Found 44 hits Enz. Inhib. hit(s) with all data for entry = 50039347 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335202
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 |r| Show InChI InChI=1S/C14H14ClFN8O/c1-7(12-17-4-8(16)5-18-12)20-14-19-6-9(15)13(22-14)21-10-3-11(25-2)24-23-10/h3-7H,1-2H3,(H3,19,20,21,22,23,24)/t7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of TrkA |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335203
(CHEMBL1650698 | N4-(5-Cyclopropyl-1H-pyrazol-3-yl)...)Show SMILES C[C@H](Nc1ncc(F)c(Nc2cc(n[nH]2)C2CC2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C16H16F2N8/c1-8(14-19-5-10(17)6-20-14)22-16-21-7-11(18)15(24-16)23-13-4-12(25-26-13)9-2-3-9/h4-9H,2-3H2,1H3,(H3,21,22,23,24,25,26)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335212
(CHEMBL1650725 | N2-[(1S)-1-(5-fluoropyrimidin-2-yl...)Show SMILES C[C@H](Nc1ncc(C)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17FN8/c1-8-5-19-15(20-10(3)14-17-6-11(16)7-18-14)22-13(8)21-12-4-9(2)23-24-12/h4-7,10H,1-3H3,(H3,19,20,21,22,23,24)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335210
(5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2Cl)[nH]n1 |r| Show InChI InChI=1S/C18H21ClFN9O2/c1-10(15-21-8-11(20)9-22-15)23-18-25-16(24-12-7-13(30-2)28-27-12)14(19)17(26-18)29-3-5-31-6-4-29/h7-10H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335209
(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2F)[nH]n1 |r| Show InChI InChI=1S/C18H21F2N9O2/c1-10(15-21-8-11(19)9-22-15)23-18-25-16(24-12-7-13(30-2)28-27-12)14(20)17(26-18)29-3-5-31-6-4-29/h7-10H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335205
(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)[nH]n1 |r| Show InChI InChI=1S/C14H14BrFN8O/c1-7(12-17-4-8(16)5-18-12)20-14-19-6-9(15)13(22-14)21-10-3-11(25-2)24-23-10/h3-7H,1-2H3,(H3,19,20,21,22,23,24)/t7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335211
(5-Fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(F)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14F2N8/c1-7-3-11(24-23-7)21-13-10(16)6-19-14(22-13)20-8(2)12-17-4-9(15)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335209
(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2F)[nH]n1 |r| Show InChI InChI=1S/C18H21F2N9O2/c1-10(15-21-8-11(19)9-22-15)23-18-25-16(24-12-7-13(30-2)28-27-12)14(20)17(26-18)29-3-5-31-6-4-29/h7-10H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335206
(5-chloro-N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-N2...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(n[nH]2)N(C)C)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17ClFN9/c1-8(13-18-5-9(17)6-19-13)21-15-20-7-10(16)14(23-15)22-11-4-12(25-24-11)26(2)3/h4-8H,1-3H3,(H3,20,21,22,23,24,25)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335215
((S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-...)Show SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(Cl)c(n1)N1CCOCC1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C18H21ClFN9O/c1-10-7-13(28-27-10)24-16-14(19)17(29-3-5-30-6-4-29)26-18(25-16)23-11(2)15-21-8-12(20)9-22-15/h7-9,11H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t11-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335208
(CHEMBL1650735 | N2-[(1S)-1-(5-fluoropyrimidin-2-yl...)Show SMILES COc1cc(Nc2cc(nc(N[C@@H](C)c3ncc(F)cn3)n2)N2CCOCC2)[nH]n1 |r| Show InChI InChI=1S/C18H22FN9O2/c1-11(17-20-9-12(19)10-21-17)22-18-24-13(23-14-8-16(29-2)27-26-14)7-15(25-18)28-3-5-30-6-4-28/h7-11H,3-6H2,1-2H3,(H3,22,23,24,25,26,27)/t11-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335214
(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)Show SMILES C[C@H](Nc1ncc(Br)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14BrFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335207
(CHEMBL1650731 | N4-[5-(dimethylamino)-1H-pyrazol-3...)Show SMILES C[C@H](Nc1ncc(F)c(Nc2cc(n[nH]2)N(C)C)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17F2N9/c1-8(13-18-5-9(16)6-19-13)21-15-20-7-10(17)14(23-15)22-11-4-12(25-24-11)26(2)3/h4-8H,1-3H3,(H3,20,21,22,23,24,25)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335213
((S)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)Show SMILES C[C@H](Oc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H13ClFN7O/c1-7-3-11(23-22-7)20-13-10(15)6-19-14(21-13)24-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H2,19,20,21,22,23)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blotting |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 5A
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blotting |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335208
(CHEMBL1650735 | N2-[(1S)-1-(5-fluoropyrimidin-2-yl...)Show SMILES COc1cc(Nc2cc(nc(N[C@@H](C)c3ncc(F)cn3)n2)N2CCOCC2)[nH]n1 |r| Show InChI InChI=1S/C18H22FN9O2/c1-11(17-20-9-12(19)10-21-17)22-18-24-13(23-14-8-16(29-2)27-26-14)7-15(25-18)28-3-5-30-6-4-28/h7-11H,3-6H2,1-2H3,(H3,22,23,24,25,26,27)/t11-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335216
(CHEMBL1650732 | N2-[(1S)-1-(5-Fluoropyrimidin-2-yl...)Show SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)cc(n1)N1CCOCC1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C18H22FN9O/c1-11-7-15(27-26-11)23-14-8-16(28-3-5-29-6-4-28)25-18(24-14)22-12(2)17-20-9-13(19)10-21-17/h7-10,12H,3-6H2,1-2H3,(H3,22,23,24,25,26,27)/t12-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Signal transducer and activator of transcription 5A
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blotting |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Signal transducer and activator of transcription 3
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blotting |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335210
(5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2Cl)[nH]n1 |r| Show InChI InChI=1S/C18H21ClFN9O2/c1-10(15-21-8-11(20)9-22-15)23-18-25-16(24-12-7-13(30-2)28-27-12)14(19)17(26-18)29-3-5-31-6-4-29/h7-10H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335205
(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)[nH]n1 |r| Show InChI InChI=1S/C14H14BrFN8O/c1-7(12-17-4-8(16)5-18-12)20-14-19-6-9(15)13(22-14)21-10-3-11(25-2)24-23-10/h3-7H,1-2H3,(H3,19,20,21,22,23,24)/t7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335202
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 |r| Show InChI InChI=1S/C14H14ClFN8O/c1-7(12-17-4-8(16)5-18-12)20-14-19-6-9(15)13(22-14)21-10-3-11(25-2)24-23-10/h3-7H,1-2H3,(H3,19,20,21,22,23,24)/t7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335208
(CHEMBL1650735 | N2-[(1S)-1-(5-fluoropyrimidin-2-yl...)Show SMILES COc1cc(Nc2cc(nc(N[C@@H](C)c3ncc(F)cn3)n2)N2CCOCC2)[nH]n1 |r| Show InChI InChI=1S/C18H22FN9O2/c1-11(17-20-9-12(19)10-21-17)22-18-24-13(23-14-8-16(29-2)27-26-14)7-15(25-18)28-3-5-30-6-4-28/h7-11H,3-6H2,1-2H3,(H3,22,23,24,25,26,27)/t11-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335204
((R)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)Show SMILES C[C@@H](Oc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H13ClFN7O/c1-7-3-11(23-22-7)20-13-10(15)6-19-14(21-13)24-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H2,19,20,21,22,23)/t8-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 346 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using Km ATP concentration |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335206
(5-chloro-N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-N2...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(n[nH]2)N(C)C)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17ClFN9/c1-8(13-18-5-9(17)6-19-13)21-15-20-7-10(16)14(23-15)22-11-4-12(25-24-11)26(2)3/h4-8H,1-3H3,(H3,20,21,22,23,24,25)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 488 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335207
(CHEMBL1650731 | N4-[5-(dimethylamino)-1H-pyrazol-3...)Show SMILES C[C@H](Nc1ncc(F)c(Nc2cc(n[nH]2)N(C)C)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17F2N9/c1-8(13-18-5-9(16)6-19-13)21-15-20-7-10(17)14(23-15)22-11-4-12(25-24-11)26(2)3/h4-8H,1-3H3,(H3,20,21,22,23,24,25)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 815 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50335204
((R)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)Show SMILES C[C@@H](Oc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H13ClFN7O/c1-7-3-11(23-22-7)20-13-10(15)6-19-14(21-13)24-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H2,19,20,21,22,23)/t8-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK2 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335201
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335210
(5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2Cl)[nH]n1 |r| Show InChI InChI=1S/C18H21ClFN9O2/c1-10(15-21-8-11(20)9-22-15)23-18-25-16(24-12-7-13(30-2)28-27-12)14(19)17(26-18)29-3-5-31-6-4-29/h7-10H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335214
(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)Show SMILES C[C@H](Nc1ncc(Br)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14BrFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335211
(5-Fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1ncc(F)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14F2N8/c1-7-3-11(24-23-7)21-13-10(16)6-19-14(22-13)20-8(2)12-17-4-9(15)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335212
(CHEMBL1650725 | N2-[(1S)-1-(5-fluoropyrimidin-2-yl...)Show SMILES C[C@H](Nc1ncc(C)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17FN8/c1-8-5-19-15(20-10(3)14-17-6-11(16)7-18-14)22-13(8)21-12-4-9(2)23-24-12/h4-7,10H,1-3H3,(H3,19,20,21,22,23,24)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335215
((S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-...)Show SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(Cl)c(n1)N1CCOCC1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C18H21ClFN9O/c1-10-7-13(28-27-10)24-16-14(19)17(29-3-5-30-6-4-29)26-18(25-16)23-11(2)15-21-8-12(20)9-22-15/h7-9,11H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t11-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335213
((S)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)Show SMILES C[C@H](Oc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H13ClFN7O/c1-7-3-11(23-22-7)20-13-10(15)6-19-14(21-13)24-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H2,19,20,21,22,23)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335204
((R)-5-Chloro-2-[1-(5-fluoropyrimidin-2-yl)ethoxy]-...)Show SMILES C[C@@H](Oc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H13ClFN7O/c1-7-3-11(23-22-7)20-13-10(15)6-19-14(21-13)24-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H2,19,20,21,22,23)/t8-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335202
(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 |r| Show InChI InChI=1S/C14H14ClFN8O/c1-7(12-17-4-8(16)5-18-12)20-14-19-6-9(15)13(22-14)21-10-3-11(25-2)24-23-10/h3-7H,1-2H3,(H3,19,20,21,22,23,24)/t7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335217
(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(F)c(n1)N1CCOCC1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C18H21F2N9O/c1-10-7-13(28-27-10)24-16-14(20)17(29-3-5-30-6-4-29)26-18(25-16)23-11(2)15-21-8-12(19)9-22-15/h7-9,11H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t11-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335205
(5-bromo-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)[nH]n1 |r| Show InChI InChI=1S/C14H14BrFN8O/c1-7(12-17-4-8(16)5-18-12)20-14-19-6-9(15)13(22-14)21-10-3-11(25-2)24-23-10/h3-7H,1-2H3,(H3,19,20,21,22,23,24)/t7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335207
(CHEMBL1650731 | N4-[5-(dimethylamino)-1H-pyrazol-3...)Show SMILES C[C@H](Nc1ncc(F)c(Nc2cc(n[nH]2)N(C)C)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17F2N9/c1-8(13-18-5-9(16)6-19-13)21-15-20-7-10(17)14(23-15)22-11-4-12(25-24-11)26(2)3/h4-8H,1-3H3,(H3,20,21,22,23,24,25)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335206
(5-chloro-N4-[5-(dimethylamino)-1H-pyrazol-3-yl]-N2...)Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(n[nH]2)N(C)C)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C15H17ClFN9/c1-8(13-18-5-9(17)6-19-13)21-15-20-7-10(16)14(23-15)22-11-4-12(25-24-11)26(2)3/h4-8H,1-3H3,(H3,20,21,22,23,24,25)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50335209
(5-fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N3CCOCC3)c2F)[nH]n1 |r| Show InChI InChI=1S/C18H21F2N9O2/c1-10(15-21-8-11(19)9-22-15)23-18-25-16(24-12-7-13(30-2)28-27-12)14(20)17(26-18)29-3-5-31-6-4-29/h7-10H,3-6H2,1-2H3,(H3,23,24,25,26,27,28)/t10-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D
Curated by ChEMBL
| Assay Description Inhibition of JAK3 using 5 mM of ATP |
J Med Chem 54: 262-76 (2011)
Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM |
More data for this Ligand-Target Pair | |