Compile Data Set for Download or QSAR

Found 75 hits Enz. Inhib. hit(s) with all data for entry = 50039597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380636 (CHEMBL2017060) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N4CCCOCC4)c3-c2cc1OC Show InChI InChI=1S/C22H24N4O4S/c1-28-16-10-14-4-6-26-13-24-19(20(26)15(14)11-17(16)29-2)18-12-23-21(31-18)22(27)25-5-3-8-30-9-7-25/h10-13H,3-9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380643 (CHEMBL2017067) Show SMILES COc1cc2CCn3cnc(-c4cnc(CN5CCCOCC5)s4)c3-c2cc1OC Show InChI InChI=1S/C22H26N4O3S/c1-27-17-10-15-4-6-26-14-24-21(22(26)16(15)11-18(17)28-2)19-12-23-20(30-19)13-25-5-3-8-29-9-7-25/h10-12,14H,3-9,13H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380637 (CHEMBL2017061) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)NC4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C22H24N4O4S/c1-28-16-9-13-3-6-26-12-24-19(20(26)15(13)10-17(16)29-2)18-11-23-22(31-18)21(27)25-14-4-7-30-8-5-14/h9-12,14H,3-8H2,1-2H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380657 (CHEMBL2017081) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1cccc(c1)N1CCOCC1 Show InChI InChI=1S/C23H25N3O3/c1-27-20-13-16-6-7-26-15-24-22(23(26)19(16)14-21(20)28-2)17-4-3-5-18(12-17)25-8-10-29-11-9-25/h3-5,12-15H,6-11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380642 (CHEMBL2017066) Show SMILES COc1cc2CCn3cnc(-c4cnc(CN5CCOCC5)s4)c3-c2cc1OC Show InChI InChI=1S/C21H24N4O3S/c1-26-16-9-14-3-4-25-13-23-20(21(25)15(14)10-17(16)27-2)18-11-22-19(29-18)12-24-5-7-28-8-6-24/h9-11,13H,3-8,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380656 (CHEMBL2017080) Show SMILES CCOc1cccc(c1)-c1ncn2CCc3cc(OC)c(OC)cc3-c12 Show InChI InChI=1S/C21H22N2O3/c1-4-26-16-7-5-6-15(10-16)20-21-17-12-19(25-3)18(24-2)11-14(17)8-9-23(21)13-22-20/h5-7,10-13H,4,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380632 (CHEMBL2017057) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N(C)C(C)(C)C)c3-c2cc1OC Show InChI InChI=1S/C22H26N4O3S/c1-22(2,3)25(4)21(27)20-23-11-17(30-20)18-19-14-10-16(29-6)15(28-5)9-13(14)7-8-26(19)12-24-18/h9-12H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380635 (CHEMBL2017059) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C21H22N4O4S/c1-27-15-9-13-3-4-25-12-23-18(19(25)14(13)10-16(15)28-2)17-11-22-20(30-17)21(26)24-5-7-29-8-6-24/h9-12H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380663 (CHEMBL2017088) Show SMILES COc1cc2CC(C)n3cnc(c3-c2cc1OC)-c1cccnc1 Show InChI InChI=1S/C19H19N3O2/c1-12-7-14-8-16(23-2)17(24-3)9-15(14)19-18(21-11-22(12)19)13-5-4-6-20-10-13/h4-6,8-12H,7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380634 (CHEMBL2017058) Show SMILES COc1cc2CCn3c(C)nc(-c4cncs4)c3-c2cc1OC Show InChI InChI=1S/C17H17N3O2S/c1-10-19-16(15-8-18-9-23-15)17-12-7-14(22-3)13(21-2)6-11(12)4-5-20(10)17/h6-9H,4-5H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380636 (CHEMBL2017060) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N4CCCOCC4)c3-c2cc1OC Show InChI InChI=1S/C22H24N4O4S/c1-28-16-10-14-4-6-26-13-24-19(20(26)15(14)11-17(16)29-2)18-12-23-21(31-18)22(27)25-5-3-8-30-9-7-25/h10-13H,3-9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380662 (CHEMBL2017086) Show SMILES COc1cc2CCn3c(C)nc(c3-c2cc1OC)-c1cccnc1 Show InChI InChI=1S/C19H19N3O2/c1-12-21-18(14-5-4-7-20-11-14)19-15-10-17(24-3)16(23-2)9-13(15)6-8-22(12)19/h4-5,7,9-11H,6,8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380641 (CHEMBL2017065) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)N4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C20H22N4O3S/c1-25-15-9-13-3-4-24-12-22-18(19(24)14(13)10-16(15)26-2)17-11-21-20(28-17)23-5-7-27-8-6-23/h9-12H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380640 (CHEMBL2017064) Show SMILES COc1cc2CCn3cnc(-c4cnc(CO)s4)c3-c2cc1OC Show InChI InChI=1S/C17H17N3O3S/c1-22-12-5-10-3-4-20-9-19-16(14-7-18-15(8-21)24-14)17(20)11(10)6-13(12)23-2/h5-7,9,21H,3-4,8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380659 (CHEMBL2017083) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1cccnc1 Show InChI InChI=1S/C18H17N3O2/c1-22-15-8-12-5-7-21-11-20-17(13-4-3-6-19-10-13)18(21)14(12)9-16(15)23-2/h3-4,6,8-11H,5,7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380653 (CHEMBL2017078) Show SMILES COc1cccc(c1)-c1ncn2CCc3cc(OC)c(OC)cc3-c12 Show InChI InChI=1S/C20H20N2O3/c1-23-15-6-4-5-14(9-15)19-20-16-11-18(25-3)17(24-2)10-13(16)7-8-22(20)12-21-19/h4-6,9-12H,7-8H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380645 (CHEMBL2017069) Show SMILES COc1cc2CCn3cnc(-c4cnco4)c3-c2cc1OC Show InChI InChI=1S/C16H15N3O3/c1-20-12-5-10-3-4-19-8-18-15(14-7-17-9-22-14)16(19)11(10)6-13(12)21-2/h5-9H,3-4H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380655 (CHEMBL2016583) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1cccc(Br)c1 Show InChI InChI=1S/C19H17BrN2O2/c1-23-16-9-12-6-7-22-11-21-18(13-4-3-5-14(20)8-13)19(22)15(12)10-17(16)24-2/h3-5,8-11H,6-7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380650 (CHEMBL2017075) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H17ClN2O2/c1-23-16-9-12-6-7-22-11-21-18(13-4-3-5-14(20)8-13)19(22)15(12)10-17(16)24-2/h3-5,8-11H,6-7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380633 (CHEMBL2017087) Show SMILES COc1cc2CCn3cnc(-c4cncs4)c3-c2cc1OC Show InChI InChI=1S/C16H15N3O2S/c1-20-12-5-10-3-4-19-8-18-15(14-7-17-9-22-14)16(19)11(10)6-13(12)21-2/h5-9H,3-4H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380638 (CHEMBL2017062) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)NCc4ccccc4)c3-c2cc1OC Show InChI InChI=1S/C24H22N4O3S/c1-30-18-10-16-8-9-28-14-27-21(22(28)17(16)11-19(18)31-2)20-13-26-24(32-20)23(29)25-12-15-6-4-3-5-7-15/h3-7,10-11,13-14H,8-9,12H2,1-2H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380661 (CHEMBL2017085) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1cncnc1 Show InChI InChI=1S/C17H16N4O2/c1-22-14-5-11-3-4-21-10-20-16(12-7-18-9-19-8-12)17(21)13(11)6-15(14)23-2/h5-10H,3-4H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380635 (CHEMBL2017059) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C21H22N4O4S/c1-27-15-9-13-3-4-25-12-23-18(19(25)14(13)10-16(15)28-2)17-11-22-20(30-17)21(26)24-5-7-29-8-6-24/h9-12H,3-8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380660 (CHEMBL2017084) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1ccncc1 Show InChI InChI=1S/C18H17N3O2/c1-22-15-9-13-5-8-21-11-20-17(12-3-6-19-7-4-12)18(21)14(13)10-16(15)23-2/h3-4,6-7,9-11H,5,8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	101	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380654 (CHEMBL2017079) Show SMILES COc1ccc(cc1)-c1ncn2CCc3cc(OC)c(OC)cc3-c12 Show InChI InChI=1S/C20H20N2O3/c1-23-15-6-4-13(5-7-15)19-20-16-11-18(25-3)17(24-2)10-14(16)8-9-22(20)12-21-19/h4-7,10-12H,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	114	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380648 (CHEMBL2017073) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1ccccc1 Show InChI InChI=1S/C19H18N2O2/c1-22-16-10-14-8-9-21-12-20-18(13-6-4-3-5-7-13)19(21)15(14)11-17(16)23-2/h3-7,10-12H,8-9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	121	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380653 (CHEMBL2017078) Show SMILES COc1cccc(c1)-c1ncn2CCc3cc(OC)c(OC)cc3-c12 Show InChI InChI=1S/C20H20N2O3/c1-23-15-6-4-5-14(9-15)19-20-16-11-18(25-3)17(24-2)10-13(16)7-8-22(20)12-21-19/h4-6,9-12H,7-8H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	136	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380642 (CHEMBL2017066) Show SMILES COc1cc2CCn3cnc(-c4cnc(CN5CCOCC5)s4)c3-c2cc1OC Show InChI InChI=1S/C21H24N4O3S/c1-26-16-9-14-3-4-25-13-23-20(21(25)15(14)10-17(16)27-2)18-11-22-19(29-18)12-24-5-7-28-8-6-24/h9-11,13H,3-8,12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	148	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380632 (CHEMBL2017057) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N(C)C(C)(C)C)c3-c2cc1OC Show InChI InChI=1S/C22H26N4O3S/c1-22(2,3)25(4)21(27)20-23-11-17(30-20)18-19-14-10-16(29-6)15(28-5)9-13(14)7-8-26(19)12-24-18/h9-12H,7-8H2,1-6H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	149	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380641 (CHEMBL2017065) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)N4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C20H22N4O3S/c1-25-15-9-13-3-4-24-12-22-18(19(24)14(13)10-16(15)26-2)17-11-21-20(28-17)23-5-7-27-8-6-23/h9-12H,3-8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	177	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380651 (CHEMBL2017076) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H17ClN2O2/c1-23-16-9-13-7-8-22-11-21-18(12-3-5-14(20)6-4-12)19(22)15(13)10-17(16)24-2/h3-6,9-11H,7-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	183	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380639 (CHEMBL2017063) Show SMILES COc1cc2CCn3cnc(-c4cnc(C)s4)c3-c2cc1OC Show InChI InChI=1S/C17H17N3O2S/c1-10-18-8-15(23-10)16-17-12-7-14(22-3)13(21-2)6-11(12)4-5-20(17)9-19-16/h6-9H,4-5H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	186	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380647 (CHEMBL2017072) Show SMILES COc1cc2CCn3cnc(C4CCCCC4)c3-c2cc1OC Show InChI InChI=1S/C19H24N2O2/c1-22-16-10-14-8-9-21-12-20-18(13-6-4-3-5-7-13)19(21)15(14)11-17(16)23-2/h10-13H,3-9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	199	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380652 (CHEMBL2017077) Show SMILES COc1ccccc1-c1ncn2CCc3cc(OC)c(OC)cc3-c12 Show InChI InChI=1S/C20H20N2O3/c1-23-16-7-5-4-6-14(16)19-20-15-11-18(25-3)17(24-2)10-13(15)8-9-22(20)12-21-19/h4-7,10-12H,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	212	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380643 (CHEMBL2017067) Show SMILES COc1cc2CCn3cnc(-c4cnc(CN5CCCOCC5)s4)c3-c2cc1OC Show InChI InChI=1S/C22H26N4O3S/c1-27-17-10-15-4-6-26-14-24-21(22(26)16(15)11-18(17)28-2)19-12-23-20(30-19)13-25-5-3-8-29-9-7-25/h10-12,14H,3-9,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	224	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380658 (CHEMBL2017082) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1ccccn1 Show InChI InChI=1S/C18H17N3O2/c1-22-15-9-12-6-8-21-11-20-17(14-5-3-4-7-19-14)18(21)13(12)10-16(15)23-2/h3-5,7,9-11H,6,8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50380632 (CHEMBL2017057) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N(C)C(C)(C)C)c3-c2cc1OC Show InChI InChI=1S/C22H26N4O3S/c1-22(2,3)25(4)21(27)20-23-11-17(30-20)18-19-14-10-16(29-6)15(28-5)9-13(14)7-8-26(19)12-24-18/h9-12H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	243	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380646 (CHEMBL2017071) Show SMILES COc1cc2CCn3cnc(-c4cncn4C)c3-c2cc1OC Show InChI InChI=1S/C17H18N4O2/c1-20-9-18-8-13(20)16-17-12-7-15(23-3)14(22-2)6-11(12)4-5-21(17)10-19-16/h6-10H,4-5H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	264	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50380636 (CHEMBL2017060) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N4CCCOCC4)c3-c2cc1OC Show InChI InChI=1S/C22H24N4O4S/c1-28-16-10-14-4-6-26-13-24-19(20(26)15(14)11-17(16)29-2)18-12-23-21(31-18)22(27)25-5-3-8-30-9-7-25/h10-13H,3-9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	269	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380656 (CHEMBL2017080) Show SMILES CCOc1cccc(c1)-c1ncn2CCc3cc(OC)c(OC)cc3-c12 Show InChI InChI=1S/C21H22N2O3/c1-4-26-16-7-5-6-15(10-16)20-21-17-12-19(25-3)18(24-2)11-14(17)8-9-23(21)13-22-20/h5-7,10-13H,4,8-9H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	277	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380659 (CHEMBL2017083) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1cccnc1 Show InChI InChI=1S/C18H17N3O2/c1-22-15-8-12-5-7-21-11-20-17(13-4-3-6-19-10-13)18(21)14(12)9-16(15)23-2/h3-4,6,8-11H,5,7H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	449	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50380638 (CHEMBL2017062) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)NCc4ccccc4)c3-c2cc1OC Show InChI InChI=1S/C24H22N4O3S/c1-30-18-10-16-8-9-28-14-27-21(22(28)17(16)11-19(18)31-2)20-13-26-24(32-20)23(29)25-12-15-6-4-3-5-7-15/h3-7,10-11,13-14H,8-9,12H2,1-2H3,(H,25,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	507	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380631 (CHEMBL2017070) Show SMILES COc1cc2CCn3cnc(-c4cocn4)c3-c2cc1OC Show InChI InChI=1S/C16H15N3O3/c1-20-13-5-10-3-4-19-8-17-15(12-7-22-9-18-12)16(19)11(10)6-14(13)21-2/h5-9H,3-4H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	508	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380640 (CHEMBL2017064) Show SMILES COc1cc2CCn3cnc(-c4cnc(CO)s4)c3-c2cc1OC Show InChI InChI=1S/C17H17N3O3S/c1-22-12-5-10-3-4-20-9-19-16(14-7-18-15(8-21)24-14)17(20)11(10)6-13(12)23-2/h5-7,9,21H,3-4,8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50380637 (CHEMBL2017061) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)NC4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C22H24N4O4S/c1-28-16-9-13-3-6-26-12-24-19(20(26)15(13)10-17(16)29-2)18-11-23-22(31-18)21(27)25-14-4-7-30-8-5-14/h9-12,14H,3-8H2,1-2H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380633 (CHEMBL2017087) Show SMILES COc1cc2CCn3cnc(-c4cncs4)c3-c2cc1OC Show InChI InChI=1S/C16H15N3O2S/c1-20-12-5-10-3-4-19-8-18-15(14-7-17-9-22-14)16(19)11(10)6-13(12)21-2/h5-9H,3-4H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	555	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50380635 (CHEMBL2017059) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)N4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C21H22N4O4S/c1-27-15-9-13-3-4-25-12-23-18(19(25)14(13)10-16(15)28-2)17-11-22-20(30-17)21(26)24-5-7-29-8-6-24/h9-12H,3-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	613	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE7A1 assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50380649 (CHEMBL2017074) Show SMILES COc1cc2CCn3cnc(c3-c2cc1OC)-c1ccccc1Cl Show InChI InChI=1S/C19H17ClN2O2/c1-23-16-9-12-7-8-22-11-21-18(13-5-3-4-6-15(13)20)19(22)14(12)10-17(16)24-2/h3-6,9-11H,7-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	628	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380662 (CHEMBL2017086) Show SMILES COc1cc2CCn3c(C)nc(c3-c2cc1OC)-c1cccnc1 Show InChI InChI=1S/C19H19N3O2/c1-12-21-18(14-5-4-7-20-11-14)19-15-10-17(24-3)16(23-2)9-13(15)6-8-22(12)19/h4-5,7,9-11H,6,8H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	727	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50380637 (CHEMBL2017061) Show SMILES COc1cc2CCn3cnc(-c4cnc(s4)C(=O)NC4CCOCC4)c3-c2cc1OC Show InChI InChI=1S/C22H24N4O4S/c1-28-16-9-13-3-6-26-12-24-19(20(26)15(13)10-17(16)29-2)18-11-23-22(31-18)21(27)25-14-4-7-30-8-5-14/h9-12,14H,3-8H2,1-2H3,(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	828	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as inhibition of [3H]cAMP hydrolysis by scintillation proximity assay				Bioorg Med Chem Lett 22: 2585-9 (2012) Article DOI: 10.1016/j.bmcl.2012.01.113 BindingDB Entry DOI: 10.7270/Q2319WX5
					More data for this Ligand-Target Pair

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