)c1c(CCC)nc(nc1OC)-c1c(C)cc(C)cc1OC Show InChI InChI=1S/C23H35N3O2/c1-8-11-18-21(26(12-9-2)13-10-3)23(28-7)25-22(24-18)20-17(5)14-16(4)15-19(20)27-6/h14-15H,8-13H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272640
(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)Show InChI InChI=1S/C20H29N3O2/c1-8-15(9-2)22-18-14(5)21-19(23-20(18)25-7)17-13(4)10-12(3)11-16(17)24-6/h10-11,15,22H,8-9H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272697
(2-(2,6-dimethoxyphenyl)-4-methoxy-6-methyl-N,N-dip...)Show InChI InChI=1S/C20H29N3O3/c1-7-12-23(13-8-2)18-14(3)21-19(22-20(18)26-6)17-15(24-4)10-9-11-16(17)25-5/h9-11H,7-8,12-13H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 277 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272752
(2-mesityl-4-methoxy-6-methyl-N,N-dipropylpyrimidin...)Show InChI InChI=1S/C21H31N3O/c1-8-10-24(11-9-2)19-17(6)22-20(23-21(19)25-7)18-15(4)12-14(3)13-16(18)5/h12-13H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 354 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272701
(2-(2,4-dimethoxyphenyl)-4-methoxy-6-methyl-N,N-dip...)Show InChI InChI=1S/C20H29N3O3/c1-7-11-23(12-8-2)18-14(3)21-19(22-20(18)26-6)16-10-9-15(24-4)13-17(16)25-5/h9-10,13H,7-8,11-12H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 507 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272696
(2-(2-methoxy-4,6-dimethylphenyl)-4-methyl-N,N-dipr...)Show InChI InChI=1S/C20H29N3O/c1-7-9-23(10-8-2)17-13-21-20(22-16(17)5)19-15(4)11-14(3)12-18(19)24-6/h11-13H,7-10H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 561 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272699
(1-(5-(dipropylamino)-6-methoxy-2-(2-methoxy-4,6-di...)Show SMILES CCCN(CCC)c1c(CC(C)(C)O)nc(nc1OC)-c1c(C)cc(C)cc1OC Show InChI InChI=1S/C24H37N3O3/c1-9-11-27(12-10-2)21-18(15-24(5,6)28)25-22(26-23(21)30-8)20-17(4)13-16(3)14-19(20)29-7/h13-14,28H,9-12,15H2,1-8H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 604 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272698
(1-(5-(dipropylamino)-6-methoxy-2-(2-methoxy-4,6-di...)Show SMILES CCCN(CCC)c1c(CC(C)O)nc(nc1OC)-c1c(C)cc(C)cc1OC Show InChI InChI=1S/C23H35N3O3/c1-8-10-26(11-9-2)21-18(14-17(5)27)24-22(25-23(21)29-7)20-16(4)12-15(3)13-19(20)28-6/h12-13,17,27H,8-11,14H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272635
(2-(5-(dipropylamino)-2-(2-methoxy-4,6-dimethylphen...)Show SMILES CCCN(CCC)c1c(C)nc(nc1OCCO)-c1c(C)cc(C)cc1OC Show InChI InChI=1S/C22H33N3O3/c1-7-9-25(10-8-2)20-17(5)23-21(24-22(20)28-12-11-26)19-16(4)13-15(3)14-18(19)27-6/h13-14,26H,7-12H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272634
(4-isopropoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-me...)Show SMILES CCCN(CCC)c1c(C)nc(nc1OC(C)C)-c1c(C)cc(C)cc1OC Show InChI InChI=1S/C23H35N3O2/c1-9-11-26(12-10-2)21-18(7)24-22(25-23(21)28-15(3)4)20-17(6)13-16(5)14-19(20)27-8/h13-15H,9-12H2,1-8H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272639
(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)Show InChI InChI=1S/C18H25N3O2/c1-7-8-19-16-13(4)20-17(21-18(16)23-6)15-12(3)9-11(2)10-14(15)22-5/h9-10,19H,7-8H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272641
(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)Show SMILES COc1cc(C)cc(C)c1-c1nc(C)c(NCC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C20H29N3O2/c1-12-9-13(2)16(15(10-12)24-7)18-22-14(3)17(19(23-18)25-8)21-11-20(4,5)6/h9-10,21H,11H2,1-8H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272700
(2-(2,4-dichlorophenyl)-4-methoxy-6-methyl-N,N-dipr...)Show InChI InChI=1S/C18H23Cl2N3O/c1-5-9-23(10-6-2)16-12(3)21-17(22-18(16)24-4)14-8-7-13(19)11-15(14)20/h7-8,11H,5-6,9-10H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272638
(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)Show SMILES CCCN(CCC)c1c(C)nc(nc1OC)-c1c(OC)cc(Cl)cc1OC Show InChI InChI=1S/C20H28ClN3O3/c1-7-9-24(10-8-2)18-13(3)22-19(23-20(18)27-6)17-15(25-4)11-14(21)12-16(17)26-5/h11-12H,7-10H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulation |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272704
(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)Show InChI InChI=1S/C19H25ClN2O4/c1-7-13(8-2)26-17-11(3)21-18(22-19(17)25-6)16-14(23-4)9-12(20)10-15(16)24-5/h9-10,13H,7-8H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulation |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50231921
(1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N,N-dipr...)Show SMILES CCCN(CCC)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 |(18.7,-17.27,;20.04,-16.5,;21.37,-17.27,;22.7,-16.5,;22.7,-14.96,;21.37,-14.19,;21.37,-12.65,;24.04,-17.26,;25.36,-16.49,;25.36,-14.95,;26.7,-17.26,;26.71,-18.81,;28.04,-19.58,;28.04,-21.12,;26.71,-21.89,;29.37,-21.89,;30.71,-21.11,;32.04,-21.88,;30.7,-19.57,;29.37,-18.8,;29.36,-17.26,;30.69,-16.49,;25.37,-19.58,;25.37,-21.11,;24.05,-21.88,;22.71,-21.11,;22.71,-19.58,;24.04,-18.81,)| Show InChI InChI=1S/C25H32N2O/c1-7-13-27(14-8-2)25-19(5)26-24(20-11-9-10-12-21(20)25)23-18(4)15-17(3)16-22(23)28-6/h9-12,15-16H,7-8,13-14H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulation |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50272703
(4-methoxy-2-(2-methoxy-4,6-dimethylphenyl)-6-methy...)Show InChI InChI=1S/C20H28N2O3/c1-8-15(9-2)25-18-14(5)21-19(22-20(18)24-7)17-13(4)10-12(3)11-16(17)23-6/h10-11,15H,8-9H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurogen Corporation
Curated by ChEMBL
| Assay Description
Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulation |
Bioorg Med Chem Lett 18: 4486-90 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4 |
More data for this
Ligand-Target Pair | |
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