Found 14 hits Enz. Inhib. hit(s) with all data for entry = 50039425 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347929
(CHEMBL1802632)Show SMILES Cc1ccc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O)C(N)=O |(3.55,-6.94,;3.56,-8.48,;4.89,-9.25,;4.9,-10.79,;3.56,-11.57,;2.23,-10.8,;2.24,-9.26,;.9,-8.49,;.9,-6.94,;2.23,-6.16,;-.44,-6.17,;-1.77,-6.95,;-3.1,-6.18,;-4.44,-6.95,;-5.77,-6.18,;-7.09,-6.95,;-8.43,-6.18,;-8.43,-4.64,;-9.77,-3.87,;-7.1,-3.87,;-5.76,-4.64,;-4.43,-3.87,;-1.77,-8.49,;-3.1,-9.26,;-.44,-9.26,;-.44,-10.8,;3.56,-13.11,;4.9,-13.87,;2.23,-13.88,)| Show InChI InChI=1S/C21H17BrF2N2O3/c1-11-3-4-13(20(25)27)8-17(11)26-12(2)7-18(19(22)21(26)28)29-10-14-5-6-15(23)9-16(14)24/h3-9H,10H2,1-2H3,(H2,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50314073
(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50314073
(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50314073
(3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-ox...)Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(29.32,-4.45,;29.32,-2.91,;27.99,-2.14,;26.65,-2.91,;27.99,-.6,;29.32,.17,;29.31,1.72,;27.98,2.48,;27.97,4.02,;26.66,1.71,;26.65,.17,;25.32,2.48,;25.32,4.03,;26.65,4.8,;23.98,4.79,;22.65,4.02,;21.32,4.79,;19.99,4.02,;18.65,4.79,;18.65,6.33,;17.32,7.1,;16,6.33,;14.66,7.1,;15.99,4.78,;17.32,4.02,;17.33,2.48,;22.65,2.48,;21.32,1.71,;23.99,1.71,;23.99,.17,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347938
(CHEMBL1802637)Show SMILES CNC(=O)c1ccc(Cl)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(35.79,-26.5,;35.75,-24.96,;37.07,-24.16,;38.42,-24.9,;37.04,-22.63,;38.37,-21.85,;38.37,-20.31,;37.03,-19.54,;37.02,-18,;35.71,-20.32,;35.71,-21.86,;34.38,-19.55,;34.37,-18,;35.7,-17.22,;33.04,-17.23,;31.71,-18.01,;30.37,-17.24,;29.04,-18.01,;27.71,-17.24,;26.38,-18.01,;25.05,-17.24,;25.04,-15.7,;23.71,-14.93,;26.38,-14.93,;27.71,-15.7,;29.05,-14.93,;31.71,-19.55,;30.37,-20.32,;33.04,-20.32,;33.04,-21.86,)| Show InChI InChI=1S/C21H16BrClF2N2O3/c1-11-7-18(30-10-13-3-5-14(24)9-16(13)25)19(22)21(29)27(11)17-8-12(20(28)26-2)4-6-15(17)23/h3-9H,10H2,1-2H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347937
(CHEMBL1802641)Show SMILES CNC(=O)c1ccc(C)c(c1)-n1c(CO)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(2.58,-49.12,;2.54,-47.58,;3.86,-46.78,;5.21,-47.52,;3.83,-45.24,;5.16,-44.47,;5.15,-42.92,;3.82,-42.16,;3.81,-40.62,;2.5,-42.93,;2.49,-44.48,;1.17,-42.17,;1.16,-40.62,;2.49,-39.84,;2.49,-38.3,;-.17,-39.85,;-1.5,-40.62,;-2.84,-39.85,;-4.17,-40.62,;-5.5,-39.85,;-6.83,-40.62,;-8.16,-39.86,;-8.17,-38.31,;-9.5,-37.55,;-6.83,-37.54,;-5.5,-38.31,;-4.16,-37.55,;-1.51,-42.17,;-2.84,-42.94,;-.17,-42.94,;-.17,-44.48,)| Show InChI InChI=1S/C22H19BrF2N2O4/c1-12-3-4-13(21(29)26-2)7-18(12)27-16(10-28)9-19(20(23)22(27)30)31-11-14-5-6-15(24)8-17(14)25/h3-9,28H,10-11H2,1-2H3,(H,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347933
(CHEMBL1802636)Show SMILES CNC(=O)c1ccc(F)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(21.06,-26.62,;21.02,-25.08,;22.34,-24.28,;23.69,-25.02,;22.31,-22.75,;23.64,-21.98,;23.63,-20.43,;22.3,-19.67,;22.29,-18.13,;20.98,-20.44,;20.97,-21.98,;19.65,-19.67,;19.64,-18.12,;20.97,-17.35,;18.31,-17.36,;16.98,-18.13,;15.64,-17.36,;14.31,-18.13,;12.98,-17.36,;11.65,-18.13,;10.32,-17.37,;10.31,-15.82,;8.98,-15.05,;11.65,-15.05,;12.98,-15.82,;14.32,-15.05,;16.97,-19.67,;15.64,-20.44,;18.31,-20.45,;18.31,-21.99,)| Show InChI InChI=1S/C21H16BrF3N2O3/c1-11-7-18(30-10-13-3-5-14(23)9-16(13)25)19(22)21(29)27(11)17-8-12(20(28)26-2)4-6-15(17)24/h3-9H,10H2,1-2H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347930
(CHEMBL1802633)Show SMILES CN(C)C(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(19.71,-15.18,;19.71,-13.64,;21.04,-12.87,;18.37,-12.87,;17.04,-13.64,;18.37,-11.33,;19.71,-10.56,;19.7,-9.01,;18.36,-8.25,;18.36,-6.71,;17.05,-9.02,;17.04,-10.56,;15.71,-8.26,;15.7,-6.71,;17.04,-5.93,;14.37,-5.94,;13.04,-6.71,;11.71,-5.94,;10.37,-6.71,;9.04,-5.94,;7.72,-6.71,;6.38,-5.95,;6.38,-4.4,;5.04,-3.63,;7.71,-3.63,;9.05,-4.4,;10.38,-3.63,;13.04,-8.26,;11.7,-9.03,;14.37,-9.03,;14.37,-10.57,)| Show InChI InChI=1S/C23H21BrF2N2O3/c1-13-5-6-15(22(29)27(3)4)10-19(13)28-14(2)9-20(21(24)23(28)30)31-12-16-7-8-17(25)11-18(16)26/h5-11H,12H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347121
(CHEMBL1797224)Show SMILES Cc1cc(OCc2ccc(F)cc2F)c(Br)c(=O)n1-c1cccc(c1)C(N)=O Show InChI InChI=1S/C20H15BrF2N2O3/c1-11-7-17(28-10-13-5-6-14(22)9-16(13)23)18(21)20(27)25(11)15-4-2-3-12(8-15)19(24)26/h2-9H,10H2,1H3,(H2,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347934
(CHEMBL1802638)Show SMILES CNC(=O)c1ccc(OC)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(2.35,-36.25,;2.32,-34.71,;3.63,-33.91,;4.98,-34.65,;3.6,-32.37,;4.94,-31.6,;4.93,-30.05,;3.59,-29.29,;3.59,-27.75,;4.91,-26.97,;2.28,-30.06,;2.27,-31.6,;.94,-29.29,;.93,-27.74,;2.27,-26.97,;-.4,-26.98,;-1.73,-27.75,;-3.06,-26.98,;-4.4,-27.75,;-5.73,-26.98,;-7.05,-27.75,;-8.39,-26.99,;-8.39,-25.44,;-9.73,-24.67,;-7.06,-24.67,;-5.72,-25.44,;-4.39,-24.67,;-1.73,-29.3,;-3.07,-30.06,;-.4,-30.07,;-.4,-31.61,)| Show InChI InChI=1S/C22H19BrF2N2O4/c1-12-8-19(31-11-14-4-6-15(24)10-16(14)25)20(23)22(29)27(12)17-9-13(21(28)26-2)5-7-18(17)30-3/h4-10H,11H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347931
(CHEMBL1802634)Show SMILES CNC(=O)c1ccc(c(C)c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(41.54,-12.31,;40.21,-11.54,;38.88,-12.31,;38.88,-13.85,;37.54,-11.55,;36.21,-12.32,;34.87,-11.55,;34.88,-10.01,;36.2,-9.24,;36.19,-7.7,;37.53,-10,;33.54,-9.24,;33.54,-7.69,;34.87,-6.92,;32.2,-6.93,;30.88,-7.7,;29.54,-6.93,;28.21,-7.7,;26.87,-6.93,;25.55,-7.7,;24.22,-6.94,;24.21,-5.39,;22.88,-4.62,;25.55,-4.62,;26.88,-5.39,;28.22,-4.62,;30.87,-9.24,;29.54,-10.01,;32.21,-10.02,;32.21,-11.56,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-8-14(21(28)26-3)5-7-18(12)27-13(2)9-19(20(23)22(27)29)30-11-15-4-6-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347932
(CHEMBL1802635)Show SMILES CNC(=O)c1cccc(c1C)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(7.91,-18.61,;6.58,-19.39,;5.24,-18.63,;5.23,-17.09,;3.91,-19.4,;3.92,-20.95,;2.58,-21.72,;1.25,-20.96,;1.26,-19.41,;2.58,-18.64,;2.57,-17.1,;-.08,-18.65,;-.08,-17.1,;1.25,-16.32,;-1.42,-16.33,;-2.75,-17.1,;-4.08,-16.33,;-5.42,-17.1,;-6.75,-16.33,;-8.07,-17.1,;-9.41,-16.34,;-9.41,-14.79,;-10.75,-14.03,;-8.08,-14.02,;-6.74,-14.79,;-5.41,-14.03,;-2.75,-18.65,;-4.08,-19.42,;-1.42,-19.42,;-1.42,-20.96,)| Show InChI InChI=1S/C22H19BrF2N2O3/c1-12-9-19(30-11-14-7-8-15(24)10-17(14)25)20(23)22(29)27(12)18-6-4-5-16(13(18)2)21(28)26-3/h4-10H,11H2,1-3H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347936
(CHEMBL1802640)Show SMILES CNC(=O)c1ccc(CO)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(13.61,-21.01,;13.57,-19.47,;14.89,-18.67,;16.24,-19.41,;14.86,-17.13,;16.19,-16.36,;16.18,-14.81,;14.85,-14.05,;14.84,-12.51,;16.17,-11.73,;13.53,-14.83,;13.52,-16.37,;12.19,-14.06,;12.19,-12.51,;13.52,-11.73,;10.85,-11.74,;9.53,-12.51,;8.19,-11.74,;6.86,-12.52,;5.52,-11.75,;4.2,-12.52,;2.87,-11.75,;2.86,-10.21,;1.53,-9.44,;4.2,-9.43,;5.53,-10.2,;6.87,-9.44,;9.52,-14.06,;8.19,-14.83,;10.86,-14.83,;10.86,-16.37,)| Show InChI InChI=1S/C22H19BrF2N2O4/c1-12-7-19(31-11-15-5-6-16(24)9-17(15)25)20(23)22(30)27(12)18-8-13(21(29)26-2)3-4-14(18)10-28/h3-9,28H,10-11H2,1-2H3,(H,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 325 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50347935
(CHEMBL1802639)Show SMILES CNC(=O)c1ccc(C(O)=O)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(20.52,-39.27,;20.49,-37.73,;21.8,-36.93,;23.15,-37.67,;21.77,-35.4,;23.1,-34.62,;23.1,-33.08,;21.76,-32.32,;21.75,-30.77,;23.08,-29.99,;20.41,-30.01,;20.44,-33.09,;20.44,-34.63,;19.11,-32.32,;19.1,-30.77,;19.09,-29.23,;17.77,-30.01,;16.44,-30.78,;15.11,-30.01,;13.77,-30.78,;12.44,-30.01,;11.12,-30.78,;9.78,-30.02,;9.78,-28.47,;8.44,-27.7,;11.11,-27.7,;12.44,-28.47,;13.78,-27.7,;16.44,-32.32,;15.1,-33.09,;17.77,-33.09,;17.77,-34.63,)| Show InChI InChI=1S/C22H17BrF2N2O5/c1-11-7-18(32-10-13-3-5-14(24)9-16(13)25)19(23)21(29)27(11)17-8-12(20(28)26-2)4-6-15(17)22(30)31/h3-9H,10H2,1-2H3,(H,26,28)(H,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assay |
Bioorg Med Chem Lett 21: 4066-71 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.121
BindingDB Entry DOI: 10.7270/Q2SB46R2 |
More data for this
Ligand-Target Pair | |
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